A systematic approach to context-mapping to prepare for health interventions: development and validation of the SETTING-tool in four countries by Sally Singh, Bruce Kirenga, Mattijs E Numans, Hilary Pinnock, Maarten J Postma, Niels H Chavannes, Susanne Reventlow, Andy Barton, Grace Ndeezi, Janwillem Kocks, Sian Williams, Winceslaus Katagira, Rebecca Nantanda, Ioanna Tsiligianni, Sophia Papadakis, Christos Lionis, Patrick Musinguzi, Rupert Jones, Evelyn A Brakema, Rianne MJJ van der Kleij, Charlotte C Poot, Simon Walusimbi, Pham Le An, Talant Sooronbaev, Matty R Crone, Ria R Reis, Marilena Anastasaki, Azamat Akylbekov, Antonios Bertsias, Pham Duong Uyen Binh, Job FM van Boven, Dennis Burges, Lucy Cartwright, Vasiliki E Chatzea, Liza Cragg, Tran Ngoc Dang, Ilyas Dautov, Berik Emilov, Irene Ferarrio, Frederik A van Gemert, Ben Hedrick, Le Huynh Thi Cam Hong, Nick Hopkinson, Elvira Isaeva, Corina de Jong, Sanne van Kampen, Jesper Kjærgaard, Rianne MJJ van der Kleij, Le Thi Tuyet Lan, Tran Thanh Duv Linh, Kim Xuan Loan, Maamed Mademilov, Andy McEwen, Jillian Pooler, Anja Poulsen, Pippa Powell, Nguyen Nhat Quynh, Dimitra Sifaki-Pistolla, Jaime Correia de Sousa, James Stout, Marianne Stubbe Østergaard, Aizhamal Tabyshova, Tran Diep Tuan, Le Thanh Van, Nguyen Nhu Vinh, Louise Warren

“…The resulting Setting-Exploration-Treasure-Trail-to-Inform-implementatioN-strateGies (SETTING-tool) consisted of six steps: (1) Coset study priorities with local stakeholders, (2) Combine a qualitative rapid assessment with a quantitative survey (a mixed-method design), (3) Use context-sensitive materials, (4) Collect data involving community researchers, (5) Analyse pragmatically and/or in-depth to ensure timely communication of findings and (6) Continuously disseminate findings to relevant stakeholders. …”
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Single ChAdOx1 nCoV‐19 dose elicits stronger immune response in previously infected individuals than in SARS‐CoV2 naive persons by Fawzi Ebrahim, Asma Alboueishi, Inas M. Alhudiri, Salah Al Tabal, Yosra Lamami, Samira Al Dwigen, Sondos Ashleb, Noha Ejenfawi, Mohamed B. Milad, Hayat Rhoumah, Salah Edin El Meshri, Adam Elzagheid

“…A questionnaire was used to collect data on age, sex, and self‐reported history of COVID‐19 infection. …”
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A multicentre implementation trial of an Artificial Intelligence-driven biomarker to inform Shared decisions for androgen deprivation therapy in men undergoing prostate radiotherap... by Eric Wegener, Michael Ng, Mario Guerrieri, Timothy N. Showalter, Jeremy de Leon, Sagar Ramani, Marcus Dreosti, Tee Lim, Bradley Wong, Michael Chao, Kathryn Hogan, Avi Raman, Scott McClintock, Darren Foreman, Matthew Brown, Stephen McCombie, Kevin McMillan, Kieran Beattie, Mark Frydenberg, Lih-Ming Wong, Dickon Hayne, John Yaxley, Phillip Stricker, Jarad Martin

“…However, its clinical utility in real-world settings has yet to be measured prospectively. Methods This multicentre implementation trial aims to collect real-world data on the use of the previously validated Artera MMAI-driven prognostic and predictive biomarkers in men with intermediate-risk prostate cancer undergoing curative radiotherapy. …”
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Variation in Soil Organic Carbon and Total Nitrogen Stocks Across Elevation Gradients and Soil Depths in the Mount Kenya East Forest by Brian Rotich, Tamás Szegi, Yuri Andrei Gelsleichter, Márta Fuchs, Caleb Melenya Ocansey, Justine Nsima Phenson, Mustapha Abdulkadir, Harison Kipkulei, Amos Wawire, Evans Mutuma, Samuel Ayodele Mesele, Erika Michéli, Ádám Csorba

“…Samples were analysed for bulk density (BD), pH, texture, soil organic carbon (SOC), and total nitrogen (TN), using standard laboratory methods. In topsoil (0–20 cm), SOCS ranged from 109.28 ± 23.41 to 151.27 ± 17.61 Mg C ha⁻¹, while TNS varied from 8.89 ± 1.77 to 12.00 ± 2.46 Mg N ha⁻¹. …”
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Integrated serological surveillance of communicable diseases in the Paraguayan Chaco, 2019 by Patricia Galeano, Claudia Huber, Violeta Ortiz, Soraya Araya, Vilma Teresa Pérez, Guillermo Sequera, María Paz Ade, Gloria Rey-Benito, Pamela Bravo, Ana Luciañez, Romeo Montoya, Silvia Giselle Ibarra-Ozcariz, Viviana De Egea, Águeda Cabello, Ana Morice, Martha Idalí Saboyá-Díaz, E. Brook Goodhew, Gretchen Cooley, Diana Martin

