Estado del Arte en Neurotecnologías para la Asistencia y la Rehabilitación en España: Tecnologías Auxiliares, Trasferencia Tecnológica y Aplicación Clínica by Luis J. Barrios, Jesús Minguillón, Francisco J. Perales, Ricardo Ron-Angevin, Jordi Solé-Casals, Miguel A. Mañanas

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The Effects of Foot and Mouth Disease on the Profitability of Smallholder Dairy Farms: Evidence from East Java, Indonesia by Nanang Febrianto, Budi Hartono, Eko Nugroho, Anie Eka Kusumastuti, Priyo Sugeng Winarto, Puji Akhiroh, Trinil Susilawati, Aulia Puspita Anugra Yekti, Putri Utami, Nurul Nadia Ramli, Muhammad Helmi

“…Through descriptive and input?output analysis, economic losses were quantified on the basis of structured surveys and secondary data from affected dairy farmers. …”
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Non-invasive identification of TKI-resistant NSCLC: a multi-model AI approach for predicting EGFR/TP53 co-mutations by Jiayi Li, Renjie Xu, Dan Wang, Zhanlue Liang, Yangqian Li, Qinglan Wang, Lingfeng Bi, Yawen Qi, Yaojie Zhou, Weimin Li

“…Results In our cohort of 2171 patients (1,153 males, 1,018 females; median age 60 years), single-dimensional models were developed using data from 1,055 eligible patients. …”
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The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma by Xiaojing Zhang, Xitong Huang, Xianying Zhang, Lichang Lai, Baoyi Zhu, Peibin Lin, Zhanfang Kang, Dazhong Yin, Dongbo Tian, Zisheng Chen, Jun Gao

“…Dysregulation of miRNA activity in tumor-associated neutrophils (TANs) in the tumor microenvironment plays an important role in the occurrence and development of LUAD.MethodIn this study, the miReact algorithm was used to analyze the single-cell RNA sequencing data of LUAD samples to reveal the miRNA profile characteristics of TANs in LUAD patients. …”
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Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases by I. Hyun Ruisch, Joanna Widomska, Ward De Witte, Nina R. Mota, Giuseppe Fanelli, Veerle Van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Abel Fóthi, Csaba Barta, Simone Berkel, Kazi A. Alam, Aurora Martinez, Jan Haavik, Aet O’Leary, David Slattery, Mairéad Sullivan, Jeffrey Glennon, Jan K. Buitelaar, Janita Bralten, Barbara Franke, Geert Poelmans

“…Subsequently, using (additional) GWAS data, we conducted shared genetic etiology analyses between AD and SID, on the one hand, and blood and cerebrospinal fluid (CSF) metabolite levels on the other hand. …”
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急性缺血性卒中院前延迟风险预测模型的构建及评价 Construction and Evaluation of Pre-Hospital Delay Risk Prediction Model for Acute Ischemic Stroke by 倪佃丽1，陈晓兵1，张广慧2，彭庆荣1 (NI Dianli1, CHEN Xiaobing1, ZHANG Guanghui2, PENG Qingrong1 )

“…Based on pre-hospital delay conditions, the model group was further divided into the non-delayed (<3.5 h) group and the delayed (≥3.5 h) group. The data from the model group was used to establish a nomogram model, and the data from the internal validation group was used to assess the model’s generalization performance. …”
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Validity and Reliability of a Mobile Device Application for Assessing Motor Performance in the 30-Second Sit-to-Stand Test by Eduardo Candido Veloso Ferreira, Amelia Pasqual Marques, Szymon Kulis, Jan Gajewski, Anderson Antunes da Costa Moraes, Manuela Brito Duarte, Gizele Cristina da Silva Almeida, Enzo Gabriel da Rocha Santos, Gustavo Henrique Lima Pinto, Andre Dos Santos Cabral, Givago da Silva Souza, Anselmo De Athayde Costa E Silva, Bianca Callegari

