Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide by Zsombor I. Hegedűs, Márk E. Jakab, Tamás G. Gergely, Nabil V. Sayour, Andrea Kovács, Sára Antal, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga, Viktória E. Tóth

“…Animals were treated with vehicle (Veh), Lira (300 µg/day i.p.) or TZP (48 µg/day s.c.) for 14 days in the following groups: Sham/Veh (n = 7), AngII/Veh (n = 15), Sham/Lira (n = 7), AngII/Lira (n = 15), Sham/TZP (n = 8), AngII/TZP (n = 15). Cardiac structural, functional and molecular characteristics were assessed by echocardiography, ECG, immunohistochemistry, flow cytometry and qRT-PCR. …”
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Facilitators, barriers, and strategies for the implementation of peer-led tuberculosis active case finding among people who use drugs in Dar es Salaam, Tanzania. by Lilian Tina Minja, Liana Monica Minja, Kilian Mlalama, Doreen Pamba, Jerry Hella, Samwel Likindikoki, Cassian Nyandindi, Jessie Mbwambo, Klaus Reither, Jennifer M Belus

“…Despite the high incidence and prevalence of TB among people who use drugs (PWUD), there is a significant gap in data, on their perspectives, regarding the implementation of TB ACF services. …”
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Prescription of guideline‐directed medical therapy in heart failure: impact on mortality and readmission by Martin Möckel, Samipa Pudasaini, Kristina Feldmann, Henning Thomas Baberg, Benny Levenson, Jürgen Malzahn, Thomas Mansky, Guido Michels, Christian Günster, Elke Jeschke

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Evaluating the performance of ChatGPT in patient consultation and image-based preliminary diagnosis in thyroid eye disease by Yue Wang, Shuo Yang, Chengcheng Zeng, Yingwei Xie, Ya Shen, Jian Li, Xiao Huang, Ruili Wei, Yuqing Chen

“…The preliminary diagnosis of TED was deemed accurate, and the differences in the accuracy rates were further calculated.ResultsFor common TED consultation questions, ChatGPT-4o delivered more accurate information with logical consistency, adhering to a structured format of disease definition, detailed sections, and summarized conclusions. …”
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The impact of referral workload on cardiology registrars in a high-volume district general hospital: implications for workforce well-being and service efficiency by Md Imran Hossain, Jaymin Shantilal Shah

“…A structured survey was distributed to 12 cardiology registrars, achieving a 92% response rate, assessing workload perception, stress, exhaustion, bleep volume impact, consultant support and training limitations. …”
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Efficacy of a Digital Educational Intervention for Patients With Type 2 Diabetes Mellitus: Multicenter, Randomized, Prospective, 6-Month Follow-Up Study by Irene Caballero Mateos, Cristóbal Morales Portillo, María Lainez López, Ángel Vilches-Arenas

“…The intervention group received education through social networks and digital tools in a structured program of healthy lifestyle changes. This was provided by a “Digital Coach” for weekly and on-demand advice and individualized support. …”
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Menopausia y estereotipos de género: importancia del abordaje desde la educación para la salud [Menopause and gender stereotypes: the importance of the health education approach] by Alicia Botello Hermosa, Rosa Casado Mejía

“…The research was held in Seville (Spain), with 43 women of both rural and urban areas, from different age groups, namely, the young ones (18-25 years, 26-35 years), the middle aged (36-45 years, 46-55 years, 56-65 years), and the elderly (> 65 years). Data collection took place from March, 2008 to December, 2011, and made use of techniques such as semi-structured interviews and 3 focus groups. …”
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Examining the relationship between oral health indicators, obesity, and Xerostomia in older adults by Raziyehsadat Rezvaninejad, Mahdie Zeinali, Amirreza Fatemi, Maryam Alsadat Hashemipour

“…Methods This cross-sectional study involved 439 adults aged 50 years or older. Data were collected using a structured questionnaire consisting of five sections: (I) demographic information, (II) oral health (issues such as loose teeth, tooth loss, use of dentures/implants, bleeding gums - self based on reported questionnaires and dental examination), (III) general health, (IV) overweight and/or obesity ( based on BMI- Height and weight measurement by a final year dental student), and (V) xerostomia (self-reported questionnaires). …”
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<i>PRKAG2</i> Syndrome: Clinical Features, Imaging Findings and Cardiac Events by Maria Sudomir, Przemysław Chmielewski, Grażyna Truszkowska, Mariusz Kłopotowski, Mateusz Śpiewak, Marta Legatowicz-Koprowska, Monika Gawor-Prokopczyk, Justyna Szczygieł, Joanna Zakrzewska-Koperska, Mariusz Kruk, Jolanta Krzysztoń-Russjan, Jacek Grzybowski, Rafał Płoski, Zofia T. Bilińska

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We know less about phosphorus retention in constructed wetlands than we think we do: A quantitative literature synthesis by Kenneth J. Anderson, Bishwodeep Adhikari, Olivia F. Schloegel, Raissa Marques Mendonca, Michael P. Back, Nicholas Brocato, Jacob A. Cianci-Gaskill, Steven E. McMurray, Christie Bahlai, David M. Costello, Lauren Kinsman-Costello

