Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…Despite this, the archaeological literature has attempted, on the basis of the few diagnostic elements available, to reconstruct the history of the city’s water management system and its evolution in the context of the site’s urban development. This study pursues this line of research, re-examining its phases and proposals through a wide-ranging analysis of the issues tackled, but above all by proposing a new and systematic approach to the subject, from which it has been possible to take stock of some elements and to verify or arrive at new conclusions on others.While the bibliography concerning certain aspects of Pompeii’s water management is rich, dedicated and in some cases quite comprehensive, regarding which this research has demonstrated the limits of a generic approach absent excavation work, on other topics by contrast the study presented here provided an opportunity for the first time to deepen our knowledge of issues and artefacts and the possibility of bringing together the various topics.With regard to the water supply to the Archaic and Hellenistic city, therefore, it was possible to identify an integrated system of supply to the entire urban space, consisting of catchment wells and cisterns for recovering rainwater from the roofs. …”
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Mapping barriers, enablers and implementation determinants to shared models of care for physical health and sexual wellbeing among young people with mental health difficulties usin... by Allyson J Gallant, Karen O'Connor, John Paul Lyne, Donal O'Keeffe, Shaakya Anand-Vembar, Yulia Kartalova- O'Doherty, Caroline Wilson, Agnes Higgins, Mary Cannon, Greg Sheaf, Louise Doyle, Rebecca Murphy, David McEvoy, Leona Ryan, Olivia Longe, David Cotter, Sara Burke, Colm McDonald, Gary Donohoe, Catherine D Darker

“…Two independent reviewers will screen titles, abstracts and full texts, followed by data extraction and critical appraisal of included studies. …”
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Deep learning radiomics of elastography for diagnosing compensated advanced chronic liver disease: an international multicenter study by Xue Lu, Haoyan Zhang, Hidekatsu Kuroda, Matteo Garcovich, Victor de Ledinghen, Ivica Grgurević, Runze Linghu, Hong Ding, Jiandong Chang, Min Wu, Cheng Feng, Xinping Ren, Changzhu Liu, Tao Song, Fankun Meng, Yao Zhang, Ye Fang, Sumei Ma, Jinfen Wang, Xiaolong Qi, Jie Tian, Xin Yang, Jie Ren, Ping Liang, Kun Wang

“…Abstract Accurate, noninvasive diagnosis of compensated advanced chronic liver disease (cACLD) is essential for effective clinical management but remains challenging. This study aimed to develop a deep learning-based radiomics model using international multicenter data and to evaluate its performance by comparing it to the two-dimensional shear wave elastography (2D-SWE) cut-off method covering multiple countries or regions, etiologies, and ultrasound device manufacturers. …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

“…By performing integrated bioinformatic analysis of snRNA‐seq data from neonatal and adult hearts, this study identified Hnrnpa1 as a potential RBP regulating CM DACCA. …”
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CarotidSCORE.RU — risk stratification for complications after carotid endarterectomy by A. N. Kazantsev, D. D. Khasanova, A. D. Alpatskaya, A. V. Korotkikh, M. O. Dzhanelidze, M. A. Rusakova, E. U. Kharchilava, M. V. Sulimenko, V. A. Lutsenko, R. V. Sultanov, F. R. Alizada, E. O. Meleshin, E. R. Ginzburg, A. E. Gofman, E. O. Alekseeva, R. Yu. Lider, A. A. Pivovarov, A. B. Zakeryaev, G. Sh. Bagdavadze, M. M. Makoeva, A. I. Klimova, A. S. Zharova, I. A. Chernyavtsev, O. O. Abramov, K. L. Zakharova, I. M. Radzhabov, I. A. Karmokov, A. P. Kuklev, K. N. Solotenkova, M. G. Pachkoria, I. S. Sem’in, A. A. Kostenkov, K. P. Chernykh

“…The present study is based on the analysis of a multicenter Russian database including 25812 patients after CE operated on from January 1, 2010 to April 1, 2022. …”
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Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota by Cheng Wang, Siyu Wei, Bojing Liu, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang

