Role of late gadolinium enhancement in the risk stratification of pediatric hypertrophic cardiomyopathy: based on a Chinese cohortResearch in context by Xingrui Chen, Wei Xiangli, Xuan Ma, Yun Tang, Jiaxin Wang, Zhixiang Dong, Kankan Zhao, Zhuxin Wei, Xi Jia, Pengyu Zhou, Yujie Liu, Yanyan Song, Chen Cui, Minjie Lu, Kai Yang, Xiuyu Chen, Shujuan Yang, Shihua Zhao

“…This study aims to assess the prognostic value of LGE and explore its incremental utility in predicting sudden cardiac death (SCD) in pediatric HCM using data from a Chinese cohort. Methods: 231 primary HCM patients ≤18 years of age with cardiac magnetic resonance (CMR) were retrospectively and consecutively enrolled in a single center. …”
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Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy by Wuyuan Liao, Wuyuan Liao, Wuyuan Liao, Xinwei Zhou, Xinwei Zhou, Hansen Lin, Hansen Lin, Zihao Feng, Zihao Feng, Xinyan Chen, Yuhang Chen, Yuhang Chen, Minyu Chen, Minyu Chen, Mingjie Lin, Mingjie Lin, Gaosheng Yao, Gaosheng Yao, Jinwei Chen, Jinwei Chen, Haoqian Feng, Haoqian Feng, Yinghan Wang, Yinghan Wang, Zhiping Tan, Zhiping Tan, Youyan Tan, Jun Lu, Jun Lu, Pengju Li, Pengju Li, Jinhuan Wei, Jinhuan Wei, Li Luo, Li Luo, Liangmin Fu, Liangmin Fu, Liangmin Fu

“…We first screened immunosuppression-related genes (ISRGs) that might interfere with TMB's predictive role by analyzing the survival data and gene expression profiles of patients. Using LASSO regression and multivariable Cox proportional hazards analysis, we constructed a risk model based on these ISRGs. …”
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Role of the Perceived Social Responsibility of the Company and the Psychological Mechanisms to Achieve the Employees' Creative Behavior (Case Study: Electro Kavir Company of Yazd) by Marziyeh Dehghanizadeh, Fatemeh Keshavarzi Hedesh

“…The data collection tool in this research was standard questionnaires, the validity of which was confirmed using the opinions of a number of experts in this field, and Cronbach's alpha coefficient and composite reliability were used to determine the reliability of the measurement tool, and the analysis method used in this research was structural equation modeling technique. …”
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Evaluation and Its Impact of SARS-CoV-2 Inactivated Vaccine Candidate in K18-hACE2 Mice by Rofiqul A'la, Fedik Abdul Rantam, Andi Yasmin Wijaya, Helen Susilowati, Suryo Kuncorojakti, Diyantoro Diyantoro, Ahmad Aswin, Jola Rahmahani, Lucia Tri Suwanti, Bambang Sektiari Lukiswanto, Ira Sari Yudaniayanti, Boedi Setiawan

“…Body weight was monitored, and serum samples were collected to measure IL-4, IL-6, TNF-α, and IFN-γ levels using ELISA. Data were evaluated using SPSS statistical analysis software. …”
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A nomogram for predicting delirium in the ICU among older patients with chronic obstructive pulmonary disease by Chunchun Yu, Tianye Li, Mengying Xu, Hao Xu, Xiong Lei, Zhixiao Xu, Jianming Hu, Xiuyun Zheng, Chengshui Chen, Hongjun Zhao

“…Its predictive performance and clinical utility were assessed using the area under the receiver operating characteristic curve (AUC), decision curve analysis (DCA), and clinical impact curves (CIC). Results A total of 638 patients (33.4%) developed ICU delirium, with a median age of 76.00 (IQR: 71.00–83.00) years. …”
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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer by Benjamin B. Morris, Simon Heeke, Yuanxin Xi, Lixia Diao, Qi Wang, Pedro Rocha, Edurne Arriola, Myung Chang Lee, Darren R. Tyson, Kyle Concannon, Kavya Ramkumar, C. Allison Stewart, Robert J. Cardnell, Runsheng Wang, Vito Quaranta, Jing Wang, John V. Heymach, Barzin Y. Nabet, David S. Shames, Carl M. Gay, Lauren A. Byers

