Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design by Hiroshi Matsumoto, Akihiro Nomura, Hayato Tada, Hirofumi Okada, Atsushi Nohara, Masa-aki Kawashiri, Koji Maeno, Manabu Fujimoto, Shohei Yoshida, Masaya Shimojima, Toyonobu Tsuda, Mika Mori, Shin-ichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Kenshi Hayashi, Noboru Fujino, Akihiro Inazu, Shizuko Takahara, Yasuhito Imai, Takao Matsubara, Kenji Miwa, Masanobu Namura, Hidenobu Terai, Taiji Yoshida, Tsutomu Araki, Masahiro Minamoto, Toru Aburao, Yuji Ito, Chiaki Nakanishi, Suguru Kawasaki, Yasuhiro Todo, Junji Koizumi, Yoshihito Kita, Hiroaki Shintaku, Akihiko Hodatsu, Hidekazu Ino, Toshinori Higashikata, Mutsuko Takata, Katsushi Misawa, Masato Yamaguchi, Yoshihiro Noji, Kazuo Osato, Tomohito Mabuchi, Taro Ichise, Bunji Kaku, Shoji Katsuda, Katsuharu Uchiyama, Kensuke Fujioka, Takuya Nakahashi, Tsuyoshi Nozue, Ichiro Michishita, Kazuo Usuda, Kanichi Otowa, Kazuyasu Okeie, Satoshi Hirota, Isao Aburadani, Keisuke Kurokawa, Osamu Takatori, Shunichiro Hondo, Hiroyuki Oda, Shigeo Takata, Hisayoshi Murai, Masaki Kinoshita, Hideo Nagai, Yoshiteru Sekiguchi, Satoru Sakagami, Wataru Omi, Chikara Fujita, Tatsuo Katsuki, Hiroshi Ootsuji, Atsushi Igarashi, Manabu Nakano, Seiichiro Okura, Yasuhito Mitamura, Naoki Sugimoto, Masakazu Yamamoto, Hironobu Akao, Kouji Kajinami, Masayuki Takamura

“…On the other hand, few data—and in particular multicentre data—exist regarding this issue among Japanese subjects. …”
Get full text

Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2 by Fan Sun, Pengrong Yan, Yadong Xiao, Hongqiao Zhang, Steven D Shapiro, Gutian Xiao, Zhaoxia Qu

“…In this study, human clinical samples and data were used to investigate PDLIM2 genetic and epigenetic changes in lung cancer. …”
Get full text

Chemotherapeutic efficacy of curcumin against plasma and cardio-hepatorenal electrolyte disruption in dichlorvos-challenged rats via augmentation of Na⁺/K⁺-ATPase and Ca²⁺/Mg²⁺-ATP... by Adio J. Akamo, Boluwatife A. Olagunju, Iyabode A. Kehinde, Naomi M. Akamo, Adetutu O. Ojelabi, Ofem E. Eteng, Ibiyemi O. Opowoye, Adedayo A. Adebisi, Taiwo S. Oguntona, Mushafau A. Akinsanya, Tobi S. Adekunbi, Olufemi M. Ajagun-Ogunleye, Opeyemi E. Popoola, Jacob K. Akintunde, Oluseyi A. Akinloye

“…Background: Dichlorvos (2,2-dichlorovinyl dimethyl phosphate or DDVP) is an effective organophosphate pesticide extensively employed in various pest management applications. However, it elicits cytotoxicity. Curcumin is a well-known antioxidant phytochemical, but publications lack data on its influence on DDVP-occasioned electrolyte disruption in animals. …”
Get full text

Epigenetic Alterations in Ovarian Function and Their Impact on Assisted Reproductive Technologies: A Systematic Review by Charalampos Voros, Antonia Varthaliti, Despoina Mavrogianni, Diamantis Athanasiou, Antonia Athanasiou, Aikaterini Athanasiou, Anthi-Maria Papahliou, Constantinos G. Zografos, Vasileios Topalis, Panagiota Kondili, Menelaos Darlas, Sophia Sina, Maria Anastasia Daskalaki, Marianna Theodora, Panos Antsaklis, Georgios Daskalakis

“…The study followed the PRISMA recommendations to guarantee scientific rigor and repeatability. The data were combined into a thorough study of epigenetic markers linked to ovarian aging, ovarian reserve, and implantation success. …”
Get full text

A global review of acupuncture and moxibustion recommendations in guidelines/expert consensus for chemotherapy- and/or radiotherapy-induced nausea and/or vomiting by Tian-yu MING, Wei-juan GANG, Lan-jun SHI, Zhen LUO, Zi-yu TIAN, Xiao-yi HU, Huan CHEN, Rui-min JIAO, Wen-cui XIU, Xiang-yu HU, Xiang-hong JING

“…Two researchers independently screened the literature, extracted data, and used the Scientific, Transparent, and Applicable Rankings (STAR) tool to evaluate the quality of guidelines/expert consensus that contained acupuncture and moxibustion recommendations, and analyzed acupuncture and moxibustion recommendations in guidelines/expert consensus and their evidence base. …”
Get full text

