Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer by Yongzhi Wu, Chengen Deng, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Weizhong Tang, Xiaoliang Huang

“…Furthermore, using transcriptome data from 23 CRC patients, we constructed an immune cell infiltration matrix to deeply explore the biological functions associated with LNM. …”
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Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice by Lingyan Fei, Honghong Wang, Dongliang Zhao, Xiaohua Wang, Jizhen Ren, Lanyun Liu, Chun Tang, Yan Lei, Qingqing Wang, Yuanpeng Nie, Yang Liu, Na Li, Ming Zhong, Nan Xu, Jin Wei, Pontus B. Persson, Andraes Patzak, Pratik H. Khedkar, Zhihua Zheng, Shan Jiang

“…Up to 33.6% of solid organ transplantation patients receiving Tac treatment develop hyperglycemia; however, the underlying mechanisms remain poorly understood. …”
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XBB.1.5 COVID-19 mRNA Vaccines Induce Inadequate Mucosal Immunity in Patients with Inflammatory Bowel Disease by Simon Woelfel, Joel Dütschler, Daniel Junker, Marius König, Georg Leinenkugel, Claudia Krieger, Samuel Truniger, Annett Franke, Seraina Koller, Katline Metzger-Peter, Nicola Frei, STAR SIGN Study Investigators, Werner C. Albrich, Matthias Friedrich, Jan Hendrik Niess, Nicole Schneiderhan-Marra, Alex Dulovic, Wolfgang Korte, Justus J. Bürgi, Stephan Brand

“…In this sub-investigation of the ongoing STAR-SIGN study, we present the first analysis of mucosal immunity elicited by XBB.1.5 mRNA vaccines in immunocompromised patients with IBD. …”
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Global Burden of Oral Diseases in Adolescents and Young Adults Aged 10–24 Years by Wei Lu, Bing Wang, Mi Du, Shaohua Ge

“…Objectives: This study aims to analyse global trends in the burden of oral diseases, including dental caries and noncarious oral diseases (NCODs), in individuals aged 10 to 24 from 1990 to 2021 and project future trends up to 2050. Methods: Using data from the Global Burden of Disease Study (GBD) 2021, this trend analysis examines the number, age-standardised rates (ASRs), and average annual percentage changes (AAPCs) in prevalence, incidence, and disability-adjusted life years for oral diseases across different age groups, sexes, social-development index (SDI) levels, regions, and nations. …”
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CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study by Cecilia T Costiniuk, Jean-Pierre Routy, Shari Margolese, Enrico Mandarino, Joel Singer, Mohammad-Ali Jenabian, Mario Ostrowski, Jonathan B Angel, Ann Burchell, Darrell Tan, Colin Kovacs, Mark Hull, Mark Brockman, Sharon Walmsley, Aslam H Anis, Marianne Harris, Curtis Cooper, Marc-André Langlois, Iva Kulic, Judy Needham, Zabrina Brumme

“…Additional research is necessary to inform COVID-19 vaccine use in PLWH.Methods and analysis This multicentred observational Canadian cohort study will enrol 400 PLWH aged >16 years from Montreal, Ottawa, Toronto and Vancouver. …”
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Somatization symptoms and burnout: a correlational study among emergency nurses by Ningxiang Li, Ningxiang Li, Ningxiang Li, Nan Xie, Nan Xie, Nan Xie, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Hao Zhang, Hao Zhang, Hao Zhang, Luying Zhong, Luying Zhong, Luying Zhong, Dongmei Diao, Dongmei Diao, Dongmei Diao, Ling Zhu, Ling Zhu, Ling Zhu, Yue Zhou, Yue Zhou, Yue Zhou

“…These measures would support the healthy development of emergency nurses. Furthermore, nurses should prioritize self-care by engaging in activities such as psychological interventions, positive thinking training, and yoga to reduce burnout and enhance overall health.…”
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The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores by Ana Beatriz Ravagnani Salto, Giovanni A. Salum, Maurício Scopel Hoffmann, Marcos L. Santoro, André Zugman, Pedro M. Pan, Sintia I. Belangero, Lucas Toshio Ito, Victoria Fogaça Doretto, Marcos S. Croci, Marcelo J. A. A. Brañas, Carina deGiusti, Francisco Da Silva‐Jr, Sahâmia Martins Ribeiro, Euripedes Constantino Miguel, James F. Leckman

