ID1 and ID3 functions in the modulation of the tumour immune microenvironment in adult patients with B-cell acute lymphoblastic leukaemia by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita, Alba Lucia Combita, Alba Lucia Combita

“…These findings correlated with xCell data. Overexpression group showed significant differences in neutrophils, monocytes and CD4+ naive T cells compared to basal group patients. …”
Get full text

Association between neutrophil-percentage-to-albumin ratio and periodontitis: insights from a population-based study by Ziyang Zheng, Ziyang Zheng, Ziyang Zheng, Xinyu Xie, Xinyu Xie, Xinyu Xie, Lan Wang, Lan Wang, Lan Wang, Mingzhang Xu, Mingzhang Xu, Mingzhang Xu, Jiaqi He, Jiaqi He, Yunyi Deng, Yunyi Deng, Yunyi Deng, Ke Yu, Ke Yu, Ke Yu

“…Despite growing interest in its role in other chronic conditions, the specific connection between NPAR and periodontal disease remains underexplored and requires further examination to understand its potential clinical applications.MethodsA population-based analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES), with a total of 8,389 participants included with complete full-mouth periodontal examination, NPAR related index and covariates. …”
Get full text

Antibiotic susceptibility patterns of Salmonella isolates from clinical, food, and environmental sources in Addis Ababa and surrounding towns, Ethiopia by Abebe M. Aga, Demise Mulugeta, Dassalegn Muleta, Adugna Abdi Woldesemayat, Abera Motuma, Musin Kelel, Bilise Wakitole, Shambel Tadesse, Zinash Teferi, Fanos Tadesse Woldemariyam, Serkadis Oljira, Henok Ferede, Natnael Berihun, Samson Girma, Dereje Nigussie, Mesfin Tafesse Gemeda

“…This study provides a comprehensive analysis of Salmonella isolates from clinical, food, and environmental samples in Addis Ababa and nearby towns, offering current data on antimicrobial resistance patterns. By using updated laboratory standards and sampling diverse sources, the findings highlight the urgent need for improved food safety practices, sanitation, and antimicrobial stewardship.…”
Get full text

Clinical analysis of patients with idiopathic pulmonary fibrosis concurrent with surgery resectable lung cancer: a retrospective cohort study from perspective of ILD physicians by Qi Chen, Yujie Shi, Ruxuan Chen, Kai Xu, Cheng Huang, Ji Li, Zhiyi Li, Mengqi Wang, Chi Shao, Hui Huang, Mengzhao Wang

“…Clinical trial number Not applicable.…”
Get full text

Modeling the distribution of the invasive snail Physella acuta in China: Implications for ecological and economic impact by Yingxuan Yin, Anyuan Xu, Xiaowen Pan, Qing He, Aoxun Wu, Linya Huang, Yinjuan Wu, Xuerong Li

Get full text

Clinical Validation of a Machine Learning-Based Biomarker Signature to Predict Response to Cytotoxic Chemotherapy Alone or Combined with Targeted Therapy in Metastatic Colorectal C... by Duilio Pagano, Vincenza Barresi, Alessandro Tropea, Antonio Galvano, Viviana Bazan, Adele Caldarella, Cristina Sani, Gianpaolo Pompeo, Valentina Russo, Rosa Liotta, Chiara Scuderi, Simona Mercorillo, Floriana Barbera, Noemi Di Lorenzo, Agita Jukna, Valentina Carradori, Monica Rizzo, Salvatore Gruttadauria, Marco Peluso

“…By analyzing large sets of patient data and using machine learning, we hope to create a model that can identify which patients will respond to chemotherapy, either alone or combined with other targeted treatments. …”
Get full text

Multimodal machine learning-based marker enables the link between obesity-related indices and future stroke: a prospective cohort studyResearch in context by Beilei Hu, Xuan Chen, Tingyang Chen, Tong Xu, Yungang Cao, Jing Sun, Xuanyu Chen, Songfang Chen, Keyang Chen

“…Further research is needed to assess its applicability in broader cohorts. Funding: None.…”
Get full text