“…We found that, while differences among broad wetland structural groupings exist, measured rates of phosphorus retention are highly variable. …”
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Business model development for installation of rubber floor mats to support productivity in dairy farming by Suteera Chanthes, Weerasak Sawangloke, Rujira Luangsakdapich, Adisak Pattiya, Yottha Srithep

“…It also used semi-structured interviews to scrutinise the subjective experiences of farmers. …”
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Flares on TRAPPIST-1 Reveal the Spectrum of Magnetic Features on Its Surface by Valeriy Vasilyev, Nadiia Kostogryz, Alexander I. Shapiro, Astrid M. Veronig, Benjamin V. Rackham, Christoph Schirninger, Julien de Wit, Ward Howard, Jeff Valenti, Adina D. Feinstein, Olivia Lim, Sara Seager, Laurent Gizon, Sami K. Solanki

“…Our analysis rules out lingering flare decay as the cause of the flux enhancement and thus, points to structural changes on the stellar surface induced by flares. …”
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International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Through initiatives led by the Quality Control and Accreditation Committee, educational programs, and multidisciplinary stakeholder workshops, ISLB provides a structured framework to promote standardization and foster innovation. …”
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Can social adversity and mental, physical and oral multimorbidity form a syndemic? A concept and protocol paper by Easter Joury, Easter Joury, Eliana Nakhleh, Ed Beveridge, Derek Tracy, Derek Tracy, Derek Tracy, Derek Tracy, Ellie Heidari, Ellie Heidari, David Shiers, David Shiers, David Shiers, Silke Vereeken, Emily Peckham, Simon Gilbody, Simon Gilbody, Jayati Das-Munshi, Farida Fortune, Farida Fortune, Vishal R. Aggarwal, Masuma Mishu, Masuma Mishu, Joseph Firth, Joseph Firth, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui, Kamaldeep Bhui

“…Structural equation modelling (SEM) will be utilised to conceptualise syndemic factors and model complex relationships between directly observed and indirectly observed (latent) variables (syndemic constructs).Discussionthe syndemic conceptualisation provides a valuable framework to understand health and illness, and hence to better design and deliver effective and cost-effective preventative and curative integrated (syndemic) care to improve patient and population health. …”
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Pre-Implementation Assessment of a Sexual Health eClinic in Canadian Oncology Care by Taylor Incze, Dalia Peres, Steven Guirguis, Sarah E. Neil-Sztramko, Jackie Bender, Dean Elterman, Shabbir M. H. Alibhai, Antonio Finelli, Phil Vu Bach, Emily Belita, Gerald Brock, Julia Brown, Jeffrey Campbell, Trustin Domes, Andrew Feifer, Ryan Flannigan, Celestia Higano, Jesse Ory, Premal Patel, Monita Sundar, Luke Witherspoon, Andrew Matthew

“…Data were analyzed using a hybrid deductive–inductive thematic approach guided by the Consolidated Framework for Implementation Research (CFIR) 2.0. …”
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Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice by Tao Lu, Huan Liu, Xiaoqing Yuan, Desheng Li, Guanqing Zhang, Yue Wang, Qiqiang Xie, Xinhao Wang, Jingjian Chi, Zhenzhen Wang, Shaoping Wang, Yanling Gao, Ling Zhou, Maolei Xu

“…The results confirmed, for the first time, that PET MPs can induce oxidative stress, lipid accumulation, and apoptosis in liver cells, resulting in structural damage and functional abnormalities in the liver. …”
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Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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Farmers’ Perception of Ecosystem Services Provided by Historical Rubber Plantations in Sankuru Province, DR Congo by Joël Mobunda Tiko, Serge Shakanye Ndjadi, Jémima Lydie OBANDZA - AYESSA, Daniel Botshumo Banga, Julien Bwazani Balandi, Charles Mumbere Musavandalo, Jean Pierre Mate Mweru, Baudouin Michel, Olivia Lovanirina Rakotondrasoa, Jean Pierre Meniko To Hulu

“…This study used a mixed methodological approach, integrating semi-structured interviews, focus groups, and statistical analyses including chi-square testing and multiple correspondence factorial analysis (MCAFA) to obtain and analyze the data comprehensively. …”
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‘I Don't Think There Is a One‐Size‐Fits‐All’: A Qualitative Study Exploring Healthcare Professional and Service Provider Perspectives of Using Innovative Models of Cervical Screeni... by Claire Bavor, Tessa Saunders, Mikayla Wolfe, Megan A. Smith, Nicola Creagh, Deborah Bateson, Angela Kelly‐Hanku, Paula Jops, Marion Saville, Natalie Taylor, Kate Broun, Julia M. L. Brotherton, Claire Nightingale

“…Data were analyzed using template analysis, a form of thematic analysis. …”
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HSPA2 influences the differentiation and production of immunomodulatory mediators in human immortalized epidermal keratinocyte lines by Agnieszka Gogler, Agata Małgorzata Wilk, Damian Robert Sojka, Małgorzata Adamiec-Organiściok, Natalia Matysiak, Daria Kania, Klaudia Wiecha, Ewa Małusecka, Alexander Jorge Cortez, Dawid Zamojski, Michał Marczyk, Agnieszka Maria Mazurek, Sylwia Oziębło, Dorota Scieglinska

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