In situ monitoring of ligand-to-metal energy transfer in combination with synchrotron-based X-ray diffraction methods to elucidate the synthesis mechanism and structural evolution... by Ban H. Al-Tayyem, Philipp Müscher-Polzin, Kanupriya Pande, Oleksandr Yefanov, Valerio Mariani, Anja Burkhardt, Henry N. Chapman, Henry N. Chapman, Henry N. Chapman, Christian Näther, Michael Braun, Marvin Radke, Steve Waitschat, Kenneth R. Beyerlein, Huayna Terraschke

“…In addition, the structure of [Tb (bipy)2(NO3)3] is solved from serial crystallography data collected at a microfocused synchrotron X-ray beamline. …”
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Woody legacies of railroad ties from the Southern Atacama Desert used to strengthen Nothofagus obliqua tree-ring chronologies from Northern Patagonia by Isadora Schneider-Valenzuela, Ariel A. Muñoz, Duncan A. Christie, Karin Klock-Barría, María Eugenia Solari, Marcelo Madariaga-Burgos, Rocío Urrutia-Jalabert, Isabella Aguilera-Betti, Santiago Ancapichún, Alejandro Venegas-González, Mauro E. González

“…We dated this historical wood using classical crossdating ring-width methods corroborated with wiggle matching of radiocarbon series from railroad tree-rings using the hemispheric 14C curve. Correlation analysis with climate data and paleoclimate field reconstructions shows a clear hydroclimate signal contained in the resulting regional tree-ring record with a consistent spatial pattern across northern Patagonia. …”
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Digital solution for salutogenic brain health: a pilot sequential multiple assignment randomised trial (SMART) protocol for clinical implementation by Nick Sevdalis, Nicholas Graves, Jing Xu, Bibhas Chakraborty, Wentao Zhou, Yuanxi Jia, Yanhong Dong, Nicole Yun Ching Chen, Claire See Ying Chang, Vanessa Phua, Xiang Cong Tham, Wei Fong Liau

“…However, there is a lack of a targeted solution for this population. This study aims to develop a digital solution for salutogenic brain health targeting this population, assess its clinical effectiveness and evaluate the implementation in primary care settings by local champions, that is, nurses.Methods and analysis A type-I hybrid effectiveness-implementation design with a sequential multiple-assignment randomised trial will be adopted. 160 adults aged 40–64 years old with chronic conditions hypertension, hyperlipidaemia and type-II diabetes will be recruited from three National University Polyclinics in Singapore. …”
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AGRICULTURAL TRENDS IN ROMANIA IN THE CONTEXT OF THE CURRENT TRENDS OF THE WORLD ECONOMY by Nicoleta MATEOC-SÎRB, Cristina-Viorica BACĂU, Anișoara DUMA COPCEA, Teodor MATEOC-SÎRB, Camelia MĂNESCU, Simona NIȚĂ, Oana SICOE-MURG, Gabriel SUSTER

“…During the current period, it is important to know what production can be obtained in Romanian agriculture and if it can provide the food necessary for the population. An analysis regarding the dynamics of the cultivated areas and production of the main crops in Romania has been carried out, for each of its 8 development regions. …”
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A transcriptional network underlies susceptibility to kidney disease progression by Denise Laouari, Martine Burtin, Aurélie Phelep, Frank Bienaime, Laure‐Hélène Noel, David C. Lee, Christophe Legendre, Gérard Friedlander, Marco Pontoglio, Fabiola Terzi

“…We have recently shown that the susceptibility to development of renal lesions after nephron reduction is controlled by a locus on mouse chromosome 6 and requires epidermal growth factor receptor (EGFR) activation. …”
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An interpretable machine learning-assisted diagnostic model for Kawasaki disease in children by Mengyu Duan, Zhimin Geng, Lichao Gao, Yonggen Zhao, Zheming Li, Lindong Chen, Pekka Kuosmanen, Guoqiang Qi, Fangqi Gong, Gang Yu

“…We collected demographic and laboratory data from 3650 patients (2299 with KD, 1351 with similar symptoms but different diseases) and employed 10 ML algorithms to construct the diagnostic model. …”
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STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer by Xuchen Fan, Xuchen Fan, Sheng Wu, Sheng Wu, Honglong Wu, Honglong Wu, Yingying Huang, Yingying Huang, Xuhui Tong, Meiling Yu, Meiling Yu, Zhe Liu, Zhe Liu, Zhe Liu

