Clinicopathological features and outcome in elderly patients with idiopathic membranous nephropathy by Jinxiu Liang, Wenke Hao, Fangxiao Xia, Zhi Zhao, Yanhua Wu, Feng Yu, Wenxue Hu, Xiaowu Fang, Wei Liu

“…Pathological data revealed that the membranous Churg’s stage II was the most frequent (71.64%). …”
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Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience by Tony Z. Zhuang, Subir Goyal, Katherine B. Case, T. Anders Olsen, Shalini Vemuru, Ahmet Yildirim, Rohit V. Goswamy, Jacqueline T. Brown, Bradley C. Carthon, Omer Kucuk, Mehmet Asim Bilen, Viraj A. Master, Bassel Nazha

“…Three patients (14.3%) developed grade 3/4 ICI-related adverse events. Conclusions Our real-world analysis summarizes our institutional experience and provides granular clinical and molecular attributes of patients with therapeutic response, which may aid in patient stratification within ICI-based clinical trials. …”
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Mediating role of earnings management upon nexus among bank financial leverage and economic financial stability by Bisan Khalil Almasri, David Sunoco, Mohammad Al-said

“…Design/methodology/approach – In order for the researchers to analyze data, quantitative methods are processed statistically. …”
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Theory and engineering practice of coal-water coordinated mining based on constraints of formation bearing capacity by Zhenzhong PANG, Yifan ZENG, Keyao HAN, Qiang WU, Shouqiang LIU, Zhaolai HUA, Gangyi ZHAO, Shuai ZHANG, Huxiong YANG, Xuejun WANG, Feifan LI

“…BackgroundThe high-intensity mining of coal resources in the Yushen mining area has caused negative environmental effects and water disasters on coal seam roofs, seriously restricting the sustainable development of the area.Methods and Results Based on a summary of previous research results on the mitigation of the impacts of coal mining on groundwater resources and surface ecosystem, this study analyzed the contradiction between coal mining and the protection of the fragile ecosystem in the Yushen mining area in Shaanxi Province through theoretical analysis, field investigation, and data statistics. …”
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Assessment of the absorbed doses in the fetus from the computed tomography of the chest for the pregnant women by A. V. Vodovatov, L. A. Chipiga, P. A. Piven, G. E. Trufanov, G. V. Berkovich, I. A. Mashchenko, P. S. Druzhinina, V. G. Puzyrev, S. A. Ryzhov

“…Parameters of the international computed tomography protocols were collected viameta-analysis of the existing publications; Russian protocols — via data collection in computed tomography departments in St-Petersburg hospitals. …”
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SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma by Xin Tang, Junji Tao, Yuanyuan Liu, Deao Gong, Xuefeng Shan, Kai Wang, Ni Tang

“…RNA-sequencing data provided evidence that SLC27A5 plays a global role in regulating APA events in HCC. …”
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Scoping Review of Kidney Patients and Providers Perspectives on Disaster Management by Elie Fadel, Shreya Udupa, Isabelle Ethier, Alessia N. Paparella, Lindsay Hales, Caroline Stigant, Laura Horowitz, Catherine Weber, Shaifali Sandal

“…We aimed to explore the existing literature capturing patient and provider perspectives, identify research gaps, and develop research priorities in disaster management. …”
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Population and habitat assessments for conservation: Comparing national strategies for Canadian boreal caribou and Norwegian wild reindeer by Lucie Lelotte, Manuela Panzacchi, Cheryl A. Johnson, Atle Mysterud, Brage B. Hansen, Bernardo Brandão Niebuhr, Mark S. Boyce, Audun Stien, Evelyn H. Merrill, Christer M. Rolandsen, Torkild Tveraa, Vegard Gundersen, Bram Van Moorter

