Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism by Bernd K Gilsbach, Franz Y Ho, Benjamin Riebenbauer, Xiaojuan Zhang, Giambattista Guaitoli, Arjan Kortholt, Christian Johannes Gloeckner

“…Despite the availability of several high-resolution structures, the dynamic regulation of its unique intramolecular domain stack is nevertheless still not well understood. …”
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EU DEMOGRAPHIC CHARACTERISTICS: GLOBAL MEGATRENDS AND OPPORTUNITIES FOR THE RETAIL SECTOR by Олена Сергієнко, Світлана Прокопович, Марина Татар, Олександр Білоцерківський, Олександр Чернов, Олександр Кизлюк

“…The study underscores the necessity of aligning demographic data with emerging retail innovations to foster economic adaptability in an evolving global landscape. …”
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Beyond the storms: Exploring predictors of posttraumatic stress and posttraumatic growth among survivors of hurricanes Irma and Maria in Puerto Rico by Marie-Claire Meadows, Noelle Serino, Dahianira M. Camacho-Monclova, Kaumudi Joshipura, Sarah R. Lowe

“…This analysis focused on 484 individuals who completed structured interviews 20 to 34 months after the hurricanes. …”
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Improving ecosystem respiration estimates for CO2 flux partitioning by discriminating water and temperature controls on above- and below-ground sources by Shuai Wang, Shujing Qin, Lei Cheng, Kaijie Zou, Chenhao Fu, Pan Liu, Lu Zhang

“…Long-term flux measurements of six typical terrestrial ecosystems and soil chamber respiration data at two sites were collected to evaluate models. …”
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Developing a framework for medical student feedback literacy using a triangulated thematic analysis by Mohamad Nabil Mohd Noor, Jessica Grace Cockburn, Chan Choong Foong, Chiann Ni Thiam, Yang Faridah Abdul Aziz, Tiiu Sildva, Galvin Sim Siang Lin, Jamuna Vadivelu

“…A comprehensive framework that addresses diverse feedback sources, dynamic environments, and the prioritisation of patient safety can guide the development of feedback literacy in medical students.Materials and Methods The present study explored and triangulated stakeholder perspectives (medical students, medical educators and patients) on medical student feedback literacy through semi-structured interviews. This information was then used to develop a feedback literacy framework. …”
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Key Competencies of Built Environment Professionals for Achieving Net-Zero Carbon Emissions in the Ghanaian Construction Industry by Kofi Agyekum, Kezia Nana Yaa Serwaa Sackey, Felix Esahe Addoh, Hayford Pittri, John Sosu, Frederick Owusu Danso

“…A quantitative research approach was employed, utilizing a structured questionnaire survey to examine the opinions of 125 professionals, including architects, engineers, and construction managers. …”
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Insights into medication adherence among HIV-positive patients: the integrated change model by Mehdi Mirzaei-Alavijeh, Fatemeh Rahimi, Behrooz Hamzeh, Feizollah Mansouri, Nastaran Shoukohi, Farzad Jalilian

“…Methods This descriptive-analytical cross-sectional study involved 262 HIV-positive individuals from the Behavioral Diseases Counseling Centers (BDCCs) of Kermanshah University of Medical Sciences in 2021. Data were collected through structured interviews using a questionnaire based on the I-Change Model, with 255 completed responses analyzed using SPSS-16. …”
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Cyber-Physical Emulation and Threat Scenario Simulation for Enhanced Microgrid Resilience by Khandaker Akramul Haque, Mohamed Massaoudi, Leen Al Homoud, Katherine R. Davis, Mahmoud Kabalan, Hassan Salamy

“…Additionally, the Distributed Network Protocol 3 (DNP3) is leveraged to collect data in the form of DNP3 objects, enabling effective monitoring and control within this threat simulation. …”
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Observation of factors associated with visceral swallowing pattern in 2–6 year old children: A cross-sectional study by Babak Sayahpour, Magda-Anastasia Mylonas-Helbing, Nicolas Plein, Stefan Kopp, Sara Eslami, Sarah Bühling

“…Material and method: A total of 219 children (102 boys and 117 girls) were evaluated using a combination of a questionnaire and a structured clinical examination by one pediatric specialist dentist. …”
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Improving Clinical Pharmacist Performance in Oncology Care Through Education on Pharmaceutical Care Plans Documentation: A Pre-post Interventional Study by Tasbiha Ali, Adeel Siddiqui, Omar Akhlaq Bhutta, Saba Mazhar, Aleeshba Usman, Irfan Raza, Nabin Pathak, Sunil Shrestha

“…The study demonstrates that structured educational interventions significantly enhance the clinical pharmacists’ documentation of PCPs. …”
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Geology, Archaeology, and Historical Studies of the Late 16th Century Plinian Eruption of Raung Volcano: A Potential Case for Disaster Geotourism in Ijen UNESCO Global Geopark, Eas... by Firman Sauqi Nur Sabila, Mirzam Abdurrachman, Asep Saepuloh, Idham Andri Kurniawan, Abdillah Baraas, Dwi Fitri Yudiantoro, Hery Kusdaryanto

