Bicuspid aortic valve repair using geometric ring annuloplasty: A first-in-humans pilot trialCentral MessagePerspective by J. Scott Rankin, MD, Domenico Mazzitelli, MD, Theodor J.M. Fischlein, MD, Yeong-Hoon Choi, MD, Diana Aicher, MD, Lawrence M. Wei, MD, Vinay Badhwar, MD

“…A geometric annuloplasty ring has been developed, and 2-year regulatory outcomes of a first-in-humans pilot trial are reported. …”
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Novel HSA-PMEMA Nanomicelles Prepared via Site-Specific In Situ Polymerization-Induced Self-Assembly for Improved Intracellular Delivery of Paclitaxel by Yang Chen, Shuang Liang, Binglin Chen, Fei Jiao, Xuliang Deng, Xinyu Liu

“…Tremendous potential lies in these micelles for developing safer and more efficient next-generation PTX formulations for tumor treatment.…”
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Identification of Deregulated miRNAs and mRNAs Involved in Tumorigenesis and Detection of Glioblastoma Patients Applying Next-Generation RNA Sequencing by Dóra Géczi, Álmos Klekner, István Balogh, András Penyige, Melinda Szilágyi, József Virga, Andrea Bakó, Bálint Nagy, Bernadett Torner, Zsuzsanna Birkó

“…Furthermore, a protein–protein interaction (PPI) network was created from the miRNA targets by applying the NetworkAnalyst 3.0 tool. …”
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A systematic scoping review of mentoring support on professional identity formation by Lalit Kumar Radha Krishna, Hannah Yi Fang Kwok, Nila Ravindran, Xuan Yu Tan, Jasper Soh, Darius Wei Jun Wan, Varsha Rajalingam, Jun Kiat Lua, Elizabeth Yong Mei Leong, Tiat Yan Low, Aiden Wei-Jun Chan, Chong Jin Nicholas Lim, Yen Kit Ng, Arthena Anushka Thenpandiyan, Adele Yi Dawn Lim, Leia Ning Tse, Sriram PL, Sri Priyanka Rajanala, Jun Rey Leong, Elaine Li Ying Quah, Victoria Jia En Fam, Ranitha Govindasamy, Nur Amira Binte Abdul Hamid, Crystal Lim, Dorsett Shin Wei Sim, Eng Koon Ong, Stephen Mason, Nagavalli Somasundaram, Simon Yew Kuang Ong

“…The Jigsaw Perspective combined complementary themes and categories, creating broader themes/categories. The subsequent Funnelling Process formed key domains that platformed the synthesis of the discussion. …”
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Implementation of hybrid simulation training to promote collective and self-efficacy in medical students: a two-pronged approach by Calvin Yuk Wang Tam, John Ian Wilzon T. Dizon, Simon Wai Ching Sin, Gloria Kai Yan Tang, Victor Yuk Wah Lai, Yvonne Yin Wong, Fraide A. Ganotice, Pauline Yeung Ng

“…Recent innovations in virtual patient simulation software (VPS) invites the opportunity for conjoined use with basic manikins, creating a hybrid model for acute-care teaching. This study aimed to: ① Assess the impact of hybrid simulation teaching on the collective efficacy (CE) and self-efficacy (SE) of medical students, and ② evaluate psychometric measurement scales within the simulation context.Methods A prospective cross-sectional cohort study was conducted between 22 September 2023, and 19 December 2023. …”
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Distribution Shifts of <i>Acanthaster solaris</i> Under Climate Change and the Impact on Coral Reef Habitats by Shangke Su, Jinquan Liu, Bin Chen, Wei Wang, Jiaguang Xiao, Yuan Li, Jianguo Du, Jianhua Kang, Wenjia Hu, Junpeng Zhang

“…These findings highlight the need for targeted conservation efforts and the development of mitigation strategies to protect coral reefs from the growing threat posed by <i>A. solaris</i>.…”
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Six decades of global coral bleaching monitoring: a review of methods and call for enhanced standardization and coordination by Andrea Rivera-Sosa, Aarón Israel Muñiz-Castillo, Ben Charo, Gregory P. Asner, Chris M. Roelfsema, Simon D. Donner, Brianna D. Bambic, Ana Gabriela Bonelli, Ana Gabriela Bonelli, Morgan Pomeroy, Morgan Pomeroy, Derek Manzello, Paulina Martin, Helen E. Fox

“…These issues hinder comparative analyses and contribute to discrepancies in global bleaching impact assessments. We developed a typology of twenty-nine coral bleaching methods used across various scales, encompassing remote sensing tools, underwater surveys, and specimen collection. …”
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Decoding diabetic kidney disease: a comprehensive review of interconnected pathways, molecular mediators, and therapeutic insights by Esienanwan Esien Efiong, Kathrin Maedler, Emmanuel Effa, Uchechukwu Levi Osuagwu, Esther Peters, Joshua Onyeka Ikebiuro, Chisom Soremekun, Ugwunna Ihediwa, Jiefei Niu, Markéta Fuchs, Homa Bazireh, Akang Leonard Bassey, Peter Uchenna Amadi, Qiuling Dong, Njogu Mark Kimani, Rebecca Chinyelu Chukwuanukwu, Emmy Tuenter, Sapna Sharma, Harald Grallert

