Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF‐Trap by Ebru Destan, Engin Turkut, Alper Aldeniz, Jungmin Kang, Takehiko Tosha, Makina Yabashi, Baris Yilmaz, Ahmet Can Timucin, Hiroaki Matsuura, Yoshiaki Kawano, Irfan Cinkaya, Hasan DeMirci

“…Herein, the first near‐physiological temperature structures of the N‐glycan‐bound Fc fragment of IgG1 subtype from a biosimilar VEGF‐Trap are presented, determined using the SPring‐8 Angstrom Compact free electron LAser (SACLA) and the Turkish Light Source (Turkish DeLight). Comparative analysis with cryogenic structures, including existing data, reveals alternate conformations within the glycan‐binding pocket. …”
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The Resting‐State Activities of the Angular Gyrus and the Micturition Desire‐Awakening Function in Children With and Without Enuresis by Xindi Lin, Shaogen Zhong, Mengxing Wang, Yi Mao, Yuhan Wu, Jiayi Lu, Wei Zhong, Di Wu, Jun Ma

“…ABSTRACT Background Micturition desire‐awakening (MDA) function plays a pivotal role in the development of primary nocturnal enuresis (PNE); however, its neural correlates remain largely unexplored. …”
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USP7 V517F mutation as a mechanism of inhibitor resistance by Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue He

“…Furthermore, the engineered cell lines harboring the V517F mutation exhibited substantial resistance to USP7 inhibition. These data provide rationales for patient selection and the development of next-generation USP7 inhibitors designed to overcome treatment-emergent mutations.…”
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An innovative thermal simulation study of microstructure improvement by delay forging during solidification by Jiongshen Chen, Li Rong, Chenxi Ma, Wu Wei, Shengping Wen, Kunyuan Gao, Hui Huang, Zuoren Nie

“…Temperature and force data were collected using the Gleeble system for analysis. …”
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Rescuing ACE2‐Deficiency‐Mediated Nucleus Pulposus Senescence and Intervertebral Disc Degeneration by a Nanotopology‐Enhanced RNAi System by Kaiqiang Sun, Zijian Kang, Chen Yan, Yan Yu, Linhui Han, Yangyang Shi, Liang Chen, Jiangang Shi, Yu Chen, Jingchuan Sun

“…Overall, the data reveal the underlying mechanisms of ACE2 in NPC senescence and IVDD pathogenesis and propose a distinct paradigm of precise nanomedical senescence‐blockade RNAi for IVDD treatment.…”
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Implementing Wastewater-Based Epidemiology for Long-Read Metagenomic Sequencing of Antimicrobial Resistance in Kampala, Uganda by William Strike, Temitope O. C. Faleye, Brian Lubega, Alexus Rockward, Soroosh Torabi, Anni Noble, Mohammad Dehghan Banadaki, James Keck, Henry Mugerwa, Matthew Scotch, Scott Berry

“…Due to the time-dependent nature of wastewater surveillance data, this work involved cross-training researchers in Uganda to collect and analyze wastewater for future efforts in public health development.…”
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Geographic information system as a tool for assessing ponds and the potential for environmental impact caused by fish farming by Felipe Misael da Silva Morsoleto, Karen Carrilho da Silva Lira, Jhony Ferry Mendonça da Silva, Humberto Rodrigues Francisco, Fabio Bittencourt, Aldi Feiden

“…In this study, we aimed to monitor the quality of effluent water and organic and inorganic elements released by fish farming in ponds, using geomorphological and land-use and occupation data. The Terrain Analysis Using Digital Elevation Models, Digital Elevation Model software was used to delimit watersheds in the software Quantum geographic information system version 3.6.3. …”
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A targeted tiled amplicon sequencing approach for clade and subclade level differentiation of monkeypox virus from wastewater by Mathew Fisher, Jennifer Ali, Shayna Giesbrecht, Raveena Roopra, Veronica Carroll, Amber Papineau, Cody Buchanan, Nicholas Duan, Chrystal Landgraff

“…Notably, clade-informing data was also achieved from partial sequences recovered from lower abundance samples. …”
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The burden of ischemic heart disease among women of childbearing age in China from 1990 to 2021, and projections for the next 15 years by Chuankun Zhang, Penghui Yang, Qijian Yi

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Is non-conveyance solo-ambulances a useful mean to meet the increasing demand for emergency medical services in Denmark? by Frederikke Amalie Møller, Mads Lillethorup Persson, Elisabeth Larsen Engholm, Penille Horsbøl Kirkegaard Jensen, Ulla Vaeggemose, Tine Bennedsen Gehrt

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Research on the Spatiotemporal Characteristics and Influencing Mechanisms of Sustainable Plateau Urban Building Carbon Emissions: A Case Study of Qinghai Province by Haifa Jia, Bo Su, Jianxun Zhang, Pengyu Liang, Wanrong Li, Shuai Wu, Shan Wang