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Inhibition of MEK1/2 Signaling Pathway Limits M2 Macrophage Polarization and Interferes in the Dental Socket Repair Process in Mice by Angélica Cristina Fonseca, Priscila Maria Colavite, Michelle de Campos Soriani Azevedo, Daniela Carignatto Passadori, Jessica Lima Melchiades, Rafael Carneiro Ortiz, Camila Oliveira Rodini, Ana Paula Favaro Trombone, Gustavo Pompermaier Garlet

“…C57Bl/6-WT 8-week-old male mice were submitted to the extraction of the right upper incisor and treated (or not, control group) with MEK1/2 inhibitor PD0325901 (10 mg/kg/24 h/IP, MEK1/2i group) and analyzed at 0, 3, 7, and 14 days using microcomputed tomography, histomorphometry, birefringence, immunohistochemistry, and PCR array analysis. The results demonstrate that MEK1/2 inhibition limits the development of M2 response over time, being associated with lower expression of M2, MSCs, and bone markers, lower levels of growth and osteogenic factors, along with a higher expression of iNOS, IL-1b, IL-6, and TNF-α, as well inflammatory chemokines, indicating a predominantly M1 pro-inflammatory environment. …”
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Supporting mental health of medical students: Needs and demands concerning an e-mental health application within medical education by Grüneberg, Catharina, Bäuerle, Alexander, Karanukaran, Sophia, Darici, Dogus, Jansen, Christoph, Dörrie, Nora, Benson, Sven, Teufel, Martin, Robitzsch, Anita

“…N=229 students were incorporated in the final data evaluation. The survey comprised standardized and established self-generated inquiries. …”
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Concept and Design of Cutting Tools for Osseodensification in Implant Dentistry by Alexander Isaev, Maria Isaeva, Oleg Yanushevich, Natella Krikheli, Olga Kramar, Aleksandr Tsitsiashvili, Sergey Grigoriev, Catherine Sotova, Pavel Peretyagin

“…Thereon, the structural model of osseodensification bur is first represented as a hypergraph. Based on the analysis of previous research, functional relationships between design parameters of osseodensification burs, osseodensification procedure conditions, and procedure performance data were established and, for the first time, described in the comprehensive form of a hypergraph. …”
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The Human Pathology Atlas for deciphering the prognostic features of human cancersResearch in context by Meng Yuan, Cheng Zhang, Kalle Von Feilitzen, Martin Zwahlen, Mengnan Shi, Xiangyu Li, Hong Yang, Xiya Song, Hasan Turkez, Mathias Uhlén, Adil Mardinoglu

“…We integrated data from 10 independent cancer cohorts, creating a cross-validated, reliable collection of prognostic genes. …”
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Pulmonary Embolism in COVID-19: Trends from a Single-Center Study Across Ten Pandemic Waves in Romania by Alexandra Herlo, Adelina Raluca Marinescu, Talida Georgiana Cut, Ruxandra Laza, Adina Maria Marza, Claudia Raluca Balasa Virzob, Cristian Iulian Oancea, Lucian-Flavius Herlo, Ioana-Melinda Luput-Andrica, Voichita Elena Lazureanu

“…Data on demographics, clinical features, inflammatory markers, comorbidities, and treatment were collected from medical records. …”
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Measurement of purpose in life among Arabic-speaking adolescents: psychometric properties of an Arabic-language version of the Claremont purpose scale (CPS) by Amir Noureddine, Souheil Hallit, Souheil Hallit, Souheil Hallit, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Tylor Cosgrove, Sahar Obeid, Feten Fekih-Romdhane, Feten Fekih-Romdhane, Ahmed A. Moustafa, Ahmed A. Moustafa

“…BackgroundPurpose in life is considered a protective factor related to one's ability to thrive, supporting positive development and overall psychological wellbeing of the adolescent. …”
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Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness by Xiaodan Zhang, Tianhong Cheng, Ellie Cho, Wenjia Lu, Delphine Denoyer, Paul McMillan, Kalyan Shobhana, Swati Varshney, Nicholas A. Williamson, Alastair Stewart

