Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors by Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel

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Temperature and excipient mediated modulation of monoclonal antibody interactions revealed by kD, rheology, and Raman spectroscopy by Olivia Noelle Eskens, Sabitoj Singh Virk, Akashdeep Singh Virk, Deepika Venkataramani, Maureen Crames, Maria Calderon Vaca, Matthew Matusewicz, Connor Smith, Joshin George, Collin Taylor, Michael S. Marlow, Samiul Amin

“…Raman spectral analysis of Amide I/III regions confirmed structural invariance under thermal and shear stress, attributing viscosity modulation to colloidal rather than conformational perturbations. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Despite studies conducted, there are no unambiguous data showing how IMQ affects the condition of tumor blood vessels. …”
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Evaluating acceptability and experiences of pregnant women at high risk of developing gestational diabetes who take part in antenatal intervention trials: a qualitative systematic... by Gözde Sultan Çakır, Manar Abduljalil Bakhsh, Ola F. Quotah, Olivia Righton, Catherine V. George, Lucilla Poston, Sara L. White, Angela C. Flynn, Zoë Bell

“…All were pilot RCTs using semi-structured interviews in high-income countries (UK n = 3, USA n = 1). …”
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EXPERIMENTAL EVALUATION OF LONG-TERM ADVERSE SIDE EFFECTS OF CYTOSTATIC DRUGS ON FEMALE REPRODUCTIVE FUNCTION AND PHARMACOLOGICAL WAYS TO REDUCE THEM by T. G. Borovskaya, V. E. Goldberg, M. E. Poluektova, A. V. Vychuzhanina, Yu. A. Shchemerovа, V. A. Grigoreva, A. A. Ligacheva, E. A. Bokhan

“…Statistical processing of obtained experimental data was performed using Mann-Whitney U-test and Fisher angular transformation.Results. …”
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Development of the 10-question household foodwork interactional assessment questionnaire (FIA-Q10) by Leah E. Cahill, Sharon I. Kirkpatrick, Catherine L. Mah, Jennifer LP. Protudjer, Cynthia Kendell, Mary E. Jung, Helen Wong, Ellen T. Crumley, Meghan Day, Karen T. Y. Tang, Yan Huang, Jyoti Sihag, Laura Brady, Karthik K Tennankore, Navdeep Tangri, Rebecca C. Mollard, Dylan MacKay

“…An optional accompanying module was developed to collect self-identified demographic data to provide context for understanding how social-structural positionality factors may interact to influence foodwork. …”
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Preliminary observations of glucose metabolism dysregulation in pediatric Huntington’s disease by Federica Graziola, Federica Rachele Danti, Martina Penzo, Antonio Spagarino, Eleonora Minacapilli, Marco Moscatelli, Federica Zibordi, Caterina Mariotti, Giovanna Zorzi, Giovanna Zorzi

“…Clinical, neuroimaging, and neuropsychological data were collected alongside metabolic assessments, including cerebrospinal fluid (CSF) and plasma glucose and lactate levels, CSF-to-serum glucose ratio, and red blood cell GLUT1 expression using the METAglut1 test. 18F-FDG PET imaging and brain MRI were performed to assess cerebral metabolism and structural changes.ResultsBoth patients exhibited progressive motor and cognitive decline with dystonia-parkinsonian features, learning disabilities, and behavioral disturbances. …”
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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark

“…Furthermore, binding of one mAb, DCR‐2, to CD300f exposes a structural epitope recognized by a second CD300f mAb, UP‐D2. …”
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Genome-wide identification of the AcBAM family in kiwifruit (Actinidia chinensis cv. Hongyang) and the expression profiling analysis of AcBAMs reveal their role in starch metabolis... by Xuchen Gong, Mengfei Lin, Jie Song, Jipeng Mao, Dongliang Yao, Zhu Gao, Xiaoling Wang

“…., Glu186 and Glu380) and exhibited similar structural properties. Phylogenetic and collinearity analyses grouped the genes into three main clusters, with segmental and tandem duplications contributing to their expansion. …”
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Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain by Philip J. Peyton, Sabine Braat, Anurika De Silva, David Story, Lisbeth Evered, Paul S. Myles, Matthew Chan, Stephan Schug, Malcolm Hogg, Alex Holmes, Sofia Sidiropoulos, Kate Leslie

“…Incidence of pain in the area of the index surgery is measured by structured telephone interview at 3 months (primary trial endpoint) and 12 months. …”
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The Relationship between Personality Disorders and Parent\'s Social Capital with the Social Health of Children and Adolescents in Yazd by Nastaran Ahmadi, Parvane Rashidpour, Mohammadreza Mohammadi, Mohammadhadi Farahzadi, Javad Ardeshirpay, Hosein Abouzari, Malihe Mobini, Masoud Mirzaei, Amirhoushang Mehrparvar, Fatemeh Rismanian Yazdi

