Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer by Xu Y, Chen X, Zhang L, Li P, He J, Zhu M, Makvandi P, Jin X

“…The in vivo distribution and anti-tumor effects of B-PDA@Danu were studied in a mouse lung carcinoma in situ model.Results: The synthesized B-PDA@Danu nanoparticles were spherical, negatively charged, with an average particle size of (172.96± 1.61) nm, exhibited good stability, and efficiently loaded Danu. B-PDA@Danu promoted cellular uptake in vitro, inhibited cell viability (P < 0.001), induced G2/M cell cycle arrest (P < 0.001), and increased apoptosis (P < 0.001). …”
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Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis by Dongwei Guan, Pengju Huang, Xinlei Liu, Qing Li, Xiaoxun Zhang, Nan Liu, Yong Wang, Ying Wan, Jin Chai, Shiying Cai, Rui Chen, Zhijia Ye

“…Introduction: Niemann-Pick C1 (NPC1), a lysosomal cholesterol transport protein, is required for efficient efferocytosis. Patients with Npc1 mutation are frequently accompanied with hepatic symptoms, including hepatomegaly, elevated liver transaminases, or even acute liver failure, but the pathogenic mechanism remains unknown. …”
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Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing by Ning Zhang, Ning Zhang, Ning Zhang, Shuoming You, Shuoming You, Jingjing Guo, Jingjing Guo, Xingyu Chang, Xingyu Chang, Junjun Qiu, Junjun Qiu, Keqin Hua, Keqin Hua

“…These variant sites are conserved among species and were predicted to be damaging according to functional algorithms and protein analyses. …”
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Insight into Antiviral Activity of Ag/TiO2 Nanocomposites Against Influenza H1N1 Virus and Its Antiviral Mechanism by Ma Y, Xiao X, Wang Y, Sun J, Tang P, Li J, Sun X, Xu D, Yang Z, Chen S, Liu X

“…It reduces the infection efficiency of influenza by suppressing the activity and expression of hemagglutinin and neuraminidase. …”
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Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…This approach can be used for targeting cancer and autoimmune diseases in which CD19+ B lineage cells cause host damage.…”
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Advancing digital health in Yemen: challenges, opportunities, and way forward by Omar Abdulkarim Saeed Alhammadi, Hajer Ibrahim Mohamed, Shuaibu Saidu Musa, Mohamed Mustaf Ahmed, Misha Abayneh Lemma, Uwamahoro Joselyne, Bananeza Roméo, Yinusa Abdullahi, Zhinya Kawa Othman, Mohammed Raihanatu Hamid, Omar Kasimieh, Don Eliseo Lucero-Prisno III, Safouane Labyad, Olalekan John Okesanya

“…This study highlights the urgent need for the strategic implementation of health interventions in a country where fully functional healthcare facilities, low-income levels, damaged infrastructure, and suboptimal governance limit the effectiveness of traditional interventions. …”
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Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke by Xiao He, Jiadong Chen, Yan Zhong, Peili Cen, Li Shen, Fei Huang, Jing Wang, Chentao Jin, Rui Zhou, Xiaohui Zhang, Anxin Wang, Jing Fan, Shuang Wu, Mengjiao Tu, Xiyi Qin, Xiaoyun Luo, Yu Zhou, Jieqiao Peng, Youyou Zhou, A. Cahid Civelek, Mei Tian, Hong Zhang

“…Furthermore, these FOXG1 forebrain progenitor cells demonstrate robust cortical neuronal differentiation, rapid functional maturation and efficient synaptic integration after transplantation into the sensory cortex of stroke-injured adult rats. …”
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Advances in stem cell-based therapeutics for acute high-altitude illness: research progress and prospects by Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Dan Chen, Dan Chen, Dan Chen, Cheng-Wei Yang, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Hao Yao, Hao Yao, Hao Yao, Hao Yao, Hao Yao

“…Nonetheless, several translational challenges persist, including suboptimal homing efficiency, potential immunogenicity, and uncertain long-term safety profiles in high-altitude settings. …”
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Double Braking Effects of Nanomedicine on Mitochondrial Permeability Transition Pore for Treating Idiopathic Pulmonary Fibrosis by An Lu, Zhiyi Xu, Zhixia Zhao, Yi Yan, Linxia Jiang, Jing Geng, Hongwei Jin, Xiangyu Wang, Xiaoyan Liu, Yuanjun Zhu, Yujie Shi, Lihong Liu, Huaping Dai, Jian‐Cheng Wang

“…In vitro results demonstrated that these NPs effectively inhibit mPTP opening by 3D‐lipid binding with CypD and siRNA downregulating MCU expression, thereby decreasing damage‐associated molecular patterns (DAMPs) release and suppressing epithelial‐to‐mesenchymal transition (EMT) process in bleomycin‐induced A549 cells. …”
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Evidence for alcohol-mediated hemolysis and erythrophagocytosis by Chaowen Zheng, Siyuan Li, Johannes Mueller, Cheng Chen, Huanran Lyu, Guandou Yuan, Ane Zamalloa, Lissette Adofina, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Stephan Immenschuh, Ines Silva, Vanessa Rausch, Seddik Hammad, Steven Dooley, Shilpa Chokshi, Antonio Riva, Songqing He, Sebastian Mueller

