Enabling new insights from old scans by repurposing clinical MRI archives for multiple sclerosis research by Philipp Goebl, Jed Wingrove, Omar Abdelmannan, Barbara Brito Vega, Jonathan Stutters, Silvia Da Graca Ramos, Owain Kenway, Thomas Rossor, Evangeline Wassmer, Douglas L. Arnold, D. Louis Collins, Cheryl Hemingway, Sridar Narayanan, Jeremy Chataway, Declan Chard, Juan Eugenio Iglesias, Frederik Barkhof, Geoff J. M. Parker, Neil P. Oxtoby, Yael Hacohen, Alan Thompson, Daniel C. Alexander, Olga Ciccarelli, Arman Eshaghi

“…MindGlide uniquely enables quantitative analysis of archival single-contrast MRIs, unlocking insights from untapped hospital datasets.…”
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Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses by Alina Renz, Mirjam Hohner, Raphaël Jami, Maximilian Breitenbach, Jonathan Josephs-Spaulding, Johanna Dürrwald, Lena Best, Victoria Dulière, Chloé Mialon, Stefanie M. Bader, Georgios Marinos, Nantia Leonidou, Filipe Cabreiro, Marc Pellegrini, Marcel Doerflinger, Manuel Rosa-Calatrava, Andrés Pizzorno, Andreas Dräger, Michael Schindler, Christoph Kaleta

“…Abstract The SARS-CoV-2 pandemic has reemphasized the urgent need for broad-spectrum antiviral therapies. We developed a computational workflow using scRNA-Seq data to assess cellular metabolism during viral infection. …”
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The Betting Odds Rating System: Using soccer forecasts to forecast soccer. by Fabian Wunderlich, Daniel Memmert

“…It is shown how the novel model can help to gain valuable insights into the quality of soccer teams and its development over time, thus having a practical benefit in performance analysis. …”
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Using qualitative research methods to understand how surgical procedures and devices are introduced into NHS hospitals: the Lotus study protocol by Jane M Blazeby, Natalie S Blencowe, Anni Skilton, Jenny Donovan, Kerry Avery, Sian Cousins, Daisy Elliott, Hollie Richards, Jesmond Zahra, Sangeetha Paramasivan, Johnny Mathews, Barry Main, Shelley Potter, Cynthia Ochieng, Christin Hoffmann, Angus GK McNair, Sina Hossaini, Darren L Scroggie

“…Introduction The development of innovative invasive procedures and devices are essential to improving outcomes in healthcare. …”
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Effect of the time factor on the hydraulic activity of mechanically activated saponin-containing powder by Marina V. Morozova, Maria A. Frolova

“…The article examines the problem of the development of transport infrastructure in the Solovetsky archipelago and proposes a solution to reduce the cost of manufacturing reinforced concrete slabs for the road surface. …”
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Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages by Mariana Kleinecke, Edwin Sutanto, Angela Rumaseb, Kian Soon Hoon, Hidayat Trimarsanto, Ashley Osborne, Paulo Manrique, Trent Peters, David Hawkes, Ernest Diez Benavente, Georgia Whitton, Sasha V. Siegel, Richard D. Pearson, Roberto Amato, Anjana Rai, Nguyen Thanh Thuy Nhien, Hoang Chau Nguyen, Ashenafi Assefa, Tamiru S. Degaga, Dagimawie Tadesse Abate, Awab Ghulam Rahim, Ayodhia Pitaloka Pasaribu, Inge Sutanto, Mohammad Shafiul Alam, Zuleima Pava, Tatiana Lopera-Mesa, Diego Echeverry, Tim William, Nicholas M. Anstey, Matthew J. Grigg, Nicholas P. Day, Nicholas J. White, Dominic P. Kwiatkowski, Aimee R. Taylor, Rintis Noviyanti, Daniel Neafsey, Ric N. Price, Sarah Auburn

“…Our results demonstrate the potential to derive new information on P. vivax treatment and transmission using IBD generated by amplicon sequencing data that can be further improved with time-to-event models.…”
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Immune modulation in solid tumors: a phase 1b study of RO6870810 (BET inhibitor) and atezolizumab (PD-L1 inhibitor) by Daniel Marbach, Jurriaan Brouer-Visser, Laura Brennan, Sabine Wilson, Iakov I. Davydov, Nicolas Staedler, José Duarte, Iris Martinez Quetglas, Eveline Nüesch, Marta Cañamero, Evelyne Chesné, George Au-Yeung, Erika Hamilton, Stephanie Lheureux, Debra L. Richardson, Iben Spanggaard, Bruno Gomes, Izolda Franjkovic, Mark DeMario, Martin Kornacker, Katharina Lechner

