Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…We created tumor maps and derived plots showing the fraction of CD4 and CD8 T cells against the distance to the nearest vessel and oxygen pressure. …”
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Cohort profile: Understanding the influence of early life environments and health and social service system contacts over time and across generations through the Western Australian... by Alex Brown, Sarah E Johnson, Peter Richmond, Peter Azzopardi, Stephen R Zubrick, Melissa O'Donnell, Juli Coffin, Asha C Bowen, Jenny Downs, Elizabeth A Davis, Hayley M Passmore, Heather A D'Antoine, Helen Milroy, Glenn Pearson, Francis Mitrou, Sharynne L Hamilton, Christopher G Brennan-Jones, Stefanie Schurer, Katherine M Conigrave, Matthew M Cooper, Kathryn A Ramsey, Anna Ferrante, Leah Cave, Philip Vlaskovsky, Katrina D Hopkins, Ted Wilkes

“…Child health outcomes for the WAACHS children (Cohort 1) are described from birth into adulthood along with other outcomes including child protection and juvenile justice involvement.Future plans Analysis of data from both the child and carer cohorts will seek to understand the contribution of individual, family (intergenerational) and community-level influences on Aboriginal children’s developmental and health pathways, identify key developmental transitions or turning points where interventions may be most effective in improving outcomes, and compare service pathways for Aboriginal and non-Aboriginal children. …”
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Case Reports: The core of practice-based evidence by Antonio Villa

“…Case reports are particularly useful to: 1) recognize rare or uncommon clinical presentation of common diseases or clinical features of rare illnesses; 2) identify new diseases; and 3) establish the cost-effectiveness of medical treatments [2]. Furthermore, a case report is often the most important source of information on adverse effects following therapies. …”
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PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging by Kim EK, Hong SE, Choi YS, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Hwang WM, Yun SR, Park Y, Park MH, Lee J, Yoon KR, Lerman LO, Yoon SH

“…For the in vivo experiment, PEG-CZNPs were administered intraperitoneally at a dose of 10 mg/kg (2 mL/kg), twice per week, with normal saline used as the vehicle control. Biochemical analysis, histological staining, and immunohistochemistry were performed on the liver, kidney and adipose tissue of the mice at 12 and 24 weeks after initiating the HFD.Results: PEG-CZNPs successfully reduced lipid droplet accumulation palmitate-treated HK-2 cells by effectively restoring impaired autophagy flux. …”
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Ambiguous results of balloon angioplasty for central vein stenosis in hemodialysis patients with native arteriovenous fistula by Z. B. Kardanakhishvili, A. B. Zulkarnaev, B. V. Baykov, V. A. Stepanov

“…Objective: to conduct comprehensive comparative analysis of the patency rate of native arteriovenous fistula (AVF) for central vein stenosis (CVS) after endovascular balloon angioplasty and palliative surgery. …”
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Utilizing tumor deposit count as a stratification criterion in revising TNM staging system for patients with colorectal cancer: a nomogram review study by Lifei Zhang, Lifei Zhang, Yunna Ma, Jiantao Dong, Jiantao Dong, Jianhui Cai, Jianhui Cai, Jianhui Cai, Jianhui Cai

“…Using the Cox proportional hazards model, univariate and multivariate analyses were performed to identify significant factors in the revised TNM staging system. A nomogram was then created. The C-index, calibration plots, and receiver operating characteristic (ROC) curve were used to verify the model’s accuracy.ResultsA total of 60,145 patients who satisfied all inclusion requirements were ultimately included in the datasets for analysis. …”
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Development and validation of scales measuring self-efficacy and behavioral capability in managing common medical emergencies in dental clinics by Yasmine N. Alawaji, Hussam M. Alqahtani, Abdulmohsen Alfadley, Aram Alshehri, Ali Aboalela, Sahr H. Altuwaijri, Farraj Albalawi, Sara A. Kalagi, Abdulrhman Alghamdi, Abdullah Alshibani, Meshal Alharbi, Meshary Binhotan, Nesrin A. Alharthy

“…Methods Two newly created 13-item self-efficacy and 19-item behavioral capability were validated for their construct validity and psychometric properties. …”
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The Trend of Residential-Livelihood Changes in Nomadic Ecosystems with Environmental Sustainability Approach (Case Study: Farsimadan Tribe Ecosystem, Fars Province) by Siamak Tahmasbi, Seyed Ali Badri, Mohammad Reza Rezvani

“…The data were collected from snowball sampling technique and interview with 12 people reached theoretical saturation to understand the changing of effective mechanism in residential- Livelihood patterns. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…More research is needed on how approaches shown to be effective in other settings such as mental health could be tailored for people with learning disability. …”
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Global digital elevation model (GDEM) product generation by correcting ASTER GDEM elevation with ICESat-2 altimeter data by B. Li, B. Li, B. Li, B. Li, H. Xie, H. Xie, S. Liu, Z. Ye, Z. Hong, Q. Weng, Q. Weng, Q. Weng, Y. Sun, Q. Xu, X. Tong

“…The results from the validation comparison show that the elevation accuracy of IC2-GDEM is evidently superior to that of the ASTER GDEM product: (1) the RMSE reduction ratio of the corrected GDEM elevation is between 16 % and 82 %, and the average reduction ratio is about 47 %; and (2) from the analysis of the different topographies and land covers, this error reduction is effective even in areas with high topographic relief (<span class="inline-formula">&gt;15<i>°</i></span>) and high vegetation cover (<span class="inline-formula">&gt;60 %</span>). …”
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Intelligent Environmental Health Risk Assessment System for the Elderly in Cold Regions Based on Artificial Intelligence Integrated Development Environment by Tianheng ZHANG, Yao FU, Jian GAO, Huanran XUE

