Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma by Mingxian Xu, Yu Xu, Yaping Huang, Jixiang Shi, Lifeng Yin, Jian Tu, Junqiang Yin, Changye Zou

“…Methods: This study analyzed residential and environmental data from 345 pediatric osteosarcoma patients diagnosed between 2000 and 2019 to explore potential correlations with environmental PAH exposure. …”
Get full text

Cancer-associated fibroblasts gene signature: a novel approach to survival prediction and immunotherapy guidance in colon cancer by Wenbing Zhang, Chi Yang, Ye Lu, Ye Lu, Chenling Tang, Mengyu Zhao, Zhaohui Wang, Jidong Gao, Jidong Gao, Shuangjiu Hu, Zhihua Chen

“…BackgroundFibroblasts can regulate tumour development by secreting various factors. For COAD survival prediction and CAFs-based treatment recommendations, it is critical to comprehend the heterogeneity of CAFs and find biomarkers.MethodsWe identified fibroblast-associated specific marker genes in colon adenocarcinoma by single-cell sequencing analysis. …”
Get full text

Taraxacum sinicum Kitag. (Binpu-3) root extract inhibits tumor invasion via Notch signaling in Drosophila and human breast cancer MDA-MB-231 cells by Jiawei Wu, Jianbo Zhang, Wanyu Shu, Wei Feng, Ran Meng, Lingyu Kong, Huijuan Cao, Chunhua Jiang, Sitong Wang, Fanwu Wu, Chenxi Wu, Chenxi Wu, Xiuping Wang

“…Cell viability, wound healing, transwell, and Western blotting assays data implied that Binpu-3RE reduced cell growth, migration, invasion, and the expression of Notch1, Jagged1, and HES1 in human breast cancer MDA-MB-231 cells. …”
Get full text

Inaccuracies of venous thromboembolism risk assessment and prevention practices among medically ill patients by Brandyn D. Lau, Aditya Bhave, Jennifer C. Yui, Rakhi Naik, Kathryn E. Dane, John Lindsley, Dauryne L. Shaffer, Peggy S. Kraus, Erik H. Hoyer, Elliott R. Haut, Michael B. Streiff

“…Leveraging existing structured data to autopopulate VTE risk assessments can assist providers in improving accuracy. …”
Get full text

Seropersistence of SII-ChAdOx1 nCoV-19 (COVID-19 vaccine): 6-month follow-up of a randomized, controlled, observer-blind, phase 2/3 immuno-bridging study in Indian adults by Prasad S. Kulkarni, Chandrasekaran Padmapriyadarsini, Johan Vekemans, Ashish Bavdekar, Madhu Gupta, Praveen Kulkarni, B.S. Garg, Nithya J. Gogtay, Muralidhar Tambe, Sanjay Lalwani, Kiranjit Singh, Renuka Munshi, Sushant Meshram, T.S. Selvavinayagam, Krishna Pandey, Devi Madhavi Bhimarasetty, S.R. Ramakrishnan, Chetanraj Bhamare, Abhijeet Dharmadhikari, Chandrashekhar Budhawant, Cyrille J. Bonhomme, Madhuri Thakar, Swarali N. Kurle, Elizabeth J. Kelly, Manish Gautam, Nivedita Gupta, Samiran Panda, Balram Bhargava, Cyrus S. Poonawalla, Umesh Shaligram, Dhananjay Kapse, Bhagwat Gunale

Get full text

高敏感特質中高齡學習者面對數位學習壓力及疫情焦慮之學習滿意度與後疫情調適：復原力之中介效果 Learning Satisfaction and Post-Pandemic Adaptation in Highly Sensitive Middle-aged and Elderly Learners in the Face of Digital Learni... by 王雅鈴 Ya-Ling Wang, 張伶瑜 Lin-Yu Chang, 羅淇文 Chi-Wen Luo, 林郁文 Yu-Wen Lin

“…A total of 208 valid responses were collected (72 male, 136 female, mean age = 57.93, SD = 6.79). The collected data were analyzed using structural equation modeling (SEM) with the Bootstrap statistical method for mediation analysis. …”
Get full text

