The First Experience of Aortic Valve Repeated Replacement Using the “Valve in Valve” Technique in a Patient With Dysfunction of a Biological Prosthesis by V. V. Vladimirov, L. S. Kokov, A. I. Kovalyov, S. S. Niyazov, M. V. Parkhomenko, A. V. Redkoborody, N. V. Rubtsov, N. M. Bikbova, R. Sh. Muslimov

“…Aortic valve replacement in cardiopulmonary bypass with suture fixation of the prosthesis is the “gold standard” in cardiac surgery. Currently, the frequency of use of heart valve bioprostheses is increasing in older patients. …”
Get full text

Multi-Branch CNN-LSTM Fusion Network-Driven System With BERT Semantic Evaluator for Radiology Reporting in Emergency Head CTs by Selene Tomassini, Damiano Duranti, Abdallah Zeggada, Carlo Cosimo Quattrocchi, Farid Melgani, Paolo Giorgini

“…Currently, no AI solutions address this need. Thus, our research aims to develop an automatic radiology reporting system by directly analyzing brain anomalies in head CT data. …”
Get full text

Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspective by Bruna Silva, Marco Domingos, Sandra Amado, Juliana R. Dias, Paula Pascoal-Faria, Ana C. Maurício, Nuno Alves

“…Each layer exhibits unique structural and mechanical properties, necessitating a layer-specific modeling approach. …”
Get full text

Dorsal root ganglion-targeted analgesic delivery for effective relief of neuropathic pain by Jiajia Sun, Jia Gu, Yan Ding, Xinyi Tu, Xiaohui Cai, Baochun Jiang, Zhongping Chen

“…Dorsal root ganglion (DRG) is currently an important therapeutic target and DRG-targeted analgesic delivery through systemic injection is however not reported. …”
Get full text

Simulation of interferometric imaging with EISCAT_3D for fine-scale in-beam incoherent scatter spectra measurements by D. Huyghebaert, D. Huyghebaert, B. Gustavsson, J. Vierinen, A. Kvammen, M. Zettergren, J. Swoboda, I. Virtanen, S. M. Hatch, K. M. Laundal

“…<p>The 233 MHz EISCAT_3D radar system currently under construction in northern Fennoscandia will be able to resolve ionospheric structures smaller than the transmit beam dimensions through the use of interferometric imaging. …”
Get full text

Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases by Sabrina Rossi, Isabella Giovannoni, Sara Patrizi, Andrea Mafficcini, Eleonora Piccirilli, Giuseppe Kenneth Ricciardi, Giacomina Megaro, Francesca Arienzo, Chantal Tancredi, Emanuele Agolini, Andrea Carai, Angela Mastronuzzi, Caterina Giannini, Franco Locatelli, Rita Alaggio, Giovanna Stefania Colafati, Viola Alesi, Evelina Miele, Valeria Barresi

“…Confirmatory dimensionality reduction (t-SNE) showed clustering within (Case #2) or near (Case #1) the HPAP group. Patient #1 is currently receiving maintenance temozolomide following concomitant chemo-radiotherapy, 10 months post-surgery. …”
Get full text

Clinical case of semilobar holoprosencephaly by A. V. Serezhkina, I. G. Khmelevskaya, N. S. Razinkova, T. A. Minenkova, I. I. Zhiznevskaya, A. S. Plekhanova

“…After a course of maintenance therapy, the patient was discharged in a stable condition. Currently, there is no specific treatment for holoprosencephaly. …”
Get full text

PALEOZOIC INTRAPLATE MAGMATISM OF THE EAST EUROPEAN PLATFORM: COMPARATIVE ANALYSIS OF THE PRIPYAT-DNIEPER-DONETS RIFT ZONE AND THE KOLA-ARKHANGELSK PROVINCE by E. V. Yutkina, A. V. Kargin, A. A. Nosova, O. F. Kuzmenkova, L. V. Sazonova, I. A. Kondrashov

“…The Pripyat-Dnieper-Donets rift zone is subject to reverse lateral geochemical zonality of the mantle sources – from those depleted in the axial zone of the Dnieper-Donets trough to more enriched in the marginal parts – trough shoulders (Azov region, Voronezh crystalline massif): along the southeast to northwest axis of the rift zone to the Zhlobin saddle (orangeites, alkaline picrites of the Zhlobin alkaline-ultramafic complex) and in the Pripyat trough (Pripyat alkaline and subalkaline mafic complex) as well was perpendicular to the axis from the central part of the Dnieper-Donets trough to the southwest towards the Eastern Azov region (non-diamondiferous kimberlites) and to the northeast towards the Voronezh crystalline massif.Currently available petrological-mineralogical and isotopic-geochemical data on magmatites of both large magmatic structures suggest significant lithospheric heterogeneity, different types of sources of formation of rocks, and a significant influence exerted by the crustal component both in the southern and northern parts of the East European platform.…”
Get full text

Overexpression of Heme Oxygenase-1 in Mesenchymal Stem Cells Augments Their Protection on Retinal Cells In Vitro and Attenuates Retinal Ischemia/Reperfusion Injury In Vivo against... by Li Li, GaiPing Du, DaJiang Wang, Jin Zhou, Guomin Jiang, Hua Jiang

“…Retinal ischemia/reperfusion (I/R) injury, involving several ocular diseases, seriously threatens human ocular health, mainly treated by attenuating I/R-induced oxidative stress. Currently, mesenchymal stem cells (MSCs) could restore I/R-injured retina through paracrine secretion. …”
Get full text

Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase by Yu-Lin Yao, Yun Luo, Qi Wang, Rong Geng, Ying Chen, Mei-Qin Liu, Bei Li, Jing Chen, Chun-Guang Wu, Jing-Kun Jia, Jing-Yi Luo, Yan-Tong He, Ting-Ting Jiang, Yan Zhu, Ben Hu, Peng Zhou, Zheng-Li Shi

“…Swine acute diarrhea syndrome coronavirus (SADS-CoV), originating from a bat HKU2-related CoV, causes devastating swine diseases and poses a high risk of spillover to humans. Currently, licensed therapeutics that can prevent potential human outbreaks are unavailable. …”
Get full text

Scientific basis for design low-speed synchronous permanent magnet generators for wind power plants by A. A. Tatevosyan

“…Currently, the development of advanced WPP designs is receiving increased attention around the world. …”
Get full text

Cross-cultural adaption of the Knee injury and Osteoarthritis Outcome Score (KOOS) into Punjabi for knee injury and osteoarthritis patients in Canada by Nitya Suryaprakash, Jackie L. Whittaker, Marie Westby, Richard Sawatzky, Stirling Bryan, Kusum Soni, Kamaljit Sidhu, Santosh Powar, Laurie J. Goldsmith

“…Abstract Background The Knee injury and Osteoarthritis Outcome Score (KOOS) is a knee-specific patient-reported outcome that is used to assess knee-related symptoms, function and quality of life across a variety of knee conditions in patient populations. Currently there is no Punjabi version of the tool available. …”
Get full text

Integrative analysis of saliva-derived exosomal proteome and lipidome for the diagnosis of esophageal squamous cell carcinoma by Wei Zhong, Jian Liu, Junhua Xie, Zhiyan Zhang, Zhiwen Gong, Zhixiang Yan, Qingdong Cao

“…Abstract Background Early diagnosis of esophageal squamous cell carcinoma (ESCC) is crucial for improving patient prognosis. Currently, the diagnosis of ESCC primarily relies on endoscopic biopsy. …”
Get full text

Full recovery over one year of the overlap syndrome scleromyositis to maintenance therapy with mycophenolate mofetil and rituximab, which relapsed within 8 months of discontinuatio... by Inês Amarante, Catarina Faustino, Bruna Mota, Mariana Cascais, Jorge Almeida, Marta Valentim

“…It can carry a poorer prognosis due to multisystem involvement and extramuscular complications, with no consensus on treatment strategies currently available. We report on a 20-year-old woman with a history of recurrent infections over the past year, who presented with persistent myalgias for four months. …”
Get full text

Combination of dry planetary ball milling and Lactobacillus plantarum fermentation improves nutritional and functional value of okara by Jing-Yu Feng, Wang-Wei Zhang, Kiran Thakur, Fei Hu, Jian-Guo Zhang, Zhao-Jun Wei

“…Okara, a soybean by-product, holds significant industrial potential but is currently limited by its unfavorable physicochemical properties. …”
Get full text

Ultrasonographic Study of Gallbladder Wall Thickness and Emptying in Cirrhotic Patients without Gallstones by Massimiliano Loreno, Salvatore Travali, Anna Maria Bucceri, Giuseppe Scalisi, Carla Virgilio, Alfio Brogna

“…Gallbladder wall thickening and impaired contractility are currently reported in cirrhotic patients and often related to portal hypertension and hepatic failure. …”
Get full text

Knowledge, Attitudes, and Perceptions of Wet Cupping Therapy (Hijamah) among the Public in Northern Saudi Arabia: A Cross-sectional Study by Mohamed M Abd El Mawgod, Hassan Mohammad, Nawaf S Alenezi, Omar Mosab M Alenazi, Ashwaq Ibrahim H Alanazi, Taif Saleem Alanazi

“…Introduction: Traditional medicine, particularly cupping therapy (Hijamah), is prevalent in both developed and developing nations, especially in the Kingdom of Saudi Arabia. Currently, it provides numerous health benefits, such as the prevention and treatment of various health problems including headaches, fatigue and bone aches. …”
Get full text

VERY LOW CALORIE DIETS AFFECT LONG TERM WEIGHT LOSS AND HEALTH OUTCOMES: A SYSTEMATIC REVIEW by Sheila Amara Putri, Shintia Yunita Arini, Dominikus Raditya Atmaka, S.Gz, MPH, Ardyanisa Raihan Kusuma, Anisah Firdaus Rahmawati, Mutiara Arsya Wijanarko, Norfezah Md Nor, Nadiatul Syima Mohd Shahid

“…Very low calorie diets (VLCD) are currently gaining popularity to reduce weight, but can lead to inadequate nutrition and potentially negative health consequences. …”
Get full text

Investigation of biomolecular dynamics by sensitivity-enhanced 1H–2H CPMAS NMR using matrix-free dynamic nuclear polarization by Thomas Biedenbänder, Aryana Rodgers, Mirjam Schröder, Liliya Vugmeyster, Björn Corzilius

“…Molecular dynamics of functional groups contain valuable information about structural properties and functional activities in biomolecules. …”
Get full text

Approachable Synthetic Methodologies for Second-Generation <i>β</i>-Lactamase Inhibitors: A Review by Noor Fatima, Shehla Khalid, Nasir Rasool, Muhammad Imran, Bushra Parveen, Aqsa Kanwal, Marius Irimie, Codrut Ioan Ciurea

“…Several combinations are still only used in preclinical or clinical research, although only a few are currently used in clinics. This review comprises materials on the research progress of BLIs over the last five years. …”
Get full text