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6661
The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice
Published 2025-06-01“…Further, we show that the neuronal cell death is observed in the Unc5c KI/KI mice by 12 months of age by TUNEL analysis and activated Caspase 3/7 assay. Proteomic analysis of hippocampal samples showed upregulation of oxidative stress and downregulation of chaperone proteins at 18 months corroborating the biochemical and histological results showing increased c-Jun N-terminal Kinase (JNK) phosphorylation, NADPH oxidase, and decreased Netrin1 levels. …”
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6662
From Crisis to Transformation: Lessons Learned and Recommendations for LIS Graduate Programs in Thailand Post-Pandemic
Published 2024-12-01“…Based on the results, this research proposes that hybrid learning is applicable for the advancement of LIS graduate programs in the post-pandemic era. Additionally, creating more effective online teaching and learning environments and expanding collaborative teaching and learning networks are essential for the success of the programs.…”
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6663
Interval-valued spherical fuzzy extension of SWARA for prioritizing strategies to unlock Africa's potential in the carbon credit market
Published 2024-09-01“…It highlights three critical strategies for maximizing Africa's carbon credit market potential: harnessing natural resources for carbon sequestration, creating effective legal and regulatory frameworks, and enhancing capacity building and knowledge sharing. …”
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6664
Reviewing History of Earthquake in 21st Century and Possible Infectious Diseases
Published 2024-12-01“…In addition, methods are proposed for effectively preventing infectious diseases brought on by earthquakes. …”
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6665
Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration
Published 2025-03-01“…Among the most promising innovations, mineral-based nanoparticles and nanocomposite hydrogels have emerged as effective strategies for enhancing osteoinductive potential. …”
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6666
Activities of navy chaplains in organising libraries on ships of the Russian Imperial Navy at the turn of the 19th and 20th centuries
Published 2024-12-01“…Some clerics acted quite effectively in this field, but they could not significantly change the general situation that had developed with librarianship on the ships of the Russian Imperial Navy.…”
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6667
Strategic planning of human resources in crisis situations
Published 2025-01-01“…This paper explores the effectiveness of strategic approaches to human resource management during economic disruptions, technological changes, and global crises. …”
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6668
Harvesting thermal energy with green-synthesised copper oxide / silver nanocomposites
Published 2025-12-01“…The Energy-dispersive X-ray spectroscopy analysis verified the existence of Ag, Cu, and O elements in the created nanocomposites. …”
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6669
Assessment of the Coverage and Timeliness of Immunization against Selected Vaccine-Preventable Infections in Children in Russia in 2019–2022
Published 2025-03-01“…Vaccination is the most effective preventive measure. The effectiveness of immunization mainly depends on achieving the necessary vaccination coverage and meeting the deadlines for their implementation. …”
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6670
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation
Published 2024-05-01“…Macrophages were cultured with FPHA extract to investigate the effects of FPHA on their polarization and the related osteo-immune microenvironment. …”
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6671
Rosa rugosa R2R3-MYB transcription factors RrMYB12 and RrMYB111 regulate the accumulation of flavonols and anthocyanins
Published 2024-12-01“…Furthermore, it was observed that RrMYBs displayed binding specificity to the promoter region of CsFLS.The functional characterization of the flavonol synthesis regulatory factors RrMYB12 and RrMYB111 offers a deeper understanding of the regulatory mechanism governing flavonol biosynthesis in roses, while also presenting an effective tool for genetic manipulation aimed at creating new varieties.…”
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6672
The function of irony in the composition of a neo-romantic short story
Published 2024-12-01“…This article raises the issue of ironic effects manifestation at the composition level. The novelistic part of the work of the neo-romanticist A. …”
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6673
Evaluation of the Seismic Behavior Based on the Performance of Special Steel Moment Frames by Modified Energy Method and Force Design Method
Published 2022-01-01“…Performance level criteria of the ASCE41-17 code have been applied in the design, and the P−Δ effects have also been considered in the nonlinear analysis. …”
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6674
Transversal approach to digital risk management
Published 2021-03-01“…When studying the main areas of the emergence of digital risks in an organization, the authors concluded that it is necessary to develop a universal approach to creating an effective risk management mechanism in the digital environment. …”
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6675
ORGANIZATIONAL AND PEDAGOGICAL CONDITIONS OF USE OF INFORMATION TECHNOLOGIES IN BLENDED LEARNING OF FUTURE OFFICERS
Published 2024-06-01“…The blended system of education enables teachers of the higher education institutions to combine the best methods of traditional pedagogy with modern technological tools, which contributes to a more flexible, interactive and effective learning process that meets the requirements of the modern military environment. …”
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6676
GenomicGapID: leveraging spatial distribution of conserved genomic sites for broad-spectrum microbial identification
Published 2025-05-01“…While we found that the use of amplicon size signatures alone would require an impractical number of universal primer sets, we demonstrate that this challenge can be effectively mitigated through concurrent melt analysis. …”
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6677
Why Do Heterogeneous Outcomes Emerge in Urban Village Redevelopment? A Comparative Study of Four Cases in China
Published 2024-11-01“…A comparative case study method is adopted to analyze the transaction costs and the processes applied under distinct institutional arrangements. The analysis of four cases demonstrates how institutional arrangements affect transaction costs by creating a power structure that encompasses the different participants, who represent the different interests of constituent groups in exchanges of land and housing. …”
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6678
Unleashing EFL Learning in The Digital Age: Online Resources and Student Engagement
Published 2024-11-01“…While, the type of research was content analysis. The results show that through the use of relevant and engaging content, combined with technology-based tools and a student-centered approach, a dynamic learning environment is created. …”
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6679
Intellectual property protection as catalyst for radical technological innovation in national research program teams through innovation milieu and group potentials
Published 2024-10-01“…Survey data from 336 national research project team members from universities and enterprises were used to analyze the theoretical model of this study, bringing in the chain-mediated effects of innovation milieu (IM) and group potential (GP) for analysis, as well as two-stage hybrid partial least squares structural equation modeling (PLS-SEM) and artificial neural network techniques (ANN) to evaluate the hypotheses. …”
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6680
MARKET LEVEL OF AGRI-FOOD PRODUCTS IN ALBANIA, LOCAL PRODUCTION, COMPETITIVENESS AND IMPACT OF MARKETING
Published 2024-01-01“…The purpose of this paper is the analysis of the existing situation in the development of the competitiveness of agri-food products as a result of the application of marketing, through which the market will be studied and make the agricultural producer aware of the increase of their performance in the market, through the production of quality and cost-effective products. …”
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