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Evaluating the population impact of hepatitis C direct acting antiviral treatment as prevention for people who inject drugs (EPIToPe) – a natural experiment (protocol) by Jeremy Horwood, Andrew Radley, John F Dillon, Peter Vickerman, Rory N Gunson, Mary Ramsay, Chris Metcalfe, William Hollingworth, Hannah Fraser, Helen Harris, Ellen Heinsbroek, Lawrie Elliott, Paul Flowers, Sema Mandal, Matthew Hickman, David Goldberg, Natasha Martin, Emma Hamilton, Daniela De Angelis, Graham Foster, Peter Donnan, Ann Eriksen, Samreen Ijaz, David Liddell, Lewis J Z Beer, Kate Drysdale, Rachel Glass, Lesley Graham, Ross Harris, Vivian Hope, Sarah Karen Inglis, Hamish Innes, Athene Lane, Jade Meadows, Andrew McAuley, Stephanie Migchelsen, Alex Murray, Gareth Myring, Norah E Palmateer, Anne Presanis, Pantelis Samartsidis, Ruth Simmons, Katy Sinka, Gabriele Vojt, Zoe Ward, David Whiteley, Alan Yeung, Sharon J Hutchinson

“…Through the qualitative data we will systematically explore key mechanisms of TasP real world implementation from provider and patient perspectives to develop a manual for scaling up HCV treatment in other settings. …”
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Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative by Carlos A. Valencia-Hernández, Zhebin Yu, Ulrike Gehring, Gerard H. Koppelman, Marie Standl, Claudia Flexeder, Tamara Schikowski, Sara Kress, Erik Melén, Olena Gruzieva, Mare Lõhmus, Rosa Faner, Alvar Agusti, Jadwiga A. Wedzicha, Judith Garcia-Aymerich, Sarah Koch, Mark Nieuwenhuijsen, Aitana Lertxundi, Ana Esplugues, Ferran Ballester, Ane Arregi, Iana Markevych, Chloe I. Bloom, Elaine Fuertes

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Feasibility of extracting specimens from the site of preventive ileostomy and its impact on stoma retraction of laparoscopic low anterior resection for rectal cancer by Bai Junge, Wang Zhexue, Yang Ming, Ma Xiaolong, Liu Zheng, Chen Haipeng

“…[Methods] A retrospective analysis was conducted on the clinical data of 223 patients who underwent laparoscopic low anterior resection of rectal cancer combined with preventive ileostomy in Cancer Hospital of Peking Union Medical College, Chinese Academy of Medical Sciences from September 2015 to September 2019. …”
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In vitro and in silico investigations of Propolis-derived phytochemicals as potential inhibitors of Plasmodium falciparum by Dhrubo Ahmed Khan, Md. Nazmul Hasan, Rachasak Boonhok, Suthinee Sungkanu, Yutatirat Singhaboot, Afsana Amin Shorna, Anamul Hasan, Kesinee Chotivanich, Polrat Wilairatana, Abolghasem Siyadatpanah, Roghayeh Norouzi, Imran Sama-ae, Watcharapong Mitsuwan, Alok K. Paul, Maria de Lourdes Pereira, Shanmuga S. Sundar, Tooba Mahboob, Christophe Wiart, Ryan V. Labana, Siriphorn Chimplee, Veeranoot Nissapatorn

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The application of ultrasound-guided cannulated screw removal after proximal tibial fracture surgery: a retrospective study by Kai Gu, Jiaqiang Qin, Meizhen Guo, Ruiliang Chu, Jiaxu Chen, Fusheng Qian, Yi Zhong

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Bioinformatics Identification of Lactate‐Associated Genes in Hepatocellular Carcinoma: G6PD's Role in Immune Modulation by Hao‐ran Qu, Chao‐qun Wang, Su‐juan Sun, Wen‐wen Zhang, Cheng‐hao Liu, Xuan‐shuang Du, Yao‐yi‐ao Shu, Xi‐cheng Wang, Qin Pan, Feng‐ling Luo, Hong‐yan Wu, Xiao‐lian Zhang, Min Liu

“…Methods We analyzed RNA‐seq and clinical data from 374 patients with HCC from The Cancer Genome Atlas (TCGA) database. …”
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A core outcome set for damage control laparotomy via modified Delphi method by Deborah M Stein, Elliott R Haut, Jeffry Nahmias, Scott Brakenridge, Jason W Smith, Andrew Bernard, John A Harvin, Kenji Inaba, Jose J Diaz, Clay Cothren Burlew, Thomas Scalea, Karim Brohi, Ben L Zarzaur, Jeffrey D. Kerby, Miklosh Bala, Preston R. Miller, Juan Duchesne, Saskya Byerly, Rondi Gelbard, Markus Ziesmann, Melissa Boltz, Bryan Collier, Michael Cripps, Bruce Crookes, Rao Ivatury, Kevin Kasten, Margaret Lauerman, Tyler Loftus, D Dante Yeh

