Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study by Dagfinn Lunde Markussen, Jannicke Slettli Wathne, Christian Ritz, Cornelis H. van Werkhoven, Sondre Serigstad, Rune Oskar Bjørneklett, Elling Ulvestad, Siri Tandberg Knoop, Synne Jenum, Harleen M. S. Grewal

“…Patients were selected from two cohorts, with data on clinical and microbiologic test results collected. …”
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COVID-19 policies and tuberculosis services in private health sectors of India, Indonesia, and Nigeria by Nathaly Aguilera Vasquez, Charity Oga-Omenka, Vijayashree Yellappa, Bony Wiem Lestari, Angelina Sassi, Surbhi Sheokand, Bolanle Olusola-Faleye, Lavanya Huria, Laura Jane Brubacher, Elaine Baruwa, Bachti Alisjahbana, Madhukar Pai

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An evidence-based digital prescription opioid safety toolkit for national dissemination: co-design and user testing by Alex Waddell, Jessica L. Watterson, Jessica L. Watterson, Dhruv Basur, Christopher Owen Prawira, Louisa Picco, Tina Lam, Patrick Olivier, Joshua Paolo Seguin, Liam Kay, Suzanne Nielsen

“…User testing was conducted with the penultimate version of the Toolkit.Results13 consumers with lived experience of prescription opioid use and 14 professionals including prescribers, pharmacists, pain specialists, researchers and consumer advocates participated in up to three separate workshops. 15 consumers participated in user testing interviews. Analysis of workshops identified factors promoting safety behaviours including increased public awareness of naloxone, understanding personal risk (TDF domain of Knowledge); healthcare professional's role in education and consumers' experience of stigma (Social/professional role and identity); use of conversational aids to scaffold conversations, material resources and data ownership (Environment, context and resources). …”
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Interrelations of physical state parameters and biological age of students in the process of physical education by Oleksandr Pryimakov, Marek Sawczuk, Stanislav Prysiazhniuk, Nataliya Mazurok, Oleksandr Petrachkov

“…We recorded 55 indices of students' functional state and physical fitness, and determined their Body Mass Index (BMI). The experimental data were processed using methods of correlation, dispersion, and regression analysis. …”
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Perancangan dan Implementasi Sistem Informasi Deteksi Kesesuaian Pemanfaatan Ruang Berbasis Web dengan Fitur Geo-Intersection Pada POSTGIS by Issa Arwani, Widhy Hayuhardhika Nugraha Putra, Ghazian Hamdi, Tsania Dzulkarnain

“…The system is developed in the waterfall method and built with PHP Yii framework and Leaflet JS to form an interactive webGIS. …”
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Prophylactic IL-23 blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy by Ting Chen, Lin Zhao, Jiaojiao Zhang, Mingyi Ju, Zhuoyuan Deng, Minjie Wei, Lianghua Ma

“…However, currently, the role of IL-23 in irAEs onset and severity remains poorly understood.Methods The pro-inflammatory cytokines most associated with severe irAEs onset were identified by retrospective analysis based on GSE186143 data set. To investigate the efficacy of prophylactic IL-23 blockade administration to prevent irAEs, refer to a previous study, we constructed two irAEs murine models, including dextran sulfate sodium salt (DSS)-induced colitis murine model and a combined-ICIs-induced irAEs murine model. …”
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Energy and Macronutrient Dietary Intakes of Serbian Adults 18–64 Years Old: EFSA EU Menu Food Consumption Survey in Serbia (2017–2022) by Jelena Milešević, Milica Zeković, Ivana Šarac, Marija Knez, Irena Krga, Marija Takić, Jasmina Debeljak Martačić, Vuk Stevanović, Nevena Vidović, Slavica Ranković, Agnes Kadvan, Mirjana Gurinović

“…This study offers a comprehensive analysis of the anthropometric and nutritional status among Serbian adults aged 18–64 years, using the data from the EFSA EU Menu food consumption survey conducted between 2017 and 2022. …”
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Systematic review of the impact of ginger extract and alpinetin on pregnancy outcomes in animal models by Jonquile T. Williams, Kendra A. Tiani, Margaret J. Foster, Amanda J. MacFarlane, Regan L. Bailey, Patrick J. Stover, Martha S. Field

“…Studies on fetal development reported improvements in birth weight, growth metrics, and reductions in death rates when ginger was administered at moderate doses, specifically ginger tea 20 g/L-50 g/L or gingerol 25 mg/kg/body weight. …”
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A Multicomponent Strategy to Improve HIV Pre-Exposure Prophylaxis in a Southern US Jail: Protocol for a Type 3 Hybrid Implementation-Effectiveness Trial by Ank E Nijhawan, Jana Kholy, Julia L Marcus, Timothy P Hogan, Robin T Higashi, Jacqueline Naeem, Laura Hansen, Brynn Torres, Barry-Lewis Harris, Song Zhang, Douglas Krakower

“…An HIV risk prediction model based on EHR data to identify individuals most likely to benefit from PrEP has been developed and internally validated and is ready to be deployed. …”
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Division, Naming, and Spatial Distribution Characteristics of Small Watersheds in Mixed Terrains:A Case Study of Yingwen River Basin by CHEN Fei-yong, CHEN Qian-xun, JIANG Qian-qian, MA Shu-juan, XU Jing-tao, REN Guang-xin, CHENG Xiao-xiang, WANG Jin

