NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…Recent drug-discovery studies have identified a series of small molecules, including NPT100-18A, which reduce αSyn oligomerization by preventing misfolding and dimerization. NPT100-18A and structurally similar compounds (such as NPT200-11/UCB0599, currently being assessed in clinical studies) point towards a promising new approach for disease-modification. …”
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Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Beatrice Amboko, Jacinta Nzinga, Benjamin Tsofa, Peter Mugo, Anita Musiega, Beryl Maritim, Ethan Wong, Caitlin Mazzilli, Wangari Ng’ang’a, Brittany Hagedorn, Gillian Turner, Anne Musuva, Felix Murira, Nirmala Ravishankar, Salim Hussein, Edwine Barasa

“…We will use a random sample of 228 health facilities and 2560 clients in four currently implementing PCNs, four planning to implement and four control counties at baseline and post-implementation. …”
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Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF by E. Riveland, A. Ushakova, T. Valborgland, T. Karlsen, H. Dalen, E. Prescott, T. Omland, A. Linke, M. Halle, M. Marber, Ø. Ellingsen, A.I. Larsen, the SMARTEX‐HF Study Group

“…It is also associated with outcome in patients with acute heart failure. It is currently unclear how it relates to cardiac troponins in patients with chronic heart failure undergoing exercise training. …”
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Implementing innovative technology promoting self-awareness of brain health and self-determination in obtaining a timely dementia diagnosis: protocol for a multimethods, concurrent... by Sharon L Naismith, Helen Macpherson, Bernice Redley, Alison M Hutchinson, Lidia Engel, Liliana Orellana, Loren Mowszowski, Tanita Botha, Tracey K Bucknall, Rajesh Vasa, Kon Mouzakis, Eva Yuen, Tanya Petrovich, Terence W H Chong, Kelly Burns, Stephanie Daly, Justine Lomas, Jessica Rivera Villicana, Andrew Vouliotis

“…In Study 2, general practitioners (~n=20) currently practising in Australia will participate in semi-structured interviews conducted via online teleconferencing. …”
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Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor by Luke N. Yaeger, David Sychantha, Princeton Luong, Shahrokh Shekarriz, Océane Goncalves, Annamaria Dobrin, Michael R. Ranieri, Ryan P. Lamers, Hanjeong Harvey, George C. diCenzo, Michael Surette, Jean-Phiippe Côté, Jakob Magolan, Lori L. Burrows

“…ABSTRACT Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and structural integrity, and is a key antibiotic target. …”
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Prompt-based three-dimensional tooth segmentation method based on pre-trained SAM(基于预训练SAM的提示式三维牙齿分割方法) by 刘复昌(LIU Fuchang), 蔡煜晨(CAI Yuchen), 缪永伟(MIAO Yongwei), 范然(FAN Ran)

“…Currently, most studies employ supervised learning techniques to train networks on three-dimensional tooth data to perform annotation tasks. …”
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THE INFLUENCE OF HEART RATE VARIABILITY ON CLINICAL COURSE OF CHRONIC HEART FAILURE AND RENAL FUNCTION IN ATRIAL FIBRILLATION PATIENTS by E. A. Polyanskaya, S. V. Mironova, N. A. Koziolova

“…Aim. Evaluation of structural and functional condition of the left ventricle (LV) and kidneys in permanent atrial fibrillation patients (AF) with ischemic chronic heart failure (CHF) according to mean 24 hour heart rate and heart rate variability.Material and methods. …”
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Intellectual-Social Dynamics at State Islamic University in Indonesia: The Role of Alumni of Islamic Boarding Schools from Bangka Island by Rusydi Sulaiman, Pebri Yanasari

“…The data was collected through observation, semi-structured interviews, and documentation. The "Snow-ball Sampling" method obtained 57 informants and narrowed them down to eight. …”
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Sentidos de profissionalidade docente compartilhados por professores da educação superior by Maria da Conceição Valença da Silva, Maria da Conceição Carrilho de Aguiar

“…Therefore, we carried out semi-structured interviews with teachers from a bachelor's undergraduate program, in a locus research institution. …”
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Does Pelleted Starter Feed Restriction and Provision of Total Mixed Ration Ad Libitum during Weaning Influence the Behavior of Dairy Calves? by Anna Antonella Spina, Marina Tortadès, Domenico Britti, Raffaella Grande, Valeria Maria Morittu

“…Currently, in dairy farming, there is growing concern for the welfare of calves during the critical period between the separation from their dams and weaning. …”
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Empowering Aging with Dignity: The Need for Geriatric Home-based Primary Care in Pakistan by Rabeeya Saeed

