Current experience and future potential of facilitating access to digital NHS primary care services in England: the Di-Facto mixed-methods study by Gary Abel, Helen Atherton, Jon Sussex, Nurunnahar Akter, Abodunrin Q Aminu, Wiktoria Bak, Carol Bryce, Christopher E Clark, Emma Cockcroft, Hamish Evans, Evangelos Gkousis, Georgia Jenkins, Caroline Jenkinson, Nada Khan, Jeffrey Lambert, Brandi Leach, Christine Marriott, Jennifer Newbould, Sarah Parkinson, Jo Parsons, Emma Pitchforth, Laura Sheard, Stephanie Stockwell, Chloe Thomas, Bethan Treadgold, Rachel Winder, John L Campbell

“…We conducted semistructured interviews with stakeholders providing a level of insight beyond individual practices, including policy-makers, commissioners and third- sector organisations. Data from the focused ethnographic case studies and stakeholder interviews were analysed together using thematic analysis. …”
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Short- and long-term outcomes of Impella-protected, high-risk, elective PCI in patients with multivessel coronary disease and low ejection fraction — Polish Impella Registry by Wojciech J. Skorupski, Arkadiusz Pietrasik, Aleksandra Gąsecka, Jerzy Sacha, Tomasz Pawłowski, Gabriel Bielawski, Wojciech Balak, Adam Sukiennik, Paulina Burzyńska, Adam Witkowski, Mateusz Warniełło, Łukasz Rzeszutko, Stanisław Bartuś, Artur Pawlik, Mateusz Kaczyński, Robert Gil, Wiktor Kuliczkowski, Krzysztof Reczuch, Marcin Protasiewicz, Jacek Legutko, Paweł Kleczyński, Piotr Wańczura, Sebastian Gurba, Anna Kochanowska, Michał Łomiak, Maciej Krajsman, Włodzimierz Skorupski, Maciej Zarębiński, Piotr Pawluczuk, Szymon Włodarczak, Adrian Włodarczak, Krzysztof Ściborski, Artur Telichowski, Mieszko Pluciński, Jarosław Hiczkiewicz, Karolina Konsek, Michał Hawranek, Mariusz Gąsior, Jan Peruga, Marcin Fiutowski, Robert Romanek, Piotr Kasprzyk, Dariusz Ciećwierz, Andrzej Ochała, Wojciech Wojakowski, Janusz Kochman, Maciej Lesiak, Marek Grygier

“…IMPELLA-PL is a multicenter registry developed to share clinical data and experiences using Impella technology in Poland. …”
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Antibiogram use on dairy cattle for bovine respiratory disease: Factors associated with bacterial pathogen identification and prediction of bacterial recovery using machine learnin... by Hugo F. Monteiro, Alejandro Hoyos-Jaramillo, Adriana Garzon, Heather M. Fritz, Craig C. Miramontes, Isabelle M. Matos, Terry W. Lehenbauer, Sharif Aly, Fabio S. Lima, Richard V. Pereira

“…Limited information is available on factors associated with herd-level bacterial pathogen recovery for BRD clinical cases, which are important data to help identify strategies to support the successful collection of a minimum number of each organism over time to generate cumulative antibiogram susceptibility testing reports. …”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…Methods: We analyzed publicly available patient databases and conducted studies using human and mouse liver cancer cells, xenograft and allograft models, mouse models of high-fat diet-related liver cancer, and CPEB4 knockout and knockdown mice and cell lines. Results: Patient data analysis (n = 87) showed a strong correlation between low CPEB4 levels and reduced survival rates (p <0.001). …”
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The Utility of C-Reactive Protein, Procalcitonin, and Leukocyte Values in Predicting the Prognosis of Patients with Pneumosepsis and Septic Shock by Melek Doganci, Guler Eraslan Doganay, Hilal Sazak, Ali Alagöz, Mustafa Ozgur Cirik, Derya Hoşgün, Emine Banu Cakiroglu, Murat Yildiz, Maside Ari, Tarkan Ozdemir, Derya Kizilgoz