“…These findings provide the first data revealing that an MFD drives neonate gut microbiota development and ameliorates the colonic inflammation by regulating the gut microbiota. …”
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Rare damaging variants in the sex differences of congenital heart disease: an exome sequencing studyResearch in context by Hairui Sun, Xiaoyan Hao, Hankui Liu, Siyao Zhang, Jiancheng Han, Ye Zhang, Tingting Liu, Xian Yang, Hairui Wang, Jiaqi Fan, Yuxuan Guan, Ni Peng, Jiaoyang Xie, Hongmei Xia, Xueqin Ji, Yan Xu, Jianguo Zhang, Jianbin Wang, Feng Lan, Hongjia Zhang, Xiaoyan Gu, Yihua He

“…Functional enrichment analysis was conducted to assess functional differences in genetic variants between sexes. …”
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Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial by Mark Howard, Wendyl D’Souza, Emma Foster, Patrick Carney, Zanfina Ademi, Patrick Kwan, David N Vaughan, James Lee, Clare Stapleton, Zongyuan Ge, Zhibin Chen, Natasha A Lannin, Udaya Seneviratne, Robert Sparrow, Piero Perucca, Armin Nikpour, Chong Wong, John-Paul Nicolo, Michelle Kiley, Terence O’Brien, Jacqui-Lyn Saw, Dean Jones, David Reutens, Sandra Reeder, Richard Shek-kwan Chang, Ernest Somerville, Tania Farrar, Daniel Thom, Lata Vadlamudi

“…Introduction Selection of antiseizure medications (ASMs) for newly diagnosed epilepsy remains largely a trial-and-error process. We have developed a machine learning (ML) model using retrospective data collected from five international cohorts that predicts response to different ASMs as the initial treatment for individual adults with new-onset epilepsy. …”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy. Methods RNA-seq data and immunofluorescence analysis of relapsed NSCLC patient samples were used to explore ROR1 expression. …”
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Prospective observational study to assess the performance accuracy of clinical decision rules in children presenting to emergency departments with possible cervical spine injuries:... by Franz E Babl, Simon Craig, Susan M Donath, Meredith L Borland, Natalie Phillips, Amit Kochar, Gavin A Davis, Shane George, Stuart Dalziel, Arjun Rao, Nathan Kuppermann, Stacy Goergen, Sarah Watson, Amanda Williams, Eunicia Tan, Catherine L Wilson, Michelle Davison, Blessy John-Denny, Sonia Singh, Sharon O’Brien, Geoffrey N Askin, Chris J Selman, Julie C Leonard

“…Data will be collected on presenting features (history, injury mechanism, physical examination findings) and management (diagnostic imaging, admission, interventions, outcomes). …”
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Echocardiographic Tissue Characterization Using Radiomics in Patients With Transthyretin-Related Cardiac Amyloidosis by Sara Mori, MD, Noemi Montobbio, MSc, Maria Pia. Sormani, MSc, PhD, Cristina Campi, MSc, PhD, Carlotta Mazzoni, MD, Alessia Argirò, MD, PhD, Giulia Elena Mandoli, MD, Francesca Rubina Ginetti, MD, Margherita Zanoletti, MD, Pier Filippo Vianello, MD, Valeria Rella, MD, Lia Crotti, MD, PhD, Michele Piana, MSc, PhD, Matteo Cameli, MD, PhD, Francesco Cappelli, MD, PhD, Italo Porto, MD, PhD, Luigi Paolo Badano, MD, PhD, Marco Canepa, MD, PhD

“…Objectives: This study aimed to develop a radiomic model for characterizing ATTR-infiltrated myocardium via echocardiography. …”
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Failure Risk Investigation of Transmission Tower-line System Under Sequential Earthquake Considering Input Directionality by LIU Juncai, DONG You

“…A substantial amount of historical seismic data has indicated that ground motion generally occurs in the form of sequences, with randomness and multi-dimensional characteristics. …”
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Identification and pathogenicity of Colletotrichum species associated with Guanximiyou pomelo anthracnose by DAI Ruiqing, ZENG Tianbao, CHEN Shumei, PAN Yonghong, HE Yunyan, LAI Baochun

“…In the edge, tip or middle of damaged leaves develop brown spots, which form a “V” shape then withering and falling off after the diseased leaves die. …”
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Investigating the preliminary adaptation of plants to different levels of salinity (Case study: Dust hotspot No 4, Khuzestan) by Maasoumeh Movaghari, bijan khalili moghadam, Leila Khalasi Ahvazi, Ashkan Yousefi, Amin Zorati Pour, Masoumeh Forouzani, seyed ata Siadat, zeinab Hazbavi, Mohammad Hossein Salehe Shooshtari

