A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain by Sarah Nickolls, Hannah Mace, Rebecca Fish, Michelle Edye, Rachel Gurrell, Magnus Ivarsson, Tom Pitcher, Sachi Tanimoto-Mori, Denise Richardson, Catherine Sweatman, Janet Nicholson, Cameron Ward, John Jinks, Christine Bell, Kimberly Young, Huw Rees, Andrew Moss, Ross Kinloch, Gordon McMurray

“…GABAA receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. …”
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Monitoring Welfare of Individual Broiler Chickens Using Ultra-Wideband and Inertial Measurement Unit Wearables by Imad Khan, Daniel Peralta, Jaron Fontaine, Patricia Soster de Carvalho, Ana Martos Martinez-Caja, Gunther Antonissen, Frank Tuyttens, Eli De Poorter

“…Monitoring animal welfare on farms and in research settings is attracting increasing interest, both for ethical reasons and for improving productivity through the early detection of stress or diseases. …”
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Image-based honey bee larval viral and bacterial diagnosis using machine learning by Duan C. Copeland, Brendon M. Mott, Oliver L. Kortenkamp, Robert J. Erickson, Nathan O. Allen, Kirk E. Anderson

“…When tested on an independent dataset from Illinois containing additional viral pathogens not present in training data, the models showed higher accuracy for EFB (72–88%) than viral infections (28–68%), highlighting both the promise and current limitations of this approach. …”
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An explainable AI-driven deep neural network for accurate breast cancer detection from histopathological and ultrasound images by Md. Romzan Alom, Fahmid Al Farid, Muhammad Aminur Rahaman, Anichur Rahman, Tanoy Debnath, Abu Saleh Musa Miah, Sarina Mansor

“…While deep learning has demonstrated potential, many current models struggle with limited accuracy and lack of interpretability. …”
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High dynamic range capillary electrophoresis method for sensitive detection of low-frequency driver mutations by Nobue Tamamura, Yoshihiko Hagiwara, Hirokazu Kato, Yusuke Ono, Kenji Takahashi, Kazuya Koyama, Hiroki Sato, Tetsuhiro Okada, Hidemasa Kawabata, Yu Ohtaki, Chiho Maeda, Miyuki Mori, Shin-ichi Chiba, Mishie Tanino, Kenzui Taniue, Takashi Anazawa, Ryoji Inaba, Yusuke Mizukami

“…Abstract Cancer genomics aims to personalize treatments by identifying genetic abnormalities in cancer cells. However, current analytical techniques face limitations in simplicity and cost-effectiveness. …”
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Pharmacological correction of hepatotoxicity induced by anti-tuberculosis drugs by D. S. Sukhanov, E. V. Timofeev, Y. S. Alekseeva, K. A. Nagornova

“…Hepatoprotective drugs of various origin and chemical composition are used for the correction and prevention of drug-induced liver injury. Currently, preparations of plant origin (from milk thistle, licorice, soy), animal origin, preparations of bile acids, and some others are isolated. …”
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Hybrid surface layers with antibacterial and anti-inflammatory activity for implants materials by Mariia A. Piatkova, Konstantine V. Nadaraia, Arina I. Ponomarenko, Igor V. Manzhulo, Mariia S. Gerasimenko, Arina I. Pleshkova, Evgeny A. Belov, Igor M. Imshinetskiy, Ksenia A. Fomenko, Ivan S. Osmushko, Aleksey G. Kozlov, Sergey V. Gnedenkov, Dmitry V. Mashtalyar

“…Currently, there is an essential need for bioresorbable bone implants with antibacterial, anti-inflammatory properties as well as osteoinductivity. …”
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Gene Editing Anxiety by Angelo Osofsky

“…Health and Genetic Risks of Germline Editing Editing the human germline to prevent psychiatric disorders poses serious health risks to individuals. Currently, scientists warn that genetically altering the human genome can result in off-target mutations that increase the risk of disease. …”
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Research hotspots and trends in the application of diffusion tensor imaging in ischemic stroke: a bibliometric analysis (2003–2024) by Xu Chen, Xu Chen, Meifang Liu, Xiaolin Yang, Mengqi Yue, Haocheng Yu, Haiqiang Wang, Zirong Wang, Jing Shi, Jing Shi, Yong Qiu

“…The number of DTI-related publications in IS has been increasing year by year. The three primary publishing nations are the United States, China, and the United Kingdom. …”
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Why non-aureus Staphylococcus (NAS) isolated from bovine milk should be a concern for the rise of superbugs by Bruna Lourenço Crippa, Rafaela da Silva Rodrigues, Rafaela de Melo Tavares, Rafaela Martins Morasi, Jaqueline Milagres de Almeida, Ricardo Seiti Yamatogi, Nathália Cristina Cirone Silva

