Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics by Kenneth K. Y. Ho, Johanna M. Buschhaus, Anne Zhang, Alyssa C. Cutter, Brock A. Humphries, Gary D. Luker

“…In addition to increased CXCR4 expression, a stiff ECM also increases basal activation of Akt and ERK as well as signaling through these kinases in response to CXCL12-α and EGF and promotes migration of triple negative breast cancer (TNBC) cells. These data implicate receptor dynamics as a key mediator of Akt and ERK signaling as a mechanism for adverse effects of enhanced ECM stiffness on disease progression in TNBC.…”
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Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry by Eirini Chatzopoulou, Galinos Fanourakis, Nikolaos Papanikolaou, Ioulia Chatzistamou, Xanthippi Dereka, Heleni Vastardis

“…Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. …”
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A map of human protein interactions derived from co‐expression of human mRNAs and their orthologs by Arun K Ramani, Zhihua Li, G Traver Hart, Mark W Carlson, Daniel R Boutz, Edward M Marcotte

“…We further validate uncharacterized proteins implicated by the associations in ribosome biogenesis, including WBSCR20C, associated with Williams–Beuren syndrome. …”
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Integrated single-cell analysis reveals heterogeneity and therapeutic insights in osteosarcoma by Dongan He, Xiaoqian Che, Haiming Zhang, Jiandong Guo, Lei Cai, Jian Li, Jinxi Zhang, Xin Jin, Jianfeng Wang

“…Integration of copy number variation (CNV) data highlighted genomic alterations in osteoblastic and chondroblastic cells, implicating potential therapeutic targets. …”
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The Role of <i>Blastocystis</i> spp. in the Etiology of Gastrointestinal and Autoimmune Diseases by Oliwia Pawelec-Pęciak, Natalia Łanocha-Arendarczyk, Konrad Grzeszczak, Danuta Kosik-Bogacka

“…This study aimed to present current data on the impact of <i>Blastocystis</i> spp. on the development and progression of gastrointestinal and autoimmune diseases, as well as to explore potential treatment options for <i>Blastocystis</i> spp. infections. …”
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Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder. by René A W Frank, Allan F McRae, Andrew J Pocklington, Louie N van de Lagemaat, Pau Navarro, Mike D R Croning, Noboru H Komiyama, Sophie J Bradley, R A John Challiss, J Douglas Armstrong, Robert D Finn, Mary P Malloy, Alan W MacLean, Sarah E Harris, John M Starr, Sanjeev S Bhaskar, Eleanor K Howard, Sarah E Hunt, Alison J Coffey, Venkatesh Ranganath, Panos Deloukas, Jane Rogers, Walter J Muir, Ian J Deary, Douglas H Blackwood, Peter M Visscher, Seth G N Grant

“…Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. …”
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Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients: Alteration of the PPARγ-Dependent Pathways by Martine Caron, Corinne Vigouroux, Jean-Philippe Bastard, Jacqueline Capeau

“…Treatment of patients with agonists of PPARγ could improve, at least partially, the subcutaneous lipoatrophy. These data indicate that decreased PPARγ expression and PPARγ-related function, resulting from ART-induced adipose tissue toxicity, play a central role in HIV-related lipoatrophy and metabolic consequences.…”
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Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity by Mohammed R. Shaker, Salam Salloum-Asfar, Rowaida Z. Taha, Ibrahim Javed, Ernst J. Wolvetang

“…Abstract Klotho, a well-known aging suppressor protein, has been implicated in neuroprotection and the regulation of neuronal senescence. …”
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Influence of Fever and Hospital-Acquired Infection on the Incidence of Delayed Neurological Deficit and Poor Outcome after Aneurysmal Subarachnoid Hemorrhage by G. Logan Douds, Bi Tadzong, Akash D. Agarwal, Satish Krishnamurthy, Erik B. Lehman, Kevin M. Cockroft

“…Although fever and infection have been implicated in the causation of delayed neurological deficits (DND) and poor outcome after aneurysmal subarachnoid hemorrhage (SAH), the relationship between these two often related events has not been extensively studied. …”
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How the Merdeka Curriculum Enhances the Pancasila Student Profile in Education by Dwi Rahmad Julianto, Ali Mustadi, Anwar Senen, Ujang Sugara