“…Inconsistency in reporting standards have hindered careful scrutiny of DCL outcomes. We sought to develop a core outcome set (COS) for DCL clinical studies to facilitate future pooling of data via meta-analysis and Bayesian statistics while minimizing reporting bias.Methods A modified Delphi study was performed using DCL content experts identified through Eastern Association for the Surgery of Trauma (EAST) ‘landmark’ DCL papers and EAST ad hoc COS task force consensus.Results Of 28 content experts identified, 20 (71%) participated in round 1, 20/20 (100%) in round 2, and 19/20 (95%) in round 3. …”
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A retrospective study on beta-blocker use and outcomes in hematopoietic stem cell transplant patients by Matthew A. Bergens, John T. Bokman, Ernaya J. Johnson, Matthew L. Braun, Yan Li, Amy T. Bush, Lauren Hill, Jolien Van Opstal, Alessandro Racioppi, Rebecca Fan, Sejal Kaushik, Edwin Alyea, Nelson Chao, Taewoong Choi, Cristina Gasparetto, Mitchell Horwitz, Richard Lopez, Sendhilnathan Ramalingam, Keith Sullivan, Paul Wischmeyer, Anthony D. Sung

“…We analyzed 10 years of data (January 2010 to May 2020), including 105 patients who received a BB for more than four days before and after HCT, and 669 control patients who did not receive a BB. …”
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Velocity-Constraint Kalman Filtering for Enhanced Bubble Tracking in Motion-Compensated Ultrasound Localization Microscopy by Yifei Zhu, Lingyin Jiang, Qi Zhang, Jun Yin, Bingze Du, Guofeng Zhang, Haijun Zhang, Bo Ding, Han Lin, Honghui Xue, Xiasheng Guo, Xiao-Yang Zhang, Jing-Ning Zhu, Dong Zhang, Juan Tu, Ning Gu

“…To address these issues, an enhanced ULM approach (shorten as vc-Kalman) integrating rapid motion compensation was developed to achieve excellent image quality. Unlike traditional methods relying on observed bubble positions, the proposed algorithm combined statistical information derived from historical data with Kalman-filter-predicted positions to enable more accurate bubble localization. …”
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Clinical characteristics associated with peripartum maternal bloodstream infection by Xiao-Li Gao, Xiao-Li Gao, Yang Li, Yang Li, Su-Juan Hou, Su-Juan Hou, Wen-Jun Fan, Wen-Jun Fan, Ling-Yi Fang, Ling-Yi Fang, Shi-Jun Ni, Shi-Jun Ni, Ye Yan, Ye Yan, Jie Li, Jie Li, Cha Han, Cha Han

“…ObjectiveBloodstream infection (BSI) during the peripartum period is a major cause of maternal morbidity and mortality. However, data on maternal BSI during hospitalization for delivery are limited. …”
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Exploring perceptions and awareness of artificial light: A qualitative study among medical and non-medical college students in an urban area of Southern India by Mithra Prasanna, Thapar Rekha, Mallya Ajay, Prabhakar Madhu Malar, Pandey Sonali, Agrawal Yash, Vats Anmol, Agarwal Shreya, Maurya Sarthak, Patel Sneha, Mohanty Marmit, Hooda Divya

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A framework of crop water productivity estimation from UAV observations: A case study of summer maize by Minghan Cheng, Ni Song, Josep Penuelas, Matthew F. McCabe, Xiyun Jiao, Yuping Lv, Chengming Sun, Xiuliang Jin

“…The methodology establishes novel methodological benchmarks for crop-water relationship studies through its innovative fusion of multi-source remote sensing data and multiple model combination.…”
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“Our work is recognized and we are prepared:” A qualitative evaluation of a peer-led research best practices training for community health workers and promotoras by Alexandra E. Harper, Analay Perez, M. Miaisha Mitchell, Daphne Watkins, Gina M. Jay, Vanessa I. Trujillo, Kristen Weeks-Norton, Shannen McIntosh, Brenda Eakin, Elias Samuels, Gretchen Piatt, Catherine Striley, Linda Cottler, Sergio Aguilar-Gaxiola, Susan L. Murphy

“…Three coders analyzed the interviews using a combination of the rigorous and accelerated data reduction (RADaR) technique and thematic text analysis. …”
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