“…Blood samples were taken on filter paper to measure IgG antibodies using a multiplex bead assay. Data collection was carried out through interviews with parents and caregivers. …”
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Impact of different front-of-package labeling models on food choices among residents in Shanghai, China: a randomized controlled trial by Zhuo Sun, Xiao Chen, Jiangyue Yu, Jiangyue Yu, Wei Lu, Zehuan Shi, Kunyi Huang, Liping Shen, Wenqing Ma, Shupeng Mai, Qi Song, Zhengyuan Wang, Jiajie Zang

“…Here, we evaluated the impact of different FOPL models on the food purchasing behaviors of Shanghai residents.MethodsThis randomized controlled trial included 7,346 respondents, who were randomly assigned to one of four FOPL groups: Nutri-Choice (NC), Nutrition Information Panel (NIP), Comprehensive Nutri-Choice (CNC), and Warning Label (WL). …”
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Circulating innate lymphoid cells are dysregulated in patients with prostate cancer by Daniela Claudia Maresca, Evelina La Civita, Benedetta Romano, Maria Rosaria Ambrosio, Fabio Somma, Tania Wyss, Bernardo Rocco, Valentina Rubino, Luigi Cari, Philippe Krebs, Antonio Rodriguez-Calero, Matteo Ferro, Sara Trabanelli, Camilla Jandus, Felice Crocetto, Angela Ianaro, Daniela Terracciano, Giuseppe Ercolano

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Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe by Paul Kelly, Lisa Langhaug, Robert Ntozini, Kuda Mutasa, Bernard Chasekwa, Andrew Prendergast, Batsirai Mutasa, Naume V Tavengwa, Tim Brown, Laura E Smith, Dexter. T Chagwena, Claire Bourke, Ruairi Robertson, Shamiso Fernando, Jill Cairns, Thokozile Ndhlela, Exhibit Matumbu, Kavita Datta, Alice Tengende, Dzivaidzo Chidhanguro, Maggie Makanza, Jonathan Swann

“…Research nurses will collect data plus blood, urine and stool samples at baseline (5–6 months of age) and endline (9–11 months of age). …”
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Anterior Peripheral Rim Instability Is Prevalent in Young, Skeletally Immature Patients With Discoid Lateral Meniscus and Has Favorable Postoperative Outcomes by Steven Maxwell Henick, M.D., Zachariah Samuel, B.S., Joseph Nicholas Charla, B.S., Emily Ferreri, B.S., Emmanuel Mbamalu, B.S., Edina Gjonbalaj, B.S., Leila Mehraban Alvandi, Ph.D., Jacob Foster Schulz, M.D., Eric Daniel Fornari, F.A.O.A., M.D., Mauricio Drummond, Jr., M.D.

“…Patients were divided into 2 groups: anterior PRI (isolated anterior PRI and anterior combined with posterior PRI) and nonanterior PRI (nonanterior PRI designated as isolated posterior or no PRI). Data collection included demographics, clinical presentation, MRI results, arthroscopic findings, reoperation rates, complications, and PROs. …”
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The dose–effect relationship between acupuncture and its effect on primary insomnia: a systematic review and meta-analysis by Xiaoni Zhang, Xiaoni Zhang, Yue Wang, Chengyong Liu, Shan Qin, Liyu Lin, Liyu Lin, Can Dong, Wenzhong Wu, Wenzhong Wu, Zhaoming Chen

“…Although sham acupuncture needling at the same points as those in acupuncture may not be a true placebo control, this was utilized in a minority of studies. Collectively, the data suggest that at least three sessions per week for 3–4 weeks and a total of at least 12 acupuncture sessions would be the optimal clinical response.Systematic review registrationhttps://www.crd.york.ac.uk/, identifier CRD42024560078.…”
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Low-level viremia increases the risk of diabetes mellitus in people with HIV in China: a 7-year retrospective longitudinal cohort study by Chunxing Tao, Liangjia Wei, Minn Thit Aung, Longyu Liao, Aidan Nong, Li Huang, Rongye Huang, Lijing Huang, Shuixia Wang, Xiaohuan Huang, Yanbing Yao, Li Ye, Hao Liang, Chuanyi Ning, Salma Gayed, Lijuan Bao, Bingyu Liang

“…This study aims to assess the association between HIV viremia exposure during ART and DM using retrospective cohort data. Methods People with HIV (PWH) who started ART in 2003 or later were identified from China’s National Free ART Program database. …”
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Exploring the determinants of malnutrition in 2–5 year Iranian children using structural equation modeling: national food and nutrition surveillance by Samira Rabiei, Samira Ebrahimof, Hamid Rasekhi, Maryam Amini, Delaram Ghodsi, Zahra Yari, Zahra Abdollahi, Mina Minaie, Bahareh Nikooyeh, Tirang R. Neyestani

