Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis by Qing Shi, Xiang Pan, Shiheng Zhang, Mengyuan Wu, Meiqi Xu, Yun-Qi Li, Li Zhong, Zi-Qi Wang, Wanhai Xu, Yakun Luo

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Circulating miR-323–3p as a novel potential plasma biomarker for multimorbidity burden and cognitive decline in middle-aged and older adults: Results from the national institute fo... by Wei-Min Chu, Mio Goto, Keiko Kabetani, Yukiko Nishita, Shu Zhang, Hiroshi Shimokata, Meng-Chih Lee, Akiko Satoh, Rei Otsuka

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Entre sofrimento e prazer: a vulnerabilidade para enfermeiros nas relações interpessoais com pacientes com HIV/AIDS [Between suffering and pleasure: vulnerability to nurses in thei... by Érick Igor dos Santos, Antonio Marcos Tosoli Gomes, Denize Cristina de Oliveira, Caren Camargo do Espírito Santo

“…It was used the semi-structured interview. With regard to the data analysis, the thematic content analysis performed through the software NVivo 9, was adopted. …”
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Прийоми реновації замкових комплексів та їх пристосування під сучасне використання на прикладі замку Свірж... by Sergiy Buravchenko, Oleksandr Pivovarov, Oleksandr Khlyupin, Iryna Shashkova

“…The methods of renovation and adaptation of castles are of practical value. The data obtained were used in the development of a competitive project for adaptation to a cultural and tourist complex and a house of creativity of the National Union of Architects of Ukraine - an architectural monument of national importance - a castle in the village Svirzh Lviv region …”
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Household perceptions of healthy broiler meat and their impacts on purchasing practices in the Greater Jakarta Area, Indonesia by Ening Ariningsih, Sumaryanto Sumaryanto, Mewa Ariani, Nyak Ilham, Eni Siti Rohaeni, Adang Agustian, Sri Hastuti Suhartini, Achsanah Hidayatina, Suharyon Suharyon, Dwi Priyanto, Dedi Sugandi, Thomas Agoes Soetiarso, Gontom Citoro Kifli, Mat Syukur, Handewi Purwati Saliem

“…We surveyed 521 households using a multistage random sampling. Data analysis employed Multiple Indicators Multiple Causes models and ordered probit regression. …”
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External Validation of AI Models for Skin Diseases: A Systematic Review by Thayana Ribeiro Silva Fernandes, Ariel Soares Teles, Jacks Renan Neves Fernandes, Lucas Daniel Batista Lima, Daniel Lima Sousa, Raimundo de Castro Soares, Silmar Silva Teixeira

“…While numerous AI models for skin conditions have been developed, their successful translation into real-world clinical practice critically depends on rigorous external validation to ensure generalizability and reliability beyond their development environment. …”
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Integrating the Water Footprint and DPSIR Model to Evaluate Agricultural Water Sustainability in Arid Regions: A Case Study of the Turpan–Hami Basin by Lingyun Zhang, Yang Yu, Zengkun Guo, Xiaoyun Ding, Lingxiao Sun, Jing He, Chunlan Li, Ruide Yu

“…Water resources are a key constraint on sustainable development in arid regions, especially for agricultural production where water use is intensive. …”
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Evaluation Methods for the Human–Land Coupling Coordination Relationship in a Metro Station Area: A Case Study of Chengdu Metro Line 1 by Zhiyue Qiu, Shirui Wen, Hong Yuan, Ziyi Liu, Yao Wei, Siqi Yanling, Runlong Dai, Xiang Li, Yuxin Gu

“…At present, more than 200 cities in the world have developed metro systems. Under the agglomeration effect of traffic nodes, rapid population agglomeration and land development and utilization have formed around metro stations in cities. …”
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The consequences of micro-discretions and boundaries in the social prescribing link worker role in England: a realist evaluation by Stephanie Tierney, Debra Westlake, Geoffrey Wong, Amadea Turk, Steven Markham, Jordan Gorenberg, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Anthony Meacock, Catherine Pope, Kamal R Mahtani