“…LL1 effectively reversed CAF induced osimertinib resistance in NSCLC.DiscussionThis project contributes to a deeper understanding of the molecular mechanism of tumor microenvironment mediated EGFR-TKI resistance in NSCLC, and provides theoretical basis and experimental data for the development of novel resistance reversal agents against the tumor microenvironment.…”
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Planar-electroporated cell biosensor for investigating potential therapeutic effects of ectopic bitter receptors by Changming Chen, Jianguo Wu, Chunlian Qin, Yong Qiu, Nan Jiang, Qifei Wang, Mengxue Liu, Deming Jiang, Qunchen Yuan, Xinwei Wei, Liujing Zhuang, Ping Wang

“…In comparison to conventional biosensors that utilize extracellular action potentials (EAPs) for data analysis, the IAPs recorded by the PECB provided high-resolution insights into action potentials, characterized by increased amplitudes and an enhanced signal-to-noise ratio (SNR). …”
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Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets by Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia, Andrea Marcello Isidori, Antongiulio Faggiano, Rita Mancini, Claudia De Vitis

“…Clinical and pathological data were systematically documented at diagnosis and during follow-up. …”
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QUALITATIVE AND QUANTITATIVE ANALISIS OF ORGANIC ACIDS IN MIXTURE OF MULTIVITAMIN RAW MATERIAL by V. Yu. Zhilkina, A. I. Marakhova, Ya. M. Stanishevskiy

“…Thin layer chromatography method was confirmed to contain apple, citric and ascorbic acids. Quantitative analysis of the amount of organic acids and ascorbic acid was conducted by potentiometric titration method developed by the authors. …”
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COVID-19 mRNA vaccine immune response to the addition of osteopathic manipulative treatment with lymphatic pumps: a randomized controlled trial by Eric S. Martinez, Sebastien Fuchs, Hendrik Szurmant, Xunxuan Chen, Andrew Comer, Edward Lee, Raymond Hruby, Rebecca Giusti, Brian Loveless, Julieanne P. Sees, Paula Crone, Laura J. Peek, Gary Pestano, Bin Xie, Joseph Zammuto, Sir Robert Hostoffer, Jr., Jesus Sanchez, Jr.

“…COVID19-naïve subjects were selected for analysis based on data homogeneity. In this cohort, the OMT group showed significantly increased anti-SARS-CoV-2 spike protein antibody titers at 3 weeks vs controls (p = 0.038). …”
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An Integrated Approach Utilizing Single-Cell and Bulk RNA-Sequencing for the Identification of a Mitophagy-Associated Genes Signature: Implications for Prognostication and Therapeu... by Yuke Zhang, Li Ding, Zhijin Zhang, Liliang Shen, Yadong Guo, Wentao Zhang, Yang Yu, Zhuoran Gu, Ji Liu, Aimaitiaji Kadier, Jiang Geng, Shiyu Mao, Xudong Yao

“…<b>Conclusions</b>: This study analyzed mitophagy-related genes in PARD, predicting prognosis and aiding in subtype identification and immunotherapy response analysis. This approach offers new strategies for treating prostate cancer with specific molecular subtypes and helps develop potential biomarkers for personalized medicine strategies.…”
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Biological activities and phytochemical characterization of Sideritis germanicopolitana subsp. viridis and S. libanotica subsp. linearis extracts and extract-loaded nanoparticles by Turgut Taşkın, Turgut Taşkın, Beyza Nur Yılmaz, Beyza Nur Yılmaz, Beyza Nur Yılmaz, Shalaleh Hasan Niari Niar, Shalaleh Hasan Niari Niar, Shalaleh Hasan Niari Niar, Mizgin Ermanoğlu, Mizgin Ermanoğlu, Duygu Taşkın, Duygu Taşkın, İsmail Şenkardeş, Talip Şahin, Elif Çalışkan Salihi, Elif Çalışkan Salihi, Ali Demir Sezer, Ali Demir Sezer, Oya Kerimoğlu, Oya Kerimoğlu, Hatice Kübra Elçioğlu, Hatice Kübra Elçioğlu

