Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations by Alejandro Álvarez‐Bustos, Helio José Coelho‐Junior, Riccardo Calvani, Leocadio Rodriguez‐Mañas, Matteo Tosato, Matteo Cesari, Antonio Cherubini, Alfonso J. Cruz‐Jentoft, Pálmi V. Jónsson, Fabrizia Lattanzio, Marcello Maggio, Regina Roller‐Wirnsberger, Ingrid Rýznarová, Annemie M. W. J. Schols, Cornel C. Sieber, Alan J. Sinclair, Anna Skalska, Timo Strandberg, Achille Tchalla, Eva Topinková, Bruno Vellas, Stephan vonHaehling, Francesco Landi, Emanuele Marzetti, for the SPRINTT consortium

“…Methods This is a secondary analysis of an evaluator blinded, randomised controlled trial, developed in 16 clinical sites across 11 European countries, from January 2016 to 31 October 2019. …”
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Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq by Daniil K. Lukyanov, Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Irina A. Shagina, Dmitry B. Staroverov, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstantin A. Blagodatskikh, Kelly L. Miners, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Andre Franke, David A. Price, David A. Price, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov

“…The clear distinction between the Th17 and Th22 subsets should influence the development of vaccine- and T-cell-based therapies. …”
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A chemical autonomous robotic platform for end-to-end synthesis of nanoparticles by Fan Gao, Hongqiang Li, Zhilong Chen, Yunai Yi, Shihao Nie, Zihao Cheng, Zeming Liu, Yuanfang Guo, Shumin Liu, Qizhen Qin, Zhengjian Li, Lisong Zhang, Han Hu, Cunjin Li, Liang Yang, Yunhong Wang, Guangxu Chen

“…To overcome these challenges, we developed a data-driven automated platform integrating artificial intelligence (AI) decision modules with automated experiments. …”
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Climate Change Risk, Performance, and Value Added in Agricultural Sector by Ramin Amani, Zanko Ghorbani, Zana Mozaffari

“…The study period spans from 2010 to 2020, and the quantile regression method is employed on panel data to conduct the analysis. Methodology The general definition of quantile regression states that if the linear regression model is assumed as the following equation, we have: yi=ˊxiβτ+uτi.  0<τ<1                                                                                 (1) Quantτ(yi|xi)=xiβτ                                                                                  (2) Equation (2) shows the τth conditional quantile function of the y distribution under the condition of random variables x in which the following condition holds: Quantτ(uτi|xi)=0                                                                                              (3) In the quantile regression structure, the effect of observable features on the conditional distribution is estimated through the process of minimizing the absolute value of the error element. …”
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Impact of a pain education program for people with spinal cord injury who experience neuropathic pain by Nicholas P. Cherup, Kimberly D. Anderson, Marlon L. Wong, Gabriel E. Fernandez, Linda E. Robayo, Kathryn Roach, Roberta Vastano, Eva Widerstrom-Noga, Eva Widerstrom-Noga

“…Despite the availability of various treatments, many report inadequate pain relief, and various side effects.ObjectiveThe primary purpose of the current study was to explore participants’ perspectives on a brief, four-week virtual pain education program and second to evaluate any effects on pain and psychosocial factors.MethodsThis study included 36 participants with SCI who experienced moderate to severe neuropathic pain and explored their perspectives on the pain program using qualitative interviews and evaluated a small set of self-reported pain outcomes.ResultsThe analysis and coding of the qualitative interview data resulted in two primary overarching themes: Benefits of pain education and Content and delivery of pain education. …”
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Circulating B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus by Joanna Kosałka-Węgiel, Bogdan Jakieła, Radosław Dziedzic, Mamert Milewski, Andżelika Siwiec-Koźlik, Lech Zaręba, Stanisława Bazan-Socha, Marek Sanak, Jacek Musiał, Mariusz Korkosz

“…Finally, the percentage of plasmablasts correlated with SLE duration (r = 0.42, <i>p</i> = 0.016). In the follow-up analysis, during a median observation of 5 years, 5 out of the initially 23 inactive SLE patients developed a disease flare. …”
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Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches by Xuemin Fu, Luling Wu, Luling Wu, Jingna Xun, Benno Pütz, Zhihang Zheng, Yanpeng Li, Yanpeng Li, Yinzhong Shen, Hongzhou Lu, Jun Chen, Bertram Müller-Myhsok

