Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis by Ruth Steinberg, Nadja Mostacci, Elisabeth Kieninger, Bettina Frauchiger, Carmen Casaulta, Jakob Usemann, Alexander Moeller, Daniel Trachsel, Isabelle Rochat, Sylvain Blanchon, Dominik Mueller-Suter, Barbara Kern, Maura Zanolari, Urs Frey, Kathryn A. Ramsey, Markus Hilty, Philipp Latzin, Insa Korten, SCILD study group, BILD study group

“…While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF. …”
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Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region by F. Sh. Kamolova, A. M. Mudunov, P. A. Zeynalova, L. Yu. Grivtsova, G. F. Allakhverdieva, R. I. Azizyan, A. A. Akhundov, I. A. Zaderenko, M. V. Bolotin, D. K. Stelmakh, V. I. Sokorutov, K. D. Il’kaev, V. T. Tsiklauri, I. M. Gelfand, M. B. Pak, O. L. Timofeeva, Yu. E. Ryabukhina, F. M. Abbasbeyli, Ts. Chzhao

“…Neoplastic process often develops in head and neck area, including the integumentary tissues, orbit, nasal cavity, paranasal sinuses, oral cavity, pharynx, salivary glands, thyroid gland, as well as neck lymph nodes. …”
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Overexpression of the Kiwifruit Transcription Factor <i>AaMYB44</i> Decreases the Cold Tolerance in <i>Arabidopsis thaliana</i> by Yihang Li, Miaomiao Lin, Qina Zhang, Peng Zhang, Zhenzhen Zhang, Yukuo Li, Leiming Sun, Sumei Li, Congcong Li, Dixin Chen, Xiujuan Qi

“…Cold stress is one of the main abiotic stresses that affect the development and growth of kiwifruit (<i>Actinidia arguta</i>). …”
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Deep Learning for Weed Detection and Segmentation in Agricultural Crops Using Images Captured by an Unmanned Aerial Vehicle by Josef Augusto Oberdan Souza Silva, Vilson Soares de Siqueira, Marcio Mesquita, Luís Sérgio Rodrigues Vale, Thiago do Nascimento Borges Marques, Jhon Lennon Bezerra da Silva, Marcos Vinícius da Silva, Lorena Nunes Lacerda, José Francisco de Oliveira-Júnior, João Luís Mendes Pedroso de Lima, Henrique Fonseca Elias de Oliveira

“…Artificial Intelligence (AI) has changed how processes are developed, and decisions are made in the agricultural area replacing manual and repetitive processes with automated and more efficient ones. …”
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New findings into the genetic population structure of two commercially valuable and threatened sharks, Mustelus mustelus (Linnaeus, 1758) and M. punctulatus (Risso, 1827), allow re... by Matteo Barbato, Matteo Barbato, Matteo Barbato, Sara Bonanomi, Sara Bonanomi, Diego Borme, Ilija Ćetković, Francesco Colloca, Manfredi Di Lorenzo, Manfredi Di Lorenzo, Ilaria A. M. Marino, Ilaria A. M. Marino, Carlotta Mazzoldi, Carlotta Mazzoldi, Carlotta Mazzoldi, Ana Pešić, Antonello Sala, Lorenzo Zane, Lorenzo Zane, Lorenzo Zane, Massimo Mezzavilla

“…This study provides valuable data that should be integrated into a broader approach to define management units, improving the development of an effective management strategy for these threatened species in the Central Mediterranean Sea.…”
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Design and feasibility of acid gas reinjection with corrosion mitigation: A case study from Tahe Oilfield, China by Shijian Lu, Fei Yang, Ling Liu, Guojun Kang, Xulin Yu, Qingfang Li, Deyin Zhao, Lirong Yao, Qianlin Zhu

