Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…An additional total cost was calculated, which also included inpatient events (planned surgery due to musculoskeletal condition). Data were available on 348 complete data sets at all time points for total costs. …”
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The role of offensive and creative priming videos in enhancing youth football players’ performance during small-sided games by Diogo Coutinho, Diogo Coutinho, Bruno Gonçalves, Bruno Gonçalves, Sara Santos, Sara Santos, Sigrid Olthof, Rafael Ballester Lengua, André Roca, Bruno Travassos, Bruno Travassos, Bruno Travassos

“…Coaches can leverage offensive priming to improve structured passing and positioning, while creative priming may inspire exploratory movements and innovative shooting attempts.…”
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Transition from child to adult health services for young people with cerebral palsy in Ireland; implications from a mixed-methods study [version 2; peer review: 2 approved] by Owen Hensey, Amanda Breen, Aisling Walsh, Mary Owens, Claire Kerr, Sebastian Koppe, Grace Lavelle, Meriel Norris, Michael Walsh, Jennifer M. Ryan, Thilo Kroll, Jennifer Fortune

“…Methods A convergent parallel mixed-methods study was conducted. Data were collected from people with cerebral palsy aged 16–22 years, parents, and health professionals using surveys and semi-structured interviews, which were both informed by a framework of nine key transition practices. …”
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Investigation of an extensive outbreak of HIV infection among children in Sindh, Pakistan: protocol for a matched case–control study by Victoria Simms, Rashida Ferrand, Baseer Achakzai, Iqbal Azam, Amna R Siddiqui, Apsara Ali Nathwani, Syed H Abidi, Syed Faisal Mahmood, Sobiya Sawani, Abdul M Kazi, Aneeta Hotwani, Sikander Ali Memon, Jamila Soomro, Saqib Ali Shaikh, Quaid Saeed, Palwasha Khan, Fatima Mir

“…Following written informed consent from the guardian, a structured questionnaire will be administered to collect data on sociodemographic indices and exposure to risk factors for parenteral, vertical and sexual (only among those aged above 10 years) HIV transmission. …”
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Optimising Paediatric Transition to Intensive Care for Adults (OPTICAL): study protocol for a mixed method study by Padmanabhan Ramnarayan, Louise Rose, Julie Taylor, Christina Pagel, Jo Wray, Sarah E Seaton, Kate Oulton, Sonya Crowe, Rum Thomas, Qi Huang, Paul R Mouncey, Katherine Malbon, Anjalika Mallick, Charmaine Kohn, Sue Ben Abraham, Clare Windsor

“…To do this, we will: (1) link and analyse UK national data (years 2017–2024) on paediatric and adult ICU admissions, hospital inpatient, outpatient and emergency care visits and survival status, to determine the clinical characteristics and healthcare resource utilisation from teenage years to early adulthood of people admitted to an ICU as a young person (admission aged 14 and 15), and how these relate to ICU admissions after age 16; (2) conduct semistructured interviews, online forums and surveys with TYA patients, carers and health professionals to understand their experience of transition in ICU services; and (3) synthesise these strands of evidence and use a structured process of stakeholder engagement to propose potential targeted improvements as appropriate.Ethics and dissemination This study was approved by the East of England - Cambridge South Research Ethics Committee on 1 August 2024 (research ethics committee number 24/EE/0108), and the Health Research Authority Confidentiality Advisory Group (CAG) on 7 October 2024 (CAG number 24/CAG/0068). …”
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Vulvovaginal candidiasis: knowledge, practices and occurrence among pregnant women receiving antenatal care in a teaching hospital, Ghana by Florence Shine Edziah, Florence Shine Edziah, Princess Ruhama Acheampong, Philip Apraku Tawiah, Cedric Dzidzor Amengor, Godsway Edem Kpene, Grace Otobea Amponsah, Priscilla Appiah Baffoe, Georgina Korankye, John Gameli Deku