“…Follow-up interviews were conducted with 41 patients and with link workers 9–12 months later. Data were coded and developed into statements to identify how context around the link worker triggers mechanisms that lead to intended and unintended outcomes. …”
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How to interpret and use the results of epidemiological studies in healthcare practice. Methodological Rationale by S. A. Shalnova, Yu. A. Balanova, V. G. Vilkov, A. A. Zelenina, S. E. Evstifeeva, A. E. Imaeva, A. V. Kapustina, N. S. Karamnova, M. B. Kotova, V. A. Kutsenko, S. A. Maksimov, G. A. Muromtseva, O. B. Shvabskaya, E. B. Yarovaya, O. M. Drapkina

“…The sphere of the implementation of epidemiological data covers both the planning of preventive programs for the modification of risk factors in the population, and monitoring the effectiveness of preventive measures. …”
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Operation of Photo Electron Spectrometers for Non-Invasive Photon Diagnostics at the European X-Ray Free Electron Laser by Joakim Laksman, Florian Dietrich, Theophilos Maltezopoulos, Jia Liu, Danilo Enoque Ferreira de Lima, Natalia Gerasimova, Ivars Karpics, Naresh Kujala, Philipp Schmidt, Suren Karabekyan, Svitozar Serkez, Jan Grünert

“…In this contribution, we demonstrate and characterize the performance of our two operational photoelectron spectrometers for the application of hard X-rays and soft X-rays as well as new automation tools and online data analysis that enable continuous support for machine operators and instrument scientists. …”
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A comprehensive study on the longissius dorsi muscle of Ashdan yaks under different feeding regimes based on transcriptomic and metabolomic analyses by Tong Wang, Xiaoming Ma, Qingbo Zheng, Chaofan Ma, Zhilong Zhang, Heping Pan, Xian Guo, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan

“…A combined transcriptomic and metabolomic analysis revealed 31 co-enriched pathways, among which arginine metabolism, proline metabolism and glycerophospholipid metabolism may be involved in the development of the longissimus dorsi muscle of yak and the regulation of meat quality-related traits. …”
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Evaluating snow depth retrievals from Sentinel-1 volume scattering over NASA SnowEx sites by Z. Hoppinen, Z. Hoppinen, R. T. Palomaki, G. Brencher, D. Dunmire, D. Dunmire, E. Gagliano, A. Marziliano, J. Tarricone, J. Tarricone, H.-P. Marshall

“…We further investigate the underlying Sentinel-1 data for a snow signal through an exploratory analysis of the cross- to co-backscatter ratio (<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M2" display="inline" overflow="scroll" dspmath="mathml"><mrow><msub><mi mathvariant="italic">σ</mi><mi mathvariant="normal">VH</mi></msub><mo>/</mo><msub><mi mathvariant="italic">σ</mi><mi mathvariant="normal">VV</mi></msub></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="43pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="e6818905d8dace62fa04bcbb48435b9f"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="tc-18-5407-2024-ie00001.svg" width="43pt" height="14pt" src="tc-18-5407-2024-ie00001.png"/></svg:svg></span></span>; i.e., cross ratio) relative to lidar snow depths. …”
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Evaluating Cardiac Impairment From Abnormal Respiratory Patterns: Insights From a Wireless Radar and Deep Learning Study by Chun-Chih Chiu, Wen-Te Liu, Jiunn-Horng Kang, Chun-Chao Chen, Yu-Hsuan Ho, Yu-Wen Huang, Zong-Lin Tsai, Rachel Chien, Ying-Ying Chen, Yen-Ling Chen, Nai-Wen Chang, Hung-Wen Lu, Kang-Yun Lee, Arnab Majumdar, Shu-Han Liao, Ju-Chi Liu, Cheng-Yu Tsai

