Graph neural networks-based prediction of drug gene association of P2X receptors in periodontal pain by Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Seyed Ali Mosaddad, Artak Heboyan

“…Leveraging graph neural networks (GNNs) presents an innovative approach to model graph data, aiding in the identification of drug targets and prediction of their efficacy, complementing advancements in genomics and proteomics for therapeutic development. …”
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Predicting response to anti-VEGF therapy in neovascular age-related macular degeneration using random forest and SHAP algorithms by Peng Zhang, Jialiang Duan, Caixia Wang, Xuejing Li, Jing Su, Qingli Shang

“…Methods: In this retrospective study, we extracted data including demographic characteristics, laboratory test results, and imaging features from optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). …”
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Antimicrobial resistance: Linking molecular mechanisms to public health impact by Ghazala Muteeb, Raisa Nazir Ahmed Kazi, Mohammad Aatif, Asim Azhar, Mohamed El Oirdi, Mohd Farhan

“…Previous studies separating their attention between molecular genetics and clinical outcomes have been combined into our approach which delivers an all-encompassing analysis of AMR. Key insights: The report investigates the resistance mechanisms which feature enzymatic degradation and efflux pump overexpression together with target modification and horizontal gene transfer because these factors represent important contributors to present-day AMR developments. …”
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Bioinformatics and Expression Profiling of the DHHC-CRD S-Acyltransferases Reveal Their Roles in Growth and Stress Response in Woodland Strawberry (<i>Fragaria vesca</i>) by Si Gu, Xinghua Nie, Amal George, Kyle Tyler, Yu Xing, Ling Qin, Baoxiu Qi

“…S-acylation plays important roles in plant growth, development, and stress responses. Here, we report the genome-wide analysis of the <i>PAT</i> family genes in the woodland strawberry (<i>Fragaria vesca</i>), a model plant for studying the economically important Rosaceae family. …”
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Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study by Chen Jin, Chen Jin, Wen-Li Xiu, Wen-Li Xiu, Yao Liu, Yao Liu, Xi-Wei Hao, Qian Dong, Qian Dong

“…Furthermore, the rate of CTX metabolism and excretion may play a key role in PL development. Overall, the findings demonstrate that ultrasound is an effective tool for monitoring the development of PL in children receiving CTX and that discontinuation of CTX could be an effective treatment for PL.…”
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Physician group practice in China's healthcare reform: a national survey on physicians' perspectives and implementation challenges by Rui Fan, Qing Meng, Long Zhang, Chao Liu, Li Han, Meng Liu, Leiyu Shi

“…The survey assessed participants’ views on PG advantages, concerns, and overall support. Data analysis included descriptive statistics and variance analyses to explore correlations between physicians’ characteristics and their perspectives.ResultsKey facilitators for PG development included “New career direction outside the existing system” (75.1%) and “Improved income levels” (74.4%). …”
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Exploring the potential associations between single and mixed volatile compounds and preserved ratio impaired spirometry using five different approaches by Chenyuan Deng, Yu Jiang, Yuechun Lin, Hengrui Liang, Wei Wang, Ying Huang, Jianxing He

“…Methods: This study analyzed a subset of data from NHANES collected between 2007 and 2012. …”
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Clinical characteristics and risk factors of chronic critical illness in children with sepsis by Lin Yang, Lin Yang, Na Zang, Na Zang, Cong Liu, Cong Liu, Ying Yang, Ying Yang, Kai Bing Pu, Kai Bing Pu, Li Ping Tan, Li Ping Tan, En Mei Liu, En Mei Liu

“…ObjectivesThis study aimed to examine the clinical characteristics and risk factors associated with the development of chronic critical illness (CCI) in children with sepsis.MethodsA retrospective analysis was conducted on children diagnosed with sepsis and admitted to the Pediatric Intensive Care Unit (PICU) at Chongqing Medical University Affiliated Children's Hospital between January 2015 and December 2022. …”
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Intraspecific Differentiation of <i>Francisella tularensis</i> Strains Using Multilocus Real-Time Polymerase Chain Reaction by N. A. Osina, D. A. Sitmbetov, E. G. Bulgakova, S. S. Chekmareva, E. V. Sazanova, A. M. Senichkina, O. Yu. Lyashova, A. V. Osin, S. A. Shcherbakova

“…The aim of the study was to develop a method for intraspecific differentiation of the tularemia microbe: subspecies tularensis (subpopulations AI and AII), holarctica (biovars japonica, EryS/R), mediasiatica, and novicida using multilocus real-time PCR. …”
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Temporal dynamics of soil microbial symbioses in the root zone of wolfberry: deciphering the effects of biotic and abiotic factors on bacterial and fungal ecological networks by Mengyuan He, Mengyuan He, Mengyuan He, Qianqian Wang, Yiming Wang, Junhua Zhang