“…This study assessed the knowledge, practices and occurrence of Vulvovaginal candidiasis among pregnant women accessing antenatal care at a teaching hospital in Ghana.MethodsA cross-sectional study was conducted among 336 pregnant women receiving antenatal care at the Ho Teaching Hospital. A structured questionnaire was used to assess their knowledge of the infection and practices on vaginal hygiene. …”
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The experience of immersive virtual reality in patients with heart failure during cardiac rehabilitation: a qualitative study by Valentina Micheluzzi, Valentina Micheluzzi, Gavino Casu, Gavino Casu, Francesco Burrai, Antonella Canu, Antonio Sircana, Pierluigi Merella, Pierluigi Merella, Angelo Laconi, Angelo Laconi, Andrea Chelo, Andrea Chelo, Piero Cozzula, Michela Piredda, Ercole Vellone, Ercole Vellone

“…The intervention group experienced iVR in natural settings, while the control group received standard care. Semi-structured individual interviews were conducted in person after the intervention group’s eighth rehabilitation session. …”
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Strengthening neonatal care through ward assistants: a Kenyan case study in enhancing infection prevention and control practices by Michuki Maina, Nancy Odinga, Vincent Kagonya, Gloria Ngaiza, Sebastian Fuller, Onesmus Onyango, Caroline Waithira, Dorothy Oluoch, David Gathara, Peter Mwangi, Loise Mwangi, Penina Musyoka, Lucy Kinyua, Lydia Thuranira, Virginia Njoroge, Ngina Mwangi, Zainab Kioni, Mike English, Edna Mutua

“…Methods This study employed a mixed methods approach in four public neonatal units in Kenya to assess the impact of deploying ward assistants on IPC practices. Data collection included structured and unstructured observations, in-depth interviews, and focus group discussions with healthcare workers and caregivers. …”
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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…The interviews were conducted by two researchers who have extensive experience interviewing KOA patients, and data were gathered through face-to-face, semi-structured interviews to ensure a high level of information power. …”
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Effects of timely case conferencing between general practitioners and specialist palliative care services on symptom burden in patients with advanced chronic disease: results of th... by Tina Mallon, Josefine Schulze, Nadine Pohontsch, Thomas Asendorf, Jan Weber, Silke Böttcher, Uta Sekanina, Franziska Schade, Nils Schneider, Judith Dams, Michael Freitag, Christiane Müller, Friedemann Nauck, Tim Friede, Martin Scherer, Gabriella Marx

“…Methods The cluster-randomised controlled trial compared a structured palliative care nurse visit followed by an interprofessional case conference to usual care. …”
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The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial by R.D. Singh, J.T.J.M. van Dijck, T.A. van Essen, H.P. Nix, R.J.G. Vreeburg, H.F. den Boogert, G.C.W. de Ruiter, B. Depreitere, W.C. Peul

“…Furthermore, non-structured interviews with involved clinical research personnel were conducted. …”
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Retention of medical officers in the district health services of the Western Cape, South Africa: An exploratory descriptive qualitative study by Robert J. Mash, Werner Viljoen, Steve Swartz, Mumtaz Abbas, Leigh Wagner, Herma Steyn, Gavin Hendricks, Dusica Stapar, Andrew Williams, Adeloye Adeniji, Johan Schoevers, Paul Kapp

“…Medical officers were purposefully selected in terms of districts, facility types, gender, seniority and perceived likelihood of leaving in the next four years. Semi-structured interviews were performed by family physicians, and the qualitative data were analysed using the framework method. …”
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Impact of young people’s admissions to adult mental health wards in England: national qualitative study by Anne-Marie Burn, Josephine Holland, James Roe, Elinor Hopkin, Lorna Wild, Michelle Fisher, Tamsin Ford, Saeed Nazir, Bernadka Dubicka, Anthony James, Helena Tuomainen, Nicole Fung, Adam Wagner, Richard Morriss, Kapil Sayal

“…Aims To explore the impact of young people’s admissions to adult wards, from the perspectives of young people, parents/carers and mental health professionals working in adult services. Method Semi-structured interviews were conducted with 29 participants to explore experiences of receiving and delivering care in adult mental health wards. …”
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Protocol for PD SENSORS: Parkinson’s Disease Symptom Evaluation in a Naturalistic Setting producing Outcome measuRes using SPHERE technology. An observational feasibility study of... by Catherine Morgan, Walter Maetzler, Oliver Watson, Lynn Rochester, Ian Craddock, Helen Matthews, Emma L Tonkin, Kirsi M Kinnunen, Roisin McNaney, Sam Whitehouse, Majid Mirmehdi, Farnoosh Heidarivincheh, Ryan McConville, Julia Carey, Michal Rolinski, Rachel Eardley, Alan L Whone

