TERT c.3150 G > C (p.K1050N): a founder Ashkenazi Jewish variant associated with telomere biology disorders by Kelvin César de Andrade, Emilia M. Pinto, Tianna Zhao, Logan P. Zeigler, Jung Kim, Neelam Giri, Jeremy S. Haley, Lisa J. McReynolds, Oscar Florez-Vargas, Aaron H. Phillips, Richard W. Kriwacki, Sherifa A. Akinniyi, Scott B. Cohen, Matthew R. Emerson, Diane T. Smelser, Gretchen M. Urban, Cintia Fridman, Gerard P. Zambetti, Tracy M. Bryan, David J. Carey, Christine Kim Garcia, Douglas R. Stewart, Sharon A. Savage

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Co-developing a health promotion programme for indigenous youths in Brazil: A concept mapping report. by Paulo T C Jardim, Josiliane M Dias, Antonio J Grande, André B Veras, Érika K Ferri, Fatima A A Quadros, Clayton Peixoto, Francielle C S Botelho, Maria I M G Oliveira, Ieda M A V Dias, Majella O'Keeffe, Christelle Elia, Paola Dazzan, Ingrid Wolfe, Seeromanie Harding

“…The little routinely collected population-level data from Indigenous communities in the region available shows stark inequities in health and well-being. …”
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Telehealth services for acute diseases management: principles, trends and challenges in selected health facilities in the greater Accra region, Ghana by Jonathan Kissi, Godwin Adzakpah, Caleb Annobil, Nathan Kamasenu Mensah, Daniel Kwame Kwansah Quansah, Kennedy Dzamvivie, Vivian Kruh, Grace Amoah-Anomah, Abdul-Basit Kassim

“…A total of 439 participants, representing approximately 70% of the eligible population (n = 628), who actively use electronic health records systems, were recruited. Data were analysed using Structural Equation Modelling (SEM) with STATA Version 15 and SPSS Version 23. …”
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Level of matrix metalloproteinase-9 and myocardium remodeling in patients with acute postinfarction aneurism of left ventricle by V. D. Syvolap, S. M. Kyselov

“…Level of matrix metalloproteinase-9, structural and functional indexes of myocardium remodeling were studied in patients with acute postinfarction aneurism of left ventricle. …”
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Utilization and dose optimization of beta-blockers in chronic heart failure therapy: a mixed-methods study by Sisay Sitotaw Anberbr, Tilaye Arega Moges, Abebech Tewabe Gelaye, Aragaw Dagnew Lakew, Samuel Berihun Dagnew, Gebremariam Wulie Geremew, Getachew Yitayew Tarekegn, Fisseha Nigussie Dagnew

“…A total sample size of 420 patients was determined using a systematic random sampling technique. Data were collected through structured questionnaires capturing socio-demographic details, clinical characteristics, and medication usage. …”
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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

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SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors by Naveen Thakur, Poushali Chakraborty, JoAnn M. Tufariello, Christopher F. Basler

“…ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 14 (Nsp14) possesses an N-terminal exonuclease (ExoN) domain that provides a proofreading function for the viral RNA-dependent RNA polymerase and a C-terminal N7-methyltransferase (N7-MTase) domain that methylates viral mRNA caps. …”
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The Intervened effect of place attachment on the relationship between community attachment and environmental behaviors (case study: Tajrish neighborhood) by Atousa Soleimani, Ahmad Nohegar

“…The participants were asked to fill out the research questionnaire whose reliability and validity were confirmed. The obtained data were statistically analyzed using the correlation analysis and structural equation modeling in SPSS-21 and AMOS-21. …”
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Manganese mitigates atrazine-induced oxidative stress and hepatorenal toxicity: insights from network pharmacology and in vivo experimentation by Solomon E. Owumi, Tella T. Adedayo, Joseph Chimezie, Bayode Oluwawibe, Harieme Agbarogie, Jesutosin O. Babalola, Oludare M. Ogunyemi, Uche O. Arunsi, Moses T. Otunla, Chioma E. Irozuru, Ahmad Altayyar, Eziuche A. Ugbogu

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Knowledge, Attitudes, and Practices of Healthcare Professionals Toward Internet-Based Hypertension Management: A Cross-Sectional Study by Zhang Y, Zhang Q, Ren Q, Wang Y, Wang J, Wu Y, Shang M, Zhou Y, Liu R, Li X, Wang Z, Wang F, Yuan F

“…KAP scores was collected using a structured questionnaire. Data were analyzed using descriptive statistics, Pearson correlation, logistic regression, and structural equation modeling (SEM).Results: The study included 1, 199 valid questionnaire responses. …”
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White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder by Xiaofu He, Diana V. Rodriguez-Moreno, Yael M. Cycowicz, Keely Cheslack-Postava, Huilan Tang, Zhishun Wang, Lawrence V. Amsel, Megan Ryan, Lupo Geronazzo-Alman, George J. Musa, Adam Bisaga, Christina W. Hoven

“…We acquired diffusion tensor-imaging (DTI) and resting state fMRI data across the whole brain. Structural connectivity was examined by measuring fractional anisotropy (FA) using DTI, to indicate integrity of the white matter tracts. …”
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Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia by Haeun Yang, Vladimir Li, Su Jung Park, Sang Won Cheon, Anne Lorant, Aloran Mazumder, Jin Young Lee, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Gilbert Kirsch, Dag Erlend Olberg, Guy Bormans, Hyoung Jin Kang, Byung Woo Han, Michael Schnekenburger, Marc Diederich

