Modular assembled biomimetic nanobubbles for synergistic therapy of ischemic stroke via cascade modulation thrombo-inflammatory network by Mingxi Li, Xuan Xu, Guoyan Tang, Huan Wu, Yakun Wang, Chen Cheng, Hongde Liu, Fang Yang

“…Such modular assembled PFNBs can promote the effective presentation of targeted proteins and drug molecular functions on the biointerface, enabling precise sequential lesion targeting, enhanced blood-brain barrier penetration and inflammatory microglial uptake, significantly improving drug delivery efficiency. Therapeutic efficacy analysis via whole-genome RNA sequencing demonstrated a virtuous cycle between anti-inflammatory regulation and vascular protection, ultimately mitigating the brain tissue damage. …”
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Experiments to classify in-ground stilling basins and determine the factors affecting the optimization of flood mitigation dams by Ebi Meshkati, Sameh A. Kantoush, Tetsuya Sumi, Binh Quang Nguyen, Hossein Sohrabzadeh Anzani

“…A ''stilling basin'' is a structure used downstream of a dam to reduce energy flow and prevent damage to the dam structure or erosion downstream. …”
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Geochemical insights and model optimisation for pilot-scale passive treatment of manganese and zinc in a legacy mine in Japan by Sereyroith Tum, Taiki Katayama, Naoyuki Miyata, Miho Watanabe, Yohey Hashimoto, Miu Nishikata, Tetsuo Yasutaka

“…Comprehensive suspended solid mineralogy analyses and geochemical and numerical modelling were conducted to optimise the passive treatment efficiency. Mn2+ removal (efficiency reaching 98 %) primarily depended on the activity of Mn-oxidising bacteria. …”
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Redox signaling modulates axonal microtubule organization and induces a specific phosphorylation signature of microtubule-regulating proteins by Christian Conze, Nataliya I. Trushina, Nanci Monteiro-Abreu, Lisha Singh, Daniel Villar Romero, Eike Wienbeuker, Anna-Sophie Schwarze, Michael Holtmannspötter, Lidia Bakota, Roland Brandt

“…Many life processes are regulated by physiological redox signaling, but excessive oxidative stress can damage biomolecules and contribute to disease. Neuronal microtubules are critically involved in axon homeostasis, regulation of axonal transport, and neurodegenerative processes. …”
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Hemoglobin-loaded hollow mesoporous carbon-gold nanocomposites enhance microwave ablation through hypoxia relief by Yitian Zhang, Bitao Li, Jiawen He, Ya Meng, Meixiao Zhan, Cuixia Lu, Yong Li, Feiyu Niu, Liewei Wen

“…Upon microwave irradiation, HMCN/Au@Hb not only improves the microwave-thermal conversion efficiency of tumor lesion but also promotes the ROS generation by increasing oxygen content in the hypoxic tumor microenvironment. …”
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The potential effects of nanoparticles in gene regulation and expression in mammalian, bacterial and plant cells – A comprehensive review by Ayesha Javaid, Neelma Munir, Zainul Abideen, Bernardo Duarte, Zamin Shaheed Siddiqui, Rukhama Haq, Shagufta Naz

“…Nanoparticles have been employed as gene regulatory systems that can efficiently modulate gene expression owing to their unique physiochemical properties. …”
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Nanostructure and plant uptake: Assessing the ecological footprint and root-to-leaf dynamics by Shadma Afzal, Nand Kumar Singh, Arnica F Lal, Saima Sohrab, Nivedita Singh, Pushpraj S. Gupta, Sanjay Kumar Mishra, Muhammad Adeel, Mohammad Faizan

“…Nanostructure design is presented as one of the economically viable technical alternatives for increasing the efficiency of agrochemical use (fertilizers and pesticides) by reducing runoff, increasing foliar uptake and bioavailability, and reducing environmental impact. …”
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Understanding the interplay between COVID-19 and diabetes: insights for the post-pandemic era by Xuefei Zhao, Linlin Jiang, Linlin Jiang, Wenjie Sun, Shanshan Tang, Xiaomin Kang, Qing Gao, Qing Gao, Zehua Li, Zehua Li, Xuedong An, Fengmei Lian

“…From a mechanistic perspective, we investigated the following factors: SARS-CoV-2-mediated direct damage to islet beta cells, dysregulation of the RAAS system, impairment of islet function by oxidative stress, and the effects of the integrated stress response, stress response, and reduced adiponectin levels on insulin utilization efficiency and glucose metabolism. …”
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Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion by Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu

“…Here it is discovered that chemotherapeutic drugs induce DNA damage and activate the cyclic guanosine monophosphate (GMP)–adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING) signaling pathway. …”
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The Functional and Imaging Implications of Left Bundle Branch Pacing in Ischemic Cardiomyopathy by Fulvio Cacciapuoti, Ciro Mauro, Ilaria Caso, Salvatore Crispo, Rossella Gottilla, Valentina Capone, Saverio Ambrosino, Ciro Pirozzi, Orlando Munciguerra, Mario Volpicelli