“…Non-aureus Staphylococci (NAS) are most often reported as a group, but there are currently over 70 recognized species. Some species are becoming increasingly antibiotic-resistant, mainly by acquiring resistance genes. …”
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Combined single- and dual-energy CT workflow for dose calculation in radiotherapy by Hella Sand, Jens Edmund, Ane Appelt, Patrick Wohlfahrt, Vicki Trier Taasti, Laurids Østergaard Poulsen, Jimmi Søndergaard, Martin Skovmos Nielsen

“…Background and purpose: Dual-energy computed tomography (DECT) is increasingly used in radiotherapy delineation due to its enhanced soft tissue contrast. …”
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Highly sensitive multiplex PCR for convenient quantification and differentiation of canine Oomycota pathogens: Pythium insidiosum, Lagenidium giganteum f. caninum, and Paralagenidi... by Asfiha Tarannum, Subarna Barua, Leonel Mendoza, Raquel Vilela, Priscilla Barger, Terri Hathcock, Amelia White, Kelly Chenoweth, Chengming Wang

“…ABSTRACT Oomycota mammalian pathogens, including Pythium (P.) insidiosum, Lagenidium (L.) giganteum f. caninum, and Paralagenidium (Para.) karlingii, are increasingly recognized as causes of life-threatening infections in dogs, with diagnosis complicated by their clinical and phenotypic resemblance to fungal pathogens. …”
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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

“…Abstract Globally the current research is going for cancer disease management by different strategies as frequency and severity of this disease are increasing day by day. …”
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Assessment of Nurse's Health Promotion of Their Lifestyles at Al-Kut City Hospitals, Iraq by Ammar A. Okab

“…Poor lifestyle choices lead to chronic diseases or even death. It increases healthcare costs in a time of economic downsizing. …”
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Features of “Inverted” Educational Resources for Distance Learning of Pupils by D. A. Barkhatova, A. L. Simonova, P. S. Lomasko, L. B. Khegay

“…The main idea behind the development of such tools is that the “inverted” learning resources, on the one hand, implement a non-linear approach to the implementation of learning activities in accordance with the individual characteristics of a particular student (the current level of training, knowledge gaps, specific interests and difficulties), with the other - they create conditions for the initial systematization and complex internalization of the acquired knowledge and methods of action, contain a “cognitive challenge” aimed at increasing educational motivation through the implementation of mechanisms of formative self-control at the initial stage. …”
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Using the Smath Computer Package in School Mathematics Lessons by Valery F. Ochkov, Inna E. Vasileva, Yuliya V. Shatskikh

“…Numerous examples of the graphical capabilities of the package implemented directly by students are given. This significantly increases the awareness and clarity of perception of the material by schoolchildren. …”
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Shaping the future of nanotechnology: a perspective on education, dissemination and ethics by Jordi Díaz-Marcos, Jordi Díaz-Marcos, Joan Mendoza Gonzálvez

“…We analyze the available tools and highlight the current state of nanodissemination through a comprehensive review of mature and successful dissemination initiatives in nanosciences and nanotechnologies. …”
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A novel proof of concept approach towards generating reference microplastic particles by Simon D.J. Oster, Paul E. Bräumer, Daniel Wagner, Max Rösch, Martina Fried, Vinay K.B. Narayana, Eva Hausinger, Helena Metko, Eva C. Vizsolyi, Matthias Schott, Christian Laforsch, Martin G.J. Löder

“…Abstract For almost two decades now, scientists have increasingly focused on the occurrence of microplastic particles (MPs) in the environment and their impact on environmental and human health. …”
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Research progress on the control of reactive elements in remelted ingots during the electroslag remelting process by Shengchao DUAN, Lifeng ZHANG

“…Additionally, the physical parameters of the slag system play a crucial role in determining the surface quality and solidification characteristics of the ingots. Current research on the physical parameters of remelting slag systems containing TiO2, SiO2, B2O3, and rare earth oxides has primarily focused on viscosity and crystallization behavior. …”
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Digital Fire and Salvage Unit: A New Level of Training for Emercom Cadets by Igor A. Malyj, Vladislav V. Bulgakov, Irina Yu. Sharabanova

“…The practical training of cadets currently being implemented on the basis of the fire and rescue training unit has a time-limited training format, in the form of a day on duty in three days, which does not allow without the widespread use of digital technologies to increase the level of organization of the educational process and its effectiveness, for example, by ensuring constant access of trainees to educational materials.Materials and methods. …”
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