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50461
Evaluation of dengue virus seroprevalence in four boroughs of Mexico City among persons aged 5-35 years in 2022
Published 2025-02-01“…However, it is important to note that the structural conditions of the dwellings in these boroughs, which offer minimal barriers to vector infestation, could facilitate the establishment of local transmission under favorable conditions. …”
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50462
Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies
Published 2025-06-01“…Nevertheless, challenges persist regarding hepatic safety, pharmacodynamic variability, and limited long-term outcome data. This review integrates current structural, pharmacological, and clinical evidence, highlights key mechanistic innovations—including biased agonism, covalent binding strategies, and allosteric modulation—and discusses future directions for this rapidly evolving therapeutic class in metabolic disease management.…”
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50463
Counseling and mental health interventions in sports: A systematic review of current practices and outcomes
Published 2025-06-01“… This study aimed to highlight the importance of structured psychological intervention in supporting athletes' recovery from injury, managing stress, and preventing future injuries. …”
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50464
Comprehensive Dissolution Study on Two Double Ce(IV) Phosphates with Evidence of Secondary CeO<sub>2</sub> Nanoparticle Formation
Published 2025-05-01“…For the first time, experimental dissolution data were obtained for both compounds over a wide pH range (1.5–10) under long-term equilibration. …”
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50465
USP7 V517F mutation as a mechanism of inhibitor resistance
Published 2025-03-01“…We discovered a key treatment-emergent heterozygous mutation (V517F) in USP7 in the binding pocket of compounds as the primary cause of resistance to the USP7 inhibitor USP7-797. Our structural analysis, supported by AlphaFold2 predictions, indicates that the V517F mutation altered the conformation of the compound binding pocket, causing steric hindrance and reducing the affinity between USP7 and its inhibitors. …”
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50466
A hybrid CFD and machine learning study of energy performance of photovoltaic systems with a porous collector: Model development and validation
Published 2025-05-01“…This study investigates the predictive modeling of temperature (T(K)) using a dataset of over 128,000 data points characterized by x, y, and z coordinates as inputs. …”
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50467
Overcoming barriers to optimizing cash waqf linked sukuk: A DEMATEL-ANP approach
Published 2025-01-01“…This study investigates the factors behind low CWLS sales using the Decision Making Trial and Evaluation Laboratory (DEMATEL) and the Analytic Network Process (ANP) methods to analyze the interrelationships between various barriers to CWLS adoption. Primary data was collected from experts in Islamic finance, waqf management, and regulatory institutions through structured interviews and surveys. …”
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50468
Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors
Published 2025-01-01“…We conducted a global survey involving healthcare professionals (n =204) to understand the role of various determinants in adopting ICTs and their implications for organizational performance. Data was analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) and multiple regression for micro-level constructs. …”
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50469
The Expression and Molecular Roles of MAMDC2 in MSS Colorectal Cancer with a High Tumor Stromal Ratio
Published 2025-05-01“…The meprin/A5/PTPmu (MAM) domain, a conserved structural motif in transmembrane proteins, remains undercharacterized in CRC pathogenesis. …”
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50470
Perceptions of positive and negative clinician communication in obstetrical visits from the perspectives of pregnant patients who use substances
Published 2025-06-01“…Methods: We analyzed qualitative data from 85 semi-structured interviews with pregnant patients who reported or tested positive for substance use, which explored their interaction with obstetric providers during their first prenatal visit. …”
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50471
Socio-Demographic Correlates of Health and Nutrition Among Rural and Plantation Communities of the western Dooars, Jalpaiguri district, West Bengal, India
Published 2025-06-01“…A community-based cross-sectional study was done from September 2024 to January 2025. Data were collected from 156 adult participants (101 males, 55 females) using a pre-structured questionnaire through a multi-stage random sampling technique. …”
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50472
Anthropogenic and natural influence on vegetation ecosystems from 1982 to 2023
Published 2025-01-01“…In addition, frequent land cover changes promoted the growth of greening trends (∼23%), which is linked to enhanced structural plasticity of vegetation. This effect has become more pronounced since 2000, with 92% of such changes occurring during this period. …”
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50473
Linking Education, Culture and Community: A Proposal for an Intercultural Educational Triad
Published 2025-06-01“…The study used a semi-structured interview script to collect data, and in the analysis plan the Grounded Theory (GT) was used, to conceptualize the emerging patterns in categorized concepts and theories. …”
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50474
TET dioxygenases localize at splicing speckles and promote RNA splicing
Published 2025-12-01“…This study explores the relationship between RNA splicing and the TET dioxygenase activity, shedding light on the role of hm5C (RNA 5-hydroxymethylcytosine), and TET proteins in RNA metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, and different functional assays, including in vitro splicing, TET proteins were found to regulate splicing. …”
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50475
Visual Impairment Among Undergraduates: A Situational Analysis of Eye Health in Bowen University Iwo, Nigeria
Published 2025-04-01“…Materials and methods: A cross-sectional study was conducted among 1407 undergraduate students at the institution. Data obtained includes sociodemographic characteristics, vital signs, and visual acuity using a structured questionnaire. …”
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50476
Determinants of digital health literacy among older adult patients with chronic diseases: a qualitative study
Published 2025-03-01“…ObjectiveThis study aimed to identify the factors influencing digital health literacy in older adult patients with chronic diseases.MethodsA descriptive qualitative approach incorporated purposive and snowball sampling methods. Semi-structured interviews were conducted with 32 older adult patients with chronic diseases from three hospitals in Anhui Province between October 2023 and May 2024. …”
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50477
Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder
Published 2024-03-01“…Conclusion: The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics; however, EOS exhibits greater structural variation, while ASD presents with more subtle connectomic abnormalities. …”
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50478
Fluid characteristics, gas accumulation controlling factors and gas enrichment modes in coal reservoirs: A case study of the Upper Paleozoic in the central-eastern Ordos Basin, NW...
Published 2025-04-01“…Based on the test and experimental data from exploration well cores of the Upper Paleozoic in the central-eastern Ordos Basin, combined with structural, burial depth and fluid geochemistry analyses, this study reveals the fluid characteristics, gas accumulation control factors and accumulation modes in the Upper Paleozoic coal reservoirs. …”
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50479
Rebuilding lives in Nagaya, a public housing for older victims of the great East Japan earthquake: An interview survey
Published 2025-10-01“…The current interview survey aimed to report the living conditions of such older victims in Nagaya and accordingly suggest strategies for supporting the older population who experience disasters. We conducted semi-structured interviews with 32 Nagaya residents, who relocated there due to the earthquake, and performed a thematic analysis of the data. …”
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50480
Thai Guideline for Nuclear Medicine Investigations of Neurocognitive Disorders: Nuclear Medicine Society of Thailand, the Neurological Society of Thailand, and Thai Medical Physici...
Published 2024-11-01“…By providing functional and molecular data via brain imaging, nuclear medicine investigations offer valuable insights that complement clinical evaluations and structural imaging in the early detection, diagnosis, and differentiation of various types of dementia, leading to more accurate diagnosis and personalized treatment planning. …”
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