“…The motor behavior of the CoM was subsequently observed during task execution. Data were processed offline using routines developed for MatLab software, focusing on the longitudinal axis and describing the event cycles. …”
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Radiogenomic method combining DNA methylation profiles and magnetic resonance imaging radiomics predicts patient prognosis in skull base chordoma by Xiaoyu Deng, Peiran Li, Kaibing Tian, Fan Zhang, Yumeng Yan, Yanghua Fan, Zhen Wu, Junting Zhang, Jiang Du, Wei Chen, Liang Wang

“…HLG patients had higher progression-free survival times than LLG patients. Combined analysis with external single-cell RNA-seq data revealed higher tumor cell proportions and lower natural killer cell proportions in the HLG than in the LLG. …”
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UNDERSTANDING EDUCATORS’ EXPERIENCE AND ATTITUDE TO GAMIFIED LEARNING APPLICATIONS by Anastasiia V. Tokarieva, Inna V. Сhyzhykova

“…This article is devoted to the analysis of the experiences and attitudes of Ukrainian educators to gamified learning applications (GLAs) in the context of a new educational paradigm formation. …”
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Functional characterization of seven terpene synthases from Ophiopogon japonicus via engineered Escherichia coli by Wen Xu, Qing Ma, Tong Chen, Haiyan Zhang, Guanglei Ma, Sibongile Mafu, Juan Guo, Xiaohui Fan, Guanghong Cui, Baolong Jin

“…Results. This study developed a rapid expression system for monoterpene and sesquiterpene synthases based on engineered E. coli. …”
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Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination by Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska

“…These epivariants were detected in epigenome-wide data collected from isolated B cell samples from 41 responders and 30 non-responders (age range 22–62 years) to vaccination against HBV. …”
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RNA mis‐splicing in children with congenital myotonic dystrophy is associated with physical function by Julia M. Hartman, Kobe Ikegami, Marina Provenzano, Kameron Bates, Amanda Butler, Aileen S. Jones, Kiera N. Berggren, Jeanne Dekdebrun, Marnee J. McKay, Jennifer N. Baldwin, Kayla M. D. Cornett, Joshua Burns, Michael Kiefer, Nicholas E. Johnson, Melissa A. Hale, the DMCRN Consortium

“…Multiple linear regression analysis was performed to predict [MBNL]inferred using clinical outcome measures alone. …”
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Morphometrical and Molecular Characterization of Oesophagostomum columbianum (Chabertiidae: Oesophagostominae) and Haemonchus contortus (Trichostrongylidae: Haemonchinae) Isolated... by Tilak Chandra Nath, Dongmin Lee, Hansol Park, Seongjun Choe, Barakaeli Abdieli Ndosi, Yeseul Kang, Mohammed Mebarek Bia, Chatanun Eamudomkarn, Uday Kumar Mohanta, Kazi Mehetazul Islam, Jamal Uddin Bhuiyan, Hyeong-Kyu Jeon, Keeseon S. Eom

“…This study, for the first time, illustrates the characteristics of O. columbianum and H. contortus in Bangladesh, combining both morphological and molecular data. The universal primer-based polymerase chain reaction (PCR) protocol could be an economical and efficient option for researchers from poor resource settings for precise identification of nematodes. …”
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TB death surveillance and response (TBDSR) - A step towards zero deaths due to TB. Lessons learnt from West Bengal, India by Abhijit Dey, Santosh Kumar Roy, Poulami Basu, Dhrubajyoti Deka, Rajat Basu, Simran Keshri, Bandita Sengupta, Sandip Roy

“…This was the study population. A secondary analysis was done on the routinely collected data from the TBDSR portal. …”
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Prevalence and predictors of chronic disease among rural and medically underserved populations using smokeless tobacco by Elaine Sang, Elaine Sang, Susan Silva, Sarah Grenon, Courtney Swinkels, Shamatree Shakya, Salsa Deshmukh, Laura J. Fish, Laura J. Fish, Mariana Da Costa, Leigh Ann Simmons, Herbert H. Severson, Kathryn I. Pollak, Kathryn I. Pollak, Devon Noonan, Devon Noonan

