Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics by Fengxian Du, Huiling Wu, Junwei Xue, Shenglan Yao, Ronghui Li, Jinde Zhang, Haitao Wang, Qi Cheng, Fan Zhao, Ying Huang, Zijian Zhou, Feng Liang, Xiufei Gu, Valery V. Tuchin, Qingliang Zhao

“…Abstract Background Rapid, label-free and depth-resolved imaging of atopic dermatitis (AD) at high resolution has long been a challenge due to current dermoscopes are limited by inadequate resolution, sensitivity and the lack of three-dimensional (3D) imaging capability. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…BackgroundInflammatory bowel disease (IBD) presents unpredictable therapeutic responses and complex immune dysregulation. Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.MethodsWe performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature. …”
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Artificial Intelligence-based Approaches for Characterizing Plaque Components From Intravascular Optical Coherence Tomography Imaging: Integration Into Clinical Decision Support Sy... by Michela Sperti, Camilla Cardaci, Francesco Bruno, Syed Taimoor Hussain Shah, Konstantinos Panagiotopoulos, Karim Kassem, Giuseppe De Nisco, Umberto Morbiducci, Raffaele Piccolo, Francesco Burzotta, Fabrizio D’Ascenzo, Marco Agostino Deriu, Claudio Chiastra

“…While these technologies represent significant progress, current solutions remain limited in the range of plaque features these methods can assess. …”
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Automated sample annotation for diabetes mellitus in healthcare integrated biobanking by Johannes Stolp, Christoph Weber, Danny Ammon, André Scherag, Claudia Fischer, Christof Kloos, Gunter Wolf, P. Christian Schulze, Utz Settmacher, Michael Bauer, Andreas Stallmach, Michael Kiehntopf, Boris Betz

“…The central idea of the current work is to establish an automated workflow for sample annotation, selection and storage for diabetes mellitus. …”
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The most common errors in automatic ECG interpretation by Krzysztof Kraik, Krzysztof Kraik, Irena Anna Dykiert, Irena Anna Dykiert, Joanna Niewiadomska, Joanna Niewiadomska, Marta Ziemer-Szymańska, Karolina Mikołajczak, Karolina Mikołajczak, Mikołaj Kreń, Mikołaj Kreń, Piotr Kukiełka, Piotr Kukiełka, Adrian Martuszewski, Adrian Martuszewski, Tomasz Harych, Rafał Poręba, Paweł Gać, Małgorzata Poręba

“…Future perspectives should include the application of AI in algorithms used in ECG analysis by manufacturers and paying more attention to accessing proper feedback from clinicians to device manufacturers.…”
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Use of a convolutional neural network for direct detection of acid-fast bacilli from clinical specimens by Paul English, Muir J. Morrison, Blaine Mathison, Elizabeth Enrico, Ryan Shean, Brendan O'Fallon, Deven Rupp, Katie Knight, Alexandra Rangel, Jeffrey Gilivary, Amanda Vance, Haleina Hatch, Leo Lin, David P. Ng, Salika M. Shakir

“…By building on our work, researchers can develop better algorithms to improve the diagnosis of AFB, reducing the burden on laboratory staff and improving diagnostic speed and accuracy of these medically important organisms.…”
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Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopula... by Nikolett Gémes, Benedek Rónaszéki, Szabolcs Modok, Zita Borbényi, Imre Földesi, Éva Trucza, Blanka Godza, Zsuzsanna László, Balázs Csernus, László Krenács, Enikő Bagdi, Enikő Szabó, László G. Puskás, László G. Puskás, Valeria Bertagnolo, Gábor J. Szebeni, Gábor J. Szebeni, Gábor J. Szebeni

“…Unsupervised clustering algorithms such as Uniform Manifold Approximation and Projection for Dimension Reduction (UMAP) and Flow cytometry data that builds Self-Organizing Maps (FlowSOM) were used to reveal the LAIP. …”
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A Hierarchical Machine Learning-Based Strategy for Mapping Grassland in Manitoba’s Diverse Ecoregions by Mirmajid Mousavi, James Kobina Mensah Biney, Barbara Kishchuk, Ali Youssef, Marcos R. C. Cordeiro, Glenn Friesen, Douglas Cattani, Mustapha Namous, Nasem Badreldin

“…This study developed a novel pixel-based grassland classification approach using three supervised machine learning (ML) algorithms, which were assessed in the province of Manitoba, Canada. …”
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Identifying low-risk breast cancer patients for axillary biopsy exemption: a multimodal preoperative predictive model by Jiaqi Zhang, Jianing Zhang, Zhihao Liu, Yudong Zhou, Xiaoni Zhao, Yalong Wang, Danni Li, Jinsui Du, Chenglong Duan, Yi Pan, Qi Tian, Feiqian Wang, Ke Wang, Lizhe Zhu, Bin Wang

“…Abstract Background As the most prevalent female malignancy worldwide, breast cancer frequently involves axillary lymph node metastasis (ALNM), which critically affects therapeutic algorithms. Current guidelines mandate preoperative ultrasound-guided axillary biopsy for suspicious lymph nodes, potentially exposing some low-risk patients with negative results to invasive risks. …”
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Evaluation criteria of centralization options in the architecture of multicomputer systems with traps and baits by Antonina Kashtalian, Sergii Lysenko, Anatoliy Sachenko, Bohdan Savenko, Oleg Savenko, Andrii Nicheporuk

