Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated wit... by E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian

“…Analysis of exome sequencing data from a 46-year-old patient with a clinical diagnosis of Parkinson’s disease revealed the presence of the pathological variant c.2013T>G (rs63750756) in the MAPT gene, which is associated with frontotemporal dementia with parkinsonism-17. …”
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Revealing key regulatory factors in lung adenocarcinoma: the role of epigenetic regulation of autophagy-related genes from transcriptomics, scRNA-seq, and machine learning by Xianchang Zeng, Lingyun Wei, Lu Lv, Di Wu, Yingying Shen, Xinliang Lu, Xianghui Kong, Zhijian Cai, Jianli Wang, Jianli Wang

“…Autophagy, a key cellular process, is tightly linked to cancer development; genes like ATG5 and ATG10 influence lung cancer progression, and epigenetic regulators modulate autophagy-related carcinogenesis. …”
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Dissecting Trichoderma antagonism: Role of strain identity, volatiles, biomass, and morphology in suppressing cacao pathogens by Insuck Baek, Jishnu Bhatt, Jae Hee Jang, Seunghyun Lim, Amelia Lovelace, Minhyeok Cha, Dilip Lakshman, Moon S. Kim, Lyndel W. Meinhardt, Sunchung Park, Ezekiel Ahn

“…., which prioritizes the development of sustainable control solutions. This study evaluated the in vitro antagonistic potential of three Trichoderma strains (T. virens 11C-65-1, T. virens 29-8, Trichoderma spp. …”
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A predictive model for hospital death in cancer patients with acute pulmonary embolism using XGBoost machine learning and SHAP interpretation by Zhen-nan Yuan, Yu-juan Xue, Hai-jun Wang, Shi-ning Qu, Chu-lin Huang, Hao Wang, Hao Zhang, Min-ze Zhang, Xue-zhong Xing

“…A retrospective cohort study was conducted using the MIMIC-IV 2.2 database and external data from the intensive care unit of Cancer hospital, Chinese Academy of Medical Sciences, collected between May 1, 2021, and April 30, 2023. …”
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Barriers and enhancers to COVID-19 vaccination among healthcare workers in a metropolitan city in Nigeria by Adewale V. Opayele, Adeniyi F. Fagbamigbe, Chinwe L. Ochu, Rodgers R. Ayebare, Adedayo O. Faneye, Adewemimo C. Olaosebikan, Oluwaseun E. Falayi, Gloria O. Nwiyi, Sunday O. Eziechina, Ikemefule R. Uzoma, Priscilla Ibekwe, Prosper Okonkwo, Tamrat Shaweno, Nebiyu Dereje, Suzan Nakasendwa, Tonny Muwonge, Mosoka P. Fallah, Georgina N. Odaibo

“…Methods: A questionnaire administered using REDCap assessed HCW vaccination status, attitudes and access using the Behavioural and Social drivers (BeSD) framework. Data analysis performed using STATA version 17 included descriptive statistics and modified Poisson regression. …”
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Multicentre external validation of the Neonatal Healthcare-associated infectiOn Prediction (NeoHoP) score: a retrospective case–control study by Andrew Whitelaw, Michael Sharland, Cecilia Ferreyra, Angela Dramowski, Adrie Bekker, Sithembiso Christopher Velaphi, Daynia Elizabeth Ballot, Trusha Nana, Lizel G Lloyd, Mirjam Maria van Weissenbruch, Birgitta Gleeson, Jeannette Wadula

“…This study aims to validate the Neonatal Healthcare-associated infectiOn Prediction (NeoHoP) score, designed for LMICs, across diverse neonatal populations.Methods Prospective data from three South African neonatal units in the Neonatal Sepsis Observational (NeoOBS) study were analysed. …”
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Determinants of Child Growth in Palestine (Ages 5–17): A Structural Equation Modeling Approach to Food Insecurity, Nutrition, and Socioeconomic Factors by Suleiman Thwib, Radwan Qasrawi, Ghada Issa, Malak Amro, Razan Abu Ghoush, Sabri Saghir, Doa’a Mujahed, Maysaa Nemer, Mousa Halaika, Manal Badrasawi, Ayoub Al-Jawaldeh, Ibrahim Elmadfa, Lara Nasreddine, Diala Abu Al-Halawa, Maisan Nimer