“…This research aims to substantiate Raung as the likely source of the major eruption by integrating geological, archaeological, and historical data. This study synthesizes current findings and explores ongoing debates surrounding historical volcanic activities. …”
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Graph-Based COVID-19 Detection Using Conditional Generative Adversarial Network by Imran Ihsan, Azhar Imran, Tahir Sher, Mahmood Basil A. Al-Rawi, Mohammed A. Elmeligy, Muhammad Salman Pathan

“…These reconstructed features serve as input to a classification module, comprising a multi-layer neural network, GCN, adept at processing graph-structured data, alongside conventional machine learning classifiers such as Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), and Random Forest (RF), facilitating categorization of chest X-ray images into COVID-19, pneumonia, and normal cases. …”
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Dynamic Error Modeling and Predictive Compensation for Direct-Drive Turntables Based on CEEMDAN-TPE-LightGBM-APC Algorithm by Manzhi Yang, Hao Ren, Shijia Liu, Bin Feng, Juan Wei, Hongyu Ge, Bin Zhang

“…Our methodology comprises four key stages: Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN)-based decomposition of historical error data, development of component-specific prediction models using Tree-structured Parzen Estimator (TPE)-optimized Light Gradient Boosting Machine (LightGBM) algorithms for each Intrinsic Mode Function (IMF), integration of component predictions to generate initial values, and application of the Adaptive Prediction Correction (APC) module to produce final predictions. …”
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Challenges to Promoting Resilience in Supply Chains Observed during the COVID-19 Pandemic: An Exploratory Study of the Amazon Region Using the TOPSIS Technique by Dhiordan Cunha Tadaiesky, Joaquim Lima das Neves Neto, André Cristiano Silva Melo, Rosley Anholon, Eliane de Castro Coutinho, Vitor William Batista Martins

“…This study conducted a structured questionnaire containing 10 challenges related to SCM during the pandemic period to generate a ranking of these challenges using data analysis using means and comparative ordering using the TOPSIS Multicriteria Technique. …”
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Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms by Lucia Lage, Ana I. Rodriguez-Perez, Jose Luis Labandeira-Garcia, Antonio Dominguez-Meijide

“…The effects of fasudil are mostly related to ROCK inhibition, which we have shown using two structurally different ROCK inhibitors and knockdown data, and further supported by using RT-QuiC.…”
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Preclinical approaches in regenerative medicine for treating end-stage renal disease: a scoping review by Andrea Vigezzi, Paola Brani, Daniela Dalla Gasperina, Lorenzo Azzi, Cristina Giaroni, Davide Inversini, Giuseppe Pettinato, Matthew Massaad, Giulio Carcano, Giuseppe Ietto, Andreina Baj

“…Regenerative medicine emerged as a promising alternative, leveraging stem cells technologies and tissue engineering to develop functional renal tissues with the potential to restore or replace damaged kidney structures. Our review protocol was developed in accordance with the PRISMA-ScR guidelines and was prospectively registered on Figshare. …”
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Potential and limitations of noise-based surface-wave tomography for numerical site effect estimation: a case study in the French Rhône valley by Lavoué, François, Froment, Bérénice, Gélis, Céline, Boué, Pierre,  Chaljub, Emmanuel, Stehly, Laurent, Beauprêtre, Sophie, De Martin, Florent,  Gisselbrecht, Loïc, Pilz, Marco, Moiriat, Denis, Cushing, Edward Marc

“…The obtained ANSWT model well reproduces the main geological structures of the basin, with lateral variations of velocities at depth depicting the deeper parts of the basin. …”
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Dermatoscopic Patterns in Mycosis Fungoides: Observations from a Case-Series Retrospective Analysis and a Review of the Literature by Corrado Zengarini, Federica Tugnoli, Alessio Natale, Martina Mussi, Giacomo Clarizio, Claudio Agostinelli, Elena Sabattini, Alberto Corrà, Bianca Maria Piraccini, Alessandro Pileri

“…The dermoscopic evaluation revealed that all the lesions were pigment-free, with vascular structures as the predominant feature. Linear vessels (40%) and serpentine vessels (13.3%) were the most frequently observed, along with dotted vessels (36.7%) and clods (10%). …”
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Identification of inflow sources and pathways to a waste rock dump located in a former river channel in a mountainous abandoned mine of Japan: A case study 60 years post-constructi... by Shinji Matsumoto, Sereyroith Tum, Tagiru Ogino, Miu Nishikata, Tetsuo Yasutaka, Tomoko Oguri, Tsuyoshi Shintani

“…These processes could have been influenced by the degradation of impermeable structures around the WD, emphasizing the need for continuous water quality monitoring and repair of these structures. …”
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Healthcare providers' perspectives on the organization of health services to manage people with multiple long-term conditions in primary care settings in Kerala, India: a qualitati... by Thoniparambil Ravindranathanpillai Lekha, Linju Joseph, Linju Joseph, Neethu Vasantha Sasidharan, Athira Krishnan, Justine Davies, Paramjit Gill, Sheila Greenfield, Sivadasanpillai Harikrishnan, Jissa Vinoda Thulaseedharan, Mathew Joseph Valamparampil, Semira Manaseki-Holland, Panniyammakal Jeemon, Panniyammakal Jeemon

“…We aimed to explore the challenges healthcare providers (HCPs) face in managing people with MLTCs in a south Indian primary care setting.MethodsSemi-structured interviews were conducted with HCPs in four districts of Kerala, India. …”
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