“…The population consisted of all IPAS Learning Outcomes for phases A, B, and C at the elementary school level, while the sample included IPAS knowledge Learning Outcomes linked to the six dimensions of the Pancasila Student Profile. Data were analyzed using content analysis techniques on both the IPAS Learning Outcomes document and the Pancasila Student Profile strengthening project guidelines. …”
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NUTRITIONALLY VARIANT STREPTOCOCCI BACTEREMIA IN CANCER PATIENTS: A RETROSPECTIVE STUDY, 1999-2014 by Abraham Tareq Yacoub, Jayasree Krishnan, Ileana M. Acevedo, Joseph Halliday, John Norman Greene

“…Backgound Nutritionally variant Streptococci (NVS), Abiotrophia and Granulicatella are implicated in causing endocarditis and blood stream infections more frequently than other sites of infection. …”
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There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients by Mariana Nogueira Coutinho, Aluizio Barbosa Carvalho, Maria Aparecida Dalboni, Margaret Gori Mouro, Elisa Mieko Suemitsu Higa, Valéria Costa-Hong, Luiz Aparecido Bortolotto, Rejane Augusta de Oliveira Figueiredo, Maria Eugênia Fernandes Canziani

“…Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. …”
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Neonatal delirium: fact or fiction? A study protocol of a prospective, observational study at the Neonatal Intensive Care Unit (NICU) by Richel Lousberg, Kim AM Tijssen, Husam KZ Salamah, Kelly MP Hauman, Danilo AWD Gavilanes-Jimenez, Jan NM Schieveld, Jacqueline JMH Strik

“…However, although the METC waived the need for approval, informed consent will be collected for consent for publication of the collected data.…”
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A potential tumor suppressor role of PLK2 in glioblastoma by Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao

“…Polo‐like kinase 2 (PLK2), a member of the polo‐like kinase family, has been variably implicated in cancer, but its role in GBM has not been fully elucidated. …”
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Dopamine Treatment and Cognitive Functioning in Individuals with Parkinson’s Disease: The “Cognitive Flexibility” Hypothesis Seems to Work by Alberto Costa, Antonella Peppe, Ilenia Mazzù, Mariachiara Longarzo, Carlo Caltagirone, Giovanni A. Carlesimo

“…Background. Previous data suggest that (i) dopamine modulates the ability to implement nonroutine schemata and update operations (flexibility processes) and that (ii) dopamine-related improvement may be related to baseline dopamine levels in target pathways (inverted U-shaped hypothesis). …”
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Internal Initiative vs External Pressure: Evidence from Halal Standard Adoption in Indonesian Food Small and Medium Industries (SMIs) by Nilda Tri Putri, Meuthia Meuthia, Ikhsan Rapi Saputra, Rini Rahmahdian S, Iwan Vanany, Norhayati Zakuan

“…Results also exhibited that HFS adoption and traceability systems had a significant implication for compliance with HAS. The limitation lies in variables related to halal food standard adoption factors. …”
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Can Ecosystem Transformations by Non-Indigenous Mussel Introductions Inform Shellfish Reef Restoration? by Alan Cottingham, Rachel Newsome, Chris Gillies, James R. Tweedley

“…Due to the lack of long-term data on the ecological impact of restored mussel reefs, information to assist restoration practitioners in identifying potential positive and negative outcomes is limited. …”
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Targeting Drug Resistance in Cancer: Dimethoxycurcumin as a Functional Antioxidant Targeting ABCC3 by Jochem Nelen, Valeria Naponelli, José Manuel Villalgordo-Soto, Marco Falasca, Horacio Pérez-Sánchez

“…These results suggest that dimethoxycurcumin may sensitize cancer cells to chemotherapy by targeting resistance pathways. The data presented contribute to the growing body of evidence suggesting that bioactive plant-derived compounds, including chemically modified derivatives, may hold therapeutic potential in oncology by modulating multidrug resistance pathways. …”
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CRISPR-Cas9 screening identifies a gene signature predictive of prognosis in glioblastoma by Xing Ren, Xiang-rong Yao, Kun Chen, Wen-tao Xiao, Jun-yan He

“…In this study, genome-wide CRISPR-Cas9 screening data from the dependency map (DepMap) database were analyzed to explore proliferation-related essential genes and pathways in GBM. …”
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Model Pembelajaran Self Organized Learning Environment (SOLE) Terhadap Berpikir Kritis Peserta Didik Kelas V Sekolah Dasar by Yuli Yanti, Elisa Siswanto, Chairul Amriyah

“…This research sample consisted of two classes, namely the control class which received conventional learning and the experimental class which received learning using the Self Organized Learning Environment (SOLE) model. Data was collected through previously validated critical thinking test instruments. …”
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