“…Millon's test of fathers demonstrates a significant correlation with the average scores of structural social capital, cognitive social capital, communicative social capital, and total social capital (P-value < 0.001). …”
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Navigating the decision landscape: understanding interstitial cystitis/bladder pain syndrome patients’ motivations and medical support needs for fecal microbiota transplantation: a... by Hongyuan Liu, Yaodi Wei, Peng Jiang, Siyu Fan, Yu Zhao, Zhi Li, Shiyu Wang, Na Zhang, Junjie Zhi, Qun Wei, Yifeng Gu, Bihong Yang, Ninghan Feng, Yufan Wu, Fengping Liu

“…Data analysis was conducted using a thematic approach. …”
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Eco-anxiety, climate concern, and fatalistic outlooks: Insights from U.S. crisis text conversations on climate distress by Jennifer D. Runkle, Kelsey Herbst, Sophie Ryan, Kelly Sewell, Ashley Mallare, Ian Berry, Emma Getz, Arden McKee, Martie P. Thompson, Margaret M. Sugg

“…Methods: We analyzed anonymized text data from Crisis Text Line (CTL), a free, U.S.-based digital crisis platform with over nine million conversations since 2017, focusing on a sample of texts mentioning ''climate change.” …”
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Promoting active behaviours in schoolchildren using the socio-ecological model in the physical education class: study protocol of the ACTIBESE project by Fernando Rodríguez-Rodríguez, Carlos Cristi-Montero, Natalia Zurita-Corvalán, Caroline Brand, Jorge Mota, Palma Chillón, Anelise Reis Gaya, Javier Brazo-Sayavera, Nicolás Aguilar-Farias

“…The research will use mixed models, ANCOVA, and logistic regressions for data analysis, network analysis, exploratory factors analysis, and structural equation modelling. …”
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The role of neotectonics and climate variability in the Pleistocene-to-Holocene hydrological evolution of the Fuente de Piedra playa lake (southern Iberian Peninsula) by A. Jiménez-Bonilla, L. Martegani, L. Martegani, M. Rodríguez-Rodríguez, F. Gázquez, F. Gázquez, M. Díaz-Azpíroz, S. Martos, K. Reicherter, I. Expósito

“…We conducted an interdisciplinary study combining structural, geomorphic, sedimentological, mineralogical and hydrological analyses to better understand the evolution of the Fuente de Piedra (FdP) playa lake in southern Spain. …”
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Farmers’ knowledge, perceptions, and practices on animal trypanosomosis and the tsetse fly vector: A cross-sectional study around Kenya’s Arabuko-Sokoke Forest Reserve at the lives... by Joel L Bargul, Erick K Serem, Osman A Abdullahi, Moses M Ngari, David M Mburu

“…Methods: A cross-sectional study was conducted during November and December 2017 to collect data from 404 randomly selected cattle-rearing households using a structured questionnaire. …”
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Co-designing a peer support programme for carers of people treated under the Mental Health Act: views from stakeholders by Imogen Wells, Kelly Wintsch, Abigail G-Medhin, Brynmor Lloyd-Evans, Steve Gillard, Rose McCabe, Mohamed Yaasir Mohamudbucus, Candelaria Mahlke, Katharina Nagel, Zhenreenah Muhxinga, Swaran Singh, Stefan Priebe, Domenico Giacco

“…Conclusions These findings highlight the need for structured training for peer supporters and a flexible, accessible peer support programme for carers. …”
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Care coordinator delivered Method of Levels therapy for people reporting first-episode psychosis: Experiences and views of service user, care coordinator, and team manager particip... by Robert Griffiths, Sara Tai, Susan Ormrod, Natalie Welsh, Adam Jones, Jasper Palmier-Claus, James Dixon, Alison Dawber, Karina Lovell

“…Interviews and focus groups were transcribed and reflexive thematic analysis was used to analyse the data. Results Three themes were identified: ‘Digging deeper to find my own solutions’; (2) ‘Prepared for practice?’…”
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Assessing the foreign economic security of Ukraine by Yuliia Yehorova, Svitlana Chorna, Yuriy Petrushenko, Fedir Zhuravka, Khrystyna Potapenko, Iryna D’yakonova, Oksana Zamora

“…At the same time, the growth of foreign economic security is recorded in the period of stabilization during the implementation of structural reforms: 2005–2008 – the period after the Orange Revolution, 2014–2016 – the period of growth after the Revolution of Dignity, 2021 – post-pandemic recovery. …”
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Bioactive Chalcones from <i>Aizoon africanum</i>: Isolation and Cytotoxicity Against Liver and Neural Cancer Cells by Ali O. E. Eltahir, Naeem Sheik Abdul, Taskeen F. Docrat, Paolo Bristow, Elias Chipofya, Robert C. Luckay, Monde A. Nyila, Jeanine L. Marnewick, Kadidiatou O. Ndjoubi, Ahmed A. Hussein

“…The methanolic extract of <i>A. africanum</i> was re-investigated and subjected to various chromatographic techniques, including preparative HPLC, resulting in the isolation of eight compounds (<b>1</b>–<b>8</b>). Structural elucidation was primarily based on NMR data. …”
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