“…<b>Methods</b>: A cross-sectional survey conducted in 2022 in the WB collected data from 1400 households, of which 500 with children aged 5–17 years and were selected for analysis. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Dalia Ali, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…Global gene expression profiling was conducted using the Agilent microarray platform, and data normalization and bioinformatics were performed using GeneSpring software. …”
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Individual Choices of Wintering Areas Drive Adult Survival Heterogeneity in a Long‐Lived Seabird by M. Genovart, R. Ramos, J. M. Igual, A. Sanz‐Aguilar, G. Tavecchia, A. Rotger, T. Militão, D. Vicente‐Sastre, B. Garcia‐Urdangarin, R. Pradel, J. González‐Solís, D. Oro

“…Additionally, when utilising geolocators, data become accessible only upon individual recapture, presenting a potential source of bias. …”
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Proteomic profiling improves prognostic risk stratification of the Sarculator nomogram in soft tissue sarcomas of the extremities and trunk wall by Madhumeeta Chadha, Sara Iadecola, Andrew Jenks, Valeriya Pankova, Yuen Bun Tam, Jessica Burns, Amani Arthur, Christopher P. Wilding, Liang Chen, Priya Chudasama, Dario Callegaro, Dirk C. Strauss, Khin Thway, Alessandro Gronchi, Robin L. Jones, Rosalba Miceli, Sandro Pasquali, Paul H. Huang

“…This study highlights the utility of integrating protein signatures for the development of next‐generation nomograms.…”
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Exercise‐induced dynamic mitral regurgitation is associated with outcomes in patients with ischaemic cardiomyopathy by Maximilian Spieker, Jonas Sidabras, Hannah Lagarden, Lucas Christian, Niklas Günther, Stephan Angendohr, Alexandru Bejinariu, P. Christian Schulze, Roman Pfister, Can Öztürk, Ralf Westenfeld, Patrick Horn, Amin Polzin, Malte Kelm, Obaida Rana

“…Multivariate analysis identified MR severity during exercise [HR 1.998 (1.367–2.938)] and exercise TAPSE [HR 0.913 (0.853–0.973)] as predictors of the combined endpoint. …”
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An atomistical elucidation of the 6FDA-durene-based mixed matrix membrane and ionic liquid mixed matrix membrane for CO2/CH4 separation by Jia Cheng Loh, Serene Sow Mun Lock, Bobby Kwong Yii Lee, Mehtab Ali Darban, Dun-Yen Kang, Mohd Hafiz Dzarfan Othman, Zhen Hong Ban

“…Validation against experimental data showed a mean averaged relative deviation (MARD) below 0.1362. …”
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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…The interviews were conducted by two researchers who have extensive experience interviewing KOA patients, and data were gathered through face-to-face, semi-structured interviews to ensure a high level of information power. …”
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Interventions to improve the quality of cataract services: protocol for a global scoping review by Nathan Congdon, João M Furtado, Matthew J Burton, Jacqueline Ramke, Stephen Gichuhi, Helen Burn, Iris Gordon, William H Dean, John Buchan, Ada Aghaji, Miho Yoshizaki, Ana P Marques

“…For included articles, data regarding publication characteristics, study details and quality-related outcomes will be extracted by two reviewers independently. …”
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Construction of an anaplastic thyroid cancer stratification signature to guide immune therapy selection and validation of the pivotal gene HLF through in vitro experiments by Li Pengping, Yin Kexin, Xie Yuwei, Sun Ke, Li Rongguo, Wang Zhenyu, Jin Haigang, Wang Shaowen, Huang Yuqing

