Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy by Francesco Formaggio, Asia Pizzi, Cecilia Delprete, Davide Pasqualini, Isabella Mataloni, Roberto Rimondini, Ludovica Campolongo, Vincenzo Donadio, Anna Maria Ghelli, Rocco Liguori, Marco Caprini

“…The reduced activity was associated with a decrease of cytosolic pH which weakened the PMCA-dependent calcium extrusion. …”
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An Agent-Based Simulation and Optimization Approach for Sustainable Urban Logistics: A Case Study in Lisbon by Renan Paula Ramos Moreno, Rui Borges Lopes, Ana Luísa Ramos, José Vasconcelos Ferreira, Diogo Correia, Igor Eduardo Santos de Melo

“…This study examines the PDP-TW in an urban logistics context using an integrated approach that combines an agent-based simulation model and an optimization model. …”
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Mapping evidence of spinal manipulation therapy for headaches in South Africa: a scoping review of grey literature by Keseri Padayachy, Ismail Fatima, Morris Kahere, Alister du Rose, Katherine A. Pohlman

“…Abstract Objective Spinal manipulative therapy (SMT) has been demonstrated to be an effective management approach for primary headaches; however, current literature often excludes data from South Africa (SA). …”
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Cost-utility of aripiprazole once-monthly versus paliperidone palmitate once-monthly injectable for schizophrenia in China. by Yiping An, Gang Fang, Zhipeng Pi, Yumeng Zhang, Wei Li, Jinxi Ding

“…A cost-effectiveness threshold (CET) of 0.51 times China's 2023 gross domestic product (GDP) (US$ 6,394.536) was used to judge the economics of intervention.<h4>Results</h4>The current price of AOM in China is relatively high (US$418.140). …”
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“They tossed me up like a ball”: informal settlement residents’ experiences in accessing healthcare in Kampala, Uganda by Julia Dickson-Gomez, Kirsten Beyer, Arthur Kiconco, Ronald Anguzu, Agnes Nyabigambo

“…The focus group interviews indicated that private healthcare systems have created incentives to draw resources away from already depleted public healthcare systems, further decreasing access to the most vulnerable. Conclusions Our study reveals important and substantial gaps in the current healthcare system in Uganda. …”
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Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis. by Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Tian-Song Zhang, Di Zhang, Shi-Qing Feng

“…<h4>Context</h4>The preferred treatment for osteoporosis in men is debated, and pairwise meta-analysis cannot obtain hierarchies of these treatments.…”
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Analysis of Adaptation of Students Studying under the Flipped Classroom Model to the Conditions of Distance Learning by G. R. Chaynikova

“…At the same time, it is necessary to keep in mind the importance of pedagogical support in the context of e-learning.…”
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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…While STING is well-established in various immune cells, its role in natural killer (NK) cells, particularly within the context of liver fibrosis, remains inadequately explored. …”
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Cranberry Leaves as Feed Additive in Poultry Nutrition: Effects on Performance and Oxidative Stability by Arabela Elena Untea, Iulia Varzaru, Mihaela Saracila, Petru Alexandru Vlaicu, Alexandra-Gabriela Oancea, Tatiana Dumitra Panaite

“…The leaves belonging to that species can be considered a cost-effective alternative in the context of reducing antibiotics strategy in animal nutrition. …”
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Beyond the brain: early autonomic dysfunction in Alzheimer’s disease by Carmen Nanclares, Inés Colmena, Alicia Muñoz-Montero, Andrés M. Baraibar, Ricardo de Pascual, Aneta Wojnicz, Ana Ruiz-Nuño, Antonio G. García, Adrián Gironda-Martínez, Luis Gandía

“…These changes were accompanied by diminished sodium (INa), calcium (ICa), and nicotinic (IACh) currents, compromising CC excitability. With age, a shift toward increased potassium (IK) currents and enhanced catecholamine secretion may reflect compensatory adaptations aimed at preserving output. …”
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What type of leadership is more effective for managing change during force majeure? Achieving organizational effectiveness during the pandemic by Nazia Habib, Shaheryar Naveed, Muhammad Mumtaz, Rabia Sultana, Shoaib Akhtar

“…Hence, it was important to identify effective leadership styles to successfully manage the transformational process during the period. Therefore, the current study aims to explore and compare the effectiveness of transformational and ethical leadership (EL) in terms of achieving organizational goals during COVID-19 in public and private sector organizations in Pakistan. …”
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Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. …”
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THE IMPACT OF THE USE OF BIOFUELS ON CO2 EMISSIONS AT THE LEVEL OF EUROPEAN COUNTRIES FROM THE PERSPECTIVE OF ABSOLUTE DECOUPLING by Valentina SIMION, Liviu MARCUTA, Maricel CAZACU, Nicolae MINEA, Camelia HODOAȘAN

“…Decoupling economic growth from CO2 emissions completely is still a key goal of sustainability programs. According to the current research, nations with faster energy transitions and advanced technologies typically see a sharper decoupling, meaning that real GDP growth is attained without a rise in greenhouse gas emissions. …”
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Adverse birth outcome research case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review by Kopano R. Dube, Shani T. de Beer, Kathleen M. Powis, Michael McCaul, Amy L. Slogrove

“…Abstract Background Adverse birth outcomes (preterm birth, low birth weight, small for gestational age, and stillbirth) seem to persist in infants born to people with HIV, even in the context of maternal antiretroviral therapy. However, findings have been disparate, inconclusive, and difficult to compare directly across settings, partly owing to variable outcome definitions. …”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…Preemptive personalized treatment aimed at preventing these events is a crucial objective of patient management; however, the currently available scoring systems provide only moderate guidance. …”
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Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change by LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen

“…The framework can predict land use change and assess water conservation in the context of future climate change and different economic developments. …”
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The impacts of climate variability on conflict risk in conflict-prone regions worldwide by Xiaolan Xie, Fangyu Ding, Mengmeng Hao, Jun Zhuo, Shuai Chen, Jiajie Wu, Jiping Dong, Kai Sun, Qian Wang, Dong Jiang

“…The climate-conflict linkage is a topic of intense debate within the context of security implications. Previous quantitative studies exploring the causal link between climate variability and conflict risk present divergent findings due to the differences in modeling scale or strategies, such as the non-unified definition of conflict risk and the different settings of independent variables. …”
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Compost from the food waste for organic production of cabbage, cauliflower, and radish under sub-tropical conditions by Neha Kumari, Anit Sharma, Mamta Devi, Atif Zargar, Sunny Kumar, Umesh Thakur, Ajay Bhatia, Khushboo Badhan, Sunaina Chandel, Arpana Devi, Kriti Sharma, Shweta Kumari, Mussarat Choudhary, Arup Giri

“…Purpose In the current scenario, food wastage is a significant concern throughout the world. …”
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Comparison of the indirect immunofluorescence assay and a commercial ELISA to detect KSHV antibodies by Valentin Leducq, Léa Ben Said, Sophie Sayon, Vincent Calvez, Anne-Geneviève Marcelin, Aude Jary

“…The current gold-standard method, the indirect immunofluorescence assay (IFA), has a very good specificity of close to 100%, but a lower sensitivity of around 80–85%, which decreases to 64–67% in immunocompromised patients. …”
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Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
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