SIGNIFICANCE OF ETV6-RUNX1 FUSION GENE TRANSCRIPT DETECTION IN PEDIATRIC B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA WITH TRANSLOCATION t(12;21)(p13;q22) by G. A. Tsaur, Т. О. Riger, A. M. Popov, T. Yu. Verzhbitskaya, L. V. Vakhonina, A. A. Vlasova, Yu. V. Olshanskaya, А. N. Kazakova, O. V. Streneva, O. V. Makarova, S. V. Tsvirenko, L. I. Saveliev, О. R. Arakaev, L. G. Fechina

“…We showed good qualitative (84.8 %) and quantitative (R2 = 0.953) concordance between ETV6-RUNX1/ABL1 ratio and MRD data obtained by flow cytometry at days 15, 36, 85. …”
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Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: insights from an intensive care unit in Colombia by Rubén E. Lasso-Palomino, Rubén E. Lasso-Palomino, Diego Medina, Diego Medina, Alexis Antonio Franco, Alexis Antonio Franco, María José Soto-Aparicio, Eliana Manzi Tarapues, Eliana Manzi Tarapues, Diana Marcela Muñoz, Edgar Salazar, Jhon López, Angela Devia, Sofía Martínez-Betancur, Jimena Sierra, Anita V. Arias, Inés Elvira Gómez, Inés Elvira Gómez

“…The relationship between mortality and patient clinical characteristics was assessed using the Chi-square test or the Mann-Whitney U test, as applicable. A p-value of <0.05 was considered statistically significant. …”
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What is behind the high turnover intention among hospital nurses during the full liberalization of COVID-19 and the postpandemic era in China: a 2-wave multicentre cross-sectional... by Julan Xiao, Lili Liu, Yueming Peng, Xia Lyu, Chunfeng Xing, Yanling Tao, Shening Zhu, Aihuan Mai, Lijun Liang, Hongying Hu, Yi Fan, Weisi Peng, Haishan Xie, Jun Ren, Weixiang Luo

“…Clinical trial number Not applicable.…”
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Pakistan’s first medicine price deregulation policy: assessing its impact on prices, affordability, and availability of oral anti-diabetic medicines in private pharmacies by Amna Saeed, Amna Saeed, Sundus Shukar, Sundus Shukar, Najwa Ali Yasin, Najwa Ali Yasin, Caijun Yang, Caijun Yang, Minghuan Jiang, Minghuan Jiang, Muhammad Majid Aziz, Haris Zahoor, Muhammad Sunnan-Ud-Din, Yu Fang, Yu Fang, Zaheer-Ud-Din Babar

“…This study evaluated the access to Oral antidiabetics (OADs) and the effect of Pakistan’s recently launched price deregulation policy—applicable to medicines not included on the National Essential Medicines List (non-NEML)—on their prices and affordability by comparing NEML and non-NEML OADs.MethodsA WHO/HAI methodology-based survey in 30 private pharmacies across six regions gathered prices and availability data of 30 OADs, including the Lowest Price Generic (LPG), Highest Price Generic (HPG), and originator brand (OB). …”
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ID1 and ID3 functions in the modulation of the tumour immune microenvironment in adult patients with B-cell acute lymphoblastic leukaemia by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita, Alba Lucia Combita, Alba Lucia Combita

“…These findings correlated with xCell data. Overexpression group showed significant differences in neutrophils, monocytes and CD4+ naive T cells compared to basal group patients. …”
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Antibiotic susceptibility patterns of Salmonella isolates from clinical, food, and environmental sources in Addis Ababa and surrounding towns, Ethiopia by Abebe M. Aga, Demise Mulugeta, Dassalegn Muleta, Adugna Abdi Woldesemayat, Abera Motuma, Musin Kelel, Bilise Wakitole, Shambel Tadesse, Zinash Teferi, Fanos Tadesse Woldemariyam, Serkadis Oljira, Henok Ferede, Natnael Berihun, Samson Girma, Dereje Nigussie, Mesfin Tafesse Gemeda

