NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…Methods First, ROS-related metabolic pathways in NPM1-mutated AML were analyzed using RNA-sequencing data. Intracellular and mitochondrial ROS levels in leukemia cells were detected using flow cytometry (FCM). …”
Get full text

Occurrence, Sources, and Prioritization of Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water from Yangtze River Delta, China: Focusing on Emerging PFASs by Zixin Qian, Chao Feng, Yuhang Chen, Yuanjie Lin, Ziwei Liang, Hailei Qian, Jingxian Zhou, Jinjing Ma, Yue Jin, Dasheng Lu, Guoquan Wang, Ping Xiao, Zhijun Zhou

“…As regulations ban legacy PFASs, many emerging PFASs are being developed, leading to their release into the aquatic environment and drinking water. …”
Get full text

Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture by Hui Chen, Hanqi Zhang, Chao Niu, Bianlin Wang, Biao Gao, Zhijun Liu, Guangmin Yao, Haji Akber Aisa

“…Their structures were elucidated by comprehensive spectroscopic data analysis, including LR-HSQMBC and 1H–15N HMBC, quantum 13C NMR DP4+ and ECD calculations, and single-crystal X-ray diffraction analysis. …”
Get full text

Reconstructing coastal ponds functional classification: Integration of multi-feature remote sensing by Yijun Tong, Chen Lin, Ke Song, Tingchen Jiang, Ronghua Ma, Wenzhuo Cui, Danhua Ma, Jianchun Chen, Zhenxing Wang, Xiaofen Bai

“…Pond water surfaces (PWS) play a crucial role in the ecological sustainability and development of coastal zones. However, in these areas, different types of PWS have significant differences, and the absence of a universal pond classification system complicates the analysis of PWS characteristics. …”
Get full text

Optimization of anti-MRSA compound production by Streptomyces sp. AR05 using an integrated RSM-ANN-GA approach by Fateh Merouane, Amani Kifadji, Racha Mansouri, Meroua Safa Mechouche, Chemes El-Houda Messaad, Anfal Bellebcir

“…Sensitivity analysis of the ANN model identified peptone as the most influential factor, followed by pH and CaCO3. …”
Get full text

Shared and distinct peripheral blood immune cell landscape in MCTD, SLE, and pSS by Yanling Cui, Huina Zhang, Yaxuan Deng, Orion Fan, Junbang Wang, Zhonggang Xing, Jianping Tang, Wenmin Zhu, Bangdong Gong, Yi Eve Sun

“…Additionally, we applied MCTD scRNA-seq data, along with datasets from SLE (GSE135779) and pSS (GSE157278) from the Gene Expression Omnibus database, to characterize and compare the similarities and heterogeneity among MCTD, SLE, and pSS. …”
Get full text

Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications by Zhang Cheng, Li-Jie Wang, Yuchi Honaker, Steven A. Cincotta, Claire E. Page, Sydney Vollhardt, Victor Yuan, S. Alice Long, Yuanyuan Xiao, Joshua N. Beilke, Joseph R. Arron, Jeffrey A. Bluestone

“…We further applied fingerprinting to bulk RNA sequencing (RNA-seq) data from endogenous and expanded Treg cells in a Phase 2 clinical trial for type 1 diabetes (T1D), demonstrating its ability to capture Treg identity and expansion in an independent study.DiscussionThis Treg fingerprinting method provides a powerful tool to molecularly characterize Treg products, potentially enabling correlative analysis with the safety and efficacy outcomes of Treg-based cell therapies.…”
Get full text

Evaluation and selection of sesame mutants (Sesamum indicum L.) for optimal nutritional profiles in seeds under field drought conditions☆ by Kouighat Mohamed, Moussaoui Fatima Ezzahra, Adiba Atman, Hafid Azzedine, Bouchyoua Abdelghani, El Fechtali Mohamed, Nabloussi Abdelghani

“…Targeted traits include seed moisture, ash content, oil content, total polyphenols, anthocyanins, flavonoids, total amino acids, and antioxidant activity. Data analysis revealed that specific mutants responded favorably to water deficit, with increased levels of polyphenols, anthocyanins, antioxidant activity, oil content, and moisture. …”
Get full text

The impact of the nocebo effect on discontinuation of statin therapy due to myopathy in patients with cardiovascular disease – a review by Jakub Stanek, Patrycja Sornek, Wiktoria Izdebska, Agata Borkowska, Radosław Ciesielski, Anna Kaźmierczak, Anna Kiełb, Anna Mich, Klaudia Perkowska, Igor Pawlak

“…Results: The collected data indicate that the nocebo effect plays a significant role in the reported muscle symptoms during statin use. …”
Get full text

CUX1 variant and 9p deletion: expanding the spectrum and resolving variable GDD/ID in a family by Haiting Liu, Xiaoyong Liu, Ximin Chen, Yangmei Pu, Wen Liu, Zemin Luo, Ai Chen, Hui Zhu, Fu Xiong, Lan Zeng, Jin Wang, Xiaocheng Nie, Shuyao Zhu

“…We collected clinical data from the proband and her parents, identified the genetic etiology through testing, investigated pathogenic mechanisms, and provided family genetic counseling. …”
Get full text