Investigating the role of basement structures in controlling facies characteristics, depositional models, and diagenetic alterations of the Sarvak Formation in the eastern and west... by Marzieh Mahmoodi, Hamzeh Mehrabi, Reza Nozaem

“…Material & MethodsIn this research, core data, thin-section microscopy, and X-ray diffraction (XRD) analysis results from two wells in two different fields in the eastern and western parts of the Persian Gulf, referred to as wells A and B, are utilized. …”
Get full text

Scope of practice of primary care nurses: a protocol for an umbrella review of international literature by Kris Aubrey-Bassler, Marie-Ève Poitras, Shabnam Asghari, Michelle Swab, Lindsay Hedden, Maria Mathews, Ruth Martin-Misener, Elizabeth J Halcomb, Julia Lukewich, Leslie Meredith, Dana Ryan, Suzanne Braithwaite, Danielle Macdonald, Kathleen Leslie, Anaelle Morin, Monica McGraw, Patrick Chiu, Émilie Dufour, Sophia Myles, Annie Rioux-Dubois, Deanne Curnew, Jen Calver, Jill Bruneau

“…We will use the Risk of Bias Assessment Tool for Systematic Reviews to assess the quality and risk of bias in the included systematic and scoping reviews.Ethics and dissemination Results will be presented in a PRISMA Scoping Review flow diagram. We will synthesise data from included studies in a detailed literature review table and develop visual aids to communicate the shared and unique roles and activities of PCN scope of practice. …”
Get full text

Clinical and Genetic Risk Factors Predict Atrial Fibrillation on the Basis of Hypertrophic Cardiomyopathy by Young Shin Lee, Pil‐Sung Yang, Eunsun Jang, Daehoon Kim, Hee Tae Yu, Tae‐Hoon Kim, Jae‐Sun Uhm, Jung‐Hoon Sung, Hui‐Nam Pak, Moon‐Hyoung Lee, Jin‐Bae Kim, Boyoung Joung

“…Methods and Results This retrospective analysis involved data from the UK Biobank cohort. …”
Get full text

The enhanced integration of proven techniques to quantify the uncertainty of forecasting extreme flood events based on numerical weather prediction models by Mitra Tanhapour, Jaber Soltani, Hadi Shakibian, Bahram Malekmohammadi, Kamila Hlavcova, Silvia Kohnova, Peter Valent

“…A Multi-Model Ensemble (MME) system was developed using the Group Method of Data Handling (GMDH) and Weighted Average-Weighted Least Square Regression (WA-WLSR) models to post-process raw precipitation forecasts. …”
Get full text

INTERNALIZATION OF ANTIMICROBIAL PEPTIDE ACIPENSIN 1 INTO HUMAN TUMOR CELLS by E. S. Umnyakova, I. V. Kudryavtsev, N. A. Grudinina, S. V. Balandin, I. A. Bolosov, P. V. Panteleev, T. A. Filatenkova, D. S. Orlov, E. V. Tsvetkova, T. V. Ovchinnikova, V. N. Kokryakov, O. V. Shamova

“…The maximum of fluorescence was reached within a period of approx. 45 seconds, with further “plateau” at the terms of >100 seconds following cell stimulation with the test compound. These data support the concept, that the antimicrobial peptides of innate immunity system possess the features of cell-penetrating peptides, and allow us to consider the studied sturgeon peptide a promising template for development of new drugs with increased ability to enter the cells implicated into pathological processes, and, therefore, higher therapeutic efficiency.…”
Get full text

Impact of pneumonitis from radiotherapy combined with immune checkpoint inhibitors therapy on tumor progression and survival in patients with non-small cell lung cancer by Ziwei Wang, Ziwei Wang, Kunpeng Xu, Han Sun, Jun Liang, Wei Jiang, Luhua Wang, Luhua Wang

