Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…For many patients, these therapies fail because the development of spontaneous immune responses is often compromised, as the tumor microenvironment (TME) lacks proinflammatory signals resulting in suboptimal activation of antigen-presenting cells (APCs). …”
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Quality of Surface and Groundwater in the Sierra de Amula Region, Jalisco, Mexico by Oscar Raúl Mancilla-Villa, Fabiola Villafaña-Castillo, Álvaro Can-Chulim, Rubén Darío Guevara-Gutiérrez, José Luis Olguín-López, Elia Cruz-Crespo, Jonas Alan Luna-Fletes, Juan Uriel Avelar-Roblero

“…Each sample was evaluated for its pH, electrical conductivity, and ionic concentration (Ca²⁺, Mg²⁺, Na⁺, K⁺, CO₃²⁻, HCO₃⁻, CI⁻, SO₄²⁻). For data analysis, we determined the ionic concentrations and the salinity and sodicity indexes, including the electrical conductivity, pH, sodium adsorption ratio (SAR), and cationic ratio of soil structural stability (CROSS). …”
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The diverse virulence potential of atypical enteropathogenic Escherichia coli isolated from diarrhea: the emergence of a hybrid pathotype? by Ana C. M. Santos, Ana C. M. Santos, Roberta S. Silva, Mônica A. M. Vieira, Cristina V. Niero, Matheus S. F. Ribeiro, Beatriz E. C. Guth, Tânia A. T. Gomes, Rosa M. Silva

“…These strains were lethal in the Galleria mellonella model for ExPEC virulence, and the comparative analysis of their genomes revealed they belong to different EPEC/ EHEC global clonal groups. …”
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Exposure to persistent organic pollutants and sarcopenia: Revealing associations, mediated modifications, and potential mechanisms by Jinlong Tao, Jinchan Zhai, Jiaqi Yang, Qiang Niu, Yunhua Hu, Yizhong Yan

“…CDKN1A, NFKBIA, CSF1R, and TFRC may be key targets through which POPs influence sarcopenia development.…”
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Predicting Disease Progression in Inoperable Localized NSCLC Patients Using ctDNA Machine Learning Model by Yuqi Wu, Canjun Li, Yin Yang, Tao Zhang, Jianyang Wang, Wanxiangfu Tang, Ningyou Li, Hua Bao, Xin Wang, Nan Bi

“…Conclusion In conclusion, we developed a cfDNA neomer profiling assay for predicting disease progression in inoperable NSCLC patients. …”
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Microstructural integrity of autonomic central nervous tracts is linked to cardiovascular health by Janis M. Nolde, Alexander Rau, Elias Kellner, Horst Urbach, Cornelius Weiller, Fabian Bamberg, Jakob Weiss, Marco Reisert, Jonas A. Hosp

“…Methods: The microstructural integrity of the CAN was evaluated using magnetic resonance imaging (MRI) of the brain from the population-based UK Biobank study applying previously developed diffusion imaging data-processing techniques. …”
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Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar by Jianhai Chen, Ivan Jakovlić, Mikhail Sablin, Shengqian Xia, Zhixiang Xu, Yapin Guo, Renzuo Kuang, Jie Zhong, Yangying Jia, Nhien Thuy Thi Tran, Hao Yang, Hong Ma, Nikica Šprem, Jianlin Han, Di Liu, Yunxia Zhao, Shuhong Zhao

“…By integrating publicly available data, we compiled a core dataset of 48 wild boar samples and an extended dataset of 445 wild boar and domestic pig samples to identify candidate genes related to cold adaptation. …”
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Sustainability index for eco-friendly cattle farming in dry climate regions by T. Simamora, M.N. Rofiq, L. Hutahaean, S. Sio, R. Hutapea, D. Irawan, Suryani ., R. Diastuti, U.N. Thiyas, B.A. Correia, L.T. Correia

“…A range of responses was collected from individuals engaged in livestock management in the dry climatic conditions of Timor Tengah Utara Regency. The data that has been collected is analyzed employing Multidimensional Scaling and expedited appraisal software. …”
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Parental influence on Chinese childhood cancer survivors’ physical activity: a mixed methods study by Fengjiao Xu, Danni Lv, Jie Zhou, Zhonghai Guan, Jieni Xiong, Jingyi Yun, Xiaojun Xu, Junqing Mao, Zhipeng Shen, Libin Jin, Yunxia Liu, Haiyan Xing, Jinhu Wang, Hongmei Wang

“…A qualitative investigation using the thematic descriptive phenomenological approach analyzed data concerning the parents of 9-18-year-old childhood cancer survivors who had completed hospitalized treatment for at least three months. …”
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Quaternary gas hydrate dissociation promotes the formation of Shenhu Canyon Group in the South China Sea by Hui Pan, Hui Pan, Hui Xie, Hui Xie, Hui Xie, Zhongxian Zhao, Jinlong Liu, Guozhong Jiang, Guozhong Jiang, Ruilong Li, Yuanping Li, Eun Young Lee, Wen Yan