“…Many drugs have been discontinued during phase II/III breast cancer clinical trials due to lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data. Nutrient availability in the tumour cell microenvironment and the dimensionality of in vitro tumour cells likely impact on drug responsiveness. …”
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Itaconate: A Nexus Metabolite Fueling <i>Leishmania</i> Survival Through Lipid Metabolism Modulation by Ayyoub Kihel, Hajar El Filaly, Dounia Darif, Aicha Assouab, Myriam Riyad, Imane Nait Irahal, Khadija Akarid

“…This study aimed to investigate the potential role of itaconate in leishmaniasis. Using transcriptomic data from <i>L. major</i>-infected BMDMs, we assessed the expression dynamics of <i>Il1b</i> and <i>Acod1</i> and performed pathway enrichment analysis to determine the profile of genes co-expressed with <i>Acod1</i>. …”
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Unlocking urban transportation carbon reduction potential: a dynamic evaluation of public transit adoption in response to carbon-centric policies by Ran Peng, Ran Peng, Ran Peng, Keyuan Ding, Keyuan Ding, Xueliang Liu, Xueliang Liu, Keyu Yao, Keyu Yao, Xu Zhou, Xu Zhou, Wei Zhang, Wei Zhang

“…The model was applied to cross-river travel in Wuhan, China, using 10,327 Origin-Destination (OD) survey data points collected between 2023 and 2024. Multiple optimization scenarios were simulated to assess responses to transit improvements.ResultsThe analysis revealed three distinct zones of carbon reduction potential: stable, unlocking, and re-stable. …”
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Personalized predictions of neoadjuvant chemotherapy response in breast cancer using machine learning and full-field digital mammography radiomics by Ye Ruan, Xingyuan Liu, Yantong Jin, Mingming Zhao, Xingda Zhang, Xiaoying Cheng, Yang Wang, Siwei Cao, Menglu Yan, Jianing Cai, Mengru Li, Bo Gao

“…ObjectiveThis study aimed to develop a comprehensive nomogram model by integrating clinical pathological and full-field digital mammography (FFDM) radiomic features to predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients, thereby providing personalized treatment recommendations.MethodsA retrospective analysis was conducted on the clinical and imaging data of 227 breast cancer patients from 2016 to 2024 at the Second Affiliated Hospital of Harbin Medical University. …”
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Iron supplementation in children to prevent deficiency and anaemia: A qualitative synthesis by Denny Mabetha, Idriss I. Kallon, Marianne Visser, Celeste Naude, Willem Odendaal, Amanda S. Brand, Sara Cooper

“…Method: We searched MEDLINE, Epistemonikos, CINAHL and PsycInfo from inception to 07 July 2023 for eligible studies. We synthesised the data using thematic analysis and assessed the methodological quality of the studies (using an adaptation of the Critical Appraisal Skills Programme tool) and confidence in the review findings (using GRADE-CERQual). …”
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Effectiveness of the guided self-change intervention for reducing alcohol use in adolescents with and without history of cannabis use by José Luis Carballo, José Luis Carballo, Miguel Ángel Martínez-León, Ainhoa Coloma-Carmona, Ainhoa Coloma-Carmona, Virtudes Pérez-Jover, Virtudes Pérez-Jover, Álvaro García del Castillo-López, Clara Sancho-Domingo, Antonia Pelegrín-Muñoz, Carlos van-der Hofstadt-Román, Carlos van-der Hofstadt-Román, Carlos van-der Hofstadt-Román

“…The consumer profile, including whether they have consumed one or more substances, may be a key variable in analyzing the effectiveness of interventions.MethodsThis study consists in a secondary analysis of data from a randomized controlled trial (PREVENALC) to examine the effectiveness of a brief intervention based on the Guided Self-Change Program (GSC) and its interaction with substance use profile. …”
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