“…Abstract Background Understanding the factors that determine distinct courses of anxiety symptoms throughout development will better guide interventions. There are scarce data‐driven longitudinal studies, using multi‐modal predictors, investigating the chronicity of anxiety symptoms from childhood to young adulthood, particularly in a middle‐income country. …”
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Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospectiv... by Pei-xin Tan, Lin-xin Wu, Shuang Ma, Shi-jing Wei, Tai-hang Wang, Bing-chen Wang, Bing-bing Fu, Jia-shuo Yang, Qing Zhao, Qing Zhao, Li Sun, Yi Liu, Tao Yan

“…Least absolute shrinkage and selection operator (LASSO) regression in combination with multivariate Cox and logistic regression were employed to identify the main impact indicators of relapse-free survival (RFS) and depression. The developed predictive model was evaluated using calibration plots, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). …”
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Isolation and possibility of vertical transmission of G9P[23] and G12P[7] group A rotavirus strains in pigs by Yang Li, Chunliu Gao, Lili Wu, Jie Qing, Minxia Zhang, Mengli Qiao, Zhiqiang Hu, Bingzhou Zhang, Chen Yang, Zewei Wang, Lulu Li, Zheng Yan, Weisheng Wu, Wei Liu, Jing Ren, Xiaowen Li

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Mental illness-related stigma and its associated factors among primary health care professionals in rural China by Yi-Yue Yang, Yi-Yue Yang, Cong Wang, Cong Wang, Jia Cai, Jia Cai, Yun-Fei Mu, Yun-Fei Mu, Lie Zhou, Lie Zhou, Yi-Zhou Wang, Tian-Ming Zhang, Xin-Yi Zhao, Ming Li, Wei Luo, Jian-Jun Luo, Yin-Ling IreneWong, Lawrence H. Yang, Siu-Man Ng, Mao-Sheng Ran, Mao-Sheng Ran

“…The results of this study are crucial for development of anti-stigma intervention among PHCPs in rural communities.…”
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Optimizing treatment for depression in primary care using psychotherapy versus antidepressant medication in a low-resource setting: protocol for the OptimizeD randomized controlled... by Julia R. Pozuelo, Anuja Lahiri, Rahul S. P. Singh, Arvind Kushwah, Mimansa Khanduri, Akanksha Shukla, Azaz Khan, Sruthi G., Varun Shende, Yashika Parashar, Yashwant K. Mehra, Anant Bhan, Ronald C. Kessler, Daisy R. Singla, John A. Naslund, Karmel W. Choi, Pim Cuijpers, Robert DeRubeis, Mohammad M. Herzallah, Chunling Lu, Jordan W. Smoller, Tyler J. VanderWeele, Abhijit R. Rozatkar, Tamonud Modak, Michelle Melwyn Joel, Debasis Biswas, Shubham Atal, Umay Kulsum, Steven D. Hollon, Vikram Patel

“…Using machine learning, we will attempt to develop a precision treatment rule that leverages baseline clinical, psychological, cognitive, socioeconomic, and biological data to predict which treatment is most likely to achieve remission for each patient. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…However, markedly downregulation of the mRNA level of pro-inflammatory cytokine il-1β (p < 0.05) was observed in 0.05 and 0.3T23 groups, compared with the control. 16S rRNA sequencing analysis data on gut microbiota indicated that supplementation of T23 at lower levels (0.05, 0.1 and 0.2) resulted in a remarkable elevation of the abundance of phylum Firmicutes and reduced the abundance of Proteobacteria, and the ratio of (Firmicutes +Bacteroidota +Fusobacteria) /Proteobacteria. …”
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Prognostic Implications of Initial Radiological Findings of Pulmonary Fibrosis in Patients with Acute SARS-CoV-2 Infection: A Prospective Multicentric Study by Roxana-Elena Cîrjaliu, Sri Vidhya Gurrala, Balaji Nallapati, Vamsi Krishna, Cristian Oancea, Emanuela Tudorache, Monica Marc, Felix Bratosin, Iulia Bogdan, Ovidiu Rosca, Paula Irina Barata, Laurentiu Tony Hangan, Sergiu Ioachim Chirilă, Ariadna-Petronela Fildan

“…Biochemical analyses, severity scores (SOFA, APACHE II, NEWS 2), and novel compound scores combining clinical and radiological data were assessed. Patients with HRCT evidence of pulmonary fibrosis had significantly higher severity scores and worse clinical outcomes. …”
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Association between anion gap and postoperative delirium in patients undergoing open heart surgery by Jun Wang, Hui Zhong, Lu Chen, Hong-Chun Ding, Zhong-Jie Lu, Bin-Su Wang, Shun-Bi Liu, Jing Luo, Li-Wen Hou, Li-Wen Hou, Yuan-Zhang Liu, Sheng Ding, Feng Gao, Li Jiang