“…The analyzed works establish the main types of centralization used in the architecture of systems: centralized, partially centralized, partially decentralized, decentralized. However, algorithms and methods for the transition of systems from one type to another in the process of their functioning are not provided. …”
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Mixed nontuberculous mycobacteria in an immunocompromised patient with progressive multifocal leukoencephalopathy by Dr Christoffel Opperman, Dr Janet Scott, Dr Aliasgar Esmail, Dr Sarishna Singh, Mr Yonas Ghebrekristos, Prof Rob warren, Dr Wynand Goosen

“…Subsequently, management was changed to rifabutin, ethambutol, azithromycin, and isoniazid. During the current admission, he received fluconazole continuation therapy for confirmed Cryptococcus neoformans. …”
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Diagnostic accuracy of artificial intelligence for the screening of prostate cancer in biparametric magnetic resonance imaging: a systematic review by Oksana V. Kryuchkova, Elena V. Schepkina, Natalia A. Rubtsova, Boris Y. Alekseev, Anton I. Kuznetsov, Svetlana V. Epifanova, Elena V. Zarya, Ali E. Talyshinskii

“…Accurate and timely detection of prostate cancer is important under the current conditions. AIM: This systematic review aimed to assess the quality of prediction models designed to detect prostate cancer during initial presentation. …”
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Multi-omic signatures of host response associated with presence, type, and outcome of enterococcal bacteremia by Charlie Bayne, Dominic McGrosso, Concepcion Sanchez, Leigh-Ana Rossitto, Maxwell Patterson, Carlos Gonzalez, Courtney Baus, Cecilia Volk, Haoqi Nina Zhao, Pieter Dorrestein, Victor Nizet, George Sakoulas, David J. Gonzalez, Warren Rose

“…Altogether, this study aims to culminate in the creation of objective risk stratification algorithms—a pivotal step toward enhancing patient management and care. …”
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Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis by Dongchen Li, Dongchen Li, Zhilong Huang, Teng Ma, Yu Su, Yu Su, Zhao Li, Zhao Li, Liang Sun, Ming Li, Zhong Li, Yao Li, Qian Wang, Yao Lu

“…BackgroundNecrosis of the Femoral Head (NFH) represents a challenging orthopedic condition, characterized by elusive early detection and rapid progression, predominantly in the middle-aged demographic. Current research on the pathophysiological and immunoregulatory mechanisms underpinning immune cell infiltration in NFH is sparse. …”
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Application of artificial intelligence in the diagnosis of malignant digestive tract tumors: focusing on opportunities and challenges in endoscopy and pathology by Yinhu Gao, Peizhen Wen, Yuan Liu, Yahuang Sun, Hui Qian, Xin Zhang, Huan Peng, Yanli Gao, Cuiyu Li, Zhangyuan Gu, Huajin Zeng, Zhijun Hong, Weijun Wang, Ronglin Yan, Zunqi Hu, Hongbing Fu

“…The effects and main limitations of AI diagnosis were summarized through comprehensive analysis of research design, algorithmic methods, and experimental results from relevant literature. …”
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CPAP management of COVID-19 respiratory failure: a first quantitative analysis from an inpatient service evaluation by Abdul Ashish, Alison Unsworth, Jane Martindale, Kanishka Kavuri, Luigi Sedda, Martin Farrier

“…A stratified Cox proportional hazard for clustered data (via generalised estimating equations) and model selection algorithms were employed to identify the effect of CPAP on patients’ survival and the effect on gas exchange as measured by alveolar arterial (A-a) gradient and timing of CPAP treatment on CPAP patients’ survival.Results CPAP was found to be significantly (HR 0.38, 95% CI 0.36 to 0.40) associated with lower risk of death in patients with hospital stay equal to, or below 7 days. …”
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Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Anne Dawnay, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs

“…Methods Participants Postmenopausal average-risk women, aged 50–74, with intact ovaries and no previous ovarian or current non-ovarian cancer. Interventions One of two annual screening strategies: (1) multimodal screening (MMS) using a longitudinal CA125 algorithm with repeat CA125 testing and transvaginal scan (TVS) as second line test (2) ultrasound screening (USS) using TVS alone with repeat scan to confirm any abnormality. …”
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Enhancing Sustainable Manufacturing in Industry 4.0: A Zero-Defect Approach Leveraging Effective Dynamic Quality Factors by Rouhollah Khakpour, Ahmad Ebrahimi, Seyed Mohammad Seyed Hosseini

“…The current work aims to present the development of ZDM by focusing on dynamic factors affecting product quality in order to improve sustainability in manufacturing processes in the era of industry 4.0.…”
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3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration by Lincong Luo, Weihan Zheng, Jiaying Li, Tingting Chen, Wanting Xue, Tao Lin, Mingrui Liu, Zi Yan, Jiaxin Yang, Jiamin Li, Jiahao Pu, Yaobin Wu, Konghe Hu, Shiyu Li, Wenhua Huang

“…Abstract Current Ti‐6Al‐4V bone implants lack trabecular structure and pro‑angiogenic cues, both essential for regeneration. …”
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Management and outcome of whole-spine epidural abscesses – institutional case series and systematic review by Erik Schulz, Linda Bättig, Felix C. Stengel, Lorenzo Bertulli, Nader Hejrati, Maximilian Wegener, Carol Strahm, Benjamin Martens, Martin N. Stienen, Stefan Motov

“…Larger multicenter studies are needed to establish reliable treatment algorithms.…”
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