“…The study offers valuable data for improving the soil quality and fruit yield of L. barbarum under long-term continuous cropping, which has implications for the sustainable development of the L. barbarum industry.…”
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The Coupling Coordination Degree and Spatio-Temporal Divergence Between Land Urbanization and Energy Consumption Carbon Emissions of China’s Yangtze River Delta Urban Agglomeration... by Zhengru Li, Yang Yu, Bo Liu, Xiaoyu Zhang, Tianyin Li, Nuo Shi, Yichen Ren

“…The strategic coordinated development of land urbanization and carbon emission systems in urban agglomerations is crucial for achieving dual carbon goals and sustainable development. …”
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Inferring Mechanical Properties of Wire Rods via Transfer Learning Using Pre-Trained Neural Networks by Adriany A. F. Eduardo, Gustavo A. S. Martinez, Ted W. Grant, Lucas B. S. Da Silva, Wei-Liang Qian

“…The neural network’s input constitutes combined numerical and visual data, and its architecture primarily consists of seven dense layers and eight convolutional layers. …”
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Predicting Suspended Sediment Transport in Urbanised Streams: A Case Study of Dry Creek, South Australia by Tesfa Gebrie Andualem, Guna A. Hewa, Baden R. Myers, John Boland, Stefan Peters

“…We employed statistical modelling to develop a sediment rating curve (SRC) that provides insights into the sediment transport dynamics in the urban stream. …”
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HDL-C and visceral adipose tissue as combined predictors of visceral fat changes following laparoscopic sleeve gastrectomy by Yilan Sun, Liang Wang, Guangyi Zhu, Xiyuan Chen, Dongbo Lian, Nengwei Zhang, Guangzhong Xu

“…Demographic, metabolic, and imaging data were collected, and patients were categorized based on the median ΔVAT change at 12 months post-LSG. …”
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Fostering holistic eye care for children with special educational needs: an interprofessional education program bridging optometry and education by Kin Wan, Kin Hei Lau, Ho Yin Wong, Wing Yan Yu, Allen Ming Yan Cheong, Eva Yin-Han Chung, Chun Wai Lum, Kuen Fung Sin, Tsz-Wing Leung

“…Methods This program incorporated lectures and workshops to impart essential knowledge about SEN and to develop the necessary attitudes and skills for conducting eye examinations. …”
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Contrast-Enhanced CT-Based Radiomics Nomogram for Prediction of Pathologic T3a Upstaging in Clinical T1 RCC by Di Yin, Keruo Wang, Hongyi Xu, Yunfei Guo, Baoxin Qian, Dengyi Duan, Yiming Li, Wenyi Zhang, Zhengyang Li, Yang Zhao

“…<b>Background/Objectives</b>: To develop a nomogram for the preoperative prediction of pathologic T3a (pT3a) upstaging in patients with clinical T1(cT1) renal cell carcinoma (RCC). …”
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Integrated smart mass spectrometry platform enables volatilomics based breath biopsy by Shangzhewen Li, Zhiheng Yu, Zhengnan Cen, Xiang Li

“…To address this technological gap, we developed a comprehensive exhaled VOCs analysis platform integrating a self-developed BreathScope sampler and a GC × GC-TOF MS/FID detection system, complemented by optimized sampling strategies and standardized workflows. …”
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Exploring the professional identity of physicians experienced in older persons’ health care - implications for medical education: A qualitative study by Annemarie Moll-Jongerius, Kirsten Langeveld, Wing Tong, Tahir Masud, Martin Smalbrugge, Anneke W.M. Kramer, Wilco P. Achterberg

“…The method of the six-step thematic analysis was applied to structure and interpret the data, using an inductive approach. …”
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Gray water dominance in water footprint assessment of shale oil: A lifecycle perspective by Qian Wang, Bo Yuan, Jian Wu, Jun Xiong, Wenshi Liu, Xi Chen, Yan Wu

“…Existing water footprint studies, which predominantly focus on shale gas, inadequately address shale oil's unique resource characteristics and neglect key factors such as wastewater treatment. This study developed a Water Footprint Assessment Tool (WFAT) that integrates regression-based empirical models derived from historical shale oilfield data with the Water Footprint Network (WFN) methodology, aiming to holistically evaluate the water footprint across the entire shale oil production lifecycle. …”
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Purinergic Receptor (P2X7R): A Promising Anti-Parkinson’s Drug Target by Saivarshini Magham, M. Lalith Kumar, Praveen Thaggikuppe Krishnamurthy, Neenu Shaji, Aishwarya Reddy Ramakkamma

“…The review covers structure, signalling, molecular mechanisms, neuroprotective role, and current developments of P2X7R antagonists in PD. Methods: A systematic analysis and review of the potential prospects of P2X7R antagonists in the treatment of PD were conducted by analyzing existing research data and reports published between 1996 and present. …”
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