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Towards a universal implementation of labor companionship: a synthesis of the policy and facility environment of eight low-and-middle income countries by Soha El-Halabi, Andrea Barnabas Pembe, Alexandre Dumont, Ana Pilar Betrán, Charles Kaboré, Effie Chipeta, Guillermo Carroli, Helle Mölsted Alvesson, Hussein Kidanto, Jean-Paul Dossou, Kristi Sidney Annerstedt, Lenka Beňová, Mechthild M. Gross, Peter Waiswa, Pisake Lumbiganon, Quoc Nhu Hung Mac, Meghan A. Bohren, Claudia Hanson, Claudia Hanson

“…Our analysis included two steps, (1) a structured data abstraction with coding to pre-defined categories to analyse the national polices and available resources on a facility level which informed the (2) categorization of implementation maturity in three implementation phases modelled by the framework by Bergh et al. and the logic model developed by Bohren et al.ResultsThree of the eight countries lacked any national-level companionship policies, four had some mentioning and only one had detailed guidance on roles of labor companions and implementation guidelines. …”
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Trends, outcomes and knowledge gaps in mobile apps for reproductive endocrinology and infertility: a scoping review protocol by Alba Regina de Abreu Lima, Emerson Roberto dos Santos, Aline Russomano de Gouvêa, Natália Almeida de Arnaldo Silva Rodriguez Castro, João Daniel de Souza Menezes, Matheus Querino da Silva, Helena Landin Gonçalves Cristóvão, Cíntia Canato Martins, Jéssica Gisleine de Oliveira, Patrícia da Silva Fucuta, Alexandre Lins Werneck, Gerardo Maria de Araújo Filho, Heloisa Cristina Caldas, Vânia Maria Sabadoto Brienze, Júlio César André, Antônio Hélio Oliani

“…Two independent reviewers will carry out the study selection using Covidence software. Data extraction will follow a standardised format and will be synthesised narratively using tables and graphs. …”
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Depositional process of hyperpycnal flow deposits: A case study on Lower Cretaceous Sangyuan outcrop in the Luanping Basin, Northeast China by De-zhi Yan, Ru-kai Zhu, Hao Shou, Zhao-hui Xu, Wei-hong Liu, Si-cheng Zhu, Zhi-cheng Lei, Jing-ya Zhang, Chang Liu, Yi Cai, Huai-min Xu

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Fluorescence spectroscopic profiling of urine samples for predicting kidney transplant rejection by Zhe Yang, Minrui Zhang, Xianduo Li, Zhipeng Xu, Yi Chen, Xiaoyu Xu, Dongdong Chen, Lingquan Meng, Xiaoqing Si, Jianning Wang

“…This research entailed collecting fluorescent fingerprint data from 120 urine samples of post-renal transplant patients using hyperspectral imaging, followed by the development of a learning model to detect various forms of immunological rejection. …”
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Exploring Interactions of Older Adults with Mild Dementia Participating in Robotherapy with Robot Cats in a Day Hospital in Spain: A Qualitative Study by Cristina Perdomo-Delgado, Minoo Dabiri-Golchin, Patricia Sánchez-Herrera-Baeza, Almudena Muñoz-Martínez, Nereida Reyes-Sosa, Marta Pérez-de-Heredia-Torres, Paula Obeso-Benítez

“…Following semi-structured interviews, a thematic qualitative analysis of the data was conducted, revealing four main themes: (1) therapeutic effects of robotherapy (relaxation, mood improvement, cognitive stimulation, and increased social interaction); (2) preferences regarding the types of robotherapy activities; (3) interaction with the robot cat during the sessions; and (4) technological characteristics of the robot cat. …”
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Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation by Marika Attili, Marika Attili, Sonia Valentini, Sonia Valentini, Maria Pesavento, Maria Pesavento, Marco Ballarotto, Viviana Scognamiglio, Alfredo Pontecorvi, Antonio Macchiarulo, Fulvio Saccoccia, Fabiola Moretti

“…Our results uncover the intrinsic plasticity of the MDM2 RING domain through different binding clefts and provide evidence of its ability to host different peptides by key residues. This data may guide the development of next-generation therapeutic inhibitors.…”
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