Post-pandemic patient safety: have the characteristics of incidents with harm changed? Comparative observational study in primary care via review of medical records with a trigger... by Gerardo Garzón González, Tamara Alonso Safont, Oscar Aguado Arroyo, Cristina Villanueva Sanz, Arancha Luaces Gayán, Esther Zamarrón Fraile, Juan José Jurado Balbuena, Inmaculada Mediavilla Herrera, Research Team “TriggerPrim®”

“…Conclusions No differences were found in the avoidability, severity, place of occurrence, or contributory factors of PSIHs before the pandemic and currently. In terms of the nature of these incidents, the outcomes revealed an increase in diagnostic errors (excluding diagnostic tests), which could be attributed to a greater frequency of remote consultations and a decrease in the longitudinality of care resulting from the shortage of professionals.…”
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The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo by Meng Wang, Xiaoshan Liang, Keqing Jin, Yinyue Liu, Suhui Luo, Qiang Zhang, Xuan Wang, Zhiping Dong, Xumei zhang

“…However, there is currently a lack of comprehensive understanding regarding the molecular mechanisms underlying Hcy-induced neurotoxicity. …”
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SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 by Hyun-Ju Cho, Joy Smith, Christopher H Switzer, Eleni Louka, Rebecca L Charles, Oleksandra Prysyazhna, Ewald Schroder, Mariana Fernandez-Caggiano, Daniel Simoes de Jesus, Seda Eminaga, Xiaoke Yin, Xiaoping Yang, Steven Lynham, Manuel Mayr, Valle Morales, Katiuscia Bianchi, Vinothini Rajeeve, Pedro R Cutillas, Adam J Mead, Philip Eaton

“…SFX-01, an α-cyclodextrin-stabilized sulforaphane complex currently in clinical development, covalently adducts cysteine residues. …”
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A novel system applying artificial intelligence in the identification of air leak sitesCentral MessagePerspective by Yuka Kadomatsu, MD, PhD, Megumi Nakao, PhD, Harushi Ueno, MD, Shota Nakamura, MD, PhD, Toyofumi Fengshi Chen-Yoshikawa, MD, PhD

“…Intraoperative leak site detection is the first step in decreasing the risk of leak-related postoperative complications. …”
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Accretion of the degenerate Fermi gas onto a Reissner-Nordström black hole by Ping Li, Jiang-he Yang, Siwei Xu

“…The expressions for the particle current density, the stress energy-momentum tensor, and three accretion rates are derived. …”
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Effects of wetting events on mass timber surface microbial communities and VOC emissions: implications for building operation and occupant well-being by Gwynne Á. Mhuireach, Susan Collins, Leslie Dietz, Patrick Finn Horve, Aurélie Laguerre, Dale Northcutt, Jason Stenson, Kevin Van Den Wymelenberg, Elliott Gall, Mark Fretz

“…IntroductionHumans have used wood as a construction material throughout history. Currently, mass timber products, such as cross-laminated timber (CLT), are becoming more popular as a structural material, since they are renewable and have a lower carbon footprint than concrete or steel. …”
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Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma by Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao, Mingbo Cao

“…Functionally, knocking down ACTR6 inhibited cell migration and proliferation, produced a G1 cell cycle arrest, and decreased the viability of liver cancer cells.ConclusionThese findings demonstrate that ACTR6 is highly expressed in HCC and is associated with poor prognosis. …”
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Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity by Valentina Paganini, Andrea Cesari, Silvia Tampucci, Patrizia Chetoni, Susi Burgalassi, Michele Lai, Giulia Sciandrone, Silvia Pizzimenti, Fabio Bellina, Daniela Monti

“…<b>Background/Objectives</b>: Melanoma is a pathology that affects a large part of the population, and the currently available therapies have many limitations, including the selective targeting of the site of action. …”
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Mesenchymal Stem Cell-Derived Small Extracellular Vesicle as A Novel Therapeutic Approach for Chemotherapy-Induced Male Infertility: A Review Article by Maryam Taher, Hanieh Jalali, Homa Mohseni Kouchesfehani, Gholamreza Kaka

“…Several lines of evidence indicate that treatment with sEVs can re­duce testicular tissue damage caused by chemotherapy by decreasing oxidative stress and inflammatory responses. sEVs boost the growth and motility of spermatogenic cells and protect them from apoptosis by activating internal pathways. …”
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Sensitivity Approach for Blood Glucose Impedance Data Using the Geselowitz Theorem by Bruna Gabriela Pedro, John Alexander Gomez Sanchez, Pedro Bertemes-Filho