What is the prevalence of COVID-19 detection by PCR among deceased individuals in Lusaka, Zambia? A postmortem surveillance study by Lawrence Mwananyanda, William B MacLeod, Donald M Thea, Rachel C Pieciak, Christopher J Gill, Geoffrey Kwenda, Zachariah Mupila, Rotem Lapidot, Leah Forman, Lauren Etter, Ruth Nakazwe, Daniel Bridges, Chilufya Chikoti, Sarah Chirwa, Charles Chimoga, Ben Katowa, James Lungu, Japhet Matoba, Gift Mwinga, Benjamin Mubemba, Walter Muleya, Mulenga Mwenda, Benard Ngoma, Diana Nzara, Natalie Pawlak, Lillian Pemba, Ngonda Saasa, Edgar Simulundu, Baron Yankonde

Get full text

Comprehensive analysis of stroke epidemiology in Vietnam: Insights from GBD 1990–2019 and RES-Q 2017–2023 by Minh Cong Tran, Lara Prisco, Phuong Minh Pham, Huy Quoc Phan, Mario Ganau, Nhat Pham, Linh Huyen Truong, Proochista Ariana, Phuong Viet Dao, Dung Tien Nguyen, Chi Van Nguyen, Hoa Thi Truong, Thang Huy Nguyen, Jeyaraj Pandian, Ton Duy Mai, Andrew Farmery

“…Method: We analyzed the data published in the Global Burden of Disease (GBD) 2019, in combination with the first-time analysis of the Registry of Stroke Care Quality Improvement (RES-Q) initiative in Vietnam from 2017 to 2023. …”
Get full text

Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexusResearch in context by Xiaonan Guo, Yu Feng, Xiaolong Ji, Ningning Jia, Aierpati Maimaiti, Jianbo Lai, Zheng Wang, Sheng Yang, Shaohua Hu

“…Methods: This study leveraged large-scale cohort data and genome-wide association study (GWAS) summary statistics, covering 8 common psychiatric disorders and 43 metabolic traits. …”
Get full text

Safety and cost analysis of selective histopathological examination following appendicectomy and cholecystectomy (FANCY study): protocol and statistical analysis plan of a prospect... by Willem A Bemelman, Pieter J Tanis, Lianne Koens, Vivian P Bastiaenen, Bartholomeus JGA Corten, Elise AJ de Savornin Lohman, Joske de Jonge, Anne C Kraima, Hilko A Swank, Jaap LP van Vliet, Gijs JD van Acker, Anna AW van Geloven, Klaas H in 't Hof, Philip R de Reuver, Charles C van Rossem, Gerrit D Slooter, Valeska Terpstra, Marcel GW Dijkgraaf

Get full text

Maternal plasma extracellular vesicles tsRNA as potential biomarkers for assessing preterm labor risk by Xinrui Sun, Ying Feng, Liang Xie, Yilun Wu, Jia Mao, Yi Zhang, Linyu Zhang, Xin Yuan, Jiangping Ni, Xue Xiao, Hanmin Liu, Li Dai, Fang Ma

“…Clinical trial number Not applicable.…”
Get full text

Evidence of Minijet Emission in a Large Emission Zone from a Magnetically Dominated Gamma-Ray Burst Jet by S.-X. Yi, C.-W. Wang, X. Shao, R. Moradi, H. Gao, B. Zhang, S.-L. Xiong, S.-N. Zhang, W.-J. Tan, J.-C. Liu, W.-C. Xue, Y.-Q. Zhang, C. Zheng, Y. Wang, P. Zhang, Z.-H. An, C. Cai, P.-Y. Feng, K. Gong, D.-Y. Guo, Y. Huang, B. Li, X.-B. Li, X.-Q. Li, X.-J. Liu, Y.-Q. Liu, X. Ma, W.-X. Peng, R. Qiao, L.-M. Song, J. Wang, P. Wang, Y. Wang, X.-Y. Wen, S. Xiao, Y.-B. Xu, S. Yang, Q.-B. Yi, D.-L. Zhang, F. Zhang, H.-M. Zhang, J.-P. Zhang, Z. Zhang, X.-Y. Zhao, Y. Zhao, S.-J. Zheng

Get full text

Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation by Keith Ly, Michael L. Italiano, Mohit N. Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H. Lovell, Socrates Dokos, Tianruo Guo

“…The model is constructed using electrophysiology, immunohistology, and optical coherence tomography imaging data from healthy and degenerate human retinas. We validated our model by replicating numerous experimental observations from human and primate retina, with a particular focus on retinal degeneration. …”
Get full text

Bicontinuous Nanophasic Conetworks of Polystyrene with Poly(dimethylsiloxane) and Divinylbenzene: From Macrocrosslinked to Hypercrosslinked Double-Hydrophobic Conetworks and Their... by Anna Petróczy, István Szanka, András Wacha, Zoltán Varga, Yi Thomann, Ralf Thomann, Rolf Mülhaupt, Laura Bereczki, Nóra Hegyesi, Béla Iván

“…The Korsmeyer–Peppas type evaluation of the swelling data indicates hindered Fickian diffusion of both solvents in the conetwork organogels. …”
Get full text

Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…., a medicinally significant orchid used for millennia in China, is systematically reviewed regarding its botany, resources, ethnomedicinal applications, phytochemistry, pharmacology, and propagation strategies to advance therapeutic utilization and conservation.MethodsUsing keywords such as “G. conopsea,” “phytochemistry,” “propagation and breeding,” “bioactive compounds,” “immunomodulatory effects,” and “neuroprotective potential,” we systematically searched literature related to G. conopsea plants from databases including Web of Science, SciFinder, PubMed, ACS Publications, CNKI, Wanfang Data, Google Scholar, and Baidu Scholar.ResultsA total of 1,074 papers were retrieved and 133 full-text articles were ultimately selected and comprehensively reviewed. …”
Get full text

Perceptions of COVID-19 among communities of Conakry (Guinea): a qualitative study exploring the context of the ANRS COV33 Coverage-Africa therapeutic trial by Joanna Orne-Gliemann, Alexandre Delamou, Mélanie Plazy, Denis Malvy, Marie-Hélène Doucet, Christine Timbo Songbono, Caroline Martin, Camille Fritzell, Mamadou Saliou Sow, Fodé Amara Traoré, Marie Jaspard, Armel Poda, Olivier Marcy

“…Objectives To explore communities’ perceptions about COVID-19 in the context of the ANRS COV33 Coverage-Africa clinical trial evaluating the efficacy of treatments in preventing clinical worsening of COVID-19.Design Descriptive qualitative study using semistructured in-depth individual interviews conducted by telephone in French and Soussou between May and September 2021. Data were transcribed, translated in French when applicable and analysed with the thematic analysis method.Setting The eight neighbourhoods most affected by COVID-19 in Conakry’s urban context, capital of Guinea.Participants 4 community leaders acting as key informants—providing insights regarding population’s opinions—and six community members, who were exposed to an information session conducted as part of Coverage-Africa.Results According to participants, community members have heterogeneous viewpoints about COVID-19: it exists and is dangerous; it is benign (‘bad cold’); or it is fictitious (eg, government conspiracy). …”
Get full text

Hyperkalaemia prevalence, recurrence and treatment in patients on haemodialysis in China: protocol for a prospective multicentre cohort study (PRECEDE-K) by Li Yao, Qing Zhao, Zhaohui Ni, Hui Peng, LI Zuo, Qun Luo, Jie Xiao, Renhua Lu, Haijiao Jin, Weimin Yu, Yuqing Ren, Qiongqiong Yang, Qinghong Zhang, Lihong Zhang, Xinzhou Zhang, Qinkai Chen, Chaosheng Chen, Guojian Shao, Shuguang Qin

“…Written informed consent will be obtained from all participants before collection of any patient data and patient information. The findings of this study will be disseminated through peer-reviewed publications and conference presentations.Trial registration number ClinicalTrials.gov Registry (NCT04799067).…”
Get full text

Conceptual frameworks, competencies, contents and teaching methods in planetary health education for health students and professionals: a global systematic scoping review by Carme Carrion, Camilla Alay Llamas, Eka Dian Safitri, Carola Domènech-Panicello, George S. Downward, Ardi Findyartini, Nadia Greviana, Indah Kartika Murni, Sie Meng Lee, Mireia Llimós, Ariadna Moreno, Shannon Leigh O’Brien, Isabel Ruiz-Mallén, Diantha Soemantri, Indah Suci Widyahening, Respati Wulansari Ranakusuma, Dewi Yunia Fitriani, Cristina O’Callaghan-Gordo

“…Clinical trial number: not applicable.…”
Get full text

A standardized MRI phantom for dissolved phase 129Xe MRI by Max Filkins, Arthur Harrison, Guilhem J. Collier, Graham Norquay, Jim M. Wild, Sean P. Rigby, Galina E. Pavlovskaya, Thomas Meersmann

“…The uptake kinetics into the non-toxic materials was sufficiently similar to pulmonary signal uptake to enable hp129Xe MRI with dissolved phase ratios that closely resembled clinical data.A phantom assembly was devised to allow for gas handling protocols that matched clinical protocols. …”
Get full text

Combining UAV Remote Sensing with Ensemble Learning to Monitor Leaf Nitrogen Content in Custard Apple (<i>Annona squamosa</i> L.) by Xiangtai Jiang, Lutao Gao, Xingang Xu, Wenbiao Wu, Guijun Yang, Yang Meng, Haikuan Feng, Yafeng Li, Hanyu Xue, Tianen Chen

Get full text

Serological Vulnerability and Active Infection Detection Among Recently Arrived Migrants in Spain: Results from a Targeted Screening Program by Guillermo Lens-Perol, Olalla Vázquez-Cancela, Magdalena Santana-Armas, Angeles Bouzas-Rodriguez, Victoria Tuñez-Bastida, Adrián Domínguez-Lago, Hugo Pérez-Freixo, Cristina Peiteado-Romay, Juan Manuel Vázquez-Lago, Cristina Fernández-Pérez

“…Sociodemographic and clinical data were collected, and individuals were offered vaccination according to an accelerated immunization schedule. …”
Get full text