“…Main body In DKD, numerous dysbalanced metabolic, haemodynamic, inflammatory signalling pathways, and molecular mediators interconnect, creating a feedback loop that promotes general kidney damage. …”
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Enhancing crop resilience to water stress through iron nanoparticles: A critical review of applications and implications by Tajwar Alam, Sanaullah Jalil, Ghulam Jilani, Arshad Nawaz Chaudhry, Zia Ul-Haq, Iram Naz, Muhammad Abbas Khan, Xinghong Yang, Marian Brestic, Milan Skalicky, Ayman El Sabagh

“…Particularly, Fe-NPs improve water use efficiency (WUE) and root development, facilitating water and nutrient uptake under stress conditions. …”
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Highly Efficient Regeneration of <i>Bombax ceiba</i> via De Novo Organogenesis from Hypocotyl and Bud Explants by Yamei Li, Qionghai Jiang, Lisha Cha, Fei Lin, Fenling Tang, Yong Kang, Guangsui Yang, Surong Huang, Yuhua Guo, Junmei Yin

“…However, its seeds lose viability rapidly after harvest, which has created hurdles in large-scale propagation. Here, we describe the development of a rapid and efficient de novo organogenesis system for <i>Bombax ceiba</i>, incorporating both indirect and direct regeneration pathways. …”
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Testing of Retail Cheese, Butter, Ice Cream, and Other Dairy Products for Highly Pathogenic Avian Influenza in the US by David L. Suarez, Iryna V. Goraichuk, Lindsay Killmaster, Erica Spackman, Nicole J. Clausen, Tristan J. Colonius, Cynthia L. Leonard, Monica L. Metz

“…Revised protocols were developed to extract RNA from solid dairy products including cheese and butter. …”
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Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations by Yusu Peng, Qingqing Feng, Ting Shao, Jiafan Zhang, Sai Liu, Huifeng Wang, Hua Li, Keli Long

“…To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. …”
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Comparing AI/ML approaches and classical regression for predictive modeling using large population health databases: Applications to COVID-19 case prediction by Lise M. Bjerre, Cayden Peixoto, Rawan Alkurd, Robert Talarico, Rami Abielmona

“…Methods: Using Ontario's population health databases, we created a cohort of residents of the city of Ottawa, Ontario, who underwent a PCR test for COVID-19 between March 10, 2020, and May 13, 2021. …”
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The study on the function and cell source of interleukin‐6 in interstitial cystitis/bladder painful syndrome rat model by Zhenming Zheng, Jiapeng Zhang, Caixia Zhang, Wenshuang Li, Kaiqun Ma, Hao Huang, Kuiqing Li, Yousheng Yao

“…Methods IC/BPS rat model was created in female rats by using long‐term intermittent intravesical hyaluronidase (0.5 ml, 4 mg/ml). …”
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Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations by Cheng Zhang, Yina Li, Fangyang Li, Wanyun Dang, Zhuo Shi, Chunqi Yang, Chengrong Xiao, Xianglin Tang, Yuguang Wang, Yuguang Wang, Yuguang Wang, Yue Gao, Yue Gao, Yue Gao, Yue Gao

“…Current assessment methods are often inefficient and costly, creating an urgent need for new strategies to evaluate herbal medicine toxicity. …”
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Computational identification of promising genetic markers associated with molecular mechanisms of reduced rice resistance to <i>Rhizoctonia solani</i> under excess nitrogen fertili... by E. A. Antropova, A. R. Volyanskaya, A. V. Adamovskaya, P. S. Demenkov, I. V. Yatsyk, T. V. Ivanisenko, Y. L. Orlov, Ch. Haoyu, M. Chen, V. A. Ivanisenko

“…The results provide a theoretical basis for experimental work on creating new rice varieties with increased pathogen resistance under excessive nitrogen nutrition. …”
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Optimization of IMU-based bending strain solving algorithm and full-scale experimental validation by Tong SHI, Xiaoben LIU, Lin ZHANG, Jun WANG, Rui LI, Ting Xie, Qingshan FENG, Qiyu HUANG

“…In addition, a simulation database was created for pipelines with a diameter of 508 mm under varying bending strain conditions. …”
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Ecological impacts of single-axis photovoltaic solar energy with periodic mowing on microclimate and vegetation by Yudi Li, Yudi Li, Alona Armstrong, Alona Armstrong, Christopher Simmons, Noah Z. Krasner, Noah Z. Krasner, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez

“…Furthermore, PV panel rotation influenced shading patterns throughout the day, creating temporal variability in air temperature and vapor pressure deficit. …”
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Do shoulder kinematics change after reverse total shoulder arthroplasty? by Itaru Kawashima, MD, PhD, Eric R. Wagner, MD, MS, Joseph J. King, MD, Zaamin B. Hussain, MD, EdM, Sameer R. Khawaja, BS, Jaden C. Hadrick, BS, Krishna N. Chopra, MA, Michael B. Gottschalk, MD, Scott A. Banks, PhD, Thomas W. Wright, MD

“…However, it remains unclear whether the kinematic changes observed in shoulders following rTSA were present preoperatively or developed as a result of the surgery. Furthermore, the impact of preoperative scapulohumeral rhythm (SHR) on the postoperative SHR after rTSA is also poorly understood. …”
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Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…Conclusively, leveraging these results, we have created an online analytical tool (https://xulymphoma.shinyapps.io/PCDI_pred/) designed for the prognostic prediction of patients with less‐defined subtype DLBCL. …”
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