“…ICU LOS may proportionally mediate the impact of AG on POD development.…”
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Evaluating an intervention to promote access to mental healthcare for low language proficient migrants and refugees across Europe (MentalHealth4All): study protocol for a pretest–p... by Fang Wang, Mike Mösko, Demi Krystallidou, Yuhui Chen, Liza G G van Lent, Saskia Hanft-Robert, Ilaria Galasso, Barbara Schouten, Antoon Cox, Sona Hodakova, Chiara Rao, Koen Kerremans, Raquel Lázaro Gutiérrez, Özlem Temizöz, Dalia Mankauskienė, Łucja Biel, Emilio Di Maria, Julia van Weert, Melanie de Looper, Gian Hernandez, Gaukhar Orkashbayeva, Tobias Kleineidam, Angeliki Tsoukaneli, Mehmet Uygun, Ily Hollebeke, Beatrice Bünsch, Leon Köchel, Mia Mengtong Li, Mara Morelli, Stefania Muzi, Cecilia Serena Pace, Carlotta Gualco, Nijolė Maskaliūnienė, Katarzyna Czarnocka-Gołębiewska, Urszula Okulska-Łukawska, Argnieszka Biernacka, Aleksandra Kalata-Zawłocka, Agnieszka Słopień, Natalia Pytlińska, Monika Šavelová, Andrej Birčák, Daniela Müglová, Carmen Valero Garcés, Carmen Pena Díaz, Elena Alcalde Peñalver, Cristina Álvaro Aranda, Silvia Damianova Radeva, Sabine Braun, Jaleh Delfani, Graham Hieke, Elena Davitti, Constantin Orasan, Lieven Buysse

“…Secondary outcomes (measured at T2) are: actual usage of the platform (ie, tracking data), perceived ease of use, usefulness of content, comprehensibility of information, attractiveness of content and emotional support. …”
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Virtual reality navigation for the early detection of Alzheimer’s disease by Sayuri Shima, Reiko Ohdake, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike, Atsushi Kasai, Epifanio Bagarinao, Epifanio Bagarinao, Kazuya Kawabata, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Junichi Hata, Shinsuke Ishigaki, Junichiro Yoshimoto, Hiroshi Toyama, Takahiko Tokuda, Akihiko Takashima, Hirohisa Watanabe, Hirohisa Watanabe

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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Total body water through dilution analysis of deuterated water. Other data observations: Changes in physical activity from baseline to 2, 6 and 12 months. …”
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Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma by Jie Sun, Xuewei Wu, Xiao Zhang, Weiyuan Huang, Xi Zhong, Xueyan Li, Kaiming Xue, Shuyi Liu, Xianjie Chen, Wenzhu Li, Xin Liu, Hui Shen, Jingjing You, Wenle He, Zhe Jin, Lijuan Yu, Yuange Li, Shuixing Zhang, Bin Zhang

“…A combined model was constructed by integrating clinical and radiomic data. A radiomic interpretability study was performed with whole slide images (WSIs) stained with hematoxylin and eosin (H&E) and immunohistochemistry (IHC). …”
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CARI Guideline: Evidence-Based Recommendations for Balanced Electrolyte Solutions to Improve Kidney Transplant Outcomes by Colm O’Reilly, David Tunnicliffe, Allan Blackley, Michael Collins, Emmy O’Neill, Siah Kim, Karthik Venkataraman, Emily See, Ross Francis

“…This guideline seeks to synthesize the available evidence and make recommendations for the Australian and New Zealand care by a multidisciplinary working group, including consumers with lived experience of kidney transplantation.A recently published systematic review and meta-analysis of randomized controlled trials (RCTs), including data from the BEST Fluids trial, evaluating balanced electrolyte solutions versus normal saline in kidney transplants was identified and absolute effects were determined using baseline risks of SONG Transplant Core outcomes from either national registries or event rates in the control arms of the included trials. …”
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Factors influencing extrauterine growth retardation in singleton-non-small for gestational age infants in China: A prospective multicenter study by Ya-Sen Wang, Wei Shen, Fan Wu, Jian Mao, Ling Liu, Yan-Mei Chang, Rong Zhang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Zhi Zheng, Xin-Zhu Lin, Xiao-Mei Tong

“…Logistic regression analysis indicated that later addition of human milk fortifier (HMF), later attainment of HMF sufficient fortification, later return to BW, more accumulative days of fasting, longer duration of parenteral nutrition, total duration of oxygen support and moderate/severe bronchopulmonary dysplasia (BPD) were risk factors for the development of EUGR in singleton-non-SGA VPIs (P < 0.001, P = 0.002, P < 0.001, P = 0.002, P = 0.017, P = 0.003 and P = 0.002, respectively). …”
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