“…Although improved risk stratification and tailored clinical management are urgently needed to enhance patient survival, such strategies remain limited.MethodsWe analyzed clinical and immunological data from 98 HIV-related cryptococcosis cases, employing machine learning techniques to model disease severity and predict survival outcomes. …”
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Top 10 palliative care research priorities in France: a 3-step, mixed-methods protocol (AXEPRO study) by Stéphane Sanchez, Guillaume Economos, Fiona Ecarnot, Cecile Barbaret, Raphaëlle Habert-Dantigny, Héloïse Rouze, Doan Huynh, Roseline Huynh, Caroline Tête, Martin Julier-Costes, Valérie Amouroux-Gorsse, Isabelle Lavault, Justine Bret

“…Following the guidance from the James Lind Alliance and the UK public consultation (‘Palliative and End of Life Care Research Priorities Project’), we developed a 3-step protocol aimed at prioritising 10 unanswered questions in palliative care (PC) research in France, from the viewpoint of patients, volunteers, healthcare professionals and family caregivers.Methods and analysis To identify unanswered questions in PC (stage 1), an unstructured questionnaire will be used. …”
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Case Report: Phenotypic heterogeneity within an NF1 family: assessment of the pathogenicity of a de novo c.6640dupA shift mutation and a splice variant with an epilepsy phenotype by Sijing Ren, Sijing Ren, Sijing Ren, Yanling Wang, Xinhua Tong, Xiaoyu Wu, Xiaoyu Wu, Huan Yan, Huan Yan, Qing-Xia Kong, Qing-Xia Kong, Qing-Xia Kong

“…Clinical data of the patient and her family members were collected, and peripheral venous blood samples were analyzed for causative genes using whole-exome sequencing. …”
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Streptococcus pneumoniae infections in an adult intensive care unit: A retrospective study from a tertiary Center in Portugal by Ana Catarina Rodrigues Gonçalves, Diogo Costa Oliveira, Rita Jorge, José Chen-Xu, Matilde Couto, Isabel Campos, José Artur Paiva

“…Data on serotypes, antimicrobial susceptibility, and vaccination status were analysed using statistical methods. …”
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MRI-based risk factors for intensive care unit admissions in acute neck infections by Jari-Pekka Vierula, Harri Merisaari, Jaakko Heikkinen, Tatu Happonen, Aapo Sirén, Jarno Velhonoja, Heikki Irjala, Tero Soukka, Kimmo Mattila, Mikko Nyman, Janne Nurminen, Jussi Hirvonen

“…Objectives: We assessed risk factors and developed a score to predict intensive care unit (ICU) admissions using MRI findings and clinical data in acute neck infections. …”
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Efficacy and safety of robot-assisted laparoscopic sacral fixation for the treatment of pelvic organ prolapse by Liu Xiaodong, Wang Jiawen, Meng Lingfeng, Zhao Shuangyi, Zhou Yunhe, Chu Xin, Wu Jianye, Zhang Yaoguang

“…[Methods] A retrospective analysis was conducted on the clinical data of 17 female patients with pelvic organ prolapse who underwent robot-assisted laparoscopic sacral fixation at Beijing Hospital between September 2019 and June 2023. …”
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Historical water environment changes in Chagan Lake (mid-19th to mid-20th century) inferred from sedimentary diatom records by Fengyang Sui, Fengyang Sui, Xinxin Du, Henglin Xiao, Henglin Xiao, Shuying Zang, Hongkuan Hui, Qi Lv, Yan Liu, Nannan Zhang, Yawen Fan