“…Electrical conduction delays exacerbate symptoms by causing uncoordinated contractions, reducing pumping efficiency, and increasing mortality. Right ventricular pacing further worsens dyssynchrony, while resynchronization therapy improves outcomes but has a high non-responder rate. …”
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A comparative parasitological, histopathological, and proteomic analysis of Schistosoma mansoni infected mice treated with ivermectin and praziquantel by Eman Sayed El-Wakil, Mona Mohamed Tolba, Mona Hasan El-Sayad, Maha Khairy Hassen, Hayat S. Al-Rashidi, Mina A. Almayouf, Wafa Abdullah I. Al-Megrin, Hind Alzaylaee, Esraa Abdelhamid Moneer

“…Besides, it highlights the role of proteomic analysis in differential protein identification that could help efficiently treat schistosomiasis.…”
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Dual application of β-sitosterol and biochar reduces copper toxicity in bamboo via improved redox homeostasis by Abolghassem Emamverdian, Abolghassem Emamverdian, Xinyu Lyu, Xinyu Lyu, Necla Pehlivan, Li Zhang, Li Zhang, Haider Sultan, Yang Li, Meisam Zargar

“…Bs and Eb, individually or combined, enhanced antioxidant activity (SOD, CAT, POD, PAL), glyoxalase cycle efficiency, and osmolyte accumulation (proline, glycine betaine), mitigating oxidative damage. …”
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Hippocampus-sparing volume-modulated arc therapy in patients with World Health Organization grade II glioma: a feasibility study by Renxian Xie, Renxian Xie, Hongxin Huang, Hongxin Huang, Qingxin Cai, Jiayang Lu, Tong Chen, Tong Chen, Keyan Xie, Jianzhou Chen, Chuangzhen Chen

“…Notably, HS VMAT plans markedly decreased doses to the ipsilateral hippocampus and the contralateral hippocampus, demonstrating its efficacy in hippocampal dose reduction.ConclusionThe HS VMAT plan can be used to efficiently lower the dosage delivered to the hippocampus and may, to some extent, help lessen the risk of cognitive damage. …”
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Methods and efficacy of processing testicular sperm samples in obstructive and non-obstructive azoospermia: a systematic review by Terrence C. Tsou, Shagnik Ray, Mahir Maruf, Taylor P. Kohn, Mohammad H. Zaman, Michael F. Ayenew, Arvin K. George, Amin S. Herati

“…Additionally, techniques such as microfluidics and magnetic levitation showed potential for improving sperm retrieval efficiency. However, the lack of standardization in outcomes and reporting impedes the establishment of best practice protocols. …”
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PhyloControl: A phylogeny visualisation platform for risk analysis in weed biological control by Stephanie H. Chen, Lauren Stevens, Ben Gooden, Michelle A. Rafter, Nunzio Knerr, Peter H. Thrall, Louise Ord, Alexander N. Schmidt-Lebuhn

“…Thorough host specificity testing is crucial to minimise the risk of off-target damage to native and economically important plant species. …”
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Rancang Bangun Green Belt Untuk Pengendalian Pencemaran Debu di Kawasan Industri Terboyo (Jalan Kaligawe) by Nurandani Hardyanti, Matthew Darmawan, Haryono Setiyo Huboyo

“…The optimum efficiency of the Green Belt will be achieved in the 2nd year with the rate of 71.40% and it will be able to reach the maximum efficiency in the 5th year with the rate of 87.92%.…”
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Characteristics of the Indian dwarf wheat variety ‘Sakara’ by D. F. Askhadullin, D. F. Askhadullin, N. Z. Vasilova, M. P. Tazutdinova, I. I. Khusainova, G. R. Gaifullina, E. S. Kirillova, R. Kh. Idiatova

“…The purpose of the current study was to show the efficiency of the ongoing breeding work with Indian dwarf, using the variety ‘Sakara’ as an example, to increase grain productivity and resistance to leaf-stem fungal diseases, while maintaining the high grain quality characteristic of shot wheats. …”
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Characterization, Antioxidant and Anti-inflammatory Activities of Quercetin-Eucommia ulmoides Polysaccharide Nanoparticles by Xiaoxia LIN, Li ZHU, Jingyi MA, Zhiqiang FENG, Tianlin WANG, Jiansheng ZHAO, Lianjun SONG, Xianqing HUANG, Qiuyan ZHAO, Tiange LI

“…The results indicated that the encapsulation efficiency of LA-EUP NPs for quercetin reached 70.4%±2.4%, with a loading capacity of 5.6%±0.2%. …”
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Targeting atrial fibrillation in HFpEF: the emerging role of pulsed field ablation by A. S. Parwani, A. S. Parwani, A. S. Parwani, B. Kossmann, B. Kossmann, V. Schweiger, V. Schweiger, V. Schweiger

“…As PFA gains traction for its procedural efficiency and favorable safety profile, its role in managing AF in HFpEF may expand. …”
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Numerical Prediction of Fatigue Life for Landing Gear Considering the Shock Absorber Travel by Haihong Tang, Panglun Liu, Jianbin Ding, Jinsong Cheng, Yiyao Jiang, Bingyan Jiang

“…Only 84 FE simulations are needed to efficiently obtain the fatigue stress spectra from the ground load spectra. …”
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