Assessing Immunization Coverage and the Negative Impact of Local Vaccine Production Cessation in Ecuador by Esteban Ortiz-Prado, Lissette Carolina Villacreses-Brito, Jorge Vasconez-Gonzalez, Cristina Anabel Jacome, Marlon Arias-Intriago, Juan S. Izquierdo-Condoy

“…For BCG, median coverage decreased from 100% during the production period to 87.8% post-cessation (<i>p</i> < 0.0001). …”
Get full text

Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis by Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang

“…Additionally, JPGS treatment decreased iron overload and oxidative stress levels while upregulating the expression of GPX4 pathway-related proteins. …”
Get full text

Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia by Emily M. Parker, Nathan L. Kindja, Rebecca A. DeGiosio, Ryan B. Salisbury, Josh M. Krivinko, Claire E. J. Cheetham, Matthew L. MacDonald, Weijia Fan, Bin Cheng, Robert A. Sweet

“…Overexpressing the gene that encodes the voltage-gated calcium channel subunit β4, CACNB4, selectively reduced small spine density in vitro. In the current study we extended this observation in an intact mammalian system within a relevant neurodevelopmental context. …”
Get full text

Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance by Elena Jechel, Alin Horatiu Nedelcu, Felicia Dragan, Vasile Valeriu Lupu, Iuliana Magdalena Starcea, Adriana Mocanu, Solange Tamara Rosu, Violeta Streanga, Ruxandra Russu, Ginel Baciu, Ciprian Danielescu, Delia Lidia Salaru, Ionela Daniela Morariu, Olga Cirstea, Emil Anton, Ancuta Lupu

“…The analysis focuses on the molecular mechanisms by which oxidative stress contributes to the progression of renal dysfunction, the role of oxidative biomarkers in disease monitoring, and the ability of antioxidants to reduce the need for immunosuppressants and corticosteroids, thus contributing to the decrease in associated morbidity. The translational perspectives of antioxidant therapy are also discussed, in the context of the urgent need for effective adjuvant strategies with a safety profile superior to conventional therapies. …”
Get full text

HPV DNA screening and vaccination strategies in Tunisia by Anas Lahdhiri, Beya Benzina, Emna Ennaifer, Haifa Tounsi, Ahlem Gzara, Soumaya Rammeh-Rommani, Oumaima Laraj, Heger Arfaoui, Robyn Stuart, Amira Kebir, Slimane BenMiled

“…The scenario combining vaccination and maintaining current screening practices is found to be the most cost-effective for the Tunisian context. …”
Get full text

High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of t... by Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami

“…The recurrence of this variant in the Tunisian cohort led us to suggest that it could be characteristic of the Tunisian population.MethodsIn this context, we conducted the current study which included 8 adults and three children with suspected aHUS and decreased factor I levels, as well as one relative. …”
Get full text

Resolution on the results of the first working meeting of the scientific advisory board «Actual problems of glycemic variability as a new criterion of glycemic control and safety o... by Mikhail B. Antsiferov, Gagik R. Galstyan, Alexey V. Zilov, Alexander Y. Mayorov, Tatyana N. Markova, Nikolay A. Demidov, Olga M. Koteshkova, Dmitry N. Laptev, Alisa V. Vitebskaya

“…The aims of the working meeting were to conduct a comprehensive data analysis of the relationship between GV and hypoglycaemia; to gather and analyse published data and the experience of decrease in GV and improved outcomes of diabetes against the background of different types of insulin therapy; to compare existing methods of glycaemia monitoring and GV assessment and examine their validity and availability in real practice in the context of limited budget and to analyse the informativeness and clinical and prognostic significance of various parameters of GV assessment and to determine their reasonable &lsquo;minimum&rsquo; for a comprehensive assessment of GV as a criterion for evaluating the effectiveness of DM treatment and the predictors of negative diabetes outcomes. …”
Get full text

Latest trends on interplay of autophagy, adipose tissue, and gut microbiota in obesity-related metabolic disorders by Claudette Butoyi, Muhammad Asad Iqbal, Isaac Duah Boateng

“…Purpose of review: This review aims to synthesize current research on the intricate relationships among visceral obesity (VO), autophagy (Atg), gut microbiota, and adipose tissue dysfunction, all of which contribute significantly to insulin resistance (IR) and associated metabolic disorders. …”
Get full text

A comprehensive review of the genetic control of cooking time in dry beans (Phaseolus vulgaris L.) by Hannah R. Jeffery, Marcelo Efrén Murillo‐Quesada, Luis Barboza‐Barquero, Karen Cichy

“…The current evidence suggests that cooking time is increased by genetic factors that decrease the amount of soluble compounds in the cotyledons, including but not limited to 1) genes that increase the abundance of calcium‐binding storage proteins and/or de‐methylesterfied pectins paired with high inter‐ or intra‐cellular calcium levels (higher calcium levels can be caused by reduced levels of phytate) and 2) genes that increase insoluble condensed tannin/lignin content in the cotyledon cell walls. …”
Get full text

Azov-type spits: long-term monitoring of morphodynamics and vegetation in response to changing environment by Oksana Tyshchenko, Volodymyr Tyshchenko, Svitlana Boychenko, Andrii Tarieiev, Vasyl Tkachenko

