Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis by Fernanda Vacante, Pamela Senesi, Anna Montesano, Stefano Paini, Livio Luzi, Ileana Terruzzi

“…In addition, METF effect on the cancer microenvironment and on the IGF axis leads to the development of new METF therapeutic use in HCC treatment.…”
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LncRNA interactomes and co-methylation in breast cancer regulation by Elena A. Filippova, Irina V Pronina, Svetlana S Lukina, Alexey M Burdennyy, Tatiana P Kazubskaya, Vitaly I Loginov, Eleonora A Braga

“…Using an RT² lncRNA PCR Array and bioinformatic analysis, we identified seven differentially expressed (DE) lncRNAs. …”
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Low COVID-19–related knowledge and access to adequate handwashing among patients with chronic diseases in rural Rwanda: a cross-sectional survey by Alphonse Nshimyiryo, Dale A. Barnhart, Fredrick Kateera, Christian Mazimpaka, Anne Niyigena, Gedeon Ngoga, Pacifique Uwamahoro, Joanna Galaris, Saidath Gato, Jean Paul Umugisha, Evrard Nahimana, Vincent K. Cubaka, Grace Umutesi

“…The study sample was randomly selected and stratified by district and clinical program. Telephone-based data collection occurred between 23 April and 11 May 2020. …”
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Tribological performance of graphene oxide reinforced PEEK nanocomposites with machine learning approach by Yagnik Patel, Unnati Joshi, Prince Jain, Anand Joshi, Sanketsinh Thakor, Swapnil Parikh

“…For friction force prediction, MAE values were 0.77 (Extra Tree) and 0.76 (XGBoost). DFFITS analysis further indicated all wear and friction force data points were influential, remaining within a narrow interval (+0.57735 to -0.57735). …”
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Protective effect of reduced glutathione on acute kidney injury in lung cancer patients treated with cisplatin: a retrospective cohort study by Ying Huang, Yang Li, Xialian Xu, Jie Teng, Xiaoqiang Ding, Jiarui Xu

“…Of these patients, 231 patients (16.8%) developed AKI. The incidence of AKI was lower in the GSH group compared with the non-GSH group (10.6% vs. 18%, p = 0.009). …”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Background: Small molecules play a crucial role in the exploration of physiological pathways and in drug development by targeting deoxyribonucleic acid (DNA). …”
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Phenol compounds in the borehole 5G, Vostok station, after the unlocking of the subglacial lake by I. A. Alekhina, A. L. Moskvin, A. A. Ekaykin, V. Ya. Lipenkov

“…The article presents results of analysis of causes for the occurrence of phenolic compounds in the central channel in the core of secondary ice, being formed by the lake water that rose into the well after the first penetration (the range of depths was 3426–3450 m). …”
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Software-architectural configuration of the multifunctional audio digital signal processor module for signal mediatesting of audio devices by A. V. Gevorsky, M. S. Kostin, K. A. Boikov

“…Visual-graphical architectural programming of audio modules in the SigmaStudio and Flowstone, as well as algorithms for real-time signal audio measurements and analysis of experimental data in the REW and Soundcard Oscilloscope are used.Results. …”
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Facilitating person-centered patient participation in kidney care—a process evaluation of a quasi-experimental study incorporating a tool and training of local implementation teams... by Liselott Årestedt, Fredrik Uhlin, Ann Catrine Eldh

“…This process evaluation was comprised of repeat interviews with managers (n = 10), internal facilitators (n = 5), recordings, and notes from the interventions, and Alberta Context Tool survey data (n = 78). Hybrid analyses comprised mixed methods: descriptive and comparative statistics, and qualitative descriptive analysis. …”
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Crafting the Organic Mindset Through Attitude: A PLS-SEM Approach by Kalisri L. Aravindan, Aysa Siddika, T. Ramayah, Farheen S. Wani, Sanmugam Annamalah, N. Ilhavenil, Lylia Hamdan Sunita

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Risk factors for poor bereavement outcomes and the support needs of adult bereaved refugees within the psychosocial-cultural concept of personhood: a systematic review by Çiğdem Fulya Dönmez, Çiğdem Fulya Dönmez, Muzeyyen Seckin, Cara Bailey