“…This study examines the spatiotemporal characteristics and influencing mechanisms of building carbon emissions (BCEs) in plateau cities using an empirical analysis of 13-year panel data (2010–2022) from two municipalities and six prefectures in Qinghai Province, China. …”
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Pediatric endocardial temporary pacemaker implantation: Clinical characteristics and outcomes from a Chinese National Regional Health Center by Zhongyuan Liu, Kaijun Zhang, Jun Ren, Penghui Yang, Mi Li, Ping Xiang

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High Hcy regulates fluid shear stress pathway activity through histone H3K79 homocysteinylation in hyperhomocysteinemia-related child hypertension by Baoling Bai, Lingyun Liu, Yanyan Liu, Shuangshuang Yang, Haojie Wu, Kexin Zhang, Lin Shi, Qin Zhang

“…Furthermore, the pediatric proteomics data gleaned from this study offer new clinical insights into the pathophysiology of HHYP in children.…”
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Evaluation of cooperative security and coupling coordination of water-energy-food-ecosystems nexus: a case study of Yulin City by Jiaqi Sun, Jianyun Zhang, Xiaojun Wang, Yonggang Liu, Jie Zhang, Xu Zhang, Dazhi Li

“…However, the index remains below 0.6, suggesting that further strengthening of water resource management, optimizing energy production, improving food production capacity, advancing ecological protection, and enhancing interdepartmental cooperation are necessary. The analysis also reveals four stages of coupling coordination in Yulin’s WEFEco nexus: 1) 2000–2008, a transitional stage with rapid economic growth but lagging management; 2) 2009–2014, a basic coordination stage with improved management measures, though still insufficient; 3) 2015–2017, a period of decline in coordination, characterized by near-coordination development and mild disorder due to environmental and social changes; and 4) 2018–2020, a basic coordination stage where reforms and policies led to improved coordination. …”
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Perinatal and postnatal markers of cerebral palsy by O.B. Bielova, S.Yu. Konopliasta, A.O. Synytsia, S.V.  Fedorenko, Yu.A. Mykhalska

“…Empirical methods included analysis, comparison, data processing, interviews, and a questionnaire for parents of children with cerebral palsy. …”
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Novel Calcium Phosphate Cement with Metformin-Loaded Chitosan for Odontogenic Differentiation of Human Dental Pulp Cells by Wei Qin, Jia-Yao Chen, Jia Guo, Tao Ma, Michael D. Weir, Dong Guo, Yan Shu, Zheng-Mei Lin, Abraham Schneider, Hockin H. K. Xu

“…For osteogenic differentiation analysis, alkaline phosphatase (ALP) activity was tested, cells were stained with Alizarin Red, and the expression of odontogenic markers was evaluated by real-time polymerase chain reaction. …”
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Sustainable Recovery of Phlorotannins from <i>Durvillaea incurvata</i>: Integrated Extraction and Purification with Advanced Characterization by Pamela Raquel Rivera-Tovar, Gabriela Contreras-Contreras, Paulina Isabel Rivas-Reyes, Jara Pérez-Jiménez, Maximiliano Martínez-Cifuentes, José Ricardo Pérez-Correa, María Salomé Mariotti-Celis

“…However, MS/MS results showed significantly lower recoveries than spectrophotometric data, revealing a novel insight into RP purification. …”
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Factors contributing to persistent shoulder pain after arthroscopic rotator cuff repair: Protocol for a scoping review [version 2; peer review: 2 approved] by G Arun Maiya, Mira Meeus, James Elliott M, Prabu Raja G, Vivek Pandey, Kiran K V Acharya, Anupama Prabhu B

“…Next, full-text screening will be conducted, and the remaining search results will be reviewed to extract data, as well as to synthesize findings from all research. …”
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The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma by Yu Gu, Zhihui Zhang, Hao Huang, Wenyong Zhu, Hongjia Liu, Rongxin Zhang, Nan Weng, Xiao Sun

“…Based on medical imaging data, we developed a radiomics tool, RCSP (Radiogenomics-based CXCL9/SPP1 Polarity), to assist in non-invasively predicting the CS polarity in HCC patients.ConclusionOur research sheds light on the regulatory roles of SPP1+ TAMs and CXCL9+ TAMs in the micro-environment and provides new therapeutic targets or insights for the reprogramming of targeted macrophages in HCC.…”
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Intraperitoneal Infusion of Mesenchymal Stem/Stromal Cells Prevents Experimental Autoimmune Uveitis in Mice by Joo Youn Oh, Tae Wan Kim, Hyun Jeong Jeong, Hyun Ju Lee, Jin Suk Ryu, Won Ryang Wee, Jang Won Heo, Mee Kum Kim

“…We here investigated whether intraperitoneal administration of human mesenchymal stem/stromal cells (hMSCs) might prevent development of experimental autoimmune uveitis (EAU) in mice. …”
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