“…In parallel, soluble CD163 (sCD163) levels declined during alcohol detoxification correlating with liver damage and fibrosis stages. Moreover, red blood cells (RBCs) from heavy drinkers exhibited increased fragility under hemolytic stress. …”
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Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study by Zongwei Liu, Zongwei Liu, Zongwei Liu, Chuang Xu, Chuang Xu, Bin Zhao, Bin Zhao, Jiayin Guo, Jiayin Guo, Jingzhong Song, Jingzhong Song, Jiaxue Bi, Jiaxue Bi, Yujun Shen, Yujun Shen, Yujun Shen, Xiangchen Dai, Xiangchen Dai

“…However, its quantitative efficiency in disrupting calcifications with different characteristics, as well as the degree of damage to normal arteries, remains to be confirmed.ObjectivesThis study aimed to: (i) quantitatively evaluate the efficacy of IVL in disrupting different types of calcifications, and (ii) assess the impact of IVL on normal vascular structures.MethodsThe gypsum models with different thicknesses and eccentricities were used to evaluate the effectiveness of IVL in disrupting calcifications with different characteristics. …”
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Immunotherapy combining tumor and endothelium cell lysis with immune enforcement by recombinant MIP-3α Newcastle disease virus in a vessel-targeting liposome enhances antitumor imm... by Lei Li, Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Guang-Hong Tan, Hengyu Chen, Cai-Chun Wang, Wu-Ping Zheng

“…The phenotypes of the immune cells were analyzed by flow cytometry. The antitumor efficiency was investigated in B16 and 4T1 tumor-bearing mice. …”
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10-YEARS ANALYSIS OF CRYOBAG FRACTURE IN A LARGE INVENTORY OF CELLULAR THERAPY PRODUCTS: RATES AND RISK FACTORS by AR Belisário, LT Mendonça, RK Andrade, MC Martins, LA Costa, KL Prata

“…Despite their widespread use and importance, cryobags are vulnerable to damage, and fractures can significantly impact both patient outcomes and the operational efficiency of cellular therapy facilities. …”
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Cytokine status in posttraumatic synovitis on the background of systemic and intra-articular use of NSAID and ozone by G. V. Poryadin, A. N. Zakhvatov, T. V. Tarasova, D. A. Khaydar, V. O. Timoshkin

“…Joint  damage  initiates aseptic  self-sustaining inflammation, which  contributes the  progression of post-traumatic destruction of tissues  not  only  in the  pathological focus,  but  also outside  it,  significantly expanding the zone of degenerative changes due to secondary alterations. …”
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Construction of Cationic Carbon Dots Carrying Survivin siRNA Delivery System and Its Active Targeting Therapy for Liver Cancer by Xue W, Du J, Wei Y, Zhou S, Wang S, Yang Y, Chen L, Yu S

“…Meantime, when the mass ratio of FA-PEI-CDs to Survivin siRNA was 3:1, the maximum transfection efficiency was 22.8% and 28.5% in HL-7702 cells and HepG2 cells, respectively. …”
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Protection of cultural heritage in Kosovo and Metohija by Jović-Lazić Ana

“…According to the author's conclusion, in order to apply comprehensive and efficient measures of restoration of the destroyed and damaged monuments of culture and protection of the remaining ones in Kosovo and Metohija it is necessary to, with no delay, ensure the co-ordination of activities of the international and domestic bodies and organisations in order to prevent the irretrievable loss of the rich cultural heritage.…”
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Key technology and equipment for fully mechanized mining with extra-large shearing height of 10 m in extra-thick coal seam by Hongpu KANG, Yajun LEI, Futang ZHAO, Gang XU, Zenglin LI, Mingzhong LI, Rui WANG, Zhizeng HUANG, Jiangbin LIU, Ying MA, Cundi HAN, Yanjun FENG, Zhen ZHANG, Jinhu ZHANG, Jianchao REN, Yejie SONG, Mingsheng ZENG, Lixing CHENG

“…Fully mechanized mining technology with extra-large shearing height is the optimal technical approach to achieve high-yield, high-efficiency and high-recovery mining for 6−10 m ultra-thick coal seam in Chinese coal mines. …”
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COVID-19 – if the cure is worse than the disease. The Italian chaos by Giuseppe FERRARI

“…On the contrary what has been enacted to fight the COVID-19 will end up in having caused more damages than the virus itself.…”

Comparative activity of some veterinary pharmaceutical products in swine dysentery by Cristina, T. Romeo, Villa, R., Olimpia-Ines Lupu (Pauta), Doma, A.

“…One of the diseases that cause great damage in the pig breeding farms, Brachyspyra swine dysentery has a special importance because involve great losses both by growth failure and high mortality andsignificant costs to the prevention and control. …”
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Probiotic Bacillus subtilis QST713 improved growth performance and enhanced the intestinal health of yellow-feather broilers challenged with coccidia and Clostridium perfringens by Lu Sun, Yangbin Liu, Pan Xiao, Keying Zhang, Shiping Bai, Jianping Wang, Qiufeng Zeng, Huanwei Peng, Yadong Mu, Yue Xuan, Shanshan Li, Xuemei Ding

“…The birds were evaluated for parameters such as average daily gain (ADG), average daily feed intake (ADFI), feed efficiency (F/G), intestinal lesion score, villus histomorphometry, intestinal tight junctions, inflammatory factors, and cecal microorganisms. …”
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