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    The role of mitochondria in iron overload-induced damage by Yangyang Zhao, Mengjiao Yang, Xiaoxue Liang

    Published 2024-11-01
    “…This review examines the mechanisms by which mitochondria are implicated in iron overload-induced damage, including increased oxidative stress, mitochondrial DNA damage, and disruptions in energy metabolism. …”
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    Environmental high temperature induced cartilage damage through triggering programmed necrosis mediated by producing left-handed DNA by Sun Yingfei, Yang Feng, Ma Haoning

    Published 2025-02-01
    “…We further studied the molecular mechanism of HS-induced cell damage. We found that HS induced genomic damage, generating substantial Z-DNA (left-handed DNA) and activating ZBP-1-mediated programmed cell necrosis, which subsequently released various inflammatory factors. …”
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    Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma by Sohum Patel, Eleanor Jenkins, Rutuj P Kusurkar, Sherry Lee, Wei Jiang, Avinoam Nevler, Matthew McCoy, Michael J Pishvaian, Rosalie C Sears, Jonathan R Brody, Charles J Yeo, Aditi Jain

    Published 2025-05-01
    “…Here, we demonstrate that BARD1 is overexpressed in PDAC and its genetic inhibition suppresses c-Myc and disrupts c-Myc dependent transcriptional program. Mechanistically, BARD1 stabilizes c-Myc through ubiquitin–proteasome system by regulating FBXW7. …”
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    Damage Strength Model of Soil–Structure Interface Based on Equivalent Damage by Huaixin LI, Changgen YAN, Jiale XIE, Weifeng SUN, Yuling SHI, Zhuolong JIA

    Published 2024-11-01
    “…During the shear process of the specimen, the proportion of shear strength is contributed by inter-particle shear resistance within the soil, and the interface shear resistance undergoes dynamic changes, exhibiting variability in the shear strength mechanism at the soil-structure interface. The total damage to the soil shear surface results from loading damage, whereas the total damage at the soil-structure interface is divided into equivalent initial damage, loading damage, and coupling damage caused by the interaction of the two. …”
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    Numerical Study of Damage Modes and Damage Assessment of CFST Columns under Blast Loading by Junhao Zhang, Shiyong Jiang, Bin Chen, Chunhai Li, Hao Qin

    Published 2016-01-01
    “…In this paper, the high-fidelity physics-based finite element program LS-DYNA was utilized to investigate the dynamic behavior and damage characteristics of the widely used concrete-filled steel tube (CFST) columns subjected to blast loads. …”
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    CLOSED ABDOMINAL INJURY WITH LIVER DAMAGE by B. V. Sigua, V. P. Zemlyanoy, A. K. Dyukov

    Published 2015-02-01
    “…An analysis of the treatment results was made in 447 patients with closed abdominal injury combined with liver damage. An individualized treatment-and-diagnostic program considering the data of field surgery- MT scale was applied in victims with closed abdominal trauma with liver damage. …”
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    Liver damage in infectious mononucleosis in children by S. V. Khaliullina, F. M. Yakupova, E. I. Nasyrova, K. V. Mikhailova, Yu. A. Raimova, O. A. Nazarova, V. A. Anokhin

    Published 2024-01-01
    “…The purpose of the study was to evaluate the clinical and laboratory features of infectious mononucleosis with liver damage in children hospitalized in an infectious diseases hospital.Materials and methods. …”
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    Effects of macrolide antibiotics on blood inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats by Ayşe Er, Enver Yazar

    “…<b>Aim:</b> The aim of this study was to determine the effect of macrolide antibiotics using in veterinary area on serum/ plasma inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats.…”
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