Impact on alcohol selection and online purchasing of changing the proportion of available non-alcoholic versus alcoholic drinks: A randomised controlled trial. by Natasha Clarke, Anna K M Blackwell, Jennifer Ferrar, Katie De-Loyde, Mark A Pilling, Marcus R Munafò, Theresa M Marteau, Gareth J Hollands

“…<h4>Background</h4>Increasing the availability of non-alcoholic options is a promising population-level intervention to reduce alcohol consumption, currently unassessed in naturalistic settings. …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

“…Finally, we speculate about the values and ethics of climate science and the nature of climate research in a world that will be increasingly affected by global warming in a geopolitical context very different from that of recent decades.…”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…General practitioners currently have no easily available assessment tools to diagnose lower urinary tract symptom causes. …”
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Prevalence and associated factors of tuberculosis among diabetic patients attending public health facilities in Ethiopia: a multicenter study by Ayinalem Alemu, Getachew Seid, Getu Diriba, Michael Hailu, Biniyam Dange, Shewki Moga, Daniel Melese, Gemechu Tadesse, Solomon H Mariam, Nega Berhe, Balako Gumi

“…Abstract Background Individuals with diabetes mellitus (DM) have high tuberculosis (TB) prevalence. Currently, the incidence of DM is increasing in low and middle-income countries including Ethiopia where TB is also endemic, which may complicate TB prevention and control efforts. …”
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NECROSIS AS A COMPLICATION OF LOCAL ANESTHESIA IN DENTISTRY by V.V. Lepsky, C. V. Osik

“…The most safe adrenaline hydrochloride 0.1% solution. In this context, the aim of our study was to investigate the causes of tissue necrosis, as complications of local anesthesia and the development of preventive measures. …”
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A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies by Gunn E. Vist, Heather M. R. Ames, Gro H. Mathisen, Trine Husøy, Camilla Svendsen, Anna Beronius, Emma Di Consiglio, Ingrid L. Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Paul Whaley

“…Context In vitro toxicology studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. …”
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Role of NLRP3 Inflammasome in Heart Failure Patients Undergoing Cardiac Surgery as a Potential Determinant of Postoperative Atrial Fibrillation and Remodeling: Is SGLT2 Cotransport... by Rodrigo L. Castillo, Jorge Farías, Cristian Sandoval, Alejandro González-Candia, Esteban Figueroa, Mauricio Quezada, Gonzalo Cruz, Paola Llanos, Gonzalo Jorquera, Sawa Kostin, Rodrigo Carrasco

“…In heart failure (HF) patients undergoing cardiac surgery, an increased activity of mechanisms related to cardiac remodeling may determine a higher risk of postoperative atrial fibrillation (POAF). …”
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Artificial intelligence in Anatomy: Potential uses and challenges by Lubna Faisal

“…One more example of AI in anatomy teaching is ChatGPT. No doubt it increases students’ engagement, and ability to learn and has strong text analysis. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…Recommendation for Simultaneous Allograft Listing Ethical research design calls for assessments of which vulnerabilities and in which contexts researchers and IRBs ought to offer additional safeguards. …”
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Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…To explore practical aspects of implementing this de-labelling programme in secondary care by investigating factors, such as organisational context, treatment pathway, protocol implementation, time taken and resources. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Support for the diversity of carers of eating disorders (fathers, partners, siblings) in different cultural contexts across the spectrum of eating disorders The current model of carers support is designed for parents (particularly mothers) of white, highly educated patients with AN. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…ObjectiveWithin human – environment systems, river basins constitute the earliest geographical units of human activity and currently represent the most critical zones of strained human – environment interactions. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…In particular, we investigate three questions regarding the performance of the sequential models compared to the non-sequential models in the context of spatial upscaling: (a) whether they lead to more realistic and robust global and regional ET, (b) whether they are able to capture the temporal dynamics of ET better, and (c) how robust they are to the covariate setup and training data subsets.…”
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Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…Given this context, the central question guiding the present research was this: What are the drivers and future scenarios of power relations in Tehran Metropolis? …”
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Regulatory culture and architectural project by Mario Losasso

“…They are attentive to a quality that does not depend on construction solutions or on techno-typological, morphological or physical-chemical characteristics, but which is linked to a system of needs to be satisfied, the outcome of the interaction between construction and cultural, socio-economic and environmental context. Today’s regulatory landscape has expanded, increasing sensitivities to environmental challenges, health and the qualities of living space. …”
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A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses by Roxanne Fouillé, Eloi R. Verrier, Amse De Meyer, Lieven Verhoye, Maud Michelet, Romain Barnault, Caroline Pons, Olivier Diaz, Michel Rivoire, Guillaume Passot, Eike Steinmann, Heiner Wedemeyer, Anna Salvetti, Nicole Pavio, Virginie Doceul, Raphaël Darteil, Philip Meuleman, David Durantel, Julie Lucifora

“…Using HEV-infected HuHep mice, we confirmed the antiviral effect of vonafexor, an FXR agonist, that is currently being tested clinically against HBV/HDV. …”
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A Legal Analysis of Liability for the Loss of the Subject Matter of Sale after Contract Termination: A New Inquiry into Sunni Jurisprudence by Mohammad Hossein Taghipour Darzi Naghibi, Umm al-Banin Ramzan Zadeh, Mostafa Firoozi Rad

“…Determining who bears the liability for this loss becomes a contentious issue: should it be the party currently in possession or the rightful owner awaiting the return? …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…This research aimed to understand if increased involvement of older people in their care in hospital would improve the safety and experience of care transitions. …”
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