“…COX regression identified prognostic factors in the pneumonitis group.ResultsAmong 86 patients, 58 (67.4%) developed TRP, including 37.2% with grade 2 pneumonitis, and no grade ≥3 cases. 12 patients (14.0%) developed mixed radiation and ICIs pneumonitis. …”
Get full text

Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein by Mengya Pan, Changqing Jiao, Menghua Sun, Duo Jin, Yin Wang, Haoxuan Wu, Yan Zhang, Enbo Chen, Bobin Su, Junjie Zhou, Xiaoying Liu, Jian Ge

“…Methods Analysis of the AML patient’s data in the BeatAML and GEO databases. …”
Get full text

Artificial intelligence-driven classification method of grapevine major phenological stages using conventional RGB imaging by Ruben Íñiguez, Fikile Wolela, María Ignacia Gonzalez Pavez, Ignacio Barrio, Javier Tardáguila, Talitha Venter, Carlos Poblete-Echeverria

“…ViT exhibited competitive classification performance but had higher computational demands, limiting its feasibility for real-time vineyard monitoring. A confusion matrix analysis highlighted misclassification trends, particularly between early shoot development and flowering, due to their visual similarities. …”
Get full text

Validation of Strategic Memory Advanced Reasoning Training as an efficient and effective approach to treating warfighters with persistent cognitive complaints associated with mild... by Andrew J. Darr, Andrew J. Darr, Andrew J. Darr, Angela Basham, Angela Basham, Angela Basham, Jessica L. Ryan, Melissa Caswell, Melissa Caswell, Melissa Caswell, Juan Lopez, Juan Lopez, Juan Lopez, Jennifer Zientz, Erin Venza, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Chapman, Jason M. Bailie, Jason M. Bailie, Jason M. Bailie

“…Only participants with data from all timepoints and adequate performance validity (SMART: n = 51; SCORE: n = 43) were used in analyses. …”
Get full text

Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma by Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang

“…Nucleotide metabolic processes are critical for cancer development, progression, and alteration of the tumor microenvironment. …”
Get full text

The evolution of sprinting performance: Technological and regulatory influences from 1976 to 2024 by Dariusz Tadeusz SKALSKI, Magdalena PROŃCZUK, Kinga ŁOSIŃSKA, Ewelina LULIŃSKA, Joanna MOTOWIDŁO, Petr STASTNY, Adam MASZCZYK, Grzegorz TRYBEK

“…Data sources include official race results, biomechanical studies, and historical records of rule changes. …”
Get full text

Virtual Health Research Capacity Strengthening in Low- and Middle-Income Countries: A Systematic Integrative Review by Chelsea M. McGuire, Nikolina Boskovic, Bolatito Betty Fatusin, Pius Ameh, Taylor Reed, Priyanka Jethwani, David Flynn, Jo Cooke, Robert Saper

“…We analyzed virtual tool usage via content analysis. Using NVivo, we coded until theoretical saturation and analyzed data using the constant comparison method. …”
Get full text

Enhancing emotional intelligence in medical education: a systematic review of interventions by Sabyasachi Maity, Samantha Michelle De Filippis, Alexander Aldanese, Melissa A. McCulloch, Alexis P. Sandor, Jan E. Perez Cajigas, Yiorgos Antoniadis, Te-keila D. T. Rochester, Lauren Elizabeth Carter, Alexander M. Preisig, Julia Ali Kobeissi, Narendra Nayak, Jaime E. Mendoza, Samal Nauhria

“…The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was applied to assess the quality of included studies. Although a meta-analysis was initially planned, substantial heterogeneity across the studies limited the pooling of quantitative data. …”
Get full text

Relational practices for meaningful inclusion in health research: Results of a deliberative dialogue study by Katrina Plamondon, Davina Banner, Miranda A. Cary, Melissa Faulkner, Heather Gainforth, Kiranpreet Ghag, Alison Hoens, Anne Huisken, Damanpreet K. Kandola, Shaheer Khan, Aline Silveira Silva, Nelly Oelke, Ashmita Rai, Kimberly Strain, Kathryn M. Sibley, Ursula Wick

Get full text