Identification of cell adhesion-related subtypes and construction of risk model to predict breast cancer prognostic and immunological properties by De-Ming Lv, Li Yang, Chen Fan, Ling-Hui Fang, Su-Fen Cheng

“…Methods Transcriptome and clinical data were obtained from The Cancer Genome Atlas (TCGA) database, while cell adhesion-related genes (CARGs) from the MSigDB database. …”
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Evaluation of Drug–Drug Interactions Between Clarithromycin and Direct Oral Anticoagulants Using Physiologically Based Pharmacokinetic Models by Zhuan Yang, Yuchen Qu, Yewen Sun, Jie Pan, Tong Zhou, Yunli Yu

“…<b>Methods:</b> PBPK models for clarithromycin, DABE–dabigatran (DAB), rivaroxaban, apixaban, and edoxaban were constructed using GastroPlus™ (version 9.9), based on physicochemical data and PK parameters from the literature. The models were optimized and validated in healthy subjects. …”
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Deep learning for automated dental plaque index assessment: validation against expert evaluations by Jin-Sun Jeong, Kyeong-Seop Kim, Yu Gu, Da-Hyun Yoon, Meng Zhang, Ling Wang, Jeong-Hwan Kim

“…Objective This study aimed to develop and evaluate a deep learning (DL)-based system that automatically detects and quantifies dental plaque, using a standardized plaque index, from intraoral images. …”
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Inversion of Moho topography in Taiwan using improved Parker-Oldenburg method by Hangtao Yu, Hangtao Yu, Hangtao Yu, Mingming Wen, Mingming Wen, Mingming Wen, Chuang Xu

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LoRA fine-tuning of Llama3 large model for intelligent fishery field by Yao Song, Chunli Lv, Kun Zhu, Xiaobin Qiu

“…In the field of fisheries, the Llama3 model fine-tuned by LoRA is used to process and analyze textual data related to fisheries, such as water quality and environmental monitoring, fish behavior analysis, fish farming techniques, and interpretation of fisheries policies. …”
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The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Specifically, hAAT completely blocked the R848 induction of germinal center T cells (GC T), B cells (GC B), and plasma cells (GC PCs), as well as T follicular T helper cells (T_FH), which are all critical in lupus development. These data demonstrated that hAAT inhibited TLR7/8 and TLR9 signaling pathways, which are critical for lupus development. …”
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Effects of variety and organomineral fertiliser rate on cucumber yield and nutritional content in early and late seasons by Kasali Asimiu Olusegun, Makinde Eyitayo Adekunle, Falaiye Olamide Oluwatosin, Odesola Kafilat Abiodun

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Strategy of the effective structure of farmers funding by Denis Y. Samygin, Nikolay G. Baryshnikov

“…The study used: data of state programs on agricultural industry during 2008-2012 and 2013–2020; analytical materials of national reports of their realization; statistical information resources of the Ministry of Agriculture of the Russian Federation; consolidated, individual financial and economic reports on agricultural producers of Penza region, which are processed by the methods of logical analytics, structural diagnostics, methodological synthesis of scientific research, the quantitative analysis and other economic-mathematical tools with the use of application programs of SPSS statistical package and mathematical Mathcad package.Results. …”
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Methodology for Estimating Communication Reliability in Shortwave Radio-Frequency Transmission Channels with Rician Fading Given Ionospheric Diffusivity by V. P. Pashintsev, D. A. Belokon, S. A. Koval, A. D. Skorik

“…The effect of Rician fading parameters on communication reliability was simulated in the MatLab environment. The initial data on ionospheric parameters were obtained using the IRI-2016 model.Results. …”
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China’s approach to malaria control and elimination: Adaptive management and policy capacity building by Wei Ding, Duoquan Wang, Shenning Lu, Xiao-Nong Zhou, Lewis Husain

“…The findings highlight how adaptive malaria policy and practice in China responded not only to the changing distribution and burden of malaria but also to shifts in institutions and the political economy as the country developed. Experimentation facilitated adaptive, sequential problem-solving, starting from a low base with limited data availability and capacity. …”
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Construction and Application of Carbon Emissions Estimation Model for China Based on Gradient Boosting Algorithm by Dongjie Guan, Yitong Shi, Lilei Zhou, Xusen Zhu, Demei Zhao, Guochuan Peng, Xiujuan He