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Landscapes of Trade by Merten Nefs

“…It analyses how spatial decisions are made in the actor-institutional dynamics behind the planning and development of DCs, through in-depth interviews and document analysis. …”
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Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day by A. A. Vilnits, Yu. V. Lobzin, N. V. Skripchenko, L. N. Mazankova, O. I. Klimova, A. Yu. Rtishchev, I. M. Osmanov, K. V. Markova, N. H. Tkhakushinova, G. P. Martinova, A. U. Sabitov, R. K. Babik, I. Ya. Izvekova, V. V. Krasnov, E. V. Sidorenkova, O. V. Borisova, N. M. Bochkareva, O. V. Samodova, V. V. Sokolovskaya, A. A. Girina, A. Yu. Kurganskaya, E. M. Simovanyan, M. A. Kim, O. A. Rychkova, L. V. Khanipova, S. G. Grigorev

“…The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality in invasive forms of the disease, but also with severe consequences in survivors, who are not recorded in our country.The aim of study: to analyze clinical manifestations, complications of the acute period and outcomes of invasive forms of meningococcal disease in children in various regions of the Russian Federation.Materials and methods: an analysis of data from 1327 inpatient medical records of children with an invasive meningococcal infection from 14 regional centers of the Russian Federation for 2012-2021 was carried out (28.3% of cases of the disease in children in the represented federal districts).Results: it was found that young children predominated among the patients – the median was 27.4 (10.7-70.4) months. …”
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Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease by Da-Ya Zhang, Da Li, Shi-Ju Chen, Li-Jun Zhang, Xu-Li Zhu, Fa-Di Chen, Chen Chen, Qi Wang, Yiping Du, Jian-Xin Xiong, Shi-Mei Huang, Xiao-Dong Zhang, Yan-Ting Lv, Fan Zeng, Run-Xiang Chen, Xianfeng Huang, Fengjiao Mao, Shuo Zhou, Qicen Yao, Yuliang Huang, Runyu Chen, Ying Mo, Yunqian Xie, Yue-Hong Jiang, Zhai Chen, Cui-Yi Mo, Jia-Jia Chen, Fei-Hu Bai

“…MAFLD was characterized by marked disruptions in fatty acid and amino acid metabolism. Combined analysis of metabolomic and metagenomic data achieved high diagnostic accuracy for MAFLD and hepatic steatosis severity (AUC = 0.93). …”
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Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum by Endrit Shahini, Donatello Marziliano, Francesco Losito, Marianna Zappimbulso, Elisabetta Cavalcanti, Raffaele Armentano, Fabio Fucilli, Raffaele Cozzolongo, Giuseppe Ingravallo, Fabrizio Pappagallo, Roberta Iatta, Vanessa Desantis, Annalisa Saracino, Angelo Vacca, Antonio Giovanni Solimando

“…This finding triggered a re-evaluation of the ulcerated skin lesion, and histological analysis confirmed concurrent cutaneous leishmaniasis. …”
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Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia by Xiaowei Zheng, Wenyang Han, Yiqun Li, Minglan Jiang, Xiao Ren, Pinni Yang, Yiming Jia, Lulu Sun, Ruirui Wang, Mengyao Shi, Zhengbao Zhu, Yonghong Zhang

“…Methods This study used data of two prospective cohorts: UK Biobank and China Health and Retirement Longitudinal Study (CHARLS) with two measurements of eGDR. …”
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‘It’s the perfect storm’: why are people with eating disorders at risk of suicide? A qualitative study by Una Foye, Saakshi Kakar, Niamh McNamara, Agnieszka Musial, Tom Jewell, Jessica R. Griffiths, Carol Kan, Gerome Breen, Rachel Rowan Olive, T. Suratwala, Aman Sidhu, Lizzie Mitchell, George Mycock, Katie Graden, Saskia Evans Perks, Elia Chitwa, Holly Whitehead, Ulrike Schmidt, Rina Dutta, Moritz Herle

“…We used a multi-perspective reflexive thematic analysis to code the data and generate the themes. …”
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