“…This study provides a comprehensive analysis of Salmonella isolates from clinical, food, and environmental samples in Addis Ababa and nearby towns, offering current data on antimicrobial resistance patterns. By using updated laboratory standards and sampling diverse sources, the findings highlight the urgent need for improved food safety practices, sanitation, and antimicrobial stewardship.…”
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Clinical analysis of patients with idiopathic pulmonary fibrosis concurrent with surgery resectable lung cancer: a retrospective cohort study from perspective of ILD physicians by Qi Chen, Yujie Shi, Ruxuan Chen, Kai Xu, Cheng Huang, Ji Li, Zhiyi Li, Mengqi Wang, Chi Shao, Hui Huang, Mengzhao Wang

“…Clinical trial number Not applicable.…”
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Membrane-associated ring–CH–type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase by Dongsheng Ni, Zhaolai Qi, Shuang Ma, Yuefeng Wang, Dehuan Liang, Xiyue Zhang, Yong Man, Jingzhou Chen, Kefei Dou, Guoping Li

“…Nevertheless, the specific enzyme molecules implicated in this regulatory process remain to be elucidated. …”
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Clinical Validation of a Machine Learning-Based Biomarker Signature to Predict Response to Cytotoxic Chemotherapy Alone or Combined with Targeted Therapy in Metastatic Colorectal C... by Duilio Pagano, Vincenza Barresi, Alessandro Tropea, Antonio Galvano, Viviana Bazan, Adele Caldarella, Cristina Sani, Gianpaolo Pompeo, Valentina Russo, Rosa Liotta, Chiara Scuderi, Simona Mercorillo, Floriana Barbera, Noemi Di Lorenzo, Agita Jukna, Valentina Carradori, Monica Rizzo, Salvatore Gruttadauria, Marco Peluso

“…By analyzing large sets of patient data and using machine learning, we hope to create a model that can identify which patients will respond to chemotherapy, either alone or combined with other targeted treatments. …”
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Multimodal machine learning-based marker enables the link between obesity-related indices and future stroke: a prospective cohort studyResearch in context by Beilei Hu, Xuan Chen, Tingyang Chen, Tong Xu, Yungang Cao, Jing Sun, Xuanyu Chen, Songfang Chen, Keyang Chen

“…Further research is needed to assess its applicability in broader cohorts. Funding: None.…”
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Fertility preservation by ovarian tissue cryopreservation of children in China——umbilical single-incision surgery and perioperative experience by Zheng Qipeng, Liu Jing, Su Yun, Li Zexi, Cao Zhenhua, Chen Meng, Zhou Yan, Zhang Hua, Wang Zecheng, Tian Yu, Ruan Xiangyan, Wu Yurui

“…This study aims to summarize the surgical techniques and perioperative experiences to provide clinical evidence for pediatric OTCT.MethodsThis retrospective study reviewed the clinical data of 89 children who underwent umbilical single-incision laparoscopic oophorectomy at Children’s Hospital, Capital Institute of Pediatrics between September 2020 and December 2024. …”
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AIRWAVE-SLSTR—An Algorithm to Estimate the Total Column of Water Vapour from SLSTR Measurements over Liquid Surfaces by Elisa Castelli, Stefano Casadio, Enzo Papandrea, Paolo Pettinari, Massimo Valeri, Andrè Achilli, Bojan R. Bojkov, Alessio Di Roma, Camilla Perfetti, Bianca Maria Dinelli

“…The new AIRWAVE algorithm makes use of parameters computed offline with a state-of-the-art radiative transfer model using the most recent spectroscopic data and continuum model. For the parameters calculation, a new climatology capable of representing the average atmospheric and sea surface status during SLSTR measurements has been developed. …”
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O-prenylchalcones inhibit cell proliferation and activate apoptosis by inducing mitochondrial dysfunction in gastric cancer cells by José C. Espinoza-Hicks, Yarely M. Salinas-Vera, Javier Camarillo-Cisneros, Alejandro A. Camacho-Dávila, Jessica L. Hernández-Rivera, Nadia Flores-Huerta, Eloisa Ibarra-Sierra, Carlos Pérez-Plasencia, María Elizbeth Álvarez-Sánchez, Ángeles C. Tecalco-Cruz, César López-Camarillo

