Evaluation of a telehealth service to support breast cancer prevention medication uptake: a protocol of a mixed methods study by Tim Spelman, Stephanie Best, Christobel Saunders, Paul A James, Sarah Latham, Louise A Keogh, Sarah Mason, Katrina Louise West, Wanda Cui, Sabine Deij, Sandy Minck, Catherine Poliness, Greg Wheeler, Kelly Anne Phillips

“…The Preventing Cancer with Medications (PCMed) Telehealth Service was therefore developed to provide this specialist support and to bridge the evidence–implementation gap. …”
Get full text

Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration by Stefan Kurbatfinski, Stefan Kurbatfinski, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Susanne Marshall, Dawn McBride, Jason Novick, Keira Griggs, Arielle Perrotta, Arielle Perrotta, Morgan Daye, Carrie McManus, Kendra Nixon

“…This study sought to: (1) develop a compendium of myths and misconceptions that SGM individuals exposed to IPV and relevant service providers shared they encountered; (2) describe the impacts of these myths and misconceptions on SGM individuals experiencing IPV; and (3) make recommendations to address these myths and misconceptions.MethodsThis qualitative study used data from a larger project focused on SGM IPV where SGM individuals who experienced IPV (n = 18) and service providers who supported SGM individuals experiencing IPV (n = 8) were interviewed using semi-structured formats. …”
Get full text

Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…Finally, enzymology and molecular dynamics simulations indicate that kinetic discrimination occurs during a later step of Mpro-mediated proteolysis following substrate binding. Together, these data provide new insights into substrate recognition by SARS-CoV-2 Mpro that could help guide future antiviral therapeutic development and show how proteolysis of TRMT1 during SARS-CoV-2 infection impairs both TRMT1 tRNA binding and tRNA modification activity to disrupt host translation and potentially impact COVID-19 pathogenesis or phenotypes.…”
Get full text

Revalorization of Vinasse as a Farmland Improver Through Multi-Objective Genetic Algorithms: A Circular Economy Approach by Aarón Montiel-Rosales, Nayeli Montalvo-Romero, Gregorio Fernández-Lambert, Horacio Bautista-Santos, Yair Romero-Romero, Juan Manuel Carrión-Delgado

“…A comparative analysis between an experimental field with and without vinasse showed a 24% increase (ton/ha) in sugarcane yield. …”
Get full text

Expanding automated multiconformer ligand modeling to macrocycles and fragments by Jessica Flowers, Nathaniel Echols, Galen J Correy, Priyadarshini Jaishankar, Takaya Togo, Adam R Renslo, Henry van den Bedem, James S Fraser, Stephanie A Wankowicz

“…However, ligands can retain some degree of conformational flexibility even when bound to a receptor. In the Protein Data Bank, a small number of ligands have been modeled with distinct alternative conformations that are supported by macromolecular X-ray crystallography density maps. …”
Get full text

High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born by Ann Hellström, Lotta Gränse, Marie Saric, Birgitta Sunnqvist, Agneta Wallin, Kristina Tornqvist, Eva Larsson, Eva Morsing, Gerd E Holmström, Pia Lundgren, Anna-Lena Hård, Lena Jacobson, Abbas Al-Hawasi, Lois LE Smith

“…We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort.Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007–2018 in Sweden were included. …”
Get full text

Dual Fine-Grained network with frequency Transformer for change detection on remote sensing images by Zhen Li, Zhenxin Zhang, Mengmeng Li, Liqiang Zhang, Xueli Peng, Rixing He, Leidong Shi

Get full text

Subcutaneous electroencephalography monitoring for people with epilepsy and intellectual disability: co-production workshops by Edward Meinert, Madison Milne-Ives, Jennifer Sawyer, Liz Boardman, Sarah Mitchell, Brendan Mclean, Mark Richardson, Rohit Shankar

“…Remote electroencephalography (EEG) monitoring could capture objective data, but particular challenges and implementation strategies for this population need to be understood. …”
Get full text

Oral microbiota related to allergy in Norwegian adults by Mikyeong Lee, PhD, Hilde Kristin Vindenes, MD, PhD, Farnaz Fouladi, PhD, Rajesh Shigdel, PhD, James M. Ward, MSc, Shayamal D. Peddada, PhD, Stephanie J. London, MD, DrPH, Randi Jacobsen Bertelsen, PhD

“…These findings could contribute to the development of novel treatment strategies.…”
Get full text

Clinical, radiological, and radiomics feature-based explainable machine learning models for prediction of neurological deterioration and 90-day outcomes in mild intracerebral hemor... by Weixiong Zeng, Jiaying Chen, Linling Shen, Genghong Xia, Jiahui Xie, Shuqiong Zheng, Zilong He, Limei Deng, Yaya Guo, Jingjing Yang, Yijun Lv, Genggeng Qin, Weiguo Chen, Jia Yin, Qiheng Wu

“…We trained five ML models using filtered data, including clinical, traditional imaging, and radiomics indicators based on non-contrast computed tomography (NCCT). …”
Get full text

Implementation of a diagnostic decision aid for people with memory complaints and their general practitioners: a protocol of a before and after pilot trial by Marcel Olde Rikkert, Marieke Perry, Marjolein de Vugt, Rudolf W H M Ponds, Ron Handels, Job Metsemakers, Trudy van der Weijden, Frans R Verhey, Iris Linden, Claire Wolfs, Carmen Dirksen