“…Methods and results Structural and biochemical analyses confirmed the efficient and selective binding of martinostat to HDAC isoenzyme ligand-binding pockets, resulting in histone and tubulin hyperacetylation in both imatinib-sensitive and resistant CML cells, outperforming vorinostat, a clinically used HDAC inhibitor (HDACi). …”
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Workload, job, and family satisfaction in dual-earning parents with adolescents: the mediating role of work-to-family conflict by Berta Schnettler, Berta Schnettler, Berta Schnettler, Berta Schnettler, Andrés Concha-Salgado, Ligia Orellana, Ligia Orellana, Mahia Saracostti, Katherine Beroiza, Héctor Poblete, Germán Lobos, Cristian Adasme-Berríos, María Lapo, Leonor Riquelme-Segura, José A. Sepúlveda, José A. Sepúlveda, Karol Reutter, Enid Thomas

“…Mothers and fathers completed assessments about workload, WtoFC, and the Overall Job Satisfaction Scale, while all three family members responded to the Satisfaction with Family Life Scale.ResultsThe data were analyzed using the mediation Actor-Partner Interdependence Model and structural equation modeling. …”
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“You do it for the patient”: a qualitative analysis of changes to primary care nurses’ workplace demands and resources during the COVID-19 pandemic in Canada by Sarah Spencer, Lindsay Hedden, Julia Lukewich, Emily Gard Marshall, Maria Mathews, Samina Idrees, Jennifer E. Isenor, Ruth Martin-Misener, Leslie Meredith, Crystal Vaughan, Dana Ryan, Dana Ryan

“…Accordingly, we sought to understand the personal and professional experiences of nurses working in primary care settings in Canada during the COVID-19 pandemic to inform future pandemic responses and health workforce planning that account for primary care nurses’ mental and physical needs.MethodsWe conducted semi-structured interviews with licensed and registered practical nurses, registered nurses, and nurse practitioners working in primary care in four Canadian provinces: British Columbia, Newfoundland and Labrador, Nova Scotia, and Ontario. …”
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Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration by Stefan Kurbatfinski, Stefan Kurbatfinski, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Susanne Marshall, Dawn McBride, Jason Novick, Keira Griggs, Arielle Perrotta, Arielle Perrotta, Morgan Daye, Carrie McManus, Kendra Nixon

“…This study sought to: (1) develop a compendium of myths and misconceptions that SGM individuals exposed to IPV and relevant service providers shared they encountered; (2) describe the impacts of these myths and misconceptions on SGM individuals experiencing IPV; and (3) make recommendations to address these myths and misconceptions.MethodsThis qualitative study used data from a larger project focused on SGM IPV where SGM individuals who experienced IPV (n = 18) and service providers who supported SGM individuals experiencing IPV (n = 8) were interviewed using semi-structured formats. …”
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Evaluating the new family medicine internship programmes in the Western Cape, South Africa by Lauren N. Hutton, Louis S. Jenkins, Robert Mash, Klaus von Pressentin, Steve Reid, Jennie Morgan, Paul Kapp

“…Many interns reported no structured teaching programme (41.7% – 55.6%). Most supervision was from medical officers and registrars. …”
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Bayesian trial of adalimumab versus secukinumab for children with juvenile idiopathic arthritis associated uveitis or chronic anterior uveitis by Athimalaipet V Ramanan, Andrew D Dick, Thomas Jaki, Gianmarco Caruso, David S Robertson, Ashley P Jones, Ben Hardwick, Sian Drake, Balini Balasubramaniam, Coziana Ciurtin, Ivan Foeldvari, Elke O Kreps, Alice Leahy, Kristina May, Pierre Quartier, Matthieu P Robert, Gabriele Simonini, Catherine Guly, Michael W Beresford

“…Methods Nine international experts in paediatric rheumatology, paediatric ophthalmology and/or paediatric uveitis took part in a structured Bayesian prior elicitation meeting. Results The final consensus was that adalimumab is expected to yield a higher response rate than secukinumab (mean 0.67 vs. 0.55). …”
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Title: race and ethnicity and the risk of community-acquired third-generation cephalosporin-resistant uropathogens: a systematic review and meta-analysis by Sweta Balaji, Sarah Blackmon, Esther E. Avendano, Samson Alemu Argaw, Rebecca A. Morin, Nanguneri Nirmala, Shira Doron, Maya L. Nadimpalli

“…Conclusions: As antibiotic resistance rises in community settings, our findings support the need to understand the structural issues that underpin differential risk of 3GC-R uropathogens across race and ethnicity. …”
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Tertiary cancer center results of sterilized auto-graft prosthetic osteo-articular complex reconstruction following bone tumor resection by Himanshu Rohela, Anupam Lahiri, Irfan Ahmed, Kundan Singh Chufal, Kripa Mishra, Rajan Arora

“…Background: Bone tumor resections necessitate complex reconstruction methods to maintain limb function and structural integrity. Various approaches, including tumor prostheses and biological reconstructions, offer distinct advantages and disadvantages. …”
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Knowledge, attitudes, practices, and vaccination coverage of medical students toward hepatitis B virus in North Sudan, 2023 by Osama M.I. Mohamed, Hassan S.H. Mohammedali, Shimaa N.A. Mohamed, Hussein A.S. Ahmed, Alaa A.M. Mohamedsalih, Ola M.A. Abdalgani, Tebian A.A. Mohammedosman, Alaa A.A. Ali, Thuiba A.H. Ali, Othman N.O. Amin, Mohamed A. Issak, Mohamed O. Abdelaziz

“…Methods A cross-sectional study was conducted from January to June 2023 among medical students in North Sudan. Data were collected using a structured scale using online Google Forms. …”
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