APPLICATIONS OF TRANSCRIPTOMICS METHODS IN BREAST CANCER by Yeşim Gökmen Polar

“…The integrated genomic/transcriptomic analysis of breast tumors (METABRIC) and the Cancer Genome Atlas (TCGA) with clinical follow-up data shaped the molecular landscape of breast cancer the last decade. …”
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Cutaneous Melanoma with Brain Metastasis: Report of 193 Patients with New Observations. by Alenka Gugger, Raymond L Barnhill, Burkhardt Seifert, Silvia Dehler, Holger Moch, Claire Lugassy, Ewerton Marques-Maggio, Elisabeth J Rushing, Daniela Mihic-Probst

“…<h4>Conclusions</h4>Of special interest in our series is the high incidence of male predominance (79%) in cases of thin metastasing melanoma (14%), implicating genetic or epigenetic (hormonal) gender differences underlying tumour progression. …”
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Population structure, case clusters, and genetic lesions associated with Canadian Salmonella 4,[5],12:i:- isolates. by Clifford G Clark, Ashley K Kearney, Lorelee Tschetter, James Robertson, Frank Pollari, Stephen Parker, Gitanjali Arya, Kim Ziebell, Roger Johnson, John Nash, Celine Nadon

“…Prospective surveillance and WGS of non-human sources and retrospective analysis by WGS of isolates from existing culture collections provides data critical for epidemiological investigations of food- and waterborne outbreaks.…”
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Development of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1). by Shagufta Rehman, Jordan T Gladman, Ammasi Periasamy, Yuansheng Sun, Mani S Mahadevan

“…FRET can be a very sensitive tool to study protein-protein and/or protein-nucleic acids interactions. RNA toxicity is implicated in a number of disorders; especially those associated with expanded repeat sequences, such as myotonic dystrophy. …”
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Predicting Gen Z’s Intention to Stay: The Role of Workplace Fun, Psychological Capital, and Work Engagement by Handwita Mufidawati, Putri Mega Desiana

“…Design/Methods/Approach: Purposive sampling was used in this study. Data were obtained through an online survey distributed cross-sectionally, and 341 Gen Z employees working in Jabodetabek participated. …”
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The CouPSTU and TarPQM transporters in Rhodopseudomonas palustris: redundant, promiscuous uptake systems for lignin-derived aromatic substrates. by Robert C Salmon, Matthew J Cliff, John B Rafferty, David J Kelly

“…RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793), which has previously been implicated in the active transport of this class of aromatic substrate. …”
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Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer by Chuanwei Yang, Xuemei Zhao, Naipeng Cui, Yulong Liang

“…Together with the important role of these SC-TFs in the stem cell regulation, our data provide novel insights into the maintenance of CSCs in TNBC and the discovery of these SC-TFs associated with the alterations of CDH2/4/6/17 has an implication in targeted therapy of TNBC.…”
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Prevalence of Acute Respiratory Infection among Under-five Children in a Rural Area of Mysore District by Likitha Sirigondanahalli Gangadhar, Amogha Shree, Divya Kindiyode Lakshmi Narayanan

“…Materials and methods: A community-based cross-sectional study was conducted over 6 months, from January to June 2023, among 400 children aged 6 months to 5 years in rural Mysuru. Data were collected using the interview method using a semi-structured interviewer-administered proforma. …”
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Intrapersonal day-to-day travel variability and duration of household travel surveys: Moving beyond the one-day convention by Wei Li, Douglas Houston, Marlon G. Boarnet, Han Park

“…Surveys that focus on the modes of walking, biking, and transit should consider data collection for at least seven days.…”
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Wnt pathway activity in breast cancer sub-types and stem-like cells. by Rebecca Lamb, Matthew P Ablett, Katherine Spence, Göran Landberg, Andrew H Sims, Robert B Clarke

“…<h4>Introduction</h4>Wnt signalling has been implicated in stem cell regulation however its role in breast cancer stem cell regulation remains unclear.…”
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New Insights to Investigate the Impact of Internal Control Mechanisms on Firm Performance: A Study in Oman by Tariq Tawfeeq Yousif Alabdullah, Essia Ries Ahmed