“…The implementation of this project provides important engineering experience and technical data for large-scale acid gas reinjection projects in China and has an important demonstration role.…”
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The Learn Together programme (part A): co-designing an approach to support patient and family involvement and engagement in patient safety incident investigations by Jane K. O’Hara, Jane K. O’Hara, Lauren Ramsey, Rebecca Partridge, Chris Redford, Siobhan McHugh, Gemma Louch, Penny Phillips, Laura Sheard, Ruth Simms-Ellis, Ruth Simms-Ellis, Justin Waring, Joe Langley

“…BackgroundWhilst patients and families can and do support patient safety in several ways, empirical evidence for the specific impact of involvement in patient safety incident investigations and their outcomes, has been limited, with little information about how to undertake involvement meaningfully.AimWe aimed to (i) develop a set of common principles to guide involvement of patients and families in patient safety incident investigations; (ii) develop a working programme theory for how these might be enacted; (iii) co-design guidance to support the meaningful involvement of patients and families in patient safety incident investigations.MethodsWe synthesised three existing data sets (a literature review, a documentary analysis of incident investigation policies and 42 interviews with patients, families, lawyers, incident investigators, and healthcare staff) relating to patient and family involvement in incident investigations. …”
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Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights by Farag M.A. Altalbawy, Bilal Abdul Majeed Mukhlif, Ahemad Hussen, Jaafaru Sani Mohammed, Renuka Jyothi S, Arshdeep Singh, Shakti Bedanta Mishra, Ashish Singh Chauhan, Mohammad Ebrahim Astaneh, Narges Fereydouni

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Experimental and analytical evaluation of mechanical properties of rubberized concrete incorporating waste tire crumb rubber by Xiaoyan Han, Li Wang, Aijiu Chen, Lingyun Feng, Yanting Ji, Zhihao Wang, Zhenzan Gao, Keliang Li, Qun Yuan, Xiaozhou Xia, Qing Zhang

“…The study further identified that the alterations in concrete's void structure due to crumb rubber inclusion significantly affect its mechanical properties. Our comprehensive analysis led to the development of evaluation equations for fts, ff, and Ec of rubberized concrete, presenting a robust method to predict the mechanical properties of rubberized concrete with varied crumb rubber incorporations. …”
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Gasdermin E links tumor cell-intrinsic nucleic acid signaling to proinflammatory cell death for successful checkpoint inhibitor cancer immunotherapy by Stefan Enssle, Anna Sax, Peter May, Nadia El Khawanky, Nardine Soliman, Markus Perl, Julius C. Enssle, Karsten Krey, Jürgen Ruland, Andreas Pichlmair, Florian Bassermann, Hendrik Poeck, Simon Heidegger

“…In humans, transcriptome analysis of melanoma samples showed strong correlation between genetic activity of the RIG-I and pyroptosis pathways. …”
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A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia by Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao

“…Our work is the first that complementarily couples transcriptomic analysis with mechanistic systems-level pathway modeling in the study of BMEC function and endothelium-based therapeutic targets in ischemic stroke.…”
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Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope (TRICORDER): design and rationale for a decentralised, real-world cluster-randomised con... by Azeem Majeed, Rasha Al-Lamee, Ceire Costelloe, Daniel B Kramer, Carla M Plymen, Carys Barton, Emanuela Falaschetti, Nicholas S Peters, Josephine Mansell, Patrik Bachtiger, Mihir A Kelshiker, Camille F Petri, Abdullah Alrumayh, Saloni Nakhare, Melanie T Almonte, Alexei Peters

“…Patient and outcome data will be captured from pooled primary and secondary care records, supplemented by qualitative and quantitative clinician surveys. …”
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A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria by Tonia Dargham, John Jairo Aguilera-Correa, Romain Avellan, Ivy Mallick, Léa Celik, Pierre Santucci, Gael Brasseur, Isabelle Poncin, Vanessa Point, Stéphane Audebert, Luc Camoin, Wassim Daher, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan

“…By identifying the proteins involved in the formation of intrabacterial lipid inclusions and revealing their impact on lipid metabolism, our data may lead to the development of new therapeutic strategies to target and control pathogenic mycobacteria, potentially improving outcomes for patients with mycobacterial infections.…”
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Factors associated with early hospital readmission for acute decompensation of cirrhosis - prospective cohort study by Tamara Liana Zocche, Cláudia Maccali, Fernanda Cristina de Augustinho, Elayne Cristina de Morais Rateke, Camila Matiollo, Ariane Borgonovo Rayes, Dariana Carla Maggi, Esther Buzaglo Dantas-Corrêa, Leonardo de Lucca Schiavon, Janaina Luz Narciso-Schiavon

“…Knowing the factors associated with early readmission in these individuals may contribute to the development of preventive strategies that avoid the risks and costs related to a new hospitalization. …”
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Exploring barriers and drivers to a modified WHO safe childbirth checklist implementation in three West African countries: a qualitative study using the updated consolidated framew... by Kadidiatou Raïssa Kourouma, Kadidiatou Raïssa Kourouma, Wambi Maurice Evariste Yaméogo, Wambi Maurice Evariste Yaméogo, Daouda Doukouré, Daouda Doukouré, Alpha Oumar Sall, Marie Laurette Agbré Yacé, Marie Laurette Agbré Yacé, Tiéba Millogo, Tiéba Millogo, Mamadou Diouldé Baldé, Issaka Tiembré, Alexandre Delamou, Séni Kouanda, Séni Kouanda

“…The mSCC was implemented in these hospitals along with training and coaching. Data was analyzed using thematic analysis, guided by the updated CFIR framework. …”
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Factors associated with early hospital readmission for acute decompensation of cirrhosis - prospective cohort study by Tamara Liana Zocche, Cláudia Maccali, Fernanda Cristina de Augustinho, Elayne Cristina de Morais Rateke, Camila Matiollo, Ariane Borgonovo Rayes, Dariana Carla Maggi, Esther Buzaglo Dantas-Corrêa, Leonardo de Lucca Schiavon, Janaina Luz Narciso-Schiavon

“…Knowing the factors associated with early readmission in these individuals may contribute to the development of preventive strategies that avoid the risks and costs related to a new hospitalization. …”
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IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis by Xiao Wang, Ruifang Yang, Sihan Liu, Yan Guan, Chunling Xiao, Chuanyou Li, Jianzhou Meng, Yu Pang, Yishuang Liu

“…There is an urgent need to develop effective anti-TB drugs with novel mechanisms of action. …”
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Serum lactate dehydrogenase isoenzymes 4 plus 5 is a better biomarker than total lactate dehydrogenase for refractory Mycoplasma pneumoniae pneumonia in children by Ta-Yu Liu, Wei-Ju Lee, Chih-Min Tsai, Kuang-Che Kuo, Chen-Hsiang Lee, Kai-Sheng Hsieh, Chin-Hao Chang, Yu-Tsun Su, Chen-Kuang Niu, Hong-Ren Yu

“…Receiver operating characteristic curve analysis showed that the area under the curve for the total LDH data was 0.812 with a cut-off of 408 IU/L (sensitivity of 75.0%, specificity of 72.2%). …”
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Water quality characteristics of municipal wastewater treatment plants and the prospect of reclaimed water utilization in lower-middle income and water-scarce areas: A case study o... by Yutong Duan, Hongbo Xi, Zhikai Qin, Ruili Guo, Fang Wang, Yue Yuan

“…Water scarcity is a key bottleneck for China's economic and social development. Reclaimed water presents a sustainable solution, but its utilization remains limited, especially in lower-middle income cities like Puyang. …”
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Enhancing fibroblast–epithelial cell communications: Serpine2 as a key molecule in Fusobacterium nucleatum–promoted colon cancer by Xueke Li, Xueke Li, Simin Luo, Yifang Jiang, Qiong Ma, Fengming You, Fengming You, Qixuan Kuang, Xi Fu, Chuan Zheng

“…These findings contribute novel insights that may inform the development of therapeutic strategies for colon cancer.…”
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