Fertility preservation by ovarian tissue cryopreservation of children in China——umbilical single-incision surgery and perioperative experience by Zheng Qipeng, Liu Jing, Su Yun, Li Zexi, Cao Zhenhua, Chen Meng, Zhou Yan, Zhang Hua, Wang Zecheng, Tian Yu, Ruan Xiangyan, Wu Yurui

“…This study aims to summarize the surgical techniques and perioperative experiences to provide clinical evidence for pediatric OTCT.MethodsThis retrospective study reviewed the clinical data of 89 children who underwent umbilical single-incision laparoscopic oophorectomy at Children’s Hospital, Capital Institute of Pediatrics between September 2020 and December 2024. …”
Get full text

Deep learning can predict cardiovascular events from liver imaging by Gregory Patrick Veldhuizen, Tim Lenz, Didem Cifci, Marko van Treeck, Jan Clusmann, Yazhou Chen, Carolin V. Schneider, Tom Luedde, Peter W. de Leeuw, Ali El-Armouche, Daniel Truhn, Jakob Nikolas Kather

“…However, further validation is necessary before clinical implementation, ensuring broad applicability and integration into existing prevention frameworks.…”
Get full text

AIRWAVE-SLSTR—An Algorithm to Estimate the Total Column of Water Vapour from SLSTR Measurements over Liquid Surfaces by Elisa Castelli, Stefano Casadio, Enzo Papandrea, Paolo Pettinari, Massimo Valeri, Andrè Achilli, Bojan R. Bojkov, Alessio Di Roma, Camilla Perfetti, Bianca Maria Dinelli

“…The new AIRWAVE algorithm makes use of parameters computed offline with a state-of-the-art radiative transfer model using the most recent spectroscopic data and continuum model. For the parameters calculation, a new climatology capable of representing the average atmospheric and sea surface status during SLSTR measurements has been developed. …”
Get full text

O-prenylchalcones inhibit cell proliferation and activate apoptosis by inducing mitochondrial dysfunction in gastric cancer cells by José C. Espinoza-Hicks, Yarely M. Salinas-Vera, Javier Camarillo-Cisneros, Alejandro A. Camacho-Dávila, Jessica L. Hernández-Rivera, Nadia Flores-Huerta, Eloisa Ibarra-Sierra, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Ángeles C. Tecalco-Cruz, César López-Camarillo

“…Conclusions Here, we report preliminary data suggesting that O-prenylchalcones inhibit cell proliferation and promote cell death by inducing mitochondrial dysfunction, caspase-3 and caspase-7 activation, and ROS generation in AGS gastric cancer cells. …”
Get full text

The Effect of Tangible and Intangible Hotel Caracteristics on Brand Loyalty with the Mediating Role of Perceived Well-Being and Brand Attitude (Case study: 4 And 5 Star Hotels In M... by Zahra Mohamadzadeh, Zahra Mohamoudi

“…The research results showed that the tested model has a good fit to the data, and all the research hypotheses were confirmed. …”
Get full text

Earth's future climate and its variability simulated at 9 km global resolution by J.-Y. Moon, J.-Y. Moon, J. Streffing, J. Streffing, J. Streffing, S.-S. Lee, S.-S. Lee, T. Semmler, T. Semmler, M. Andrés-Martínez, M. Andrés-Martínez, J. Chen, E.-B. Cho, E.-B. Cho, J.-E. Chu, C. L. E. Franzke, C. L. E. Franzke, J. P. Gärtner, R. Ghosh, J. Hegewald, J. Hegewald, S. Hong, D.-W. Kim, D.-W. Kim, N. Koldunov, J.-Y. Lee, J.-Y. Lee, Z. Lin, C. Liu, S. N. Loza, W. Park, W. Park, W. Roh, W. Roh, D. V. Sein, D. V. Sein, D. V. Sein, S. Sharma, S. Sharma, D. Sidorenko, J.-H. Son, J.-H. Son, J.-H. Son, M. F. Stuecker, Q. Wang, G. Yi, G. Yi, M. Zapponini, T. Jung, T. Jung, A. Timmermann, A. Timmermann

