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Depolymerization of tubulin as the main molecular mechanism of the cytotoxic and antitumor activity of pyrrole-containing heterocyclic compounds
Published 2024-06-01“…Thus, development of novel compounds selectively targeting tubulin and effectively overcoming multiple drugresistance phenotype in cancer is an urgent need in current oncology. Aim. To examine the cytotoxic and antitumor activities of several pyrrole-containing heterocyclic compounds (EPC-91, EPC-92 and PCA-93) against cancer cell lines with epithelial and mesenchymal origin, including those with multiple drug resistance phenotype. …”
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82
Optimization of Film-Dressings Containing Herbal Extracts for Wound Care—A Quality by Design Approach
Published 2025-04-01“…All the selected ingredients were biodegradable, aligning with the current need for a natural approach, based on their biocompatibility and reduced environmental impact. …”
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83
Antihypertensive Property of Celery: A Narrative Review on Current Knowledge
Published 2024-01-01“…Despite the availability of hypotensive drugs, they have many side effects that decrease adherence to treatments and lead to uncontrolled blood pressure. …”
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84
Bismuth-containing drugs in clinical practice in the XXI century - history or a new round of possibilities?
Published 2024-09-01“…The addition of bismuth tripotassium dicitrate to triple regimens containing clarithromycin, levofloxacin, metronidazole allows to increase the effectiveness of eradication by more than 92% with a 14-day course of use. …”
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85
Strategic fertilizer placement in containers influences liverwort (Marchantia polymorpha) growth, reproduction, and competitiveness with ornamentals
Published 2025-01-01“…One week after planting the ornamentals and gemmae application, liverwort was thinned to contain 0, 3, or 9 gemmalings per container. The percent increase in growth index of the ornamental plants, and the fresh mass of liverwort and ornamental plants were recorded at the end of the experiment. …”
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EFFECTS OF THE LITHIUM – CONTAINING SORBENT ON TERMS OF BEHAVIORAL REACTIONS UNDER CHRONIC ALCOHOL INTOXICATION MODEL
Published 2016-03-01“…It was found that the investigated lithium-containing sorbent increases: the number of mice are trained passive avoidance reflex, remembering percent of electric shock animals compared to the negative control , and – the duration of the latent time of immobility in comparison with the negative control.Conclusion. …”
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87
The influence of tuition increase on the desirability of the nursing program at Medical university – Plovdiv
Published 2018-06-01“…Objective: The aim of the study is to determine how an increase in tuition can change the positive outcome of the sacrifice-gain assessment among nursing students at Medical University – Plovdiv. …”
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88
Lipoprotein(a) and thromboembolism: current state of knowledge and unsolved issues
Published 2024-12-01“…Lipoprotein(a) [Lp(a)], a low-density lipoprotein-like particle containing a highly polymorphic apolipoprotein(a) [apo(a)] homologous in > 80% to plasminogen, was identified as a genetically determined independent risk factor for cardiovascular disease. …”
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Routine Testing–Oriented Method for Evaluating Inductive Current Transformers Accuracy Under Harmonic Distortion, Based on Maximum Current Error and Phase Displacement
Published 2025-01-01“…However, for accuracy class evaluation they are correctly represented by distorted waveform containing main component and single higher harmonics the maximum values of current error and phase displacement are determined. …”
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92
Shear Behavior of High-Strength and Lightweight Cementitious Composites Containing Hollow Glass Microspheres and Carbon Nanotubes
Published 2024-09-01“…Furthermore, the difference in the shear capacity of the HSC and HS-LWCC beams slightly decreased as the shear reinforcement ratio increased. …”
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93
A review on current and future advancements for commercialized microalgae species
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94
Current situation and prospect of coal mine water treatment technology
Published 2024-09-01“…The majority of mine water contained a significant amount of suspended solids, with considerable fluctuations in both water quality and quantity. …”
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95
Influence of Barrier Width on QWIP Operating Voltage
Published 2024-09-01“…Reduction in the barrier thickness is capable of shifting the peak of photosensitivity towards the region of lower bias voltages with a slight increase in the dark current values.Conclusion. The study of the influence of the applied bias voltage presents both scientific and practical interest. …”
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96
The clinical significance of and prospects for the use of biopolymer-based microheterogeneous collagen-containing injectable hydrogel in the therapy of osteoarthritis
Published 2020-11-01“…Extended-release symptomatic agents, Sphero®gel among them, are currently recommended for the treatment of OA. Application of Sphero®gel contributes to increased joint mobility and reduced pain, which allows the limited use of nonsteroidal anti-inflammatory drugs that cause adverse reactions, especially in the presence of comorbid diseases.…”
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97
Certain features of using modified collagen-containing raw materials with prolonged shelf life in food technology
Published 2022-04-01“…In the current circumstances, trends in nutrition of a person striving to lead a healthy life-style require intake of meat products with the reduced energy value, minimal amounts of fat, increased protein mass fraction, presence of substances improving homeostasis of the body. …”
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98
Macro-Micro Testing-Based Study on the Physical and Mechanical Properties of Cohesive Soil Containing Calcareous Nodules
Published 2025-01-01“…Under the same confining pressure, the shear strength of CSCN sample initially decreases and then increases with the increase in calcareous nodule particle size. …”
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Research Progress in the Effects of Sulfur-Containing Amino Acids on Metabolic Health and a Review of the Methods for Their Detection
Published 2025-06-01“…Sulfur-containing amino acids (SAA), primarily including methionine, cysteine and cystine, are abundant in foods and play important roles in maintaining metabolic health. …”
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ANALYSIS OF THE USE OF SPACE AND MODULE-CONFIGURED PACKAGING TO IMPROVE FRUIT EXPORT MASS IN A REFRIGERATED CONTAINER
Published 2019-05-01“…This paper analyses the current potential for increasing the mass of stone and pome fruit that is exported in reefer containers. …”
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