“…<i>Materials and Methods:</i> This single-center, retrospective, cross-sectional observational study included patients who developed sepsis and septic shock due to community-acquired pneumonia and were admitted to the ICU. …”
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Neuroprotective Effects of Inhaled Xenon for Sedation Compared With Propofol Intravenous Sedation in Severe Ischemic Stroke by O. A. Grebenchikov, A. K. Evseev, V. V. Kulabuchov, A. N. Kuzovlev, S. S. Petrikov, G. R. Ramazanov, Sh. Gh. Khusainov, R. A. Cherpakov, A. K. Shabanov, A. I. Spichko

“…Based on the obtained clinical and laboratory data, it can be concluded about the effective implementation of the neuroprotective effects of xenon in the administration scheme used in the research.…”
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Multicomponent intervention for controlling hypertension in the adult rural population of Pakistan: a protocol for a hybrid type III implementation-effectiveness cluster randomised... by Catherine Hewitt, Aziz Sheikh, Simon Walker, Sajid Soofi, Kamran Siddiqi, Zulfiqar Ahmed Bhutta, Zainab Samad, Aysha Almas, Saima Afaq, Hajra Khwaja, Shiraz Hashmi, Imran Naeem, Salim S Virani, Saira Bukhari, Sawera Hanif

“…In this study, we will develop and test strategies for the implementation and scale-up of a proven multicomponent hypertension intervention (MCHI) in Pakistan that comprises health education, blood pressure (BP) monitoring and referrals by lady health workers (LHWs) and hypertension management by physicians in primary care settings.Methods and analysis In this 24-month hybrid type III implementation-effectiveness cluster-randomised controlled trial, we will recruit 3000 adult hypertensive patients from two rural districts of Pakistan. …”
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Long-Term Blood Pressure Variability and Risk of Age-Related Macular Degeneration in Older Adults: The ALIENOR Study by Blondy Kayembe-Mulumba, MD, MPH, Karen Leffondré, PhD, Bénédicte M.J. Merle, PhD, Jean-François Korobelnik, MD, PhD, Catherine Helmer, MD, PhD, Christophe Tzourio, MD, PhD, Cécile Delcourt, PhD, Audrey Cougnard-Grégoire, PhD, Marie-Noëlle Delyfer, MD, PhD

“…Design: Prospective analysis of 14-year data from the ALIENOR (Antioxydants, LIpides Essentiels, Nutrition et maladies OculaiRes) study, a French longitudinal population-based cohort study (2006–2020). …”
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Optimising Wastewater Sample Processing for Multiple Pathogen Detection by Miss Shannon Fitz, Debora Akortia, Richard Larbi, Richard Owusu, Gifty Nkrumah, Dr Joyce Akello, Catherine Troman, Dr Jaspreet Mahindroo, Dr Anton Spader, Dr Ben Bellekom, Piya Rajendra, Professor Yaw Adu-Sarkodie, Dr Ellis Owusu-Dabo, Dr Nicholas Grassly, Dr Dilip Abraham, Professor Venkata Raghava Mohan, Dr Michael Owusu, Dr Alex Shaw

“…Expected Outcome: This study aims to provide proof of principle data for cost effective surveillance of multiple pathogens in LMICs with the development of streamlined, integrated protocols. …”
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Cloning and expression profile of an ubiquitin-conjugating enzyme-like gene OsCROC-1A in rice (Oryza sativa L.) by WANG Ya, LIU Jianping, XU Mengyun, JI Weijie, TU Jumin, ZHANG Xiaobo

“…It is constitutively expressed in all the tissues examined and is generally modulated by abiotic stress, and OsCROC-1A has functions in both nucleus and cytosol. These data provide a foundation for investigating the cellular function and molecular mechanism of OsCROC-1A.…”
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Downregulation of the p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation by Ester Ciociola, Tanmoy Dutta, Kavitha Sasidharan, Lohitesh Kovooru, Francesca R. Noto, Grazia Pennisi, Salvatore Petta, Angela Mirarchi, Samantha Maurotti, Bernardette Scopacasa, Luca Tirinato, Patrizio Candeloro, Marcus Henricsson, Daniel Lindén, Oveis Jamialahmadi, Arturo Pujia, Rosellina M. Mancina, Stefano Romeo

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Dependencia al Ejercicio Físico en Deportes de Resistencia: Relación con la Motivación deportiva y la Identidad con el Ejercicio Físico (Exercise Dependence in Endurance Sports: Re... by Itsaso Leunda-Goni