Get full text

Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy by Boji Xie, Shuting Pang, Yuli Xie, Yuli Xie, Qiuyan Tan, Shanshan Li, Mujia Jili, Mujia Jili, Yian Huang, Yian Huang, Binran Zhao, Hao Yuan, Hao Yuan, Junhao Mi, Junhao Mi, Junhao Mi, Xuesong Chen, Liangping Ruan, Hong Chen, Xiaolai Li, Boning Hu, Jing Huang, Rirong Yang, Rirong Yang, Wei Li

“…Bulk RNA sequencing (RNA-seq) of urine offers a promising approach for identifying molecular changes relevant to IgAN.MethodsWe performed bulk RNA-seq on 53 urine samples from 11 untreated IgAN patients and 11 healthy controls, integrating these data with public renal RNA-seq, microarray, and scRNA-seq datasets. …”
Get full text

A CECT-Based Radiomics Nomogram Predicts the Overall Survival of Patients with Hepatocellular Carcinoma After Surgical Resection by Peng Zhang, Yue Shi, Maoting Zhou, Qi Mao, Yunyun Tao, Lin Yang, Xiaoming Zhang

“…<b>Methods</b>: This retrospective study analyzed the preoperative enhanced CT images and clinical data of 202 patients with HCC who underwent surgical resection at the Affiliated Hospital of North Sichuan Medical College (Institution 1) from June 2017 to June 2021 and at Nanchong Central Hospital (Institution 2) from June 2020 to June 2022. …”
Get full text

An eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients With Metastatic Cancers: Protocol for a Randomized Trial by Kimberley T Lee, Briana McLeod, Brian Egleston, Sarah Brown, Sarah Howe, Dominique Fetzer, Lauren Gutstein, Cara Cacioppo, Dana Clark, Susan M Domchek, Jessica Ebrahimzadeh, Dana Falcone, Demetrios Ofidis, Hannah Griffin, Rajia Mim, Santina Hernandez, Linda Fleisher, Kelsey Karpink, Enida Selmani, Aysha Tahsin, Lynne Wagner, Michelle Weinberg, Kuang Yi-Wen, Elisabeth Wood, Angela R Bradbury

“…ResultsAs of January 2025, we have completed enrollment of 229 participants. Data analysis is ongoing, and we expect the results to be published in 2025. …”
Get full text

On the atmospheric budget of 1,2-dichloroethane and its impact on stratospheric chlorine and ozone (2002–2020) by R. Hossaini, D. Sherry, Z. Wang, Z. Wang, M. P. Chipperfield, M. P. Chipperfield, W. Feng, W. Feng, D. E. Oram, D. E. Oram, K. E. Adcock, S. A. Montzka, I. J. Simpson, A. Mazzeo, A. A. Leeson, E. Atlas, C. C.-K. Chou

“…Our findings imply substantial fugitive losses of DCE and/or substantial emissive applications (e.g. solvent use) that are poorly reported. …”
Get full text

Comparative Discrimination of Life’s Simple 7, Life’s Essential 8, and Life’s Crucial 9: Evaluating the impact of added complexity on mortality prediction by Xu Zhu, Iokfai Cheang, Yiyang Fu, Sitong Chen, Gengmin Liang, Huaxin Yuan, Ling Zhu, Haifeng Zhang, Xinli Li

“…This study aimed to assess whether the additional components in LE8 and LC9 enhance mortality prediction compared to LS7. Methods Data from 22,382 participants in the NHANES 2005–2018 were analyzed. …”
Get full text

Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank by Kristine J. S. Kwan, Shi-Shuai Xie, Hai-Lei Li, Xue-Guang Lin, Yi-Jie Lu, Bo Chen, Kai-Xin Ge, Shu-Ya Tang, Hui Zhang, Shuai Jiang, Jing-Dong Tang

“…The primary aim of this study was to evaluate the association between PhenoAge and PhenoAgeAccel with incident cardiovascular diseases (CVD) in the UK Biobank cohort. We analyzed data from 114,517 UK Biobank participants free of CVD history at baseline. …”
Get full text

Multi-dimensional Exposure Characteristics and Health Benefits Differentiation of Green Spaces within Community Life Circle by Hailin HONG, Qing CHANG

“…A total of 1,116 residents from 36 neighborhoods are examined using multi-source data, involving green space metrics, health outcomes survey, and demographic and socioeconomic indicators. …”
Get full text