“…Therefore, in the context of the Shared Decision-Making regarding Dementia Diagnosis project, a patient decision aid (PtDA) for ‘timely’ dementia diagnosis in general practice will be developed. This protocol will describe the planned before and after evaluation of its implementation.Methods and analysis In a mixed-methods pilot study, we will investigate decision-making processes and experiences regarding a diagnostic trajectory before and after the introduction of a PtDA for people with memory complaints, their significant others and their GPs. …”
Get full text

A novel gene linked to Imipenem resistance in E. coli isolate lacking known Imipenem-resistance genes by Trang Thu Hoang, Huyen Thanh Thi Le, Sang Ngoc Nguyen, Ung Dinh Nguyen, Tuan Ngoc Tran, Cuong Hung Nguyen, Thang Quang Truong, Nam S. Vo, Duc Quang Le, Son Hoang Nguyen, Minh Duc Cao, Thi Minh Ngoc Dao, Thi Huyen Bui, Thu An Nguyen, Thi Lan Anh Pham, Thi Bich Thao Le, Tho Huu Ho

Get full text

Targeted prevention of radiation-induced oral mucositis by glutathione-modified liposome coated K12 probiotics and clinical study by ZhiHui Li, Dan He, Ye Zhang, Zhou Shi, Quanjin Tang, Zixia Li, Xingchen Peng, Dong Li, Daijun Zhou

“…Subsequently, the safety and efficacy of K12@Lip@GSH were confirmed through further single-arm, single-center prospective clinical trials. The clinical trial data demonstrated a manageable safety profile in the cohort of 22 enrolled patients. …”
Get full text

Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective cohort s... by Paulo Ranaivomanana, Arimanitra Razafimahefa, Mame Ndiaye, Crisca Razafimahatratra, Haja Ramamonjisoa, Perlinot Herindrainy, Mamy Raherison, Antso Hasina Raherinandrasana, Julio Rakotonirina, Jonathan Hoffmann, Rila Ratovoson, Niaina Rakotosamimanana

“…These data reflected from immune-host based tests used to monitor the TB treatment, seemed to further suggest that TB with concomitant DM is associated with a persistent inflammatory response after TB treatment.…”
Get full text

Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein... by Katelynn E. Krick, Erica M. Weekman, Sherika N. Johnson, Tiffany L. Sudduth, Colin B. Rogers, Emma J. Nicolayson, Maureen T. Kleinhenz, Donna M. Wilcock

“…We also identified sex-specific differences in CAA burden, as well as how glial reactivity and vessel density change during disease progression. This data represents a comprehensive analysis of CAA progression and differential responses to parenchymal and vascular amyloid that could inform future basic and clinical studies.…”
Get full text

Machine learning models for predicting in-hospital mortality from acute pancreatitis in intensive care unit by Shuxing Wei, Hongmeng Dong, Weidong Yao, Ying Chen, Xiya Wang, Wenqing ji, Yongsheng Zhang, Shubin Guo

“…To enhance interpretability and identify key predictive features, we implemented Shapley Additive Explanations (SHAP) analysis for the top-performing model. Furthermore, we developed a streamlined version of the model through strategic feature reduction, followed by rigorous hyperparameter optimization (HPO) to maximize predictive performance. …”
Get full text

Transient hepatic intensity differences: correlations with treatment outcomes and adverse events following DEB-TACE in hepatocellular carcinoma by Noble Chibuike Opara, Shuwei Zhou, Weilang Wang, Shuhang Zhang, Xunjun Chen, Shenghong Ju, Yuan-Cheng Wang

“…Materials and methods This retrospective analysis included data from a prospective study conducted with 102 consecutive HCC patients treated with DEB-TACE between December 2017 and December 2020. …”
Get full text

Prognostic factors for stent restenosis in patients with coronary artery disease undergoing percutaneous coronary intervention by M. А. Meshkova, I. A. Starodubtseva, A. A. Pashkova

“…Analysis of combinations revealed that having both TGF-β and Lp(a) within normal ranges simultaneously was a protective factor against restenosis development (odds ratio=0.2 [95% confidential interval: 0.07-0.56]), as was having both Lp(a) and VEGF within normal ranges (odds ratio=0.33 [95% confidential interval: 0.14-0.82]). …”
Get full text

Antibiotics governance in aquaculture: knowledge, practices, and challenges among stakeholders on the Volta Lake in Ghana by Samuel O. Dandi, Øystein Evensen, Samuel Addo, Emmanuel D. Abarike, Seth M. Abobi, Dzigbodi A. Doke, Jan L. Lyche, Stephen Mutoloki, Amii I. Obiakara-Amaechi, Kofitsyo S. Cudjoe, Regina E. Edziyie

Get full text

Spatiotemporal characteristics and driving factors of the fractional vegetation coverage in the Ertix River Basin by LIU Yixuan, Alim SAMAT, L.I. Wenbo, Jilili ABUDUWAILI

“…Investigating the spatiotemporal changes in the FVC and its relationship with various factors in the ERB can offer scientific support for optimizing regional vegetation restoration policies and promoting the coordinated development of human–environment interactions. The Moderate-resolution Imaging Spectroradiometer (MODIS) MYD13Q1 V6 data were obtained via the Google Earth Engine platform, and methods including the pixel dichotomy method, Theil–Sen median trend analysis, and Mann‒Kendall test were employed to examine the spatiotemporal dynamics of the FVC in the ERB from 2003 to 2023, with future trend forecast using the Hurst index. …”
Get full text