RELIABILITY-BASED DESIGN OPTIMIZATION USING OPTIMUM SAFETY FACTORS FOR LARGE-SCALE PROBLEMS by Gh. Kharmanda, I. R. Antypas

“…The efficiency of the OSF method is also extended to multiple failure modes to control several out-put parameters, such as structural volume and damage criterion.Discussion and Conclusions. …”
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Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species. by Julie A Hall, Matthew K McElwee, Jonathan H Freedman

“…It has been proposed that aging results from the lifelong accumulation of intracellular damage via reactions with reactive oxygen species (ROS). …”
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Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2. by M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, Nathan Brown, Sam Peacock, Craig McAndrew, Elaine Barrie, Meirion Richards, Amin Mirza, Antony W Oliver, Rosemary Burke, Swen Hoelder, Keith Jones, G Wynne Aherne, Julian Blagg, Ian Collins, Michelle D Garrett, Rob L M van Montfort

“…Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift assay, followed by X-ray crystallography, identified a number of chemically different ligand-efficient CHK2 hinge-binding scaffolds that have not been exploited in known CHK2 inhibitors. …”
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New Materials and Structures: Anti-Escape Trap Net for Trapping <i>Eucryptorrhynchus brandti</i> (Harold, 1880) (Coleoptera: Curculionidae) by Hongyu Li, Weicheng Ding, Chao Wen, Junbao Wen

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Generation of Ugt1-deficient murine liver cell lines using TALEN technology. by Fabiola Porro, Luka Bockor, Alessia De Caneva, Giulia Bortolussi, Andrés F Muro

“…It is characterized by unconjugated hyperbilirubinemia that may result in severe neurologic damage and death if untreated. To date, liver transplantation is the only curative treatment. …”
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Data-Driven Pavement Performance: Machine Learning-Based Predictive Models by Mohammad Fahad, Nurullah Bektas

“…However, machine learning models offer a time-efficient solution for predicting pavement performance. …”
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Multistage deep learning methods for automating radiographic sharp score prediction in rheumatoid arthritis by Hajar Moradmand, Lei Ren

“…This study is the first to apply a ViT for OSS prediction in RA. It presents an efficient and automated alternative for overall damage assessment. …”
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Optimization of acousto-ultrasonic sensor networks using genetic algorithms based on experimental and numerical data sets by Ryan Marks, Alastair Clarke, Carol A Featherston, Rhys Pullin

“…Aircraft structural damage detection is becoming of increased importance. …”
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Indicators to distinguish symptom accentuators from symptom producers in individuals with a diagnosed adjustment disorder: A pilot study on inconsistency subtypes using SIMS and MM... by Cristina Mazza, Graziella Orrù, Franco Burla, Merylin Monaro, Stefano Ferracuti, Marco Colasanti, Paolo Roma

“…In the context of legal damage evaluations, evaluees may exaggerate or simulate symptoms in an attempt to obtain greater economic compensation. …”
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Evaluation of Animal Dungs and Organomineral Fertilizer for the Control of Meloidogyne incognita on Sweet Potato by Oluremi Solomon Osunlola, Bamidele Fawole

“…All organic materials and carbofuran significantly (p≤0.05) reduced nematode reproduction and root damage compared with control. Poultry dung (10 and 20 t/ha) and carbofuran were, however, more efficient in nematode control than other organic materials. …”
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Revolutionising Glaucoma Care with Optical Coherence Tomography: A New Horizon by Subathra Gnanavelu, Madhavi R. Pillai

“…Optical coherence tomography (OCT) has become a commonly utilised imaging modality in the detection and monitoring of structural glaucomatous damage. OCT has undergone several evolutionary phases, advancing from time-domain OCT, through spectral-domain OCT, to swept-source OCT. …”
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To Solution of Ecological Problems in Power Systems / by A. M. Gashimov, G. J. Guseinov, K. B. Gurbanov

“…The paper analyses a possibility to minimize damage due to operation of power systems using fossil fuels. …”
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Discovery of a pyridophenoselenazinium-based photosensitizer with high photodynamic efficacy against breast cancer cells by Guiling Li, Peixia Li, Qiaoyun Jiang, Qianqian Zhang, Jingru Qiu, Donghai Li, Gang Shan

“…Development of efficient photosensitizers with minimal side effects is highly desirable for photodynamic therapy. …”
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Hydrogen-Sulfide-Mediated PpAOS3-JA Module Provides Insight into Salt Stress Resistance in Peach by Xiaolan Gao, Miao Li, Qingtao Gong, Guixiang Li, Haixiang Yu, Xiaomin Dong, Xiaoyou Wang, Zheng Gong, Zhongtang Wang, Yuansong Xiao, Anning Zhang

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Inflammatory targeted nanoplatform incorporated with antioxidative nano iron oxide to attenuate ulcerative colitis progression by Haojun Chen, Wei Sun, Can Li, Qiuyang Wang, Xucai Wang, Yingjie Du, Wenbo Chen, Min Wang, Caoxing Huang, Rong Wang

“…HA@ZIF-8@IONPs effectively reduced damage to intestinal tissues in the UC mouse model. …”
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Real-time monitoring of hydrogen composite pressure vessels using surface-applied distributed fiber optic sensors by Christos Karapanagiotis, Mathias Breithaupt, Eric Duffner, Marcus Schukar

“…To detect and quantify damage-related anomalies, we trained a simple regression model to predict strain from pressure data and used the difference between predicted and measured values as a damage indicator. …”
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Research on vehicle scheduling for forest fires in the northern Greater Khingan Mountains by Jie Zhang, Junnan He, Shihao Ren, Pei Zhou, Jun Guo, Mingyue Song

“…Abstract In the face of forest fire emergencies, fast and efficient dispatching of rescue vehicles is an important means of mitigating the damage caused by forest fires, and is an effective method of avoiding secondary damage caused by forest fires, minimizing the damage caused by forest fires to the ecosystem, and mitigating the losses caused by economic development. this paper takes the actual problem as the starting point, constructs a reasonable mathematical model of the problem, for the special characteristics of the emergency rescue vehicle scheduling problem of forest fires, taking into account the actual road conditions in the northern pristine forest area, through the analysis of the cost of paths between the forest area and the highway, to obtain the least obstructed rescue paths, to narrow the gap between the theoretical model and the problem of the actual. …”
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Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells by Seung S Lee, Philip JR Roche, Paresa N Giannopoulos, Elliot J Mitmaker, Michael Tamilia, Miltiadis Paliouras, Mark A Trifiro

“…Physical ablation therapy is immune to tumor heterogeneity, but nearby tissue damage is the limiting factor in delivering lethal doses. …”
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<i>Puccinia triticina</i> and Salicylic Acid Stimulate Resistance Responses in <i>Triticum aestivum</i> Against <i>Diuraphis noxia</i> Infestation by Huzaifa Bilal, Willem Hendrik Petrus Boshoff, Lintle Mohase

“…The priming effect of <i>Pt</i> isolates and SA in reducing RWA-induced leaf damage and increased antioxidant activities is an indication of defence responses. …”
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Physical Characteristic and Design Logics of Integrated Fast Reactor by HUO Xingkai, SONG Yingyun, MO Bu, FENG Wei, HU Yun

“…However, the harder spectrum significantly increases the damage cross-section of structural material, due to which the burnup of the fuel is restricted by the accumulation of radiation damage of the cladding. …”
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