“…The review followed the ring theory of personhood framework. A standardized data extraction tool (34) was used to analyse studies that included adult refugees who had experienced the death of a family member/friend. …”
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Long-term weight change among breast cancer patients treated with chemotherapy: a longitudinal study over 13 years by Mathilde His, Iris Baggio, Sylvie Chabaud, Louis Tassy, Olivier Trédan, Béatrice Fervers, Olivia Pérol

“…We compared weight at each time using analysis of variance for repeated data based on mixed-effect models, and examined clinical and individual factors as potential determinants of weight change over the study period. …”
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Performance of Plug-In Augmented ChatGPT and Its Ability to Quantify Uncertainty: Simulation Study on the German Medical Board Examination by Julian Madrid, Philipp Diehl, Mischa Selig, Bernd Rolauffs, Felix Patricius Hans, Hans-Jörg Busch, Tobias Scheef, Leo Benning

“…Particularly, current LLMs encounter limitations, especially in symbolic representation and accessing contemporary data. The recent version of GPT-4, alongside newly released plugin features, has been introduced to mitigate some of these limitations. …”
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Health Literacy and Behaviors of Patients and Caregivers Related to Glycemic Control Among Individuals With Type 2 Diabetes in Chiang Mai Province, Thailand by Chaimongkon S, Sakulwattana W, Ong-Artborirak P, Liyanage E, Seangpraw K

“…Mean FBS and HbA1c levels were 129.81 mg/dl and 7.3%, respectively. Linear regression analysis showed that, after adjusting for sex, age, education level, financial status, duration of diabetes, smoking, and alcohol consumption, FBS was significantly associated with patients’ HL (Beta = − 0.161), SCB (Beta = − 0.197), caregivers’ HL (Beta = − 0.217), and caregivers’ patient care behaviors (Beta = − 0.181). …”
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The effect of pre-transplant dialysis duration on the relationship between delayed graft function and recipient death by Rui-Yu Wang, Dan Jia, Shuan-Hong Wang, Shang-Guo Wang, Bin Liu, Lei Yang, Wen-Qiang Zhang, Hao Wu, Bao-Shan Gao

“…Using a retrospective database, this study collected clinical data from 1,311 patients who underwent DBD kidney transplantation. …”
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A Novel Hybrid Optimizer Based on Coati Optimization Algorithm and Differential Evolution for Global Optimization and Constrained Engineering Problems by Saptadeep Biswas, Binanda Maiti, Gyan Singh, Absalom E. Ezugwu, Kashif Saleem, Laith Abualigah, Aseel Smerat, Uttam Kumar Bera

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Exploring factors influencing number of fouls in soccer by Xuan Liu, Yuxin Zuo, Hamza Saghir Aslam, Seungmo Kim, Ming Fu

“…Multiple linear regression and one-way ANOVA were employed for statistical analysis, with the significance level set at p < 0.05. …”
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THE EFFECTIVENESS OF THE USE OF A-PRF AND ENAMEL MATRIX PROTEINS IN THE STABILIZATION OF REGIONAL HEMODYNAMICS IN PATIENTS WITH GENERALIZED PERIODONTITIS II, II-III DEGREE by S.V. Zaiats, M.M. Rozhko

“…There was a positive trend compared to the data before surgery, but the results of the treatment were significantly different from the norm. …”
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Characterizing Cross-Provincial High-Cost Patients in Rural China: Cross-Sectional Study by Minjiang Guo, Xiaotong Jiang, Yang Liu, Yang Liu, Fangyuan Zhang, Zhongyuan Zhang, Yazi Li

“…MethodsThe study used data from the cross-provincial medical immediate reimbursement system, which contains records of inpatients who used cross-province immediate reimbursement services between 2017 and 2019. …”
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Toward optimizing new nurse anaesthetist training: a qualitative study of perceptions, experiences, and systemic challenges by Tingting Yang, Xueyan Xing, Ying Sun, Jiale Hu, Jiamin Kang, Shumin Tu

“…Results Four primary themes and ten sub-themes were identified through the analysis. The themes include: (1) characteristics of new nurse anaesthetists; (2) clarification of the role of new nurse anaesthetists and establishment of training content in accordance with job requirements; (3) formation of a diversified teaching method and design of an evaluation system based on the teaching content; and (4) increased attention to new nurse anaesthetists as individuals and to their future development. …”
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