Employment and Income Insecurity Experienced by Low-to-Moderate-Income Latinas During the COVID-19 Pandemic by Stephanie Brito-Yates, Luisa Blanco, Grace Vasquez, Jocelyn Sandoval, Julie Friedman, Angel Ramos, Helen Ramos, Christine Tran, Gabrielle A. Pascua, Ryan McKenzie, Sophie Viray, Janet Pregler

“…Conclusion: The study provides evidence from qualitative data analysis supporting the development of educational and coaching programs aimed at enhancing the mental health and financial well-being of LMI Latinas. …”
Get full text

Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study by Xiaowen Bo, Qiuyu Li, Siyuan Chen, Tian Zhou, Ning Yin, Wenpeng Song, Donghui Zhao, Jinghua Liu, Qian Fan

“…Conclusion The overall development of research in this field is on the rise. …”
Get full text

Impacts of adolescent participation in a mental health education, leadership, and advocacy program (the Live4Life Crew) on outcomes after leaving secondary school in Victoria, Aust... by Lakshmi Neelakantan, Nina Logan, Monika Raniti, Nicola Reavley

“…Methods: Semi-structured in-depth interviews were conducted with Crew alumni (n = 16, 67 % female) in Victoria, Australia. Template analysis was used to analyse the data, using the Bronfenbrenner's Process-Person-Context-Time (PPCT) as an organising framework. …”
Get full text

Stress Evaluation of a Maritime A-Frame Using Limited Strain Measurements from a Real Deep-Sea Mining Campaign by Jiahui Ji, Chunke Ma, Ying Li, Mingqiang Xu, Wei Liu, Hong Zhen, Jiancheng Liu, Shuqing Wang, Lei Li, Lianjin Jiang

“…Additionally, a finite element model (FEM) of the A-Frame was developed to estimate the stress of the hot spots by integrating the measured strain data. …”
Get full text

COMBINATION OF INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS by O. V. Shadrivova, S. N. Khostelidi, Yu. V. Borzova, E. A. Desyatik, A. G. Volkova, M. O. Popova, O. S. Uspenskaya, O. S. Ruzhinskaya, T. V. Shneyder, T. S. Bogomolova, S. M. Ignatyeva, L. S. Zubarovskaya, B. V. Afanasyev, N. N. Klimko

“…Objective. Data analysis of the register of patients with invasive aspergillosis (IA), which was founded in Saint Petersburg (1998–2017), and clinical case description of successful treatment of IA and mucormycosis with lungs involvement in a patient with Hodgkin’s lymphoma.Materials and methods. …”
Get full text

Profile of Salmonella Isolates in Bullfrog Production: PFGE, MLST, and Antimicrobial Resistance by Evelyn Cristine Silva, Sthéfany da Cunha Dias, Priscila Cristina Costa, Monique Ribeiro Tiba Casas, Ricardo Seiti Yamatogi, João Pessoa Araújo Junior, Marcus Vinícius Coutinho Cossi, Fábio Sossai Possebon

“…The continued development of bullfrog farming holds great potential for expansion. …”
Get full text

CELF6 as an Oncogene in Colorectal Cancer: Targeting Stem-Cell-Like Properties Through Modulation of HOXA5 mRNA Stability by Zhiming Fu, Xiang Wang, Zhiju Chen, Baochun Wang, Weiwei Huang, Xin Liu

“…Methods: The expression levels and prognostic significance of CELF6, along with its association with homeobox A5 (HOXA5), were analyzed using University of Alabama at Birmingham Cancer Data Analysis Portal (UALCAN), PrognoScan, and Tumor Immune Estimation Resource (TIMER) databases. …”
Get full text

Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods by Jangwoo Lee, Kevin Xiang, Emily Au, Shahrzad Sarabi, Nicole Acosta, Srijak Bhatnagar, Jennifer Van Doorn, Stefania Bertazzon, John M. Conly, Elissa Rennert-May, Johann D. D. Pitout, Bonita E. Lee, Xiaoli Pang, Christine O’Grady, Kevin Frankowski, Casey R. J. Hubert, Michael D. Parkins

“…SES status was established using 2021 Canadian census data. Conducting this comparison during the height of COVID-related international travel restrictions (Dec. 2020–Oct. 2021) allowed the hypotheses linking SES and AMR to be assessed with limited confounding. …”
Get full text

It’s safe to move! A protocol for a randomised controlled trial investigating the effect of a video designed to increase people’s confidence becoming more active despite back pain... by Ian A Harris, Adrian C Traeger, James H McAuley, Siobhan M Schabrun, Benedict Martin Wand, Aidan Cashin, Christopher Michael Williams, Edel O'Hagan, Sean O'Neill

“…People over 18 years of age and fluent in English will be recruited via social media advertising. We developed a social media-based public health campaign to support recommendations for managing low back pain. …”
Get full text

A Delphi-based needs assessment to identify and prioritise procedural skills through consensus for simulation-based learning in neurosurgery by Adam F. Roche, Dara O. Kavanagh, Darach Crimmins, Vincent Healy, Gulam Zilani, Lars Konge, Leizl Joy Nayahangan, Danyal Z. Khan, Daniel Murray, Javier Francisco Cuello, Caitriona Cahir, Niamh Murphy, Claire M. Condron

Get full text