“…To overcome these limitations, this study develops and validates a high-resolution predictive model using advanced gradient boosting algorithms—Gradient Boosting Decision Tree (GBDT), Extreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM)—based on socioeconomic, industrial, and environmental data from 2732 Chinese counties during 2008–2017. …”
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A survey of availability, price, and affordability of innovative negotiated anticancer medicines: a retrospective study in Jiangsu Province, eastern China by Rui Ma, Yanyan Liu, Baolong Ding, Yuyang Sun, Hongting Yao, Man Yu, Xiaoye Wang, Lingli Zhang, Xin Li

“…This study aims to assess the accessibility of 23 Innovative Negotiated Anticancer Medicines (INAMs) in Jiangsu Province, a developed region in eastern China. Methods A retrospective survey was conducted across 319 healthcare institutions in Jiangsu Province, with 285 included for analysis. …”
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Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling by Daria Perepletchikova, Polina Kuchur, Liubov Basovich, Irina Khvorova, Arseniy Lobov, Kseniia Azarkina, Nikolay Aksenov, Svetlana Bozhkova, Vitaliy Karelkin, Anna Malashicheva

“…The findings of the study emphasize the importance of intercellular communication in the regulation of osteoblast differentiation during bone development and maintenance. Graphical Abstract…”
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Pathobiochemical aspects of alcoholic cardiomyopathy. The role of hydrogen sulfide in the mechanism of cardiocytoprotection (a review) by N. I. Voloshchuk, K. V. Rudenko, O. R. Matiash, O. M. Denysiuk

“…ACMP is characterized by left ventricular dilatation, decreased wall thickness and (at the later stages) decreased left ventricular ejection fraction (less than 40 %). Analysis of literature data about the mechanisms of alcohol-induced cardiotoxicity revealed trigger factors for myocardial damage. …”
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Engineering Lipid–Polymer Nanoparticles for siRNA Delivery to Cancer Cells by Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi

“…This methodological approach, incorporating optimal combined designs and response surface methodologies, refined the LPNPs to an optimal efficiency. <b>Results</b>: Our data revealed that DOPE and Dlin-MC3-DMA contributed to higher efficiency in selected breast cancer cells over DSPC and ALC-0315 as neutral and ionizable lipids, respectively, based on the software analysis and direct comparative experiments. …”
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Experiences and practices of people categorised as being ‘at risk’ based on age during the COVID-19 pandemic: a qualitative study in the UK and Germany by Susannah Mayhew, Stephanie Drössler, Katharina Wabnitz

“…Inclusion criteria: to be at risk for a severe course of COVID-19 due to age ≥50 years (Germany) and ≥70 years (UK) based on official communication by the respective national public health authority.Exclusion criteria: any form of dementia, pre-existing mental health issues, congenital physical or mental disabilities, being resident in a care home, having a personal relationship to the principal investigator.Methods Semistructured in-depth interviews were conducted remotely. Reflexive thematic analysis was carried out to inductively develop themes illustrative of shared patterns of meaning across the whole data set.Results Three main themes are reported. …”
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Disordered eating behaviors and associated factors among secondary school adolescents in Harar town, eastern Ethiopia: cross-sectional study by Abainash Tekola, Lemma Demissie Regassa, Hiwot Berhanu, Miheret Mandefro, Samrawit Shawel, Obsan Kassa, Kedir Teji Roba

“…BackgroundAdolescent eating disorders impair physical and mental development and are associated with poor health outcomes in adulthood. …”
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The Consequences of Mining Damage and their Impact on the Natural Environment – a Case Study of Trzebinia by Krzysztof Cygańczuk, Jacek Roguski

“…Methodology: The article uses theoretical and practical research methods, including the analysis of a report on satellite methods, which was developed on the basis of data from satellite radar interferometry. …”
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Changes in Intestinal Microbiota and Their Relationship With Patient Characteristics in Colorectal Cancer by Lu Zhao, Yongkun Fang, Jingqiu Zhang, Chen Wei, Hao Ji, Jiahao Zhao, Daorong Wang, Dong Tang

“…Methods: Together with clinical data, we collected fecal samples from patients with CRC (n = 18) and healthy controls (n = 18) and performed 16S rRNA gene sequencing and alpha and beta diversity analysis to compare microbiota richness and diversity. …”
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HIGH PREVALENCE OF ANXIETY AND 15-YEAR CARDIOVASCULAR RISK IN RUSSIA/SIBERIA INHABITANTS (WHO FRAMEWORK “MONICA-PSYCHOSOCIAL”) by V. V. Gafarov, E. A. Gromova, D. O. Panov, I. V. Gagulin, A. V. Gafarova

“…Significance of all analysis types was set with threshold at p≤0,05.Results. …”
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