“…Our study aims to identify ATC patients who might bene t from immunotherapy.MethodsOur study uses multiple algorithms by R4.2.0, and gene expression and clinical data are collected from TCGA, GEO and local cohort. …”
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Case Report: Observation of early-onset high myopia with fundus tessellation changes in Coffin–Siris syndrome 9 (CSS9) and literature review by Ruohao Wu, Ruohao Wu, Yu Li, Yu Li, Zhanwen He, Zhanwen He, Zhe Meng, Zhe Meng, Wenting Tang, Liyang Liang, Liyang Liang

“…A systematic literature review yielded 14 publications providing detailed data from 57 CSS9 cases. Quantitative analysis of the ophthalmological phenotypic spectrum of the 58 cases (including our proband) revealed that almost half (26/58, 44.83%) presented ophthalmological malformations; the most prevalent phenotype was ocular motor disorder (15/58, 29.31%); however, pathologic fundus change was only reported in our proband (1/58, 1.72%), suggesting that fundus examination may have been lacking in previous investigations of CSS9 cases. …”
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Postoperative atrial arrhythmias after bilateral lung transplantation with intraoperative V-A extracorporeal membrane oxygenation: a single-center experience by Annalisa Boscolo, Annalisa Boscolo, Nicolò Sella, Francesco Zarantonello, Raimondo Pittorru, Giulia Mormando, Carlo Alberto Bertoncello, Elena Curmaci, Roberta Ceccato, Valentina Fincati, Paola Masetti Zannini, Angela Bianco, Giordana Coniglio, Elisa Pistollato, Alessandro Zambianchi, Mustaj Sindi, Sabrina Congedi, Gabriella Roca, Arianna Peralta, Luisa Muraro, Giorgia Pacchiarini, Federico Migliore, Manuel De Lazzari, Tommaso Pettenuzzo, Federico Rea, Martina Perazzolo Marra

“…Although AAs are frequently observed in the early postoperative period, data regarding their incidence and impact on outcomes are scarce. …”
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From Reductionist Skills to Meaningful Learning: Trust and Humility in Bedside Cardiac Assessment by Meisel JL, Navedo DD, Opole IO, Cohen GM, Bernard SA, Carmona H, Nahas AH, Eiduson CM, Papps N

“…Comments affirmed the importance of attitudinal aspects of skills development; human interaction while learning; and humility, a linchpin of expertise development and patient-centered communication. …”
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Oncolytic Orf virus licenses NK cells via cDC1 to activate innate and adaptive antitumor mechanisms and extends survival in a murine model of late-stage ovarian cancer by Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton

“…Primary tumor removal, a common treatment option in human patients, was effectively combined with OrfV for optimal therapeutic outcome. Analysis of human RNA sequencing datasets revealed that cDC1s correlate with NK cells in human ovarian cancer and that intratumoral NK cells correlate positively with survival.Conclusions The data herein support the translational potential of OrfV as an NK stimulating immunotherapeutic for the treatment of advanced-stage ovarian cancer.…”
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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer by Sarah Alexandrou, Christine S. Lee, Kristine J. Fernandez, Celine E. Wiharja, Leila Eshraghi, John Reeves, Daniel A. Reed, Neil Portman, Zoe Phan, Heloisa H. Milioli, Iva Nikolic, Antonia L. Cadell, David R. Croucher, Kaylene J. Simpson, Elgene Lim, Theresa E. Hickey, Ewan K. A. Millar, Carla L. Alves, Henrik J. Ditzel, C. Elizabeth Caldon

“…Overall, we demonstrate that suppression of JNK signalling enables persistent growth during combined endocrine therapy and CDK4/6 inhibition. Our data provides the pre-clinical rationale to stratify patients based on JNK pathway activity prior to receiving combination endocrine therapy and CDK4/6 inhibition.…”
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