“…Methods To study SCLC DDR phenotypes, we developed a new DDR gene analysis method and applied it to SCLC clinical samples, in vitro, and in vivo model systems. …”
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In silico study of biological activity of 2-[5-(furan-2-yl)-4-phenyl-4n-1,2,4-triazol-3-ylthio]-1-(4-chlorophenylethanone) by N. M. Borysenko, I. V. Bushuyeva, V. V. Parchenko, O. P. Shmatenko, А. М. Solomennyi, O. K. Yerenko, O. P. Kileyeva

“…In modern conditions, where military conflicts are accompanied by significant psychological and physical stress on participants, the development of effective antiepileptic drugs has become one of the key challenges in medicine. …”
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Perceptions of COVID-19 among communities of Conakry (Guinea): a qualitative study exploring the context of the ANRS COV33 Coverage-Africa therapeutic trial by Joanna Orne-Gliemann, Alexandre Delamou, Mélanie Plazy, Denis Malvy, Marie-Hélène Doucet, Christine Timbo Songbono, Caroline Martin, Camille Fritzell, Mamadou Saliou Sow, Fodé Amara Traoré, Marie Jaspard, Armel Poda, Olivier Marcy

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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening by Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A. Comini

“…TryS attracts attention as molecular target for drug development against pathogens causing severe and fatal diseases in mammals. …”
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Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…Gene set enrichment analysis (GSEA) was utilized to characterize the molecular pathways associated with KRAS signaling. …”
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Chronic Myeloid Leukemia: Long-Term Experience of Target Therapy by KM Abdulkadyrov, VA Shuvaev, IS Martynkevich, MS Fominykh, NA Potikhonova, II Zotova, VYu Udal’eva, RA Golovchenko, NV Shakhvorostova, DI Shikhbabaeva, MN Zenina, SA Tiranova, SA Kudryashova, LS Martynenko, MP Ivanova, NYu Tsybakova, EV Petrova, LB Polushkina, EV Kleina

“…Interpretation of key aspects of pathogenesis of chronic myeloid leukemia (CML) and development and introduction of target therapy have changed the prognosis of this once fatal disease dramatically. …”
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Strengthening open disclosure in maternity services in the English NHS: the DISCERN realist evaluation study by Mary Adams, Natalie Sanford, Charlotte Bevan, Maria Booker, Julie Hartley, Alexander Heazell, Elsa Montgomery, Maureen Treadwell, Jane Sandall

“…Following a realist evaluation approach, the study objectives were to: establish initial hypotheses to focus investigation of OD improvements in NHS maternity services in England examine the scope of OD in NHS maternity services from the perspectives of regional and national stakeholders refine our initial hypotheses in relation to the analysis of regional and national stakeholder perspectives conduct an in-depth study of OD improvement within services verify data interpretation and study output development with different stakeholders (families, clinicians, service managers and national policy-makers). …”
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miR-124 coordinates metabolic regulators acting at early stages of human neurogenesis by Geurim Son, Yongwoo Na, Yongsung Kim, Ji-Hoon Son, Gregory D. Clemenson, Simon T. Schafer, Jong-Yeon Yoo, Sarah L. Parylak, Apua Paquola, Hyunsu Do, Dayeon Kim, Insook Ahn, Mingyu Ju, Chanhee S. Kang, Younghee Ju, Eunji Jung, Aidan H. McDonald, Youngjin Park, Gilhyun Kim, Se-Bum Paik, Junho Hur, Joon Kim, Yong-Mahn Han, Seung-Hee Lee, Fred H. Gage, Jong-Seo Kim, Jinju Han