“…Acceptability of the technology will be evaluated qualitatively using semi-structured interviews.Ethics and dissemination Ethical approval has been given to commence this study; the results will be disseminated as widely as appropriate.…”
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Developing a national clinical competency committee for family medicine training, South Africa by Louis S. Jenkins, Mergan Naidoo, Kefilwe Hlabyago, Dirk T. Hagemeister, Neetha Erumeda, Busisiwe Cawe, Tasleem Ras, Mulimisi Ramavhuya, Owen Eales

“…These EPAs provide a structured approach to assessing and developing the competencies required for independent practice in family medicine. …”
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Prioritising Key Concepts for informed health choices in cancer: An evidence-based online educational programme by Mengqi Li, Declan Devane, Claire Beecher, Maura Dowling, Austin G. Duffy, Caitriona Duggan, David Robert Grimes, Avril Kennan, Claire Kilty, Allen Nsangi, Andrew D. Oxman, Derek C. Stewart, Elaine Toomey, Marie Tierney

“…The process involved disseminating pre-reading materials, training sessions, and a structured judgement form to evaluate concepts for inclusion. …”
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Anaemia during pregnancy: a cross-sectional study of antenatal attendants at the Madina Pentecost Hospital, La Nkwantanang Municipality, Ghana by Richard Vikpebah Duneeh, Wina Ivy Ofori Boadu, Lois Tekutey Narh, Joseph Frimpong, Abdul-Wahab Mawuko, John Gameli Deku, Kofi Mensah, Charles Nkansah, Samuel Kwasi Appiah, Felix Osei Boakye, Enoch Odame Anto, Lilian Antwi Boateng, Benedict Sackey, Otchere Addai-Mensah

“…This cross-sectional study conveniently recruited 300 Ghanaian pregnant women attending the Madina Pentecost Hospital for antenatal care. A structured questionnaire was administered to obtain data on sociodemographics (age, marital status, level of education, occupation and religion) and knowledge level of anaemia. …”
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Functional work disability from the perspectives of persons with systemic lupus erythematosus: a qualitative thematic analysis by Behdin Nowrouzi-Kia, Aaron S. Howe, Anson Li, Jeremy Tan, Natalia Saade-Cleves, Kevon Jules, Malak Sadek, Ali Bani-Fatemi, Antonio Avina-Zubieta, Mary T. Fox, William Shaw, Derek Haaland, Janet Pope, Paul R. Fortin, Kathleen S. Bingham, Christine Peschken, Jennifer Reynolds, Catherine Ivory, Dafna D. Gladman, Murray B. Urowitz, Jorge Sanchez-Guerrero, Lily S. H. Lim, Stephanie Keeling, Patti Katz, Mahta Kavkan, Dennisse Bonilla, Wils Nielsen, Zahi Touma

“…Methods With the objective of creating an SLE-related functional profile rooted in work disability (WD) prevention, 46 SLE patients were purposively recruited from Canadian medical centres. Through semi-structured interviews guided by a WD prevention framework, factors associated with WD and lived experiences of SLE-related WD were qualitatively explored. …”
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Effects of vaping on physical and mental health in at-risk populations (VAPE): mixed-methods study of motivations for and perspectives on vaping in patients with opioid use disorde... by Alessia D’Elia, Balpreet Panesar, Nitika Sanger, Laura O’Neill, Tea Rosic, Leonora Regenstreif, Kevin Park, Claire de Oliveira, David C. Marsh, Luciano Minuzzi, Lehana Thabane, Zainab Samaan

“…Method A convergent mixed-methods study design was used, and individual, semi-structured interviews were conducted with 41 individuals with OUD who were receiving medication for OUD and also vaped. …”
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Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs by Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai

“…In the DrugBank database, 98 structurally novel candidate compounds with potential senolytic activity were identified. …”
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