“…Conclusions Here, we report preliminary data suggesting that O-prenylchalcones inhibit cell proliferation and promote cell death by inducing mitochondrial dysfunction, caspase-3 and caspase-7 activation, and ROS generation in AGS gastric cancer cells. …”
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Factors influencing smoking cessation in Lebanese patients with bladder cancer: A cross sectional study by Georges Horkoss, Joey El Khoury, Rami Halabi, Anthony Kanbar, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Maher Abdessater, Rodrigue Saad, Antoine Kassis, Raghid El Khoury

“…A sample of patients diagnosed with BCa between 2015 and 2020 were contacted and data was collected between the months of September 2022 and May 2023. …”
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The Effect of Tangible and Intangible Hotel Caracteristics on Brand Loyalty with the Mediating Role of Perceived Well-Being and Brand Attitude (Case study: 4 And 5 Star Hotels In M... by Zahra Mohamadzadeh, Zahra Mohamoudi

“…The research results showed that the tested model has a good fit to the data, and all the research hypotheses were confirmed. …”
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Earth's future climate and its variability simulated at 9 km global resolution by J.-Y. Moon, J.-Y. Moon, J. Streffing, J. Streffing, J. Streffing, S.-S. Lee, S.-S. Lee, T. Semmler, T. Semmler, M. Andrés-Martínez, M. Andrés-Martínez, J. Chen, E.-B. Cho, E.-B. Cho, J.-E. Chu, C. L. E. Franzke, C. L. E. Franzke, J. P. Gärtner, R. Ghosh, J. Hegewald, J. Hegewald, S. Hong, D.-W. Kim, D.-W. Kim, N. Koldunov, J.-Y. Lee, J.-Y. Lee, Z. Lin, C. Liu, S. N. Loza, W. Park, W. Park, W. Roh, W. Roh, D. V. Sein, D. V. Sein, D. V. Sein, S. Sharma, S. Sharma, D. Sidorenko, J.-H. Son, J.-H. Son, J.-H. Son, M. F. Stuecker, Q. Wang, G. Yi, G. Yi, M. Zapponini, T. Jung, T. Jung, A. Timmermann, A. Timmermann

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Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy by Boji Xie, Shuting Pang, Yuli Xie, Yuli Xie, Qiuyan Tan, Shanshan Li, Mujia Jili, Mujia Jili, Yian Huang, Yian Huang, Binran Zhao, Hao Yuan, Hao Yuan, Junhao Mi, Junhao Mi, Junhao Mi, Xuesong Chen, Liangping Ruan, Hong Chen, Xiaolai Li, Boning Hu, Jing Huang, Rirong Yang, Rirong Yang, Wei Li

“…Bulk RNA sequencing (RNA-seq) of urine offers a promising approach for identifying molecular changes relevant to IgAN.MethodsWe performed bulk RNA-seq on 53 urine samples from 11 untreated IgAN patients and 11 healthy controls, integrating these data with public renal RNA-seq, microarray, and scRNA-seq datasets. …”
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TECHNOLOGY-ASSISTED TEACHING ACTIVITIES IN AN ESAP CONTEXT: AN ECOLOGICAL PERSPECTIVE by Adina-Maria MEZEI

“…După aceea, se ilustrează câteva activități didactice în care sunt implicate instrumente digitale, evaluând unele din beneficiile și/sau dezavantajele lor. …”
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Threshold and Asymmetric Effects of Foreign Direct Investment on Inclusive Growth in Shanghai Cooperation Member Countries by marziyeh hosini, monireh Rafat

“…Considering its contribution and long-term implication, it is a narrow approach to lemmatize the role of FDI in promoting economic growth only. …”
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A CECT-Based Radiomics Nomogram Predicts the Overall Survival of Patients with Hepatocellular Carcinoma After Surgical Resection by Peng Zhang, Yue Shi, Maoting Zhou, Qi Mao, Yunyun Tao, Lin Yang, Xiaoming Zhang

“…<b>Methods</b>: This retrospective study analyzed the preoperative enhanced CT images and clinical data of 202 patients with HCC who underwent surgical resection at the Affiliated Hospital of North Sichuan Medical College (Institution 1) from June 2017 to June 2021 and at Nanchong Central Hospital (Institution 2) from June 2020 to June 2022. …”
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