“…The Exercise Dependence Scale (EDS-R) was used to analyze the participants' PE practice profile (dependent; symptomatic non-dependent and asymptomatic non-dependent), the Sport Motivation Scale was used to evaluate the level of each type of motivation and the PE Identification Scale was used to evaluate the level of identity of each participant related to PE. The next data analysis were performed: Kruskal-Wallis test with Bonferroni correction; Spearman's Rho; stepwise regression and multiple mediation models. 20% of the participants showed a dependent profile with the PE, 70.4% symptomatic non-dependents and 9.6% asymptomatic non-dependents. …”
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Os agentes comunitários de saúde nas práticas educativas: potencialidades e fragilidades [Community health workers in educational activities: potentials and weaknesses] [Los agente... by Elaine Franco dos Santos Araujo, Elisabete Pimenta Araújo Paz, Liane Gack Ghelman, Maria Yvone Chaves Mauro, Marilurde Donato, Sheila Nascimento Pereira de Farias

“…The study was approved by the research and ethics committee. Data were obtained by scripted, semi-structured interview and analyzed using content analysis. …”
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Combined CO₂ measurement record indicates Amazon forest carbon uptake is offset by savanna carbon release by S. Botía, S. Munassar, T. Koch, D. Custodio, L. S. Basso, S. Komiya, J. V. Lavric, D. Walter, M. Gloor, G. Martins, S. Naus, G. Koren, I. T. Luijkx, S. Hantson, J. B. Miller, W. Peters, W. Peters, C. Rödenbeck, C. Gerbig

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Estratégias de posicionamento do recém-nascido prematuro: reflexões para o cuidado de enfermagem neonatal [Positioning strategies for premature newborns: implications for neonatal... by Swya Oliveira Xavier, Maria Aparecida de Luca Nascimento, Maria Elisa Moreira Badolati, Márcia Barbosa de Paiva, Fátima Cristina Mattara de Camargo

“…Analysis of the documents showed that therapeutic positioning directly affects the premature’s physiological functions, promoting optimization of the respiratory function, reduction of reflux episodes and gastric emptying time, in addition to intervening in cerebral circulation and neurobehavioral development. …”
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Nanoscale Organic Contaminant Detection at the Surface Using Nonlinear Bond Model by Hendradi Hardhienata, Muhammad Ahyad, Fasya Nabilah, Husin Alatas, Faridah Handayasari, Agus Kartono, Tony Sumaryada, Muhammad D. Birowosuto

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Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

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Insulin-Sensitizing Properties of Decoctions from Leaves, Stems, and Roots of <i>Cucumis prophetarum</i> L. by Zewdie Mekonnen, Giuseppe Petito, Getasew Shitaye, Gianluca D’Abrosca, Belete Adefris Legesse, Sisay Addisu, Maurizio Ragni, Antonia Lanni, Roberto Fattorusso, Carla Isernia, Lara Comune, Simona Piccolella, Severina Pacifico, Rosalba Senese, Gaetano Malgieri, Solomon Tebeje Gizaw

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Paradigm Shift in the Treatment of Chronic Obstructive Pulmonary Disease Improves Patient Outcomes by Huang YJ, Wang KY, Chien WC, Chung CH, Kao LT, Kao S, Chian CF

“…It includes individuals diagnosed with COPD in two periods: 2012– 2014 and 2016– 2018.Results: The paradigm shift in COPD treatment has led to a significant transition in medication selection, moving away from single-agent or supplementary inhaled corticosteroid (ICS) regimens (from 99.61% to 20.99%) towards the use of dual bronchodilators or triple therapy (from 0.38% to 79.02%). The analysis between long-acting muscarinic antagonists (LAMAs) and long-acting beta-agonists (LABAs) revealed no statistically significant differences in emergency department visits and hospitalizations. …”
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Precision laser acupuncture at back-shu points enhances growth performance, feed efficiency, and hormonal regulation in rabbits by Mudhita Zikkrullah Ritonga, Ertika Fitri Lisnanti, Widya Pramita Lokapirnasari, Sri Hidanah, Saifur Rehman, Muhammad Fajar Amrullah, Rico Anggriawan, Mutasem Abuzahra, Denny Irmawati Hasan, Aamir Shehzad, Siti Rani Ayuti

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