“…Home-based Primary Care is currently gaining much popularity due to the potential of converting primary care from clinics to home settings. …”
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Efficiency of drug therapy for coxitis in patients with ankylosing spondylitis according to the data of a 12-month prospective follow-up by A. V. Petrov, V. A. Beloglazov, Yu. O. Shevnina, A. A. Petrov

“…However, the influence of these treatments on the time course of HJ structural changes has not been currently studied.Objective: to estimate the time course of HJ changes clinical, X-ray, and ultrasonographic examination was performed in AS patients receiving various drugs: NSAIDs, SSZ, and adalimumab (ADA) during 12 months.Subjects and methods. …”
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Pluronic P123/L64 Mixed Micelles as Immediate Release Systems to Enhance the Bioavailability of Praziquantel in Rats by Yuan J, Su W, Gao J, Ma X, Yin R, Jia T

“…This system was compared with commercially available preparations both in vitro and in vivo.Results: The particle size of the prepared PZQ-PMMs (P123:L64 1:1, w/w) was 19.33 ± 0.22 nm, with a PDI value of 0.106 ± 0.044, an EE of 86.88 ± 4.60%, and a drug loading of 4.16 ± 0.21%. Structural characterization results indicated that the spherical micelles were uniformly dispersed, with the drug existing in an amorphous form within PMMs. …”
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Overloaded Vertebral Body Following Consecutive Three‐Level Hybrid Surgery Comparing with Anterior Cervical Discectomy and Fusion by Shi‐hao Chen, Ya‐ling Li, Hao Liu, Ting‐kui Wu, Kang‐kang Huang, Ming‐he Yao, Bei‐yu Wang

“…Objective Based on the varying number and relative positions of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF) procedures, three‐segment hybrid surgery (HS) presents a diverse structural approach. Currently, the potential differential effects of HS with different segment combinations and surgical procedures on overloaded vertebral body (OVB) occurrence remain unexplored. …”
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Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis by Shao-long Wu, Shao-long Wu, Kun Wang, Xin Yang, Ning Liu, Ning Liu, Wen-xin Zou, Xiao-wei Li, Dan-hua Huang, Tian-hao Yu

“…The public hospitals in Guangdong province had implemented the zero-markup policy and national procurement policy for coronary stents. Currently, research on the zero-markup consumable policy and national procurement of coronary stents for medical consumables at the hospital level lacks analysis of changes in cost structures (other expenses) and studies on hospital response strategies.ObjectiveThis study aims to examine the effects of these reforms on hospitalization expenses for patients undergoing coronary stent implantation, including the specific changes in total hospitalization expenses, the component of total expenses, and the proportion of each expense category following the implementation of the reforms.MethodsData were obtained from the case management system of Guangdong Provincial Second People’s Hospital in China. …”
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DEVELOPMENT OF PRACTICAL SKILLS IN FOREIGN STUDENTS DURING EDUCATION AT THE DEPARTMENT OF PROPEDEUTICS OF SURGICAL DENTISTRY by I.A. Kolisnyk, A.I. Pankevych, A.M. Hohol, V.M. Novikov, E.Yu. Rezvina, M.A. Korostashova

“…Dentistry", as well as during objective structured clinical examination in dentistry. Theoretical knowledge is checked during practical classes. …”
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Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…The Delphi method and an elite panel were utilized to screen and refine these indicators. Structural analysis of the research question was conducted using the MICMAC software and Scenario Wizard, employing the Cross-Impact Balance (CIB) method. …”
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Review of Research on Supercritical Carbon Dioxide Axial Flow Compressors by Yong Tian, Dexi Chen, Yuming Zhu, Peng Jiang, Bo Wang, Xiang Xu, Xiaodi Tang

“…As for performance characteristics, currently, sCO₂ axial-flow compressors are mostly designed with large mass flow rates (>100 kg/s), near-critical inlet conditions, multistage configurations with relatively low stage pressure ratios (1.1–1.2), and high isentropic efficiencies (87–93%). …”
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Kirjeldamisest lavastamiseni. Loovuurimuslik vaade / From Describing to Staging: A Practice-as-Research Look by Karl Saks, Hedi-Liis Toome, Anu Sööt, Ele Viskus

“…Viljandi Culture Academy is currently restructuring its study curriculum for directing students. …”
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Modified costotransverse approach combined with autologous iliac bone graft fusion and internal fixation in thoracic tuberculosis by Mengcheng Wei, Shishuang Zhang, Qingbo Li, Lei Cai, Junlong Zhou, Weijun Liu

“…Currently, it is believed that the posterior approach alone is superior to both the anterior and the combined anterior-posterior surgical methods in correcting spinal kyphosis and maintaining spinal stability. …”
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