“…The present research conducts regression model to show the effect of control mechanisms on market share (M-Share) that represented by firm performance with determining other control variables. We used panel data of Muscat Stock Exchange financial firms over the period 2011-2019. …”
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The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress. by Amanda McGillivray, Nadia Abrahams Golden, Uma Shankar Gautam, Smriti Mehra, Deepak Kaushal

“…Together with the fact that the expression of Rv2745c is strongly induced in response to redox stress, these results strongly implicate a role for ClgR in the management of intraphagosomal redox stress. …”
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Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration. by Passley Hargrove-Grimes, Anupam K Mondal, Jessica Gumerson, Jacob Nellissery, Angel M Aponte, Linn Gieser, Haohua Qian, Robert N Fariss, Juan S Bonifacino, Tiansen Li, Anand Swaroop

“…Using developmental transcriptome data, we identified Rabgef1 (encoding the protein RabGEF1 or Rabex-5) as the only gene associated with Rab GTPases that exhibited strong concordance with retinal photoreceptor differentiation. …”
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New Seaport Development-Prospects and Challenges: Perspectives from Apapa and Calabar Seaports, Nigeria by Adepoju Olusegun Onifade

“…The responses of the stakeholders and shipping companies to the various challenges were collected through a well-structured questionnaire, and the 2008–2017 cargo throughputs of the selected seaports were used as the secondary data for stochastic frontier analysis (SFA). It was discovered that the challenges associated with the Calabar Seaport were the draught level, cost of shipment, accessibility to industries, and condition of other modes of transport. …”
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MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms. by Digna R Velez Edwards, Alessandra Tacconelli, Christian Wejse, Philip C Hill, Gerard A J Morris, Todd L Edwards, John R Gilbert, Jamie L Myers, Yo Son Park, Martin E Stryjewski, Eduardo Abbate, Rosa Estevan, Paulo Rabna, Giuseppe Novelli, Carol D Hamilton, Richard Adegbola, Lars Østergaar, Scott M Williams, William K Scott, Giorgio Sirugo

“…One interaction between rs2857656 and IL12B SNP rs2288831 was observed among Africans but the effect was in the opposite direction in Guineans (OR = 1.90, p = 0.001) and Gambians (OR = 0.64, p = 0.024). Our data indicate that the effect of genetic variation within MCP1 is not clear cut and additional studies will be needed to elucidate its role in TB susceptibility.…”
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Association Between Smoking and Androgenetic Alopecia: A Cross-Sectional Analysis of Severity and Dose-Response Relationship in Adult Males by Nasira Nasr, Umaima Afzal, Karishma Mushtaq

“…Several factors have been implicated in its pathogenesis, including smoking, which induces oxidative stress that potentially affects the hair follicle health. …”
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RESPON PERTUMBUHAN DAN HASIL TANAMAN JAGUNG (Zea mays L.) DI TANAH PASIRAN AKIBAT PEMBERIAN PUPUK UREA BERPELAPIS BIOCHAR by Slamet Supriyadi, Fahmi Arief Rahma, Siti Erika

“…The experiment was arranged in a Non-Factorial Completely Randomized Design (CRD) with 6 treatments, which were: P0, P1, P2, P3, P4, dan P5. Data were analyzed using ANOVA at 5%, followed by Duncan’s Multiple Range Test (DMRT) at 5% to determine the best treatment. …”
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Effects of the Interaction Between Oxidative Balance Score and Polygenic Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean Adults by Minyeong Kim, Dayeon Shin

“…Oxidative stress is implicated in insulin resistance, obesity, and metabolic syndromes (MetSs). …”
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Regulation of androgen receptor variants in prostate cancer by Yezi Zhu, Jun Luo

“…Given the important clinical implication of AR-Vs, this short review will focus on studies addressing how AR-Vs are regulated in prostate cancer. …”
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The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. by Anna L Chambers, Peter M Brownlee, Samuel C Durley, Tracey Beacham, Nicholas A Kent, Jessica A Downs

“…The RSC chromatin remodeling complex has been implicated in contributing to DNA double-strand break (DSB) repair in a number of studies. …”
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