“…Our study presents a plausible mechanism elucidating how the reduction in the thickness of GHSZ, the release of methane, and the formation of submarine pockmarks interact to influence and reshape the slope morphology, as well as drive the evolution of submarine canyons. This integrative analysis not only uncovers the complex geological processes at play in the study area but also offers valuable insights into the long term geomorphological development in submarine environments.…”
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SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia by Marianne J Mullane, Timothy C Barnett, Jeffrey W Cannon, Jonathan R Carapetis, Ray Christophers, Juli Coffin, Frieda Mc Loughlin, Vicki O'Donnell, Rebecca Pavlos, Bec Smith, Andrew C Steer, Steven Y C Tong, Roz Walker, Asha C Bowen

“…We hypothesise that the skin infection burden in remote Aboriginal communities can be reduced by implementing streamlined training and treatment pathways integrated with environmental health and health promotion activities, tested in the See, Treat, Prevent (SToP skin sores and scabies) trial.Methods and analysis SToP will evaluate a skin control programme using a stepped-wedge, cluster randomised trial design with three intervention components (the ‘SToP activities’): (1) seeing skin infections (development of training resources implemented within a community dermatology model); (2) treating skin infections (employing the latest evidence for impetigo, and scabies treatment); and (3) preventing skin infections (embedded, culturally informed health promotion and environmental health activities). …”
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Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed... by Heather K. O’Grady, Kathy Smith, Sandra Dalziel, Barbara Dolanjski, Gyan Sandhu, Marlene Santos, Jackie Bosch, Lyn S. Turkstra, Srinivas Murthy, John C. Marshall, Michelle E. Kho, for the Canadian Critical Care Trials Group

“…Phase 1: We conducted focus groups with individuals with lived experience, including ICU survivors, substitute decision makers (SDMs) and research coordinators (RCs) to refine an infographic to augment a priori REMAP-CAP consent encounters. We analyzed data using inductive content analysis. Phase 2: We piloted the infographic with patients/SDMs approached a priori to participate in REMAP-CAP, who could communicate in English, at five sites in Ontario, Canada. …”
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The association between the gut microbiome and antituberculosis drug-induced liver injury by Shengfei Pei, Li Yang, Huixia Gao, Yuzhen Liu, Jianhua Lu, Er hei Dai, Chunyan Meng, Fumin Feng, Yuling Wang

“…The samples underwent 16S rDNA sequencing, and clinical data and blood samples were also collected for further analysis. …”
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Impact of Blood Metabolic Profile and Ingestive Behaviours Registered with Noseband Sensor on Methane Emission During Transition Period in Dairy Cows by Justina Krištolaitytė, Karina Džermeikaitė, Arūnas Rutkauskas, Greta Šertvytytė, Gabija Lembovičiūtė, Samanta Arlauskaitė, Akvilė Girdauskaitė, Violeta Juškienė, Remigijus Juška, Walter Baumgartner, Ramūnas Antanaitis

“…These findings emphasise the complex interactions between feed intake, metabolism, and methane emissions, underscoring the importance of integrating behavioural and physiological indicators to develop targeted strategies for enteric methane mitigation while providing baseline data from healthy cows that could guide future research on methane emissions in cows undergoing postpartum metabolic disorders.…”
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Perceptions about chronic health conditions, multimorbidity and self-management practices in rural northeast South Africa: findings from a qualitative study by Edward Fottrell, Stephen Tollman, F Xavier Gómez-Olivé, Rochelle Burgess, Alisha N Wade, Audry Dube, Nicola Joan Christofides, Belinda J Njiro, Chodziwadziwa Whiteson Kabudula

“…An inclusive thematic approach was used for analysis.Results Participants identified most chronic health conditions and their progression. …”
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Prognostic implications of the interaction between intratumoral microbiome and immune response in gastric cancer by Sifan Liu, Lingyu Qi, Lu Dong, Wenjing Sun, Siying Liu, Peng Li, Nan Zhang

“…A prediction risk model was constructed using the LASSO regression analysis and showed great prognostic value for GC patients. …”
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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008 by Juntong Li, Juntong Li, Sheng Ye, Xiang Li, Xiang Li, Hui Liu, Yue Yang, Xuelei Lu, Heyue Jin, Li Liu, Li Liu

“…ObjectiveThis study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults.MethodsThe study utilized data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. …”
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Cultural practices, healthcare-seeking behaviors, and wildlife interface: Zoonotic disease risks among the Phu Thai Ethnic Group in Thailand by Nisachon Bubpa, Kanokwan Suwannarong, Kannika Thammasutti, Thanomsin Ponlap, Worakamon Thongkan, Paisit Boonyakawee, Phitsanuruk Kanthawee, Kangsadal Suwannarong, Withaya Chanchai

“…Thematic analysis was performed to explore cultural traditions, wildlife interactions, healthcare practices, and perceptions of COVID-19. …”
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Oral reference dose (RfD) derivation for five bisphenol A alternatives integrating BMD and NOAEL/LOAEL approaches by Yan Xia, Wenhua Ma, Jing Cao, Yanpeng Gao, Yingxin Yu, Chaoyang Long

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A Note on the Links Between Manufacturing, Goods and Services Exports by Broussolle Damien

“…The first one concerns annual one-digit headings for 13 developed countries. The last one pertains to quarterly data from 1994 to 2011 for 24 developed countries. …”
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