“…Our study examined prevalence of chronic disease and identified associated risk factors among rural and medically underserved populations using smokeless tobacco.MethodsWe conducted a cross-sectional analysis of baseline data (N = 532) from a clinical trial promoting SLT cessation among adults living in rural and/or medically underserved areas and examined the rates of eight chronic diseases: cancer, lung disease, heart disease, stroke, mental health conditions, diabetes, arthritis/orthopedic conditions, and hypertension. …”
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Defining criteria for disease activity states in juvenile dermatomyositis based on the Juvenile Dermatomyositis Activity Index by Carine Wouters, Nicolino Ruperto, Maria Trachana, Angelo Ravelli, Veronika Vargová, Troels Herlin, Angela Pistorio, Pavla Dolezalova, Claudia Bracaglia, Alessandro Consolaro, Silvia Rosina, Ana Rebollo-Giménez, Ana Guilaisne Bernard-Medina, Laura Carenini

“…Objectives To develop and validate the cut-offs in the Juvenile DermatoMyositis Activity Index (JDMAI) to distinguish the states of inactive disease (ID), low disease activity (LDA), moderate disease activity (MDA) and high disease activity (HDA) in children with juvenile dermatomyositis (JDM).Methods For cut-off definition, data from 139 patients included in a randomised clinical trial were used. …”
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Healthcare providers' perspectives on the organization of health services to manage people with multiple long-term conditions in primary care settings in Kerala, India: a qualitati... by Thoniparambil Ravindranathanpillai Lekha, Linju Joseph, Linju Joseph, Neethu Vasantha Sasidharan, Athira Krishnan, Justine Davies, Paramjit Gill, Sheila Greenfield, Sivadasanpillai Harikrishnan, Jissa Vinoda Thulaseedharan, Mathew Joseph Valamparampil, Semira Manaseki-Holland, Panniyammakal Jeemon, Panniyammakal Jeemon

“…Complexity in managing MLTCs and their adverse consequences confronts the public healthcare systems in India. However, data from India to understand how to improve capacity to manage multiple chronic conditions are limited. …”
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The mediating role of depression in the association between health-related quality of life and suicidal ideation in adolescents: findings from a longitudinal study by Martina Preisig, Isabelle Häberling, Lukasz Smigielski, Sophie Emery, Noemi Baumgartner, Mona Albermann, Michael Strumberger, Klaus Schmeck, Lars Wöckel, Suzanne Erb, Bruno Rhiner, Brigitte Contin-Waldvogel, Susanne Walitza, Susanne Walitza, Susanne Walitza, Gregor Berger

“…IntroductionAdolescent suicidality is a significant public health issue. To develop effective interventions aimed at preventing suicide in this vulnerable population, it is essential to understand the complex interplay of health-related quality of life, depression and suicidal ideation.MethodsFor this purpose, we analyzed longitudinal data of 250 children and adolescents diagnosed with major depressive disorder (M = 15.7, SD = 1.6, range 8–18 years, 74% females). …”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…Results Clinical and animal data revealed that Piezo1/ITGB1 coactivation was strongly correlated with ECM stiffness‐induced BLCA proliferation and poor clinical prognosis. …”
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Prognostic Utility of the Modified Systemic Inflammation Score for Patients Undergoing Oral Cavity Cancer Surgery by Ku-Hao Fang, Sheng-Wei Lo, Adarsh Kudva, Andrea De Vito, Yuan-Hsiung Tsai, Cheng-Ming Hsu, Geng-He Chang, Ethan I. Huang, Ming-Shao Tsai, Chia-Hsuan Lai, Ming-Hsien Tsai, Chun-Ta Liao, Chung-Jan Kang, Yao-Te Tsai

“…Methods: We retrospectively reviewed data from 320 OCSCC patients who underwent curative surgery between 2007 and 2017. …”
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