“…Although pH values and salinity thresholds remained stable, the nutrient status developed towards eutrophication after the 1950s. Sedimentological data further indicated accelerated sedimentation rates (0.34 cm·yr−1 pre-1950s vs. 1.31 cm·yr−1 post-1980s) and notable changes in grain-size characteristics, attributable to combined anthropogenic erosion, hydrological engineering, and climatic influences. …”
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Comparative child mental health and academic outcomes after primary school teachers deliver task-shifted mental health care in India by Priscilla Giri, Molly M. Lamb, Venessa C. Fuentes, Arpana Thapa, Surekha Bhattarai, Choden Dukpa, Catherine C. Shrestha, Setareh Ekhteraei, Juliana L. Vanderburg, Breanna Windsor, Abhishek K. Rauniyar, Karen Hampanda, Bradley N. Gaynes, Rinzi Lama, Michael Matergia, Christina M. Cruz

“…We conducted a pragmatic, mixed methods, post hoc analysis using data from 2019 of an open trial of Tealeaf running in parallel with the all-EUC first step of a stepped wedge cluster randomized controlled trial (SW-CRCT). …”
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National Health Policy and factors predicting its implementation at the local level in Nepal: an exploratory cross-sectional study by Dipendra Khadka, Dipendra Khadka, Dipendra Khadka, Zhang Xinyi, Zhang Xinyi, Zhang Mengjie, Zhang Mengjie, Rajan Bhusal, Chichen Zhang, Chichen Zhang

“…This study evaluated the implementation status, challenges, and opportunities of the NHP at the local level in Nepal.Materials and methodsA descriptive cross-sectional study was conducted in the Lumbini province among 166 health workers selected through simple random sampling. Data were collected from October 10 to November 15, 2024, using a structured questionnaire developed in Nepali through literature review and expert consultations. …”
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Oxytetracycline and Streptomycin Resistance Genes in Xanthomonas arboricola pv. pruni, the Causal Agent of Bacterial Spot in Peach by Austin Herbert, C. Nathan Hancock, Brodie Cox, Guido Schnabel, Daniela Moreno, Renato Carvalho, Renato Carvalho, Jeffrey Jones, Matthew Paret, Matthew Paret, Xueqing Geng, Hehe Wang

“…Six strains grew on media amended with ≤100 μg/mL OTC, while one strain, R1, grew on ≤250 μg/mL OTC. Genome sequence analysis of four representative OTCR strains revealed a 14–20 kb plasmid carrying tetC, tetR, and strAB in each strain. …”
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Mechanisms and genetic mutations of pyrethroid resistance in Aedes albopictus in the context of urbanization: a case study of Hangzhou, China by Binbin Jin, Binbin Jin, Lingya Wei, Lingya Wei, Tianxiao Duan, Yinghong Wang, Yinghong Wang, Huimin Wang, Huimin Wang, Hui Jin, Hui Jin

“…Molecular analyses were conducted to identify mutations in the voltage-gated sodium channel (VGSC) gene, with a specific focus on the F1534S mutation. The data were subjected to statistical analysis using Fisher’s exact test, chi-square test, and Pearson correlation to assess the relationship between resistance levels and urbanization.ResultsPopulations of Ae. albopictus in Hangzhou demonstrated substantial resistance to pyrethroids, with mortality rates falling below 90%. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…The pathogenesis of AAA has not been fully elucidated, and m6A RNA methylation regulators have never been implicated in AAA development. This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Relevance of choroid plexus volumes in multiple sclerosis by Britta Krieger, Barbara Bellenberg, Anna Katharina Roenneke, Ruth Schneider, Theodoros Ladopoulos, Zainab Abbas, Rebekka Rust, Tanja Schmitz-Hübsch, Claudia Chien, Ralf Gold, Friedemann Paul, Carsten Lukas

“…Enlarged ChP volumes were also significantly associated with reduced cortex volumes and increased lesion volumes in RRMS. Conclusions Our analysis confirmed that the ChP was significantly enlarged in patients with RRMS, which was related to brain lesion volumes and which suggested a dynamic development as it was associated with disease duration. …”
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A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma by Xuyan Zhao, Hanxiao Cui, Mingjing Zhou, Xueting Ren, Zihao Li, Peinan Liu, Danni Zhao, Shuai Lin, Huafeng Kang

“…However, its relationship with prognosis, tumour microenvironment (TME), and treatment response in KIRC remains unclear.Method Expression profiles and clinical data were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus databases. …”
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