“…The study provides a complex evaluation of the current anthropogenic impacts on the spits and their vegetation.…”
Get full text

Average nutrient and chlorophyll distributions in the western Mediterranean: RADMED project by María del Carmen García-Martínez, Manuel Vargas-Yáñez, Francina Moya, Rocío Santiago, María Muñoz, Andreas Reul, Teodoro Ramírez, Rosa Balbín

“…An increase of the water column stratification could inhibit winter mixing and reduce the frequency and intensity of convection processes which inject nutrients into the photic layer and are responsible for the ventilation of deep waters. In this context, the long-term monitoring of the Mediterranean waters is a basic task. …”
Get full text

Optimal Decision-Making in a Green Supply Chain Duopoly: A Comparative Analysis of Subsidy Strategies with Data-Driven Marketing by Yao Yao, Shaoqing Geng, Jianhui Chen, Feng Shen, Huajun Tang

“…In the current context of severe environmental challenges and climate change, the low-carbon green development model has become an international consensus. …”
Get full text

INTERNATIONAL EXPERIENCE AND TRENDS OF INNOVATIVE DEVELOPMENT OF ARCTIC TERRITORIES by M. Dudin, N. Ivashchenko

“…This approach is fundamentally fl awed and fraught with a number of threats, because other countries do not decrease, but only increase their interest in this issue; Territorial opposition to all those involved in the topic of causing instability in the Arctic region, but does not represent a real threat for the emergence of large-scale conflict. …”
Get full text

Quantitative dynamics of neural uncertainty in sensory processing and decision-making during discriminative learning by Soonho Shin, Joonsu Oh, Sun Kwang Kim, Yong-Seok Lee, Sang Jeong Kim

“…Our model shows that the neural representation of fS1 encodes uncertainties not only from vibratory stimuli but also from decision-making processes, emphasizing its crucial role across various biological contexts. We confirmed that uncertainty decreases as learning progresses and increases with interruptions in learning. …”
Get full text

Impact of Abiotic Stress-Reducing Cultivation Technologies and Long-Term Storage on the Oxidative Potential of Edible Potato Tubers (<i>Solanum tuberosum</i> L.) by Jarosław Pobereżny, Elżbieta Wszelaczyńska, Jarosław Chmielewski, Barbara Gworek, Wiesław Szulc, Beata Rutkowska, Joanna Korczyk-Szabó

“…Currently, in the context of the emphasis on introducing a reduction in mineral fertilization and the increase in pressure on sustainable agriculture, magnesium fertilization and the use of biostimulants are becoming an alternative tool to increase the quality of potato tuber yield. …”
Get full text

Morphological features of the poultry thymus by S. V. Huralska, N. V. Dyshliuk, S. S. Zaika, H. P. Hryshchuk, L. H. Yevtukh

“…In this context, there is a change in the ratio of cortical and cerebral substances, the growth of connective tissue stroma and adipose tissue. …”
Get full text

Administrator Turnover: The Roles of District Support, Safety, Anxiety, and Violence from Students by Andrew H. Perry, Linda A. Reddy, Andrew Martinez, Susan D. McMahon, Eric M. Anderman, Ron A. Astor, Dorothy L. Espelage, Frank C. Worrell, Taylor Swenski, Kailyn Bare, Christopher M. Dudek, Jared Hunt, Adriana I. Martinez Calvit, Hyun Ji Lee, Xi Liu

“…Findings highlight the importance of district support of administrators for reducing mental health concerns and transfer/quit intentions in the context of student violence against school administrators. …”
Get full text

Continuing the continuous harvests of food production: from the perspective of the interrelationships among cultivated land quantity, quality, and grain yield by Peng Cheng, Yang Zhang, Ke Liu, Xuesong Kong, Shiman Wu, Huafei Yan, Ping Jiang

“…This successive increase in food production in the context of decreasing acreage and ecological deterioration of CL depend mainly on the amount of chemical fertilizer usage, the total power of agricultural machinery and rural electricity consumption. …”
Get full text

Cognitive Outcomes and Functional Performance for Patients After Open Heart Surgery by Mona A. Hassenien, Sahar Y Mohammad, Dalia A. Ameen

“… Context: Open heart surgery is a lifesaving procedure for patients who need coronary artery bypass graft (CABG) and heart valve replacement or repair (HVR). …”
Get full text

Illuminating Bilateral Breast Cancer: A Multicenter Experience and Clinical Observations by Berkan Karabuğa, Mustafa Büyükkör, Ekin Konca Karabuğa, Sedat Yıldız, Mirmehdi Mehtiyev, Havva Yeşil Çınkır, Sıla Soylu Koçoğlu, Hacer Demir, Ozan Yazıcı, Doğan Uncu, Ömür Berna Öksüzoğlu, Ülkü Yalçıntaş Arslan

“…In multivariate regression analysis, hormone receptor negativity was identified as an independent risk factor for decreased DFS among all BBC patients. Our study is noteworthy for shedding light on the clinical features of BBC in the context of current knowledge and for its multicenter design.…”
Get full text