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  1. 50661
  2. 50662

    Balance of benefits and harms of different blood pressure targets in people with multiple chronic conditions: a quantitative benefit-harm assessment by Bruce Leff, Milo A Puhan, Hélène E Aschmann, Cynthia M Boyd, Craig W Robbins, Richard A Mularski, Wiley V Chan, Orla C Sheehan, Renée F Wilson, Wendy L Bennett, Elizabeth A Bayliss, Tsung Yu, Karen Armacost, Carol Glover, Katie Maslow, Suzanne Mintz

    Published 2019-08-01
    “…We aimed to quantitatively determine whether benefits of a lower SBP target justify increased risks of harm in people with MCC, considering patient-valued outcomes and their relative importance.Design Highly stratified quantitative benefit-harm assessment based on various input data identified as the most valid and applicable from a systematic review of evidence and based on weights from a patient preference survey.Setting Outpatient care.Participants Hypertensive patients, grouped by age, gender, prior history of stroke, chronic heart failure, chronic kidney disease and type 2 diabetes mellitus.Interventions SBP target of 120 versus 140 mm Hg for patients without history of stroke.Primary and secondary outcome measures Probability that the benefits of a SBP target of 120 mm Hg outweigh the harms compared with 140 mm Hg over 5 years (primary) with thresholds >0.6 (120 mm Hg better), <0.4 (140 mm Hg better) and 0.4 to 0.6 (unclear), number of prevented clinical events (secondary), calculated with the Gail/National Cancer Institute approach.Results Considering individual patient preferences had a substantial impact on the benefit-harm balance. …”
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    Article
  3. 50663

    Chitosan-grape seed oil nanoemulsion enriched diet promotes performance, antioxidant-immune metrics and modifies immune- gene action and morphological architecture in Nile tilapia... by Shaimaa A.A. Ahmed, Fatma Mahsoub, Samar A. El Gamal, Tarek Khamis, Khaled Yehia Faroh, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Mai F. Saad, Hanaa S. Ali, Simon J. Davies, Adham Al-Sagheer, Walaa El-Houseiny

    Published 2025-04-01
    “…The development of nanoemulsions has garnered interest for their potential applications. Currently, there is no data on the effects of chitosan grape seed oil nanoemulsion (CGON) on Nile tilapia. …”
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    Article
  4. 50664
  5. 50665
  6. 50666

    Ensemble Computational Intelligent for Insomnia Sleep Stage Detection via the Sleep ECG Signal by Pragati Tripathi, M. A. Ansari, Tapan Kumar Gandhi, Rajat Mehrotra, Md Belal Bin Heyat, Faijan Akhtar, Chiagoziem C. Ukwuoma, Abdullah Y. Muaad, Yasser M. Kadah, Mugahed A. Al-Antari, Jian Ping Li

    Published 2022-01-01
    “…The proposed framework includes data collection, investigation of the ECG signals, extraction of the signal HRV, estimation of the PSD, and AI-based classification via hybrid machine learning classifiers. …”
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  7. 50667
  8. 50668
  9. 50669

    Exploring Machine Learning Models for Vault Safety in ICL Implantation: A Comparative Analysis of Regression and Classification Models by Qing Zhang, Qi Li, Zhilong Yu, Ruibo Yang, Emmanuel Eric Pazo, Yue Huang, Hui Liu, Chen Zhang, Salissou Moutari, Shaozhen Zhao

    Published 2025-06-01
    “…Methods This retrospective study analyzed biometric and demographic data, including anterior chamber depth, white-to-white distance, and ICL size, among other variables. …”
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  10. 50670
  11. 50671
  12. 50672

    Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

    Published 2025-01-01
    “…The MOA was explored using L1000, Drug Gene DataBase (DGDB), and Western blotting analyses.ResultsORes significantly reduces breast cancer cell viability and proliferation in a concentration-dependent manner, with IC50 values of 104.8 μM, 150.2 μM, and 143.6 μM in MDA-MB-231, BT-549, and 4T1 cells, respectively. …”
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  13. 50673

    Opportunistic Diagnostics of Dental Implants in Routine Clinical Photon-Counting CT Acquisitions by Maurice Ruetters, Holger Gehrig, Christian Mertens, Sinan Sen, Ti-Sun Kim, Heinz-Peter Schlemmer, Christian H. Ziener, Stefan Schoenberg, Matthias Froelich, Marc Kachelrieß, Stefan Sawall

    Published 2025-06-01
    “…Photon-counting computed tomography (PCCT), a new three-dimensional modality mainly used in general medicine, has shown promising potential for dental applications. With growing digitalization and cross-disciplinary integration, using PCCT data from other medical fields is becoming increasingly relevant. …”
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  14. 50674

    Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

    Published 2025-02-01
    “…A longitudinal, large prospective study is necessary to guide the initiation of dupilumab treatment for childhood EoE, and long-term follow-up data on dupilumab are required. Clinical trial number Not applicable.…”
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  15. 50675

    Clinical review and drug sensitivity test of Corynebacterium kroppenstedtii complex isolates in non-lactating patients with severe mastitis by Zuxin Liang, Zhujun Zeng, Zhujun Zeng, Yanqiang Liao, Yaxin Cao, Dongmei Li, Ningbo Deng, Yeyan Lei, Xuanhui Long, Chenguang Shen, Chenguang Shen, Rui Xu

    Published 2024-12-01
    “…The micro broth dilution method is not applicable for EUCAST drug susceptibility testing for CKC and there is no suitable drug susceptibility evaluation procedure for daptomycin against CKC.…”
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  16. 50676
  17. 50677

    Exploring fecal microbiota signatures associated with immune response and antibiotic impact in NSCLC: insights from metagenomic and machine learning approaches by Wenjie Han, Wenjie Han, Yuhang Zhou, Yuhang Zhou, Yiwen Wang, Yiwen Wang, Xiaolin Liu, Tao Sun, Tao Sun, Junnan Xu, Junnan Xu, Junnan Xu

    Published 2025-07-01
    “…BackgroundSubstantial interstudy heterogeneity in cancer immunotherapy-associated biomarkers has hindered their clinical applicability. To address this challenge, we performed a comprehensive integration of publicly available global metagenomic datasets. …”
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  18. 50678
  19. 50679

    Standardization of epistemic trust/mistrust/credulity questionnaire: Examining validity and reliability among adolescents Standardization of ETMCQ among adolescents by Raziyeh Hashemi, Mehdi Reza Sarafraz, Habib Hadian Fard, Mohammad Reza Taghavi

    Published 2024-08-01
    “…No significant qualitative differences were observed between the two English versions. Data were then collected through the Porsall platform (https://panel.porsall.com/Research/MyResearches). …”
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  20. 50680

    Early prediction of sepsis associated encephalopathy in elderly ICU patients using machine learning models: a retrospective study based on the MIMIC-IV database by Yupeng Han, Xiyuan Xie, Jiapeng Qiu, Yijie Tang, Zhiwei Song, Wangyu Li, Xiaodan Wu, Xiaodan Wu

    Published 2025-04-01
    “…This study aimed to develop a predictive model for SAE in elderly ICU patients.MethodsThe data of elderly sepsis patients were extracted from the MIMIC IV database (version 3.1) and divided into training and test sets in a 7:3 ratio. …”
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