“…The results demonstrated a sigmoid relationship between blood glucose concentration and conductivity, with impedance decreasing non-linearly as glucose levels increased. …”
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Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023. by Klauss Kleydmann Sabino Garcia, Seyi Soremekun, Amanda Amaral Abrahão, Paola Barbosa Marchesini, Chris Drakeley, Walter Massa Ramalho, André M Siqueira

“…Pf infections remain a persistent challenge to control in the country and may require novel measures for containment. Current government supporting actions towards combating illegal goldmining activities and protecting indigenous populations may help malaria control indicators for the following years.…”
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Role of the Fe₃O₄ mass ratio in Fe₃O₄-Fe nanoparticles with the core-shell structure on their anticancer activity <i>in vitro</i> by O. V. Bakina, A. S. Lozhkomoev, S. O. Kazantsev, A. V. Avgustinovich, S. G. Afanasyev, l. V. Spirina

“…Using the MTT test, it was found that nanoparticles containing 5 wt. Fe3O4, in the presence of which, at a concentration of 1 mg/ml, the number of living cells decreased to 16 % relative to the control. …”
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Monkeypox virus (MPXV) isolation from longitudinal samples of 11 patients to infer risk of onwards transmission by Dr Helen Callaby, Dr Janie Olver, Ms Kirsty Emery, Dr Kevin Richards, Dr Marian Killip, Dr Natalie Groves, Dr Jake Dunning, Professor Malcolm G Semple, Professor J Kenneth Baillie, Dr Tommy Rampling, Dr Catherine F Houlihan

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Immuno‐Nanocomplexes Target Heterogenous Network of Inflammation and Immunity in Myocardial Infarction by Fan Su, Weifan Ye, Yi Shen, Yujie Xie, Chong Zhang, Qianyun Zhang, Zhengqi Tang, Meihua Yu, Yu Chen, Bin He

“…Abstract Despite the proceeds in the management of acute myocardial infarction (AMI), the current therapeutic landscape still suffers from limited success in the clinic. …”
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Analysis of the influence of the microbial load of poultry facilities on the development of keel “mins” in turkeys by R. I. Fedyniak, R. A. Peleno

“…The maximum values of the microbial load were from 60 to 90 days when 1 m3 contained from 5.35 ± 1.20 to 5.41 ± 0.17 lg CFU. From the 91st day until the end of the production cycle, a decrease in the microbial load of poultry houses' air was noted, from 2.5 to 3.9 %. …”
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THE ETHICAL STARTUP? by Alexis Walker

“…Instead, the view proposed here would ask companies to do more to prevent or decrease the risk of a breach of privacy, unexpected later use of data, and reidentification. …”
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The impact of dropouts in scRNAseq dense neighborhood analysis by Alisa Pavel, Manja Gersholm Grønberg, Line H. Clemmensen

“…., cell pairs consistently being in the same cluster) decreases. This implies that sub-populations within cell types are increasingly difficult to identify under increasing dropout rates because observations are not consistently close.Our results challenge the current practice of using default clustering pipelines and the general assumption of identifiable local neighborhoods on high dropout data. …”
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Dietary Erucic Acid Induces Fat Accumulation, Hepatic Oxidative Damage, and Abnormal Lipid Metabolism in Nile Tilapia (Oreochromis niloticus) by Dingfei Ma, Qiangwei Li, Yuanyuan Xie, Youqin Kong, Zhili Ding, Jinyun Ye, Chenglong Wu, Yan Liu

“…Feeding fish with diets containing EA (20 and 27 g/kg diet) significantly increased the malondialdehyde content. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
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Effect of reduced osmolality in glucose-based extenders on the post-thaw motility of Mediterranean brown trout (Salmo cettii) spermatozoa by Aleksandra Krasilnikova, Michele Di Iorio, Emanuele Antenucci, Stefano Esposito, Nicolaia Iaffaldano, Martin Pšenička

“…The current study aimed to compare the effects of decreasing osmolality in glucose-based extenders containing methanol alone versus a methanol-ethylene glycol combination on the post-thaw motility of Mediterranean brown trout (Salmo cettii) spermatozoa. …”
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