“…In this study the phenolic metabolites were examined, luteolin (27.44 μg/mg extract) and p-coumaric acid (20.03 μg/mg extract) were found at the highest concentration in the SGV plant while rosmarinic acid (8.70 μg/mg extract), caffeic acid (6.46 μg/mg extract) and p-coumaric acid (4.42 μg/mg extract) were found at the highest concentration in the SLL plant. However, the data demonstrated that the nanoparticles had lesser biological activity potential than crude extracts.ConclusionThe substantial biological activities of the nanoparticles developed as a result of this work showed that these formulations are suitable for use as antioxidant, anti-urease and anticholinesterase medicines in the future due to the benefits of using nanoparticles in the therapeutics such as the controlled release of the active agents and the diminished side effects.…”
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Assessing heat exposure and its effects on farmer health, harvest yields, and nutrition: a study protocol for Burkina Faso and Kenya by Sandra Barteit, Windpanga Aristide Ouédraogo, Charlotte Müller, Pascal Zabré, Issouf Traoré, Valentin Boudo, Ali Sié, Guillaume Compaoré, Lucienne Ouèrmi, Stephen Munga, David Obor, Aditi Bunker, Hanns-Christian Gunga, Kristine Belesova, Till Bärnighausen, Jonas Franke, Maximilian Schwarz, Martina Anna Maggioni, Rainer Sauerborn

“…The study is embedded within a larger cluster-randomized controlled trial, facilitating comparative analysis under varying thermal conditions. Findings will provide evidence-based insights into how climate-related heat stress affects health and agricultural outcomes, supporting the development of targeted adaptation strategies to enhance resilience, health, and food security in vulnerable farming communities.…”
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Ion Mobility QTOF-MS Untargeted Lipidomics of Human Serum Reveals a Metabolic Fingerprint for GNE Myopathy by Cristina Manis, Mattia Casula, Andreas Roos, Andreas Hentschel, Matthias Vorgerd, Oksana Pogoryelova, Alexa Derksen, Sally Spendiff, Hanns Lochmüller, Pierluigi Caboni

“…The multivariate statistical analysis revealed a downregulation of carnitines, as well as of lysophosphatidylcholines, in sera samples derived from GNEM patients. …”
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Effective Identification of Variety and Origin of Chenpi Using Hyperspectral Imaging Assisted with Chemometric Models by Hangxiu Liu, Youyou Wang, Yiheng Wang, Jingyi Wang, Hanqing Hu, Xinyi Zhong, Qingjun Yuan, Jian Yang

“…Convolutional neural networks (CNNs) were developed and compared with conventional machine learning models, including partial least-squares discriminant analysis (PLS-DA), support vector machines (SVMs), and a multilayer perceptron (MLP). …”
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The Primary Care Spend Model: a systems approach to measuring investment in primary care by Robert Phillips, Michael Kidd, Viviana Martinez-Bianchi, Martin Roland, Jennifer DeVoe, Hong Wang, Robert Baillieu, Michael Mueller, David Morgan, Bruce Landon, Rebecca Etz, Chris Koller, Neha Sachdev, Hannah Jackson, Yalda Jabbarpour, Andrew Bazemore

“…This unifying framework allows a more refined description of services to be included in any estimate of primary care spend and also supports measurement of primary care spending across nations of varying economic development, accommodating data limitations and international health system differences. …”
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SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway by Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang

“…The Cancer Genome Atlas (TCGA) database analysis reveals that aberrant expression of SMC4 exhibits a robust prognostic association with metastatic progression. …”
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Navigating the road ahead: using concept mapping to assess Clinical and Translational Science Award (CTSA) program goals by Cathleen Kane, William Trochim, Haim Bar, Andie Vaught, Heather Baker, Munziba Khan, Robin Wagner, Kristi Holmes, Keith Herzog, Jamie Mihoko Doyle

“…The findings of this study underscore the efficacy of concept mapping in incorporating wide-ranging perspectives, identifying areas of consensus, and informing leadership in the development of unified, data-driven evaluation frameworks —such as TSBM and/or a CTSA logic model— critical to maximizing the CTSA's transformative potential for public health.…”
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E-business cooperation between China and West Africa: Investigating the risks and challenges by Geoffrey Bentum-Micah, Shurong Zhao, Joshua Ampofo, Lois Tweneboah Kodua, Ailing Luo, Yaqi Meng

“…This study addresses this gap by employing a mixed-methods approach integrating quantitative analysis of cross-border trade data with stakeholder surveys and in-depth interviews to investigate the political, regulatory, and cultural risks that shape digital partnerships between Chinese firms and West African stakeholders. …”
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