“…The activity area demonstrates intermediate effects with non-significant SBP changes (±1.5 mmHg) and slight mood improvements. …”
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THE ROLE OF THE HUMANITIES AND SOCIAL SCIENCES IN HIGHER EDUCATION: INTERNATIONAL EXPERIENCE by N. Kliuchkovska

“…It is proved that it creates an atmosphere of increased interest concerning the choice of subjects for high school curriculum and shaping their content in order to achieve the desired and effective ability, capable to solve problems while educating new generations. …”
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A novel self-assembling peptide nanofiber hydrogel with glucagon-like peptide-1 functionality enhances islet survival to improve islet transplantation outcome in diabetes treatment by Xiangheng Cai, Mengnan Zhang, Jiaqi Zou, Le Wang, Yixiang Zhan, Dandan Li, Tingsheng Jiang, Nijat Alim, Zhaoce Liu, Jiuxia Yang, Na Liu, Tengli Liu, Peng Sun, Xuejie Ding, Boya Zhang, Zewen Liu, Xuelian Wang, Rui Liang, Jinzhen Cai, Jie Gao, Jinglin Cao, Shusen Wang

“…Bulk RNA sequencing results demonstrate that the hydrogel suppresses the expression of hypoxia-related genes, downregulates pro-inflammatory genes, and upregulates genes associated with islet function. Further analysis reveals that these effects are related to the activation of the AKT signaling pathway. …”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Among these, group dynamics and team spirit, success motivation and talent assessment and completion of talent banks of employees, documentation and continuity in learning, creating motivation and success among employees with a weighted average of 4.9 are among the most important factors identified.ConclusionThe current research was conducted with the aim of the effective factors on the design of the management dashboard framework with an emphasis on the components of human resources productivity. …”
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THE ETHICAL STARTUP? by Alexis Walker

“…But even companies that think carefully about these dynamics face challenges as they create technologies for a future that is difficult to anticipate. …”
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Beyond clinical trials: CDK4/6 inhibitor efficacy predictors and nomogram model from real‐world evidence in metastatic breast cancer by Binliang Liu, Zhe‐Yu Hu, Ning Xie, Liping Liu, Jing Li, Xiaohong Yang, Huawu Xiao, Xuran Zhao, Can Tian, Hui Wu, Jun Lu, Jianxiang Gao, Xuming Hu, Min Cao, Zhengrong Shui, Yu Tang, Quchang Ouyang

“…It is crucial to evaluate the actual effectiveness and safety of CDK4/6i in clinical practice, as well as to analyze the factors that can predict their outcomes. …”
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Evolving Cultural Experience of Historical Places: From Livability to Visibility (A Case Study of Naqsh-e Jahan Square in Isfahan) by Seyed Mahdi Etemadifard, Amirmohammad Niroumand

“…However, the changes observed in the rhythm and quality of presence within Naqsh-e Jahan Square in a two-way interaction with the subjects present had led to further transformations in relation to the city and even national elements.Whereas the visual beauty of the square was previously effective in creating and sustaining other meanings, this research suggested that the possibilities of the square were now arranged primarily to enable an appropriate visual experience. …”
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A Localized Evaluation of Surface Water Quality Using GIS-Based Water Quality Index along Satpara Watershed Skardu Baltistan, Pakistan by Ali Muhammad, Donghui Shangguan, Ghulam Rasool, Amjad Ali Khan, Asim Qayyum Butt, Ayesha Hussain, Muhammad Ahsan Mukhtar

“…The water quality index (WQI) was integrated with the Geographic Information System (GIS) to spatially envision and examine water quality data to facilitate the identification of pollution hotspots, trend analysis, and knowledge-based decision-making for effective water resource management. …”
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Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration by Enxu Liu, Enxu Liu, Yu Sun, Yu Sun, Lei Yang, Lei Yang, Haobo Jiang, Haobo Jiang, Fei Sun, Long Chen, Jiahao Duan, Jiahao Duan, Shaofeng Yang, Shaofeng Yang

“…BackgroundIntervertebral disc degeneration (IDD) significantly contributes to low back pain (LBP), yet effective treatment options are scarce. BSHXF, a classical traditional Chinese medicine formula, demonstrates dual pharmacological actions: tonifying kidneys, strengthening bones, activating blood circulation, and resolving stasis. …”
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Superhydrophobic sand mulch and date palm biochar boost growth of Moringa oleifera in sandy soils via enhanced irrigation and nutrient use efficiency by Kennedy Odokonyero, Kennedy Odokonyero, Kennedy Odokonyero, Bob Vernooij, Bob Vernooij, Bob Vernooij, Batool Albar, Batool Albar, Batool Albar, Lisa Oki Exposito, Lisa Oki Exposito, Lisa Oki Exposito, Aishah Alsamdani, Aishah Alsamdani, Aishah Alsamdani, Amin Akhtar Ghulam Haider, Amin Akhtar Ghulam Haider, Amin Akhtar Ghulam Haider, Nayara Vivian Huve Musskopf, Nayara Vivian Huve Musskopf, Nayara Vivian Huve Musskopf, Najeh Kharbatia, Adair Gallo, Himanshu Mishra, Himanshu Mishra, Himanshu Mishra

“…IntroductionIt is desirable to rehabilitate desert ecosystems with a selection of native plant species that render ecosystem services and yield natural products for creating a high-value industry, e.g., pharmaceuticals or cosmetics. …”
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