“…In this study, an android application comprising electronic questionnaires was employed for data collection. Anthropometric, dietary, food security and socioeconomic status (SES) assessments were performed. …”
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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…Herein, our work was set out to study the potential role and possible mechanism of SGD in PICI through network pharmacology, Mendelian analysis and animal experiments. Methods: First, network pharmacology analysis was performed to identify the potential active compounds and targets of SGD on PICI. …”
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Leveraging pre-vaccination antibody titres across multiple influenza H3N2 variants to forecast the post-vaccination responseResearch in context by Hannah Stacey, Michael A. Carlock, James D. Allen, Hannah B. Hanley, Shane Crotty, Ted M. Ross, Tal Einav

“…Models using pre-vaccination antibody haemagglutination inhibition (HAI) titres against the vaccine strain alone poorly predict post-vaccination responses. Methods: We combined fifteen prior H3N2 influenza vaccine studies from 1997 to 2021, collectively containing 20,000 data points, and develop of a machine learning model that uses pre-vaccination HAI titres against multiple influenza variants to predict post-vaccination responses. …”
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SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia by Marianne J Mullane, Timothy C Barnett, Jeffrey W Cannon, Jonathan R Carapetis, Ray Christophers, Juli Coffin, Frieda Mc Loughlin, Vicki O'Donnell, Rebecca Pavlos, Bec Smith, Andrew C Steer, Steven Y C Tong, Roz Walker, Asha C Bowen

“…Four community clusters in the remote Kimberley region of Western Australia will participate. Following baseline data collection, two clusters will be randomly allocated to the SToP activities. …”
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The impact of circWWC3 on neoadjuvant therapy for triple-negative breast cancer and the construction of a nomogram for predicting pathological complete response after neoadjuvant t... by Haoqi Wang, Haoqi Wang, Hongbo Liu, Hongbo Liu, Shan Gao, Lijia Wang, Zihao Bai, Yi Zhang, Peijin Zhang, Fei Liu, Fei Liu, Cuizhi Geng, Cuizhi Geng

“…Therefore, it is crucial to identify new molecular targets for precise treatment and to develop predictive models for pCR to facilitate tailored therapeutic approaches.MethodsWe conducted a study involving a cohort of TNBC patients who underwent NAT, collecting data on clinicopathological indicators, MRI parameters, and pathological remission outcomes. …”
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Ketogenic diet therapy for epilepsy during pregnancy and lactation: An international survey exploring clinician perspectives by Kelly Faltersack, Tanya J. W. McDonald, Valentina De Giorgis, Bobbie Barron, Mackenzie C. Cervenka, Anita Devlin, Laura A. Healy, Magnhild Kverneland, Elles van derLouw, Mengyang Lu, Martina P. Zanaboni, Marisa Armeno, Elizabeth A. Felton

“…Methods Between December 2023 and June 2024, an online survey was widely circulated to healthcare professionals (HCPs) working with PWECP and people with Glut1DS of childbearing potential on KDT. …”
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Sex and gender considerations in randomized controlled trials in critical care nephrology: a meta-epidemiologic study by Nuttha Lumlertgul, Anyarin Wannakittirat, Janice Y. Kung, Nattachai Srisawat, David Collister, Emily J. See, Neesh Pannu, Ravindra L. Mehta, Danielle E. Soranno, Marlies Ostermann, Sean M. Bagshaw

“…We aimed to perform a meta-epidemiologic study to describe the representation, sex and gender reporting, and sex- and gender-based analyses (SGBA) in high-impact RCTs in critical care nephrology. Methods We searched the Web of Science Core Collection for critical care nephrology papers from 2000 to 2024. …”
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Locally-tailored vs. centrally-administered strategies for implementation of primary human papillomavirus (HPV) screening in an integrated healthcare system: a qualitative research... by Erin E. Hahn, Erin E. Hahn, Corrine Munoz-Plaza, Chunyi Hsu, Nancy T. Cannizzaro, Quyen Ngo-Metzger, Michael K. Gould, Brian S. Mittman, Melissa Hodeib, Devansu Tewari, Chun R. Chao, Chun R. Chao

“…As part of an ongoing randomized trial comparing implementation strategies for primary HPV testing (a centrally administered + usual care strategy vs. centrally administered + locally tailored strategy), we evaluated clinician experiences and perceptions of large-scale implementation of primary HPV screening in an integrated healthcare system, Kaiser Permanente Southern California.Materials and methodsWe conducted qualitative interviews with internal medicine, family medicine and obstetrics/gynecology clinicians to gain insight into fidelity to the interventions and implementation strategies, barriers and facilitators to implementation, and recommendations. …”
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Cultural practices, healthcare-seeking behaviors, and wildlife interface: Zoonotic disease risks among the Phu Thai Ethnic Group in Thailand by Nisachon Bubpa, Kanokwan Suwannarong, Kannika Thammasutti, Thanomsin Ponlap, Worakamon Thongkan, Paisit Boonyakawee, Phitsanuruk Kanthawee, Kangsadal Suwannarong, Withaya Chanchai

“…Data collection included 3 focus group discussions (16 respondents), 6 in-depth interviews, and 5 key informant interviews, with a total of 27 respondents consisting of community members, leaders, and government officials. …”
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