“…Lastly, we show the potential of identified DEPs as novel metabolic regulators in early neuronal development by validating the effects of GSTK1 on cellular respiration. …”
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Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling by Xiarui Fan, Xiaomin Li, Tong Li, Bing Shao, Shan Niu, Wenhong Fan, Qi Wang, Lv Zhong, Xiangrui Wang, Ziwei Wang, Fujun Ma, Guomao Zheng, Hui Peng, Lili Chen, Zhaomin Dong

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A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome by Xingsen Zhao, Qihang Sun, Yikai Shou, Weijun Chen, Mengxuan Wang, Wenzheng Qu, Xiaoli Huang, Ying Li, Chao Wang, Yan Gu, Chai Ji, Qiang Shu, Xuekun Li

“…Genes with altered expression are related to neuronal development and neurogenesis. Single cell RNA-seq (scRNA-seq) data analysis revealed 13 clusters in healthy control and WS organoids. …”
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The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8 by Ying Yang, Zhiheng Li, Yang Yang, Peifang Xiao, Zhixu He, Zimu Zhang, Yizhen Li, Lei Shi, Xiaodong Wang, Yanfang Tao, Junjie Fan, Fenli Zhang, Chunxia Yang, Fahua Yao, Tongting Ji, Yongping Zhang, Bi Zhou, Juanjuan Yu, Ailian Guo, Zhongling Wei, Wanyan Jiao, Yumeng Wu, Yan Li, Di Wu, Yijun Wu, Li Gao, Yixin Hu, Jian Pan, Shaoyan Hu, Xiaoyan Yang

“…Results Public drug sensitivity data analysis revealed that AMKL cell lines exhibited the highest sensitivity to indisulam compared with other tumor types. …”
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Single-cell sequencing revealed the necessity of macrophages in brain microenvironment remodeling by breast cancer metastasis by Maotang Liu, CenZhu Wang, Qin Hu, XueChao Wu, Qing Wang, Jing Wang, Kun Xu, XiaoJie Lu, Wei Tian

“…Breast cancer is one of the most common cancers worldwide, 30–50 % of patients with advanced breast cancer develop brain metastasis, causing severe damage to their life quality. …”
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Dynamic Tensile Properties of Ultra–High–Performance Concrete Under Impact Splitting Tensile Load Based on Digital Image Correlation Technology by Xudong CHEN, Xuyang WANG, Tao JI, Jixuan LIU, Yingjie NING

“…The strain cloud maps of specimens under different impact strengths and the curves of the main crack width of specimens under different impact strengths as they expand over time were analyzed based on DIC technology. The above DIC analysis explains that the higher the impact strength, the faster the crack development speed, and there are distinct differences in the damage characteristics of specimens under different impact strengths. …”
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BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double‐Blind Randomised Interventional Phase 2b Trial by Roger A. Fielding, Michael M. Dao, Kevin Cannon, Moise Desvarieux, Sam S. Miller, Michael Paul Gimness, Donald M. Brandon, Dennis T. Villareal, Olivier Bruyere, Ivan Bautmans, Kyle Rickner, Robert Perry, Stephen B. Kritchevsky, Nicolas Musi, Joe M. Chehade, Judith L. Kirstein, Evelien Gielen, Paul Pickrell, Pierre Dilda, Rene Lafont, Carole Margalef, Yves Rolland, Susanna Del Signore, Jean Mariani, Samuel Agus, Cendrine Tourette, Waly Dioh, Rob vanMaanen, Stanislas Veillet

“…Taken together, efficacy and safety data of this Phase 2 trial encourage us to pursue further development of BIO101 for the treatment of sarcopenia.…”
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Molecular Genetic Abnormalities in the Pathogenesis of Hematologic Malignancies and Corresponding Changes in Cell Signaling Systems by LR Tilova, AV Savinkova, EM Zhidkova, OI Borisova, TI Fetisov, KA Kuzin, OA Vlasova, AS Antipova, OYu Baranova, KI Kirsanov, GA Belitskii, MG Yakubovskaya, EA Lesovaya,5

“…Modern classification of malignancies of hematopoietic and lymphoid tissues is based on the analysis of clinical data, morphological and functional characteristics of tumor cells and identification of specific cytogenetic and molecular-genetic changes. …”
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