“…[Methods] This study utilized high-precision SRTM-DEM data, combined with hydrological analysis modules, to extract micro-watersheds, river networks, and watershed boundaries. …”
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Adopting Positive Selection Technology and Improving Seed Quality in Smallholder Potato Farmers in South-Western Uganda. by Kajura, Tibanyendera Deo

“…Descriptive statistics were used to analyse the data. Chi-square tests, Pearson correlation and simple regression analyses were run between different variables to assess their interactive effects on adoption of the technology. …”
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Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context by Weichao Huang, Linghui Deng, Qiaorui Wen, Zilong Zhang, Jirong Yue, Chichen Zhang, Xianghong Zhou, Yuming Jin, Dan Hu, Zhongyuan Jiang, Colucci Manuel, Robesti Daniele, Valdata Aurora, Xiaoli Zou, Yu Zhan, Lei Chen, Shaoheng Luo, Zuoqiu Sophia, Qiang Wei, Lu Yang, Birong Dong, Shengfeng Wang, Shi Qiu

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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

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Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex by Sulov Saha, Clémence Debacq, Christophe Audouard, Thomas Jungas, Pierrick Dupré, Fawal Mohamad-Ali, Clément Chapat, Henri-Alexandre Michaud, Laurent Le Cam, Matthieu Lacroix, David Ohayon, Alice Davy

“…Progenitor cohort labeling revealed a time-dependent sensitivity to MR and cell cycle analysis indicated that progenitors are stalled in S/G2 phases following MR. …”
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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Annotation of in vitro cell types with reference to in vivo development reveals diverse mesendoderm lineage cell types including lateral plate and paraxial mesoderm, neural crest, and primitive gut. …”
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Discovery of two new Cortinarius species in Southern China by Yuxiao Dang, Mengjia Zhu, Nemat O. Keyhani, Ziyi Wu, Chenghao Qiu, Jinming Xiong, Huili Pu, Longbing Lin, Chengjie Xiong, Zhiying Zhao, Minghai Zheng, Taichang Mu, Yongsheng Lin, Yanbin Huang, Xin Yuan, Chunjin Qiu, Xiaohong Ji, Junzhi Qiu, Yuxi Chen

“…The developed keys provide a reference for the further analysis of the evolution and geographic distribution of these fungi.…”
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RNA transcripts serve as a template for double-strand break repair in human cells by Manisha Jalan, Alessandra Brambati, Hina Shah, Niamh McDermott, Juber Patel, Yingjie Zhu, Ahmet Doymaz, Julius Wu, Kyrie S. Anderson, Andrea Gazzo, Fresia Pareja, Takafumi N. Yamaguchi, Theodore Vougiouklakis, Sana Ahmed-Seghir, Philippa Steinberg, Anna Neiman-Golden, Benura Azeroglu, Joan Gomez-Aguilar, Edaise M. da Silva, Suleman Hussain, Daniel Higginson, Paul C. Boutros, Nadeem Riaz, Jorge S. Reis-Filho, Simon N. Powell, Agnel Sfeir

“…Of the candidate polymerases, we identify DNA polymerase zeta (Polζ) as a potential reverse transcriptase that facilitates RT-DSBR. Furthermore, analysis of cancer genome sequencing data reveals whole intron deletions - a distinct genomic signature of RT-DSBR that occurs when spliced mRNA guides repair. …”
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Real-world experience of diagnosis, disability, and daily management in parents of children with different genetic developmental and epileptic encephalopathies: a qualitative study by Cristina Garcia-Bravo, Domingo Palacios-Ceña, Ángel Aledo-Serrano, Javier Güeita-Rodríguez, Juan Francisco Velarde-García, Juan Nicolas Cuenca-Zaldivar, Romain Marconnot, María Cristina Alonso-Blanco, Jorge Pérez-Corrales, Carmen Jimenez-Antona

“…An inductive thematic analysis was performed.Results Five themes emerged: (a) the diagnostic process, which describes the path from the time parents recognize the first symptoms until diagnostic confirmation is obtained; (b) the relationship with health professionals during the search for a diagnosis, which describes how the entire process is conditioned by the relationships established; (c) the world of disability, revealing how the disease and disability impact the life of the parents; (d) living day to day, the parents continuously change their plans in anticipation of the onset of a seizure; (e) the disease progression, a cause of great concern in the parents.Conclusions Our results show the need to develop recovery programs that integrate health and social interventions to support parents of children with DEE in the process of diagnosis and disease management.…”
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Constraining 2010–2020 Amazonian carbon flux estimates with satellite solar-induced fluorescence (SIF) by A. Dayalu, M. Mountain, B. Rastogi, B. Rastogi, B. Rastogi, J. B. Miller, J. B. Miller, L. Gatti

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Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…Their construction in the middle of the 1st century AD and the commissioning of the aqueduct at the same time are probably related.The available data, which is dispersed and often old, needs complete revision, but the many contributions of preventive archaeology on the